Mitochondrial tRNA methylation in Alzheimer’s disease and progressive supranuclear palsy
Silzer T, Pathak G, Phillips N. Mitochondrial tRNA methylation in Alzheimer’s disease and progressive supranuclear palsy. BMC Medical Genomics 2020, 13: 71. PMID: 32429992, PMCID: PMC7236490, DOI: 10.1186/s12920-020-0727-9.Peer-Reviewed Original ResearchConceptsNuclear gene expressionGene-based association studyMitochondrial dysfunctionPost-transcriptional methylationRNA-seq dataSimilar expression profilesPotential molecular underpinningsNeurodegenerative disease pathophysiologyNuclear genesTOP transcriptsSequence-based methodsMitochondrial tRNAsTranslational efficiencyEnrichment testingContext of cancerGene expressionTRNA methylationDegree of methylationExpression profilesBiological processesAssociation studiesMolecular underpinningsMolecular processesMethylationMitochondrial function