2015
Integrated genomic characterization of IDH1-mutant glioma malignant progression
Bai H, Harmancı AS, Erson-Omay EZ, Li J, Coşkun S, Simon M, Krischek B, Özduman K, Omay SB, Sorensen EA, Turcan Ş, Bakırcığlu M, Carrión-Grant G, Murray PB, Clark VE, Ercan-Sencicek AG, Knight J, Sencar L, Altınok S, Kaulen LD, Gülez B, Timmer M, Schramm J, Mishra-Gorur K, Henegariu O, Moliterno J, Louvi A, Chan TA, Tannheimer SL, Pamir MN, Vortmeyer AO, Bilguvar K, Yasuno K, Günel M. Integrated genomic characterization of IDH1-mutant glioma malignant progression. Nature Genetics 2015, 48: 59-66. PMID: 26618343, PMCID: PMC4829945, DOI: 10.1038/ng.3457.Peer-Reviewed Original ResearchConceptsDevelopmental transcription factorsActivation of MYCMalignant progressionGenomic approachesPI3K pathwayGlioma malignant progressionEpigenetic silencingIDH1 mutant gliomasTranscription factorsIntegrated genomic characterizationGenomic characterizationRTK-RASOncogenic pathwaysK pathwayClonal expansionPathwaySilencingMYCProgression
2013
Hemogenic Endothelial Cell Specification Requires c-Kit, Notch Signaling, and p27-Mediated Cell-Cycle Control
Marcelo KL, Sills TM, Coskun S, Vasavada H, Sanglikar S, Goldie LC, Hirschi KK. Hemogenic Endothelial Cell Specification Requires c-Kit, Notch Signaling, and p27-Mediated Cell-Cycle Control. Developmental Cell 2013, 27: 504-515. PMID: 24331925, PMCID: PMC3994666, DOI: 10.1016/j.devcel.2013.11.004.Peer-Reviewed Original ResearchMeSH KeywordsAldehyde OxidoreductasesAnimalsAntineoplastic AgentsCell Cycle CheckpointsCell DifferentiationCore Binding Factor Alpha 2 SubunitCyclin-Dependent Kinase Inhibitor p27Embryo Culture TechniquesEndothelial CellsFemaleHematopoietic Stem CellsLac OperonLentivirusMaleMiceMice, KnockoutPregnancyProto-Oncogene Proteins c-kitProto-Oncogene Proteins c-mybReceptor, Notch1Signal TransductionTretinoinConceptsCell cycle controlEndothelial cell specificationEndothelial cell developmentNotch signalingCell specificationCell developmentPrimordial endothelial cellsHemogenic endothelial cellsRetinoic acidCell cycle regulationC-kitHuman stem cellsRas regulationEndothelial cellsMolecular signalsStem cellsSignalingP27 expressionP27RegulationCellsEmbryogenesisClinical therapyMechanismExpression