2022
Sex-Specific Genetic and Transcriptomic Liability to Neuroticism
Wendt FR, Pathak GA, Singh K, Stein MB, Koenen KC, Krystal JH, Gelernter J, Davis LK, Polimanti R. Sex-Specific Genetic and Transcriptomic Liability to Neuroticism. Biological Psychiatry 2022, 93: 243-252. PMID: 36244801, PMCID: PMC10508260, DOI: 10.1016/j.biopsych.2022.07.019.Peer-Reviewed Original ResearchConceptsGenome-wide association studiesTranscriptomic profilesAssociation studiesSingle nucleotide polymorphism heritabilityGene expression variationGenome-wide significanceSex-specific geneticChromosomal variationTranscriptomic changesRisk lociExpression variationBiological processesMolecular pathwaysLociPolygenic associationSex-specific effectsGenetic correlatesPolygenic scoresUK BiobankGenetic riskNCOA6GeneticsHeritabilityPathwayFemales
2020
Patient genetics is linked to chronic wound microbiome composition and healing
Tipton C, Wolcott R, Sanford N, Miller C, Pathak G, Silzer T, Sun J, Fleming D, Rumbaugh K, Little T, Phillips N, Phillips C. Patient genetics is linked to chronic wound microbiome composition and healing. PLOS Pathogens 2020, 16: e1008511. PMID: 32555671, PMCID: PMC7302439, DOI: 10.1371/journal.ppat.1008511.Peer-Reviewed Original ResearchConceptsFocal adhesionsMicrobiome genome-wide association studyPatient's genetic determinantsMicrobiome diversityChronic wound microbiomeWide association studyMicrobiome compositionWound microbiomeGenomic lociCytoskeletal dynamicsBacterial exploitationGenetic variationAlternative transcriptsExpression differencesChronicity of woundsAssociation studiesAdhesion phenotypePseudomonas aeruginosaCellular migrationRelative abundanceGenetic determinantsSignificant inter-patient variationLociDiversityGenetic ancestry