2024
Upper respiratory Streptococcus pneumoniae colonization among working-age adults with prevalent exposure to overcrowding
Parker A, Jackson N, Awasthi S, Kim H, Alwan T, Wyllie A, Kogut K, Holland N, Mora A, Eskenazi B, Riley L, Lewnard J. Upper respiratory Streptococcus pneumoniae colonization among working-age adults with prevalent exposure to overcrowding. Microbiology Spectrum 2024, 12: e00879-24. PMID: 39012111, PMCID: PMC11302326, DOI: 10.1128/spectrum.00879-24.Peer-Reviewed Original ResearchPneumococcal carriageStreptococcus pneumoniae</i>Pneumococcal diseaseLt;5 yearsPredictors of carriagePrecursor to pneumococcal diseaseAssociated with increased riskRisk of carriageExposure to childrenYoung childrenExposure to young childrenCycle threshold valuesPneumococcal densityVulnerable age groupRisk factorsPneumococcal transmissionIncreased prevalenceNon-carriersPneumococciAge groupsCarriageSaliva samplesAdult populationMilitary recruitsQuantitative PCR assay
2023
Saliva as an alternative sample type for detection of pneumococcal carriage in young children
Wyllie A, Rots N, Wijmenga-Monsuur A, van Houten M, Sanders E, Trzciński K. Saliva as an alternative sample type for detection of pneumococcal carriage in young children. Microbiology 2023, 169: 001394. PMID: 37819029, PMCID: PMC10634364, DOI: 10.1099/mic.0.001394.Peer-Reviewed Original ResearchConceptsNasopharyngeal swabsCarriage detectionPneumococcal carriageSaliva samplesSubset of serotypesOlder age groupsConventional cultureAlternative sample typePneumococcal colonizationPneumococcal detectionPolymicrobial growthAge groupsStudy participantsSaliva samplingSwabsDiagnostic culturesGold standardLongitudinal studyYoung childrenSalivaCarriageChildrenInfantsMolecular detection methodsPneumococci