2021
Systematic review and meta-analysis of outcomes in patients with suspected pulmonary embolism
Patel P, Patel P, Bhatt M, Braun C, Begum H, Nieuwlaat R, Khatib R, Martins C, Zhang Y, Etxeandia-Ikobaltzeta I, Varghese J, Alturkmani H, Bahaj W, Baig M, Kehar R, Mustafa A, Ponnapureddy R, Sethi A, Thomas M, Wooldridge D, Lim W, Bates S, Lang E, Le Gal G, Haramati L, Kline J, Righini M, Wiercioch W, Schünemann H, Mustafa R. Systematic review and meta-analysis of outcomes in patients with suspected pulmonary embolism. Blood Advances 2021, 5: 2237-2244. PMID: 33900385, PMCID: PMC8095140, DOI: 10.1182/bloodadvances.2020002398.Peer-Reviewed Original ResearchConceptsIncidence of VTENegative D-dimerPulmonary embolismVenous thromboembolismPretest probabilityMajor bleedingD-dimerNegative computed tomography scanRecurrent venous thromboembolismCochrane Central RegisterRecurrent pulmonary embolismLow pretest probabilityIntermediate pretest probabilityRelevant conference proceedingsComputed tomography scanHigh pretest probabilityPostthrombotic sequelaeCause mortalityCentral RegisterControlled TrialsIntracranial hemorrhagePrompt evaluationDiagnostic pathwayEligible studiesTomography scan
2020
Systematic review and meta-analysis of test accuracy for the diagnosis of suspected pulmonary embolism
Patel P, Patel P, Bhatt M, Braun C, Begum H, Wiercioch W, Varghese J, Wooldridge D, Alturkmani H, Thomas M, Baig M, Bahaj W, Khatib R, Kehar R, Ponnapureddy R, Sethi A, Mustafa A, Lim W, Le Gal G, Bates S, Haramati L, Kline J, Lang E, Righini M, Kalot M, Husainat N, Jabiri Y, Schünemann H, Mustafa R. Systematic review and meta-analysis of test accuracy for the diagnosis of suspected pulmonary embolism. Blood Advances 2020, 4: 4296-4311. PMID: 32915980, PMCID: PMC7509887, DOI: 10.1182/bloodadvances.2019001052.Peer-Reviewed Original ResearchConceptsPulmonary embolismCompression ultrasonographyPooled estimatesQ scanSystematic reviewRecurrent pulmonary embolismVentilation-perfusion scanningCertainty of evidenceRelevant conference proceedingsRisk of biasOptimal patient managementD-dimer sensitivityD-dimer assayDiagnostic Accuracy Studies-2Recommendations AssessmentPrompt diagnosisTomography pulmonaryD-dimerCochrane CENTRALTreatable conditionEligible studiesPatient managementReference listsTherapeutic interventionsRelevant reviews