Tumor-associated calreticulin variants functionally compromise the peptide loading complex and impair its recruitment of MHC-I
Arshad N, Cresswell P. Tumor-associated calreticulin variants functionally compromise the peptide loading complex and impair its recruitment of MHC-I. Journal Of Biological Chemistry 2018, 293: 9555-9569. PMID: 29769311, PMCID: PMC6016473, DOI: 10.1074/jbc.ra118.002836.Peer-Reviewed Original ResearchConceptsMyeloproliferative neoplasmsPeptide loading complexMHC-I levelsMajor histocompatibility complexEffective immunotherapyAntigen presentationImmune surveillanceImmune systemBlood tumorsSomatic frameshift mutationsTumor cellsMHCHistocompatibility complexSurface expressionGlycan-dependent mannerNeoplasmsTumorsNormal cellsReduced bindingHigh-affinity peptidesEndoplasmic reticulumBind peptidesCellsCalreticulinFrameshift mutation