Patient genetics is linked to chronic wound microbiome composition and healing
Tipton C, Wolcott R, Sanford N, Miller C, Pathak G, Silzer T, Sun J, Fleming D, Rumbaugh K, Little T, Phillips N, Phillips C. Patient genetics is linked to chronic wound microbiome composition and healing. PLOS Pathogens 2020, 16: e1008511. PMID: 32555671, PMCID: PMC7302439, DOI: 10.1371/journal.ppat.1008511.Peer-Reviewed Original ResearchConceptsFocal adhesionsMicrobiome genome-wide association studyPatient's genetic determinantsMicrobiome diversityChronic wound microbiomeWide association studyMicrobiome compositionWound microbiomeGenomic lociCytoskeletal dynamicsBacterial exploitationGenetic variationAlternative transcriptsExpression differencesChronicity of woundsAssociation studiesAdhesion phenotypePseudomonas aeruginosaCellular migrationRelative abundanceGenetic determinantsSignificant inter-patient variationLociDiversityGenetic ancestry