Circulating mitochondrial DNA: New indices of type 2 diabetes-related cognitive impairment in Mexican Americans
Silzer T, Barber R, Sun J, Pathak G, Johnson L, O’Bryant S, Phillips N. Circulating mitochondrial DNA: New indices of type 2 diabetes-related cognitive impairment in Mexican Americans. PLOS ONE 2019, 14: e0213527. PMID: 30861027, PMCID: PMC6414026, DOI: 10.1371/journal.pone.0213527.Peer-Reviewed Original ResearchConceptsComplex age-related diseasesCognitive impairmentAlzheimer's diseaseAge-related diseasesMitochondrial DNADiabetes-related cognitive impairmentType 2 diabetesCell-free mitochondrial DNACommon pathophysiological characteristicsSingle significant locusPotential roleLeucine-rich repeat kinase 2Mexican AmericansMexican American cohortMitochondrial DNA copy numberDisease exacerbationIndicators of diseaseRepeat kinase 2Total recall scoresPathophysiological characteristicsDisease progressionCI phenotypeDNA copy numberParkinson's diseaseSignificant loci