2014
Development of the Fetal Bone Marrow Niche and Regulation of HSC Quiescence and Homing Ability by Emerging Osteolineage Cells
Coşkun S, Chao H, Vasavada H, Heydari K, Gonzales N, Zhou X, de Crombrugghe B, Hirschi KK. Development of the Fetal Bone Marrow Niche and Regulation of HSC Quiescence and Homing Ability by Emerging Osteolineage Cells. Cell Reports 2014, 9: 581-590. PMID: 25310984, PMCID: PMC4266564, DOI: 10.1016/j.celrep.2014.09.013.Peer-Reviewed Original ResearchConceptsOsteolineage cellsHematopoietic stem cellsHSC developmentCellular componentsAdult-repopulating hematopoietic stem cellsBone marrow nicheEmbryonic day 16.5HSC quiescenceMultilineage progenitorsSpecialized nichesNiche formationFetal bone marrow cellsHSC activityMarrow nicheMultilineage coloniesStem cellsBone marrow cellsDay 16.5NicheHSC proliferationHoming abilityMarrow cellsCellsBone marrowStromal components
2011
The Transcription Factor E74-Like Factor Controls Quiescence of Endothelial Cells and Their Resistance to Myeloablative Treatments in Bone Marrow
Sivina M, Yamada T, Park CS, Puppi M, Coskun S, Hirschi K, Lacorazza HD. The Transcription Factor E74-Like Factor Controls Quiescence of Endothelial Cells and Their Resistance to Myeloablative Treatments in Bone Marrow. Arteriosclerosis Thrombosis And Vascular Biology 2011, 31: 1185-1191. PMID: 21350194, PMCID: PMC3100289, DOI: 10.1161/atvbaha.111.224436.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBone Marrow CellsCell CycleCell ProliferationCellular SenescenceChlorocebus aethiopsCOS CellsCyclin-Dependent Kinase 4DNA-Binding ProteinsDrug ResistanceEndothelial CellsFluorouracilHumansMiceMice, Inbred C57BLMice, KnockoutMyeloablative AgonistsNeovascularization, PhysiologicNIH 3T3 CellsPromoter Regions, GeneticRNA InterferenceTime FactorsTranscription FactorsTransfectionConceptsBone marrowEndothelial cellsSinusoidal blood vesselsCyclin-dependent kinase 4 expressionBlood vesselsCyclin-dependent kinase 4Human umbilical vein endothelial cellsBone marrow endothelial cellsUmbilical vein endothelial cellsMurine endothelial cellsMarrow endothelial cellsVein endothelial cellsMyeloablative treatmentCD45- CD31Cell cycle entryProgenitor cellsMarrowKinase 4Hematopoietic systemCycle entryVascular networkCellsProliferationLineage-specific progenitor cellsVessels
2010
Mdm2 Is Required for Survival of Hematopoietic Stem Cells/Progenitors via Dampening of ROS-Induced p53 Activity
Abbas HA, Maccio DR, Coskun S, Jackson JG, Hazen AL, Sills TM, You MJ, Hirschi KK, Lozano G. Mdm2 Is Required for Survival of Hematopoietic Stem Cells/Progenitors via Dampening of ROS-Induced p53 Activity. Cell Stem Cell 2010, 7: 606-617. PMID: 21040902, PMCID: PMC3026610, DOI: 10.1016/j.stem.2010.09.013.Peer-Reviewed Original ResearchConceptsReactive oxygen speciesPostnatal day 13Cell cycle arrestAbsence of Mdm2Bone marrowAntioxidant treatmentStem cells/progenitorsDay 13Hematopoietic stem cellsMicePostnatal bone marrowFetal liverHematopoietic failureCycle arrestHematopoietic compartmentP53 levelsHematopoietic cellsP53 activityCell deathStem cellsMDM2Survival