2010
Absence of P-Selectin in Recipients of Allogeneic Bone Marrow Transplantation Ameliorates Experimental Graft-versus-Host Disease
Lu S, Holland A, Na I, Terwey T, Alpdogan O, Bautista J, Smith O, Suh D, King C, Kochman A, Hubbard V, Rao U, Yim N, Liu C, Laga A, Murphy G, Jenq R, Zakrzewski J, Penack O, Dykstra L, Bampoe K, Perez L, Furie B, Furie B, van den Brink M. Absence of P-Selectin in Recipients of Allogeneic Bone Marrow Transplantation Ameliorates Experimental Graft-versus-Host Disease. The Journal Of Immunology 2010, 185: 1912-1919. PMID: 20622117, PMCID: PMC3752704, DOI: 10.4049/jimmunol.0903148.Peer-Reviewed Original ResearchConceptsSecondary lymphoid organsDonor T cellsAllogeneic bone marrow transplantationAlloreactive T cellsBone marrow transplantationT cellsWT T cellsP-selectinP-selectin glycoprotein ligand-1P-selectin ligandsMarrow transplantationSmall bowelInflamed tissuesDonor alloreactive T cellsHost disease (GVHD) pathophysiologyGVHD target organsAlloactivated T cellsLigand 1Wild-type recipientsGVHD mortalityGVHD prophylaxisHost diseaseLymphoid organsPeyer's patchesExperimental disease
2005
A Role for CD54 (Intercellular Adhesion Molecule-1) in Leukocyte Recruitment to the Lung During the Development of Experimental Idiopathic Pneumonia Syndrome
Gerbitz A, Ewing P, Olkiewicz K, Willmarth N, Williams D, Hildebrandt G, Wilke A, Liu C, Eissner G, Andreesen R, Holler E, Guo R, Ward P, Cooke K. A Role for CD54 (Intercellular Adhesion Molecule-1) in Leukocyte Recruitment to the Lung During the Development of Experimental Idiopathic Pneumonia Syndrome. Transplantation 2005, 79: 536-542. PMID: 15753842, DOI: 10.1097/01.tp.0000151763.16800.b0.Peer-Reviewed Original ResearchConceptsDevelopment of IPSIdiopathic pneumonia syndromeGVHD target organsBone marrow transplantationMonoclonal blocking antibodyPulmonary vascular expressionICAM-1Pneumonia syndromeLeukocyte recruitmentBlocking antibodiesVascular expressionTarget organsBronchoalveolar lavage fluid levelsExperimental Idiopathic Pneumonia SyndromeMinor histocompatibility antigenic differencesAllogeneic bone marrow transplantationEndothelial cellsAllogeneic BMT recipientsMurine BMT systemLavage fluid levelsAdhesion molecules CD54ICAM-1 deficiencyICAM-1 expressionWild-type recipientsWild-type controls