2015
Vascular Niche in HSC Development, Maintenance and Regulation
Coşkun S, Hirschi K. Vascular Niche in HSC Development, Maintenance and Regulation. Stem Cell Biology And Regenerative Medicine 2015, 191-219. DOI: 10.1007/978-3-319-21705-5_9.Peer-Reviewed Original ResearchVascular nicheVascular niche cellsExtraembryonic yolk sacStem cellsBlood cell lineagesHSC ontogenyMammalian embryogenesisAorta-gonadHSC developmentHSC maintenanceMesonephros (AGM) regionHematopoietic stem cellsCellular phenotypesNiche cellsMolecular basisNiche compositionCell lineagesMulti-potent cellsNiche typesExtracellular matrixNicheYolk sacVascular cellsUnique microenvironmentFetal liver
2010
Establishment and regulation of the HSC niche: Roles of osteoblastic and vascular compartments
Coskun S, Hirschi KK. Establishment and regulation of the HSC niche: Roles of osteoblastic and vascular compartments. Birth Defects Research Part C Embryo Today Reviews 2010, 90: 229-242. PMID: 21181885, PMCID: PMC5226239, DOI: 10.1002/bdrc.20194.Peer-Reviewed Original ResearchConceptsHematopoietic stem cellsAdult bone marrow nichesExtraembryonic yolk sacVascular endothelial cellsAdult bone marrowBone marrow nicheMammalian embryogenesisHSC formationBlood cell typesHematopoiesis changeAorta-gonadHSC generationMesonephros (AGM) regionHSC maturationMajor regulatory factorLifelong supplyMajor cellular componentHSC nicheEndothelial cellsMulti-potent cellsRegulatory factorsCellular componentsCell typesMarrow nicheDifferent tissues