S139. PROGRESSIVE DETERIORATION OF WHITE MATTER TRACTS IN SCHIZOPHRENIA: A DIFFUSION MRI STUDY ON A LARGE SINGLE COHORT USING NORMATIVE MODELS
Hwang T, Tung Y, Chen C, Yang L, Hsu Y, Hwu H, Liu C, Chien Y, Hsieh M, Lin Y, Liu C, Tseng W. S139. PROGRESSIVE DETERIORATION OF WHITE MATTER TRACTS IN SCHIZOPHRENIA: A DIFFUSION MRI STUDY ON A LARGE SINGLE COHORT USING NORMATIVE MODELS. Schizophrenia Bulletin 2020, 46: s88-s89. PMCID: PMC7234280, DOI: 10.1093/schbul/sbaa031.205.Peer-Reviewed Original ResearchFirst-episode schizophreniaGeneralized fractional anisotropyChronic schizophreniaPrefrontal lobeEarly stages of schizophreniaMean diffusivityRadial diffusivityStages of schizophreniaAbnormalities of white matterStudies of schizophreniaAxial diffusivityNeural tractsDuration of illnessWhite matter tractsSchizophreniaSingle-site cohortDiffusion MRI studiesFractional anisotropySensorimotor cortexNormative modelDiffusion-weighted imagingHealthy peopleWhite matter involvementMRI studiesNormal controlsClinical implications of oxidative stress in schizophrenia: Acute relapse and chronic stable phase
Chien Y, Hwu H, Hwang T, Hsieh M, Liu C, Lin-Shiau S, Liu C. Clinical implications of oxidative stress in schizophrenia: Acute relapse and chronic stable phase. Progress In Neuro-Psychopharmacology And Biological Psychiatry 2020, 99: 109868. PMID: 31954755, DOI: 10.1016/j.pnpbp.2020.109868.Peer-Reviewed Original ResearchConceptsChronic stable schizophreniaNon-psychiatric controlsDisorganized symptomsChronic stable patientsStable schizophreniaWeeks of antipsychotic treatmentStages of schizophreniaAcute relapseClinical implicationsAntipsychotic treatmentNegative symptomsSchizophreniaStable patientsOxidative stressPlatelet superoxide dismutasePlatelet oxidative stressTreatment responseNitric oxideLipid peroxidationLevels of nitric oxideSymptomsSuperoxide dismutaseTreatment effectsRelapsed patientsRelapse