2024
Novel physiologic predictors of positive airway pressure effectiveness (NICEPAP) study: rationale, design and methods
Anwar A, Byrne S, Sharma A, Sands S, Wellman A, Redeker N, Yaggi H, Zinchuk A. Novel physiologic predictors of positive airway pressure effectiveness (NICEPAP) study: rationale, design and methods. Sleep And Breathing 2024, 1-11. PMID: 38995327, DOI: 10.1007/s11325-024-03099-w.Peer-Reviewed Original ResearchObstructive sleep apneaPositive airway pressure effectObstructive sleep apnea traitsCPAP effectsCPAP adherencePrimary outcomePurposeContinuous positive airway pressureFunctional Outcomes of Sleep QuestionnaireEffects of CPAPPositive airway pressureAcademic sleep centerObservational cohort studyPrecision medicine approachCPAP dataCPAP efficacyBaseline polysomnographySleep apneaPrimary therapyAirway pressureSleep centerArousal thresholdPatient-centered outcomesPharyngeal collapseSleep qualityCPAPLessons About Low-Dose Morphine at the Intersection of Sleep and Breathlessness.
Domnik N, Yaggi H. Lessons About Low-Dose Morphine at the Intersection of Sleep and Breathlessness. American Journal Of Respiratory And Critical Care Medicine 2024 PMID: 38843192, DOI: 10.1164/rccm.202404-0682ed.Peer-Reviewed Original ResearchLinks Between Obstructive Sleep Apnea and Myocardial Blood Flow Changes Impacting Adverse Cardiovascular Disease-related Outcomes
Aneni E, Sinusas A, Emokpae M, Thorn S, Yaggi H, Miller E. Links Between Obstructive Sleep Apnea and Myocardial Blood Flow Changes Impacting Adverse Cardiovascular Disease-related Outcomes. Current Cardiology Reports 2024, 26: 723-734. PMID: 38806976, DOI: 10.1007/s11886-024-02072-z.Peer-Reviewed Original ResearchObstructive sleep apneaCoronary microvascular dysfunctionAbnormal myocardial blood flowSevere obstructive sleep apneaMyocardial flow reserveMyocardial blood flowSleep apneaModerate to severe obstructive sleep apneaAbnormal myocardial flow reserveRecent FindingsRecent studiesDisease-related outcomesBlood flow changesMyocardial blood flow changesCardiovascular disease-related outcomesMicrovascular dysfunctionClinical impactCPAPReviewRecent studiesStructural abnormalitiesCoronary microcirculationFindingsRecent studiesFlow reserveCardiac workBlood flowApneaInvestigating Brain State Engagement Variability in Individuals With Opioid Use Disorder Using Naturalistic and Task-Based fMRI Data
Ye J, Mehta S, Peterson H, Ibrahim A, Saeed G, Linsky S, Kreinin I, Tsang S, Nwanaji-Enwerem U, Raso A, Yip S, Tokoglu F, Arora J, Constable R, Barry D, Redeker N, Yaggi H, Scheinost D. Investigating Brain State Engagement Variability in Individuals With Opioid Use Disorder Using Naturalistic and Task-Based fMRI Data. Biological Psychiatry 2024, 95: s6. DOI: 10.1016/j.biopsych.2024.02.022.Peer-Reviewed Original Research490. Functional Connectivity Patterns Associated With Self-Reported Pain Measures in Individuals With Opioid Use Disorder
Le M, Mehta S, Peterson H, Ibrahim A, Saeed G, Linsky S, Kreinin I, Tsang S, Nwanaji-Enwerem U, Raso A, Yip S, Barry D, Redeker N, Yaggi H, Scheinost D. 490. Functional Connectivity Patterns Associated With Self-Reported Pain Measures in Individuals With Opioid Use Disorder. Biological Psychiatry 2024, 95: s300. DOI: 10.1016/j.biopsych.2024.02.989.Peer-Reviewed Original Research1. Multimodal Neuroimaging Findings in Individuals With Opioid Use Disorder
Mehta S, Peterson H, Ibrahim A, Saeed G, Linsky S, Kreinin I, Tsang S, Nwanaji-Enwerem U, Raso A, Arora J, Tokoglu F, Hahn C, Lacadie C, Greene A, Constable T, Barry D, Redeker N, Yaggi H, Scheinost D. 1. Multimodal Neuroimaging Findings in Individuals With Opioid Use Disorder. Biological Psychiatry 2024, 95: s99. DOI: 10.1016/j.biopsych.2024.02.236.Peer-Reviewed Original ResearchScreen time, sleep, brain structural neurobiology, and sequential associations with child and adolescent psychopathology: Insights from the ABCD study
Zhao Y, Paulus M, Tapert S, Bagot K, Constable R, Yaggi H, Redeker N, Potenza M. Screen time, sleep, brain structural neurobiology, and sequential associations with child and adolescent psychopathology: Insights from the ABCD study. Journal Of Behavioral Addictions 2024, 13: 542-553. PMID: 38662452, PMCID: PMC11220810, DOI: 10.1556/2006.2024.00016.Peer-Reviewed Original ResearchCross-lagged panel modelScreen media activitySleep problemsExternalizing symptomsAdolescent Brain Cognitive Development StudyLate childhoodCognitive Development StudyPredicted sleep problemsSleep durationAssociated with childrenAdolescent psychopathologyPsychopathological symptomsInternalizing symptomsExternalizing behaviorsPsychopathologyABCD studyStructural covarianceBidirectional associationsSleep concernsPredictive relationshipSleep disturbanceShort sleep durationPanel modelBrain covariesSleep0230 Comparing Subjective and Objective Measures of Chronotypes and Their Associations with Age in Older Adults
Pan Y, Cho G, Burzynski C, Polisetty L, Doyle M, Iannone L, Knauert M, Yaggi H, Gill T, Miner B. 0230 Comparing Subjective and Objective Measures of Chronotypes and Their Associations with Age in Older Adults. Sleep 2024, 47: a99-a99. DOI: 10.1093/sleep/zsae067.0230.Peer-Reviewed Original ResearchOlder adultsAssociated with ageCommunity-living older adultsSleep midpointSeven-daySelf-reported sleep complaintsDays of actigraphyChi-square testTwo-sample t-testActivity countsNo significant differencePearson correlation coefficientAdverse outcomesCT groupMinority raceVariability of chronotypeAdvanced ageObservational studyMorningness-Eveningness QuestionnaireMeasures of chronotypeDemographic factorsSleep onsetModerate correlationSleep disturbanceSignificant difference0309 Concordance in Electroencephalography-Headband versus Polysomnography by Demographics and Cognitive Status
Miner B, Pan Y, Cho G, Burzynski C, Polisetty L, Doyle M, Iannone L, Knauert M, Gill T, Yaggi H. 0309 Concordance in Electroencephalography-Headband versus Polysomnography by Demographics and Cognitive Status. Sleep 2024, 47: a133-a133. DOI: 10.1093/sleep/zsae067.0309.Peer-Reviewed Original ResearchTotal sleep timeIntraclass correlation coefficientMeasure total sleep timeMild cognitive impairmentCognitive statusSleep complaintsNight of home-based polysomnographyHome-based polysomnographySelf-reported sleep complaintsCommunity-living older adultsBetween-group differencesPaired t-testPresence of mild cognitive impairmentExcellent concordanceSleep timeAcceptable alternativeWASOPolysomnographyReduced concordancePSGSleep disturbanceOlder personsOlder adultsPeople of colorWomen0757 Association of Insomnia with Objective Short Sleep Duration and Other Phenotypes with Mortality in Older Persons
Miner B, Pan Y, Cho G, Knauert M, Yaggi H, Gill T, Stone K, Ensrud K, Zeitzer J, Yaffe K, Doyle M. 0757 Association of Insomnia with Objective Short Sleep Duration and Other Phenotypes with Mortality in Older Persons. Sleep 2024, 47: a324-a325. DOI: 10.1093/sleep/zsae067.0757.Peer-Reviewed Original ResearchAssociated with increased mortality riskAssociation of insomniaMortality riskOlder personsShort sleep durationOsteoporotic fracturesAdjusted modelsStudy of Osteoporotic FracturesSleep durationHigher mortality riskCox proportional hazards modelsMen Sleep StudyNormal sleepProportional hazards modelAssociated with mortalitySevere sleep-disordered breathingUnadjusted modelsUnadjusted analysisCausal pathwaysSleep-disordered breathingFollow-up timePrevalence ratesReference groupHazards modelRisk phenotypes0488 Exploring Study Recruitment Trends in the Acute Post-Stroke Setting
Schwarz J, Masroor K, Radulescu R, Tsang S, Sheth K, Redeker N, Yaggi H, Geer J. 0488 Exploring Study Recruitment Trends in the Acute Post-Stroke Setting. Sleep 2024, 47: a210-a210. DOI: 10.1093/sleep/zsae067.0488.Peer-Reviewed Original ResearchContinuous positive airway pressureObstructive sleep apneaPositive airway pressureAcute ischemic strokeAirway pressureUpper airway closureSleep-disordered breathingYale-New Haven HospitalCerebral blood flowOSA screeningOSA treatmentSleep apneaImpact cerebral blood flowAcademic medical centerSympathetic activityClinical trialsPatient populationHemodynamic changesRisk factorsPatientsFunctional recoveryExclusion criteriaAirway closureCardiovascular diseaseBlood flow0486 Performing Polysomnography in the Acute Post-stroke Setting
Masroor K, Schwarz J, Radulescu R, Tsang S, Sheth K, Redeker N, Yaggi H, Geer J. 0486 Performing Polysomnography in the Acute Post-stroke Setting. Sleep 2024, 47: a209-a209. DOI: 10.1093/sleep/zsae067.0486.Peer-Reviewed Original ResearchObstructive sleep apneaSleep apneaRates of obstructive sleep apneaSymptoms of obstructive sleep apneaSevere obstructive sleep apneaObstructive sleep apnea diagnosisAcute settingSleep-disordered breathingPercentage of patientsProportion of patientsYale-New Haven HospitalAHI cutoffOSA prevalenceOSA diagnosisPreventing recurrent strokeImprove stroke recoveryPolysomnography testNew Haven HospitalPolysomnographyScreening patientsTherapeutic windowApneaPatientsRisk factorsMedical records0680 Body Clock and Aging: Relationships of Circadian Rhythm with Sleep Quality, Mental Health and Geriatric Conditions
Adirim Z, Pan Y, Doyle M, Knauert M, Yaggi H, Miner B. 0680 Body Clock and Aging: Relationships of Circadian Rhythm with Sleep Quality, Mental Health and Geriatric Conditions. Sleep 2024, 47: a291-a291. DOI: 10.1093/sleep/zsae067.0680.Peer-Reviewed Original ResearchOlder adult populationMental healthGeriatric conditionsSleep midpointSleep qualityAssociated with cognitive dysfunctionOlder adultsAdult populationAssociated with mental health diagnosesCommunity-dwelling older adultsAssociated with lower cognitive scoresMental health diagnosesAssociated with sleep qualityMental health conditionsSubjective sleep qualityReduced total sleep timeLower cognitive scoresCross-sectional studyGeneral adult populationPsychiatric symptomsTotal sleep timeSelf-reported sleep complaintsCognitive dysfunctionCircadian rhythmLater sleep midpoint0495 Association of Cannabis Use and Symptoms Among Patients with Obstructive Sleep Apnea
Inaya A, Baldassarri S, Sands S, Yaggi H, Wellman A, Redeker N, Zinchuk A. 0495 Association of Cannabis Use and Symptoms Among Patients with Obstructive Sleep Apnea. Sleep 2024, 47: a213-a213. DOI: 10.1093/sleep/zsae067.0495.Peer-Reviewed Original ResearchAssociation of cannabis useCannabis useSleep latencyCannabis usersParticipants self-reported cannabis useLong-term cannabis useLong-term effects of cannabisSelf-reported cannabis useHigh prevalence of painObstructive sleep apneaEffects of cannabisPrevalence of painHigher consumption of alcoholProportion of painNo differenceUsers of cannabisSymptoms of painMann-Whitney U testIncreased sleep latencySleep durationRegular alcohol useSlow wave sleepCPAP effectsOSA severityOSA symptomsArousal threshold modifies the effects of CPAP therapy on neurocognition in men and women in the APPLES study
Zinchuk A, Walker A, Kushida C, Wellman A, Yaggi H, Sands S. Arousal threshold modifies the effects of CPAP therapy on neurocognition in men and women in the APPLES study. Sleep Medicine 2024, 115: 324-325. DOI: 10.1016/j.sleep.2023.11.876.Peer-Reviewed Original ResearchAssociation of Periodic Limb Movements and Obstructive Sleep Apnea With Risk of Cardiovascular Disease and Mortality
Zinchuk A, Srivali N, Qin L, Jeon S, Ibrahim A, Sands S, Koo B, Yaggi H. Association of Periodic Limb Movements and Obstructive Sleep Apnea With Risk of Cardiovascular Disease and Mortality. Journal Of The American Heart Association 2024, 13: e031630. PMID: 38240208, PMCID: PMC11056155, DOI: 10.1161/jaha.123.031630.Peer-Reviewed Original ResearchConceptsPeriodic limb movement indexApnea-hypopnea indexObstructive sleep apneaPeriodic limb movementsSleep apneaIncident cardiovascular diseasePrimary outcomeCardiovascular diseaseAssociation of apnea-hypopnea indexIncreased risk of primary outcomeIncreased riskRisk factorsRisk of primary outcomeAssociated with primary outcomeMedian follow-upBaseline risk of mortalityCox proportional hazards regressionRisk of cardiovascular diseaseLimb movement indexCharlson Comorbidity IndexFramingham risk scoreProportional hazards regressionRisk of mortalityCardiovascular disease eventsFollow-up
2023
Suboptimal Sleep Duration Is Associated With Poorer Neuroimaging Brain Health Profiles in Middle‐Aged Individuals Without Stroke or Dementia
Clocchiatti‐Tuozzo S, Rivier C, Renedo D, Lopez V, Geer J, Miner B, Yaggi H, de Havenon A, Payabvash S, Sheth K, Gill T, Falcone G. Suboptimal Sleep Duration Is Associated With Poorer Neuroimaging Brain Health Profiles in Middle‐Aged Individuals Without Stroke or Dementia. Journal Of The American Heart Association 2023, 13: e031514. PMID: 38156552, PMCID: PMC10863828, DOI: 10.1161/jaha.123.031514.Peer-Reviewed Original ResearchConceptsSuboptimal sleep durationWhite matter hyperintensitiesMiddle-aged individualsLong sleep durationLarger WMH volumeSleep durationMiddle-aged adultsHealth profileWMH volumeAmerican Heart Association's LifeAsymptomatic middle-aged adultsWMH presenceVolume of WMHOptimal sleepSelf-reported sleep durationModifiable risk factorsWhite matter tractsProspective magnetic resonanceSimple 7Cardiovascular healthRisk factorsShort sleepMatter hyperintensitiesHigh riskEarly intervention“What if that’s your last sleep?” A qualitative exploration of the trauma of incarceration and sleep
Elumn J, Li P, Lytell M, Garcia M, Wang E, Yaggi H. “What if that’s your last sleep?” A qualitative exploration of the trauma of incarceration and sleep. SLEEP Advances 2023, 5: zpad055. PMID: 38314119, PMCID: PMC10838125, DOI: 10.1093/sleepadvances/zpad055.Peer-Reviewed Original ResearchHistory of incarcerationSleep problemsSleep healthSleep health disparitiesMulti-level interventionsResults Three themesDescription of sleepLast sleepSleep disordersSleep qualityObjective sleepHealth disparitiesSleepHealth of peopleReflexive thematic analysisLack of accessPaucity of researchTraumaHealthIssues of safetyQualitative explorationThematic analysisPhysical environmental factorsSemi-structured interviewsIncarcerationThe sleep justice study - a prospective cohort study assessing sleep as a cardiometabolic risk factor after incarceration: a protocol paper
Elumn J, Saeed G, Aminawung J, Horton N, Lin H, Yaggi H, Wang E. The sleep justice study - a prospective cohort study assessing sleep as a cardiometabolic risk factor after incarceration: a protocol paper. BMC Public Health 2023, 23: 2107. PMID: 37884957, PMCID: PMC10605958, DOI: 10.1186/s12889-023-16985-x.Peer-Reviewed Original ResearchConceptsCVD risk factor controlPittsburgh Sleep Quality IndexRisk factor controlRisk factorsSleep healthCardiovascular healthCarceral facilitiesEpidemiology of CVDCardiometabolic risk factorsCardiovascular risk factorsCardiovascular disease eventsOngoing prospective cohortProspective cohort studySleep Quality IndexPopulation-specific risk factorsHistory of incarcerationRest-activity patternsObjective measuresSTOP-BangCardiovascular outcomesCardiovascular riskCohort studyProspective cohortCVD epidemiologyFactor controlInsomnia and Early Incident Atrial Fibrillation: A 16‐Year Cohort Study of Younger Men and Women Veterans
Gaffey A, Rosman L, Lampert R, Yaggi H, Haskell S, Brandt C, Enriquez A, Mazzella A, Skanderson M, Burg M. Insomnia and Early Incident Atrial Fibrillation: A 16‐Year Cohort Study of Younger Men and Women Veterans. Journal Of The American Heart Association 2023, 12: e030331. PMID: 37791503, PMCID: PMC10757545, DOI: 10.1161/jaha.123.030331.Peer-Reviewed Original ResearchConceptsObstructive sleep apneaIncident atrial fibrillationAtrial fibrillationHealth care utilizationSleep apneaAF onsetCohort studyCare utilizationAF riskMultivariate Cox proportional hazards modelVeterans Health Administration (VHA) careRisk of AFCox proportional hazards modelCases of AFEarly cardiovascular riskIncident AF riskAssociation of insomniaProportional hazards modelCommon sleep disorderPost-9/11 veteransElectronic health recordsAF incidenceCardiovascular riskClinical comorbiditiesLifestyle factors