Genetic heterogeneity revealed by sequence analysis of Mycobacterium tuberculosis isolates from extra-pulmonary tuberculosis patients
Das S, Roychowdhury T, Kumar P, Kumar A, Kalra P, Singh J, Singh S, Prasad H, Bhattacharya A. Genetic heterogeneity revealed by sequence analysis of Mycobacterium tuberculosis isolates from extra-pulmonary tuberculosis patients. BMC Genomics 2013, 14: 404. PMID: 23773324, PMCID: PMC3699378, DOI: 10.1186/1471-2164-14-404.Peer-Reviewed Original ResearchConceptsM. tuberculosisClinical isolatesDrug resistant tubercle bacilliExtra-pulmonary tuberculosis patientsMajor public health problemExtra-pulmonary patientsNon-pulmonary sitesResistant tubercle bacilliExtra-pulmonary TBExtra-pulmonary tuberculosisPublic health problemSingle nucleotide variationsSpread of tuberculosisTotal clinical casesNext-generation sequencing approachHIV patientsImmunocompetent patientsTuberculosis patientsClinical manifestationsPulmonary patientsM. tuberculosis H37RvPatient isolatesCerebrospinal fluidHealth problemsPatients