Emile Boulpaep, MD
Professor Emeritus of and Senior Research Scientist in Cellular And Molecular PhysiologyCards
Appointments
Additional Titles
Director Medical Studies, Director of Graduate Studies, Cellular and Molecular Physiology
Contact Info
Cellular & Molecular Physiology
PO Box 208026, 333 Cedar Street
New Haven, CT 06520-8026
United States
Appointments
Additional Titles
Director Medical Studies, Director of Graduate Studies, Cellular and Molecular Physiology
Contact Info
Cellular & Molecular Physiology
PO Box 208026, 333 Cedar Street
New Haven, CT 06520-8026
United States
Appointments
Additional Titles
Director Medical Studies, Director of Graduate Studies, Cellular and Molecular Physiology
Contact Info
Cellular & Molecular Physiology
PO Box 208026, 333 Cedar Street
New Haven, CT 06520-8026
United States
About
Titles
Professor Emeritus of and Senior Research Scientist in Cellular And Molecular Physiology
Director Medical Studies, Director of Graduate Studies, Cellular and Molecular PhysiologyAppointments
Cellular & Molecular Physiology
EmeritusPrimaryCellular & Molecular Physiology
Senior Research ScientistSecondary
Other Departments & Organizations
Education & Training
- MD
- University of Louvain (1962)
Research
Overview
Polarized kidney tubule cells have proteins in the plasma membrane facing the urine that differ from those facing the blood. We are studying the electrical characteristics of these proteins-ion channels and electrogenic transporters-in the two plasma membranes of renal tubule cells. Patch-clamp, optical and molecular biology techniques are being used.
- We study the physiological role and regulation of single small-conductance chloride channels, which are activated by cAMP through phosphorylation by protein kinase A. Our interest is in the intracellular signal transduction pathways involved in the regulation of these renal channels and their homology with the CFTR protein, known to be deficient in cystic fibrosis.
- We study the physiological role and regulation of a cGMP-sensitive non-selective cation channel in the apical membrane of a kidney cell line and its homology with a cGMP-gated non-selective channel of the vertebrate photoreceptor.
- Using confocal vital microscopy and ion-sensitive fluorescent dyes, we study a model of proximal tubule cell injury induced by angiotensin II, which is accompanied by elevation of intracellular calcium and plasma membrane blebbing.
Medical Subject Headings (MeSH)
Research at a Glance
Yale Co-Authors
Publications Timeline
Research Interests
Ming Lu, MD
Gary Désir, MD
Henry J. Binder, MD
Leonard Kaczmarek, PhD
Michael Kashgarian, MD, FASN
Frederick Wilson, MD, PhD
Publications
2019
Human Physiology
Boulpaep E, Boron W. Human Physiology. 2019 DOI: 10.1016/b978-0-12-801238-3.62186-4.Peer-Reviewed Original ResearchCitations
2016
Romk1 Knockout Mice Do Not Produce Bartter Phenotype but Exhibit Impaired K Excretion*
Dong K, Yan Q, Lu M, Wan L, Hu H, Guo J, Boulpaep E, Wang W, Giebisch G, Hebert SC, Wang T. Romk1 Knockout Mice Do Not Produce Bartter Phenotype but Exhibit Impaired K Excretion*. Journal Of Biological Chemistry 2016, 291: 5259-5269. PMID: 26728465, PMCID: PMC4777858, DOI: 10.1074/jbc.m115.707877.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and Concepts
2010
Substrate specificity of Rhbg: ammonium and methyl ammonium transport
Nakhoul N, Abdulnour-Nakhoul S, Boulpaep E, Rabon E, Schmidt E, Hamm L. Substrate specificity of Rhbg: ammonium and methyl ammonium transport. American Journal Of Physiology - Cell Physiology 2010, 299: c695-c705. PMID: 20592240, PMCID: PMC2944323, DOI: 10.1152/ajpcell.00019.2010.Peer-Reviewed Original ResearchCitationsMeSH Keywords and ConceptsMouse cystic fibrosis transmembrane conductance regulator forms cAMP-PKA–regulated apical chloride channels in cortical collecting duct
Lu M, Dong K, Egan ME, Giebisch GH, Boulpaep EL, Hebert SC. Mouse cystic fibrosis transmembrane conductance regulator forms cAMP-PKA–regulated apical chloride channels in cortical collecting duct. Proceedings Of The National Academy Of Sciences Of The United States Of America 2010, 107: 6082-6087. PMID: 20231442, PMCID: PMC2851921, DOI: 10.1073/pnas.0902661107.Peer-Reviewed Original ResearchCitationsMeSH Keywords and ConceptsMeSH KeywordsAnimalsBenzoatesChloride ChannelsCyclic AMPCyclic AMP-Dependent Protein KinasesCystic Fibrosis Transmembrane Conductance RegulatorFemaleIn Vitro TechniquesKidney CortexKidney Tubules, CollectingKineticsMiceMice, Inbred C57BLMice, Inbred CFTRMice, KnockoutMice, TransgenicMutationOocytesPatch-Clamp TechniquesPotassium Channels, Inwardly RectifyingRecombinant ProteinsThiazolidinesXenopus laevisConceptsCystic fibrosis transmembrane conductance regulatorFibrosis transmembrane conductance regulatorTransmembrane conductance regulatorCl- channel activityConductance regulatorCl- channelsApical membrane proteinsExpression of CFTRChannel activityCFTR Cl- channelApical chloride channelApical cell membraneDeltaF508 CFTR mutationMembrane proteinsCatalytic subunitXenopus laevis oocytesForm proteinPrincipal cellsCFTR channelsROMK null miceApical patchesApical membraneSingle-channel conductanceChloride channelsCell membrane
2009
CHAPTER 17 ORGANIZATION OF THE CARDIOVASCULAR SYSTEM
Boulpaep E. CHAPTER 17 ORGANIZATION OF THE CARDIOVASCULAR SYSTEM. 2009, 429-447. DOI: 10.1016/b978-1-4160-3115-4.50020-2.ChaptersCitationsCHAPTER 20 THE MICROCIRCULATION
Boulpaep E. CHAPTER 20 THE MICROCIRCULATION. 2009, 482-503. DOI: 10.1016/b978-1-4160-3115-4.50023-8.ChaptersCitationsCHAPTER 19 ARTERIES AND VEINS
Boulpaep E. CHAPTER 19 ARTERIES AND VEINS. 2009, 467-481. DOI: 10.1016/b978-1-4160-3115-4.50022-6.ChaptersCitationsCHAPTER 1 FOUNDATIONS OF PHYSIOLOGY
Boulpaep E, Boron W. CHAPTER 1 FOUNDATIONS OF PHYSIOLOGY. 2009, 3-6. DOI: 10.1016/b978-1-4160-3115-4.50004-4.ChaptersCitationsAltmetricCHAPTER 23 REGULATION OF ARTERIAL PRESSURE AND CARDIAC OUTPUT
Boulpaep E. CHAPTER 23 REGULATION OF ARTERIAL PRESSURE AND CARDIAC OUTPUT. 2009, 554-576. DOI: 10.1016/b978-1-4160-3115-4.50026-3.ChaptersCitationsCHAPTER 22 THE HEART AS A PUMP
Boulpaep E. CHAPTER 22 THE HEART AS A PUMP. 2009, 529-553. DOI: 10.1016/b978-1-4160-3115-4.50025-1.Chapters
Academic Achievements and Community Involvement
honor Bohmfalk Award for Excellence in Basic Science Teaching
Yale University AwardYale UniversityDetails05/21/2001United Stateshonor Dean's Medical Education Farr Prize
Yale University AwardYale School of MedicineDetails05/27/1996United Stateshonor Nobility title of Chevalier/Ridder.
International AwardKingdom of BelgiumDetails01/01/1996United Stateshonor Foreign Honorary Member, Royal Academy of Medicine of Belgium
International AwardRoyal Academy of Medicine of BelgiumDetails01/01/1990United Stateshonor Doctor Honoris Causa
International AwardUniversité Catholique de Louvain, BelgiumDetails01/01/1987United States
Links & Media
News
- December 19, 2016
PA graduates face changing medical profession
- April 13, 2015
Great minds: Yale scientists join global network to advance kidney research
- November 08, 2013
Expert in human polycystic diseases receives American Society of Nephrology’s top honor
- November 05, 2013
Prestigious award goes to Yale nephrologist
Get In Touch
Contacts
Cellular & Molecular Physiology
PO Box 208026, 333 Cedar Street
New Haven, CT 06520-8026
United States