Featured Publications
Recombination in Streptococcus pneumoniae Lineages Increase with Carriage Duration and Size of the Polysaccharide Capsule
Chaguza C, Andam CP, Harris SR, Cornick JE, Yang M, Bricio-Moreno L, Kamng’ona A, Parkhill J, French N, Heyderman RS, Kadioglu A, Everett DB, Bentley SD, Hanage WP. Recombination in Streptococcus pneumoniae Lineages Increase with Carriage Duration and Size of the Polysaccharide Capsule. MBio 2016, 7: e01053-16. PMID: 27677790, PMCID: PMC5040112, DOI: 10.1128/mbio.01053-16.Peer-Reviewed Original ResearchPneumococcal conjugate vaccineInvasive pneumococcal diseasePrevalence of carriageCarriage durationCarriage prevalenceComplex polysaccharide capsulePolysaccharide capsuleVaccine escape variantsSerotype-specific responsesDifferent pneumococcal serotypesResource-poor settingsLonger carriage durationPneumococcal diseaseConjugate vaccinePneumococcal serotypesEscape variantsUnivariate analysisHigh burdenMultivariate analysisStreptococcus pneumoniaeDrug resistanceClinical interventionsPneumococciPrevalenceVaccine
2021
Carriage Dynamics of Pneumococcal Serotypes in Naturally Colonized Infants in a Rural African Setting During the First Year of Life
Chaguza C, Senghore M, Bojang E, Lo SW, Ebruke C, Gladstone RA, Tientcheu PE, Bancroft RE, Worwui A, Foster-Nyarko E, Ceesay F, Okoi C, McGee L, Klugman KP, Breiman RF, Barer MR, Adegbola RA, Antonio M, Bentley SD, Kwambana-Adams BA. Carriage Dynamics of Pneumococcal Serotypes in Naturally Colonized Infants in a Rural African Setting During the First Year of Life. Frontiers In Pediatrics 2021, 8: 587730. PMID: 33489998, PMCID: PMC7820366, DOI: 10.3389/fped.2020.587730.Peer-Reviewed Original ResearchPneumococcal serotypesPneumococcal conjugate vaccineRural African settingFirst yearColonized infantsPneumococcal acquisitionConjugate vaccineCarriage prevalenceInvasive diseaseNewborn infantsWeek 35Week 1Carriage patternsDisease preventionLatex agglutinationInfantsClinical interventionsMultiple serotypesFirst weekCarriage durationAfrican settingCarriage dynamicsBaseline dataSerotypesLimited data