2018
Tumor-associated calreticulin variants functionally compromise the peptide loading complex and impair its recruitment of MHC-I
Arshad N, Cresswell P. Tumor-associated calreticulin variants functionally compromise the peptide loading complex and impair its recruitment of MHC-I. Journal Of Biological Chemistry 2018, 293: 9555-9569. PMID: 29769311, PMCID: PMC6016473, DOI: 10.1074/jbc.ra118.002836.Peer-Reviewed Original ResearchMeSH KeywordsAntigen PresentationCalreticulinHEK293 CellsHistocompatibility Antigens Class IHumansMutationNeoplasmsPeptide FragmentsSignal TransductionConceptsMyeloproliferative neoplasmsPeptide loading complexMHC-I levelsMajor histocompatibility complexEffective immunotherapyAntigen presentationImmune surveillanceImmune systemBlood tumorsSomatic frameshift mutationsTumor cellsMHCHistocompatibility complexSurface expressionGlycan-dependent mannerNeoplasmsTumorsNormal cellsReduced bindingHigh-affinity peptidesEndoplasmic reticulumBind peptidesCellsCalreticulinFrameshift mutation
2013
Cyclic nucleotide signaling in intestinal epithelia: getting to the gut of the matter
Arshad N, Visweswariah SS. Cyclic nucleotide signaling in intestinal epithelia: getting to the gut of the matter. WIREs Mechanisms Of Disease 2013, 5: 409-424. PMID: 23610087, DOI: 10.1002/wsbm.1223.Peer-Reviewed Original ResearchConceptsIntestinal epithelial cell homeostasisEpithelial cell homeostasisCyclic AMPCyclic nucleotidesWeb of interactionsNucleotidyl cyclasesSymbiotic microbiotaTranscription factorsProtein kinaseIntestinal epitheliumDownstream effectorsCell homeostasisDiverse processesIntestinal epithelial cellsSecond messengerCyclic GMPIon channelsNutrient absorptionIntrinsic cuesCell proliferationNeoplastic growthEpithelial cellsPathwayNucleotidesKey processes
2012
Familial Diarrhea Syndrome Caused by an Activating GUCY2C Mutation
Fiskerstrand T, Arshad N, Haukanes BI, Tronstad RR, Pham KD, Johansson S, Håvik B, Tønder SL, Levy SE, Brackman D, Boman H, Biswas KH, Apold J, Hovdenak N, Visweswariah SS, Knappskog PM. Familial Diarrhea Syndrome Caused by an Activating GUCY2C Mutation. New England Journal Of Medicine 2012, 366: 1586-1595. PMID: 22436048, DOI: 10.1056/nejmoa1110132.Peer-Reviewed Original ResearchConceptsCystic fibrosis transmembrane regulatorEntire candidate regionCandidate regionsExons of genesHEK293T cellsAffected family membersCyclic guanosine monophosphateSingle nucleotide polymorphismsBacterial heat-stable enterotoxinsFamily membersMutant receptorsChromosome 12GC-C signalingMutant GcRecessive mutationsLinkage analysisTransmembrane regulatorFunctional studiesMissense mutationsGenetic variantsHeterozygous missense mutationMutationsExome sequencingGUCY2C mutationGenes
2009
Receptor guanylyl cyclase C (GC-C): regulation and signal transduction
Basu N, Arshad N, Visweswariah SS. Receptor guanylyl cyclase C (GC-C): regulation and signal transduction. Molecular And Cellular Biochemistry 2009, 334: 67-80. PMID: 19960363, DOI: 10.1007/s11010-009-0324-x.Peer-Reviewed Original Research