Development of the Fetal Bone Marrow Niche and Regulation of HSC Quiescence and Homing Ability by Emerging Osteolineage Cells
Coşkun S, Chao H, Vasavada H, Heydari K, Gonzales N, Zhou X, de Crombrugghe B, Hirschi KK. Development of the Fetal Bone Marrow Niche and Regulation of HSC Quiescence and Homing Ability by Emerging Osteolineage Cells. Cell Reports 2014, 9: 581-590. PMID: 25310984, PMCID: PMC4266564, DOI: 10.1016/j.celrep.2014.09.013.Peer-Reviewed Original ResearchConceptsOsteolineage cellsHematopoietic stem cellsHSC developmentCellular componentsAdult-repopulating hematopoietic stem cellsBone marrow nicheEmbryonic day 16.5HSC quiescenceMultilineage progenitorsSpecialized nichesNiche formationFetal bone marrow cellsHSC activityMarrow nicheMultilineage coloniesStem cellsBone marrow cellsDay 16.5NicheHSC proliferationHoming abilityMarrow cellsCellsBone marrowStromal components