2023
Surgical management of breast fat necrosis: Multi-institutional data analysis of early outcomes and risk factors for complications
Knoedler S, Knoedler L, Patel H, Diatta F, Camacho J, Sofo G, Perozzo F, Evans B, Mookerjee V, Ayyala H, Pomahac B, Kauke-Navarro M. Surgical management of breast fat necrosis: Multi-institutional data analysis of early outcomes and risk factors for complications. Journal Of Plastic Reconstructive & Aesthetic Surgery 2023, 88: 292-295. PMID: 38029475, DOI: 10.1016/j.bjps.2023.11.015.Peer-Reviewed Original ResearchConceptsBreast fat necrosisChronic heart failureRisk factorsAdverse eventsHeart failureFemale patientsSurgical managementFat necrosisNational Surgical Quality Improvement ProgramSurgical Quality Improvement ProgramHigher wound classPostoperative adverse eventsNon-cancerous conditionsOutcomes of interestQuality Improvement ProgramMajority of casesPerioperative algorithmWound classComplication occurrenceComplication ratePostoperative outcomesSurgical complicationsMedical complicationsSurgical treatmentMultivariable analysisIncidence and Risk Factors of Postoperative Complications After Rhinoplasty: A Multi-Institutional ACS-NSQIP Analysis
Knoedler S, Knoedler L, Wu M, Haug V, Broer P, Kauke-Navarro M, Hundeshagen G, Prantl L, Orgill D, Panayi A. Incidence and Risk Factors of Postoperative Complications After Rhinoplasty: A Multi-Institutional ACS-NSQIP Analysis. Journal Of Craniofacial Surgery 2023, 34: 1722-1726. PMID: 37487058, DOI: 10.1097/scs.0000000000009553.Peer-Reviewed Original ResearchConceptsLow serum albuminSurgical adverse eventsAdverse eventsRisk factorsPostoperative outcomesASA scoreComplication rateMale sexSurgeons National Surgical Quality Improvement Program databaseNational Surgical Quality Improvement Program databaseQuality Improvement Program databasePreoperative nutritional optimizationSuperficial incisional infectionAverage patient ageHigher ASA scoreImprovement Program databasePreoperative laboratory valuesACS-NSQIP AnalysisMulti-institutional analysisSingle-institution reportsIncisional infectionPostoperative complicationsPreoperative albuminComplication occurrenceMost patients
2022
Perioperative Outcomes and Risk Profile of 4730 Cosmetic Breast Surgery Cases in Academic Institutions: An ACS-NSQIP Analysis
Knoedler S, Kauke-Navarro M, Haug V, Broer P, Pomahac B, Knoedler L, Panayi A. Perioperative Outcomes and Risk Profile of 4730 Cosmetic Breast Surgery Cases in Academic Institutions: An ACS-NSQIP Analysis. Aesthetic Surgery Journal 2022, 43: 433-451. PMID: 36472232, DOI: 10.1093/asj/sjac320.Peer-Reviewed Original ResearchConceptsChronic obstructive pulmonary diseaseCosmetic breast surgeryObstructive pulmonary diseaseRisk factorsSurgical complicationsPulmonary diseaseSurgeons National Surgical Quality Improvement Program databaseNational Surgical Quality Improvement Program databaseMulti-institutional national databaseMultiple proceduresQuality Improvement Program databaseImprovement Program databaseIndependent risk factorCongestive heart failurePositive safety profileObesity class 1ACS-NSQIP AnalysisAnesthesiology scoreBreast surgery casesPerioperative outcomesPerioperative protocolPostoperative outcomesClinical patternHeart failureFemale patients
2021
Long-term Outcomes After Facial Allotransplantation: Systematic Review of the Literature
Tchiloemba B, Kauke M, Haug V, Abdulrazzak O, Safi AF, Kollar B, Pomahac B. Long-term Outcomes After Facial Allotransplantation: Systematic Review of the Literature. Transplantation 2021, 105: 1869-1880. PMID: 33148976, DOI: 10.1097/tp.0000000000003513.Peer-Reviewed Original ResearchConceptsSystematic reviewAcute cell-mediated rejectionPositive risk-benefit ratioRecurrent acute rejection episodesLong-term outcome dataAcute rejection episodesChronic vascular rejectionFirst year posttransplantImmunosuppression-related complicationsCell-mediated rejectionSingle-center experiencePubMed/MEDLINE databaseLong-term outcomesRisk-benefit ratioEnglish full-text articlesQuality of lifeFull-text articlesAcute rejectionAllograft lossChronic rejectionRejection episodesVascular rejectionInfectious complicationsInfectious episodesMetabolic complicationsDonor and Recipient Matching in Facial Vascularized Composite Allotransplantation: A Closer Look at the Donor Pool
Kauke M, Haug V, Obed D, Diehm Y, Tchiloemba B, Safi AF, Pomahac B. Donor and Recipient Matching in Facial Vascularized Composite Allotransplantation: A Closer Look at the Donor Pool. Plastic & Reconstructive Surgery 2021, 148: 194-202. PMID: 34181616, DOI: 10.1097/prs.0000000000008094.Peer-Reviewed Original ResearchConceptsDonor poolHepatitis CUnited NetworkPotential donorsEpstein-Barr virus seropositivityCytomegalovirus-seropositive donorsUnderrepresented patient groupsOrgan Sharing databaseFacial Vascularized Composite AllotransplantationHigh-risk characteristicsVascularized Composite AllotransplantationActual wait timesAllotransplant patientsSeronegative patientsSeropositive donorsMost patientsAllotransplant recipientsPatient characteristicsRecipient matchingSharing databasePositive donorsPatient groupVirus seropositivityOrgan SharingOrgan donorsDynamic Maxillary Sinus Changes of Facial Vascularized Composite Allotransplants.
Kauke M, Safi AF, Palmer WJ, Kollar B, Nelms L, Tchiloemba B, Haug V, Pomahac B. Dynamic Maxillary Sinus Changes of Facial Vascularized Composite Allotransplants. Plastic & Reconstructive Surgery 2021, 147: 722-727. PMID: 33620943, DOI: 10.1097/prs.0000000000007673.Peer-Reviewed Original ResearchConceptsMaxillary sinusFace transplant recipientsTransplant recipientsAllograft rejectionTissue changesBiopsy-proven allograft rejectionDiagnosis of rejectionMedication side effectsMaxillary sinus mucosaIndividualized treatment strategiesTissue allograft rejectionVascularized composite allotransplantsFace transplant patientsDynamic tissue changesRadiologic biomarkersRejection gradeTransplant patientsMucosal swellingSinonasal tractSinus changesSinus mucosaClinical managementTomographic scanPathologic changesTreatment strategies
2020
Pathologies of oral and sinonasal mucosa following facial vascularized composite allotransplantation
Kauke-Navarro M, Tchiloemba B, Haug V, Kollar B, Diehm Y, Safi AF, Treister NS, Annino DJ, Marty FM, Lian CG, Murphy GF, Pomahac B. Pathologies of oral and sinonasal mucosa following facial vascularized composite allotransplantation. Journal Of Plastic Reconstructive & Aesthetic Surgery 2020, 74: 1562-1571. PMID: 33376080, DOI: 10.1016/j.bjps.2020.11.028.Peer-Reviewed Original ResearchConceptsNasal mucous membraneMucous membranesMucosal inflammationMucosal lesionsBanff gradeInflammatory mucosal lesionsUlceration/erosionRetrospective cohort studyClinico-pathologic variablesMucosal rejectionCohort studyCutaneous changesIndependent predictorsMucosal assessmentOral lesionsSkin rejectionSinonasal mucosaCommon lesionsMedical recordsUnivariate analysisCutaneous pathologyBuccal mucosaNasal vestibuleOral cavityComposite allotransplantationHypothermic Ex Situ Perfusion of Human Limbs With Acellular Solution for 24 Hours.
Haug V, Kollar B, Tasigiorgos S, Endo Y, Kauke M, Safi AF, Veeramani A, Abdulrazzak O, Bausk B, Walt D, Pomahac B. Hypothermic Ex Situ Perfusion of Human Limbs With Acellular Solution for 24 Hours. Transplantation 2020, 104: e260-e270. PMID: 32168040, DOI: 10.1097/tp.0000000000003221.Peer-Reviewed Original ResearchMucosa and Rejection in Facial Vascularized Composite Allotransplantation: A Systematic Review.
Kauke M, Safi AF, Zhegibe A, Haug V, Kollar B, Nelms L, Palmer WJ, Tchiloemba B, Lian CG, Murphy GF, Pomahac B. Mucosa and Rejection in Facial Vascularized Composite Allotransplantation: A Systematic Review. Transplantation 2020, 104: 2616-2624. PMID: 32053572, DOI: 10.1097/tp.0000000000003171.Peer-Reviewed Original ResearchConceptsMucosal rejectionSystematic reviewRejection gradeMucosal biopsiesPatient managementComposite allotransplantationDiagnosis of rejectionFunction of patientsFacial Vascularized Composite AllotransplantationMeta-Analyses (PRISMA) guidelinesMEDLINE/PubMedPreferred Reporting ItemsVascularized Composite AllotransplantationPosttransplant periodBiopsy gradeSkin rejectionMucosa biopsiesAllograft skinAnimal studiesReporting ItemsBiopsyRejection processFacial allotransplantsMucosaTarget tissues
2019
MMP3 Is a Non-invasive Biomarker of Rejection in Skin-Bearing Vascularized Composite Allotransplantation: A Multicenter Validation Study
Kollar B, Uffing A, Borges TJ, Shubin AV, Aoyama BT, Dagot C, Haug V, Kauke M, Safi AF, Talbot SG, Morelon E, Dakpe S, Pomahac B, Riella LV. MMP3 Is a Non-invasive Biomarker of Rejection in Skin-Bearing Vascularized Composite Allotransplantation: A Multicenter Validation Study. Frontiers In Immunology 2019, 10: 2771. PMID: 31849957, PMCID: PMC6897344, DOI: 10.3389/fimmu.2019.02771.Peer-Reviewed Original ResearchConceptsMatrix metalloproteinase-3MMP3 levelsNon-invasive biomarkersTransplant recipientsAcute rejectionHealthy controlsComposite allotransplantationRejection stateCandidate non-invasive biomarkersUpper extremity transplant recipientsSerum samplesAntibody-mediated rejectionKidney transplant recipientsSeverity of rejectionPre-transplant levelsAutoimmune skin diseaseLongitudinal serum samplesSkin disease patientsVascularized Composite AllotransplantationMulticenter validation studyFace transplant recipientsLarger validation studiesClinical VCARejection episodesVCA patientsDoes Meningioma Volume Correlate With Clinical Disease Manifestation Irrespective of Histopathologic Tumor Grade?
Kauke M, Safi AF, Stavrinou P, Krischek B, Goldbrunner R, Timmer M. Does Meningioma Volume Correlate With Clinical Disease Manifestation Irrespective of Histopathologic Tumor Grade? Journal Of Craniofacial Surgery 2019, 30: e799-e802. PMID: 31633669, DOI: 10.1097/scs.0000000000005845.Peer-Reviewed Original ResearchConceptsHigher tumor volumeTumor gradeTumor volumeClinical disease manifestationsHistopathological tumor gradeHistopathologic tumor gradeRadiological biomarkersClinical symptomsCystic degenerationTumor locationDisease manifestationsPeritumoral edemaTumor aggressivenessMeningioma volumeVolume correlateVolumetric analysisMass effectSemiautomatic image segmentationITK-SNAPEarly and late-recorded predictors of health-related quality of life of burn patients on long-term follow-up
Gojowy D, Kauke M, Ohmann T, Homann HH, Mannil L. Early and late-recorded predictors of health-related quality of life of burn patients on long-term follow-up. Burns 2019, 45: 1300-1310. PMID: 31176508, DOI: 10.1016/j.burns.2019.03.016.Peer-Reviewed Original ResearchConceptsSignificant independent predictor variablesTotal body surface areaHealth-related qualityIndependent predictor variablesHospital stayMechanical ventilationHand functionGeneral populationSummary scoresBurn Specific Health Scale-Brief (BSHS-B) questionnaireGeneric Short Form-36 (SF-36) questionnaireThickness burnsSingle-center cross-sectional studyMultivariate analysisShort Form-36 questionnaireObserver Scar Assessment ScaleIntentional burn injuriesMean burn sizePhysical summary scoreMental component scoreMental summary scoresLong-term outcomesPrimary outcome variableNorm scoresBody surface area
2018
Image segmentation-based volume approximation—volume as a factor in the clinical management of osteolytic jaw lesions
Kauke M, Safi AF, Grandoch A, Nickenig HJ, Zöller J, Kreppel M. Image segmentation-based volume approximation—volume as a factor in the clinical management of osteolytic jaw lesions. Dentomaxillofacial Radiology 2018, 48: 20180113. PMID: 30216090, PMCID: PMC6398913, DOI: 10.1259/dmfr.20180113.Peer-Reviewed Original ResearchDoes volumetric measurement of cervical lymph nodes serve as an imaging biomarker for locoregional recurrence of oral squamous cell carcinoma?
Safi AF, Kauke M, Jung H, Timmer M, Borggrefe J, Persigehl T, Nickenig HJ, Zinser M, Maintz D, Kreppel M, Zöller J. Does volumetric measurement of cervical lymph nodes serve as an imaging biomarker for locoregional recurrence of oral squamous cell carcinoma? Journal Of Cranio-Maxillofacial Surgery 2018, 46: 1013-1018. PMID: 29709330, DOI: 10.1016/j.jcms.2018.04.001.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAged, 80 and overBiomarkersCarcinoma, Squamous CellChemoradiotherapyFemaleHumansLymph NodesLymphatic MetastasisMaleMicrosurgeryMiddle AgedMouth NeoplasmsMultivariate AnalysisNeckNeck DissectionNeoadjuvant TherapyNeoplasm Recurrence, LocalPrognosisRetrospective StudiesRisk FactorsTomography, X-Ray ComputedConceptsOral squamous cell carcinomaLymph node volumeSquamous cell carcinomaLocoregional recurrenceN classificationCell carcinomaNode volumeInclusion criteriaComputed tomographyTreatment-naive oral squamous cell carcinomaIpsilateral lymph node metastasisBetter risk stratification toolsComprehensive neck dissectionPathological N classificationCervical lymph nodesNegative resection marginsRetrospective chart reviewRisk stratification toolLymph node metastasisPreoperative computed tomographyVolumetric measurementsT4b classificationUnresectable diseaseLocoregional failureNeoadjuvant chemoradiotherapyThe importance of lymph node ratio for patients with mandibular infiltration of oral squamous cell carcinoma
Safi AF, Kauke M, Grandoch A, Nickenig HJ, Zöller J, Kreppel M. The importance of lymph node ratio for patients with mandibular infiltration of oral squamous cell carcinoma. Journal Of Cranio-Maxillofacial Surgery 2018, 46: 1007-1012. PMID: 29709331, DOI: 10.1016/j.jcms.2018.03.021.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAged, 80 and overCarcinoma, Squamous CellChemoradiotherapyFemaleHumansKaplan-Meier EstimateLymph Node ExcisionLymph NodesLymphatic MetastasisMaleMandibleMiddle AgedMouth NeoplasmsMultivariate AnalysisNeck DissectionNeoadjuvant TherapyNeoplasm InvasivenessNeoplasm Recurrence, LocalNeoplasm StagingPrognosisRetrospective StudiesRisk AssessmentConceptsOral squamous cell carcinomaSquamous cell carcinomaMandibular infiltrationLocoregional recurrenceCell carcinomaLymph nodesExclusion criteriaTreatment-naive oral squamous cell carcinomaImportance of lymphPathologic N classificationLymph node ratioPositive lymph nodesNegative resection marginsRetrospective chart reviewRisk stratification toolAssessment of prognosisConventional nodalT4b classificationUnresectable diseaseNeoadjuvant chemoradiotherapyPerioperative deathsSynchronous malignanciesChart reviewResection marginsClinicopathological characteristicsVolumetric Analysis of 700 Mandibular Condyles Based Upon Cone Beam Computed Tomography
Safi AF, Kauke M, Grandoch A, Nickenig HJ, Zöller JE, Kreppel M. Volumetric Analysis of 700 Mandibular Condyles Based Upon Cone Beam Computed Tomography. Journal Of Craniofacial Surgery 2018, 29: 506-509. PMID: 29215437, DOI: 10.1097/scs.0000000000004136.Peer-Reviewed Original ResearchConceptsCone beamMandibular condyleIndividualized treatmentRight condyleRetrospective chart reviewCone-beam computerized tomographyChart reviewPathophysiological alterationsUnivariate analysisCondyle volumeComputerized tomographyLeft condyleBivariate analysisMean volumeCondyleVolumetric analysisTomographySignificant differencesP-valueVolumetric measurementsITK-SNAPVolume measurementsAge-Related Volumetric Changes in Mandibular Condyles
Safi AF, Kauke M, Grandoch A, Nickenig HJ, Zöller JE, Kreppel M. Age-Related Volumetric Changes in Mandibular Condyles. Journal Of Craniofacial Surgery 2018, 29: 510-513. PMID: 29215439, DOI: 10.1097/scs.0000000000004137.Peer-Reviewed Original ResearchConceptsCone-beam computerized tomographyMandibular condyleOcclusal supportComputerized tomographyCondylar volumeOlder patient cohortOlder patient groupRetrospective chart reviewPosterior occlusal supportSex-specific significant differencesAge-related volumetric changesSignificant differencesStudent's t-testVolumetric measurementsChart reviewPatient groupPatient cohortPathophysiological alterationsPearson correlation testCondylar changesMajority of studiesImportant additional dataCondyleVolumetric analysisT-testSarcomas of the sinonasal tract
Kauke M, Safi A, Grandoch A, Nickenig H, Zöller J, Kreppel M. Sarcomas of the sinonasal tract. Head & Neck 2018, 40: 1279-1286. PMID: 29443431, DOI: 10.1002/hed.25108.Peer-Reviewed Original ResearchConceptsDisease-free survivalSinonasal sarcomaSingle-institution retrospective cohort studyMultimodal therapeutic regimensRetrospective cohort studyOverall survival rateDFS ratesCohort studySinonasal tractTherapeutic regimensMultimodal therapyPrimary tumorDestructive neoplasmSurvival rateSarcomaTherapeutic assessmentSurgeryPrognosisAgeDisease recognitionRegimensPatientsNeoplasmsTherapyNodalFAMI Screws for Mandibulo-Maxillary fixation in mandibular fracture treatment – Clinico-radiological evaluation
Kauke M, Safi AF, Timmer M, Nickenig HJ, Zöller J, Kreppel M. FAMI Screws for Mandibulo-Maxillary fixation in mandibular fracture treatment – Clinico-radiological evaluation. Journal Of Cranio-Maxillofacial Surgery 2018, 46: 566-572. PMID: 29459185, DOI: 10.1016/j.jcms.2018.01.003.Peer-Reviewed Original ResearchConceptsMandibulo-maxillary fixationMandibular fracture treatmentVisible complicationsMMF screwsFracture siteFracture-related complicationsNerve function impairmentDental hard tissue damageFracture treatmentMucosal signsNerve damageRadiological evaluationFunction impairmentCondylar fracturesSuccessful treatmentPostoperative malocclusionArch barsComplicationsHard tissue damageTissue damageSafe methodTreatmentScrewsFixationDamageDoes volumetric measurement serve as an imaging biomarker for tumor aggressiveness of ameloblastomas?
Safi AF, Kauke M, Timmer M, Grandoch A, Nickenig HJ, Gültekin E, Büttner R, Kreppel M, Zöller J. Does volumetric measurement serve as an imaging biomarker for tumor aggressiveness of ameloblastomas? Oral Oncology 2018, 78: 16-24. PMID: 29496045, DOI: 10.1016/j.oraloncology.2018.01.002.Peer-Reviewed Original Research