About
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Research Scientist
Research
Research at a Glance
Yale Co-Authors
Frequent collaborators of Zsuzsanna Tobias's published research.
Publications Timeline
A big-picture view of Zsuzsanna Tobias's research output by year.
Clancy Mullan, MD, PhD
Daniel Jane-Wit, MD/PhD
Francesc Lopez-Giraldez, PhD
Jordan Pober, MD, PhD
W. Mark Saltzman, PhD
Thomas Manes, PhD
8Publications
98Citations
Publications
2024
IL-1β Induces Human Endothelial Surface Expression of IL-15 by Relieving let-7c-3p Suppression of Protein Translation.
Mullan C, Summer L, Lopez-Giraldez F, Tobiasova Z, Manes T, Yasothan S, Song G, Jane-Wit D, Saltzman W, Pober J. IL-1β Induces Human Endothelial Surface Expression of IL-15 by Relieving let-7c-3p Suppression of Protein Translation. The Journal Of Immunology 2024, 213: 1338-1348. PMID: 39302113, PMCID: PMC11493510, DOI: 10.4049/jimmunol.2400331.Peer-Reviewed Original ResearchConceptsIL-15Surface expressionIL-1BIL-15 transcriptsEndothelial cellsCD8 T cell activationExpression of IL-15EC surface expressionIL-15 transpresentationComplement activationGraft endothelial cellsActivity of CTLT cell activationIL-15 mRNAEndothelial surface expressionAbsence of complement activationCultured human endothelial cellsIL-1-mediated activationIL-15RAProtein translationAllograft rejectionRNA polymerase II-mediated transcriptionHuman endothelial cellsSuppression of protein translation
2009
Paricalcitol (19-nor-1,25-dihydroxyvitamin D2) and calcitriol (1,25-dihydroxyvitamin D3) exert potent immunomodulatory effects on dendritic cells and inhibit induction of antigen-specific T cells
Sochorová K, Budinský V, Rožková D, Tobiasová Z, Dusilová-Sulková S, Špíšek R, Bartůňková J. Paricalcitol (19-nor-1,25-dihydroxyvitamin D2) and calcitriol (1,25-dihydroxyvitamin D3) exert potent immunomodulatory effects on dendritic cells and inhibit induction of antigen-specific T cells. Clinical Immunology 2009, 133: 69-77. PMID: 19660988, DOI: 10.1016/j.clim.2009.06.011.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsAntigen-specific T cellsDendritic cellsT cellsVDR agonistsImmunomodulatory effectsChronic immune-mediated inflammatory diseaseEnd-stage renal disease patientsImmune-mediated inflammatory diseasesImmunomodulatory activityVitamin D receptor activatorsRenal disease patientsImmature dendritic cellsRisk of atherosclerosisPathogenesis of atherosclerosisPotent immunomodulatory effectsToll-like receptorsBioactive IL-12Functional TregsIL-12DC differentiationCalcium resorptionDisease patientsHypercalcemic effectInflammatory diseasesImmunomodulatory potency
2007
Phenotype and Function Analysis of Dendritic Cells From Patients with Prostate Carcinoma After Radical Prostatectomy
Minarik I, Tobiasova Z, Bartunkova J, Kawaciuk I. Phenotype and Function Analysis of Dendritic Cells From Patients with Prostate Carcinoma After Radical Prostatectomy. Clinical Immunology 2007, 123: s114-s115. DOI: 10.1016/j.clim.2007.03.505.Peer-Reviewed Original ResearchVitamin D Receptor Activators Calcitriol and Paricalcitol Modulate Dendritic Cell Phenotype and Function In Vitro Study
Sochorova K, Budinsky V, Tobiasova Z, Bartunkova J, Sulkova S. Vitamin D Receptor Activators Calcitriol and Paricalcitol Modulate Dendritic Cell Phenotype and Function In Vitro Study. Clinical Immunology 2007, 123: s51. DOI: 10.1016/j.clim.2007.03.322.Peer-Reviewed Original Research
2006
In vitro assessment of dendritic cells pulsed with apoptotic tumor cells as a vaccine for ovarian cancer patients
Tobiásová Z, Pospíšilová D, Miller A, Minárik I, Sochorová K, Špíšek R, Rob L, Bartůňková J. In vitro assessment of dendritic cells pulsed with apoptotic tumor cells as a vaccine for ovarian cancer patients. Clinical Immunology 2006, 122: 18-27. PMID: 17059893, DOI: 10.1016/j.clim.2006.09.003.Peer-Reviewed Original ResearchCitationsMeSH Keywords and ConceptsConceptsOvarian cancer patientsCancer patientsDendritic cellsAutologous irradiated tumor cellsLymphocyte IFN-gamma productionTumor cellsAntigen-pulsed DCsIFN-gamma ELISPOTMonocyte-derived DCsMaturation of DCsIrradiated tumor cellsIFN-gamma productionNew treatment optionsAbility of DCsResidual tumour diseaseProliferation of lymphocytesApoptotic tumor cellsTumor cell apoptosisDC vaccinesAutologous lymphocytesLymphocyte responsesStandard treatmentTreatment optionsOvarian cancerPatients
2005
Effects of human plasma proteins on maturation of monocyte-derived dendritic cells.
Tobiásová-Czetoová Z, Palmborg A, Lundqvist A, Karlsson G, Adamson L, Bartůnková J, Masucci G, Pisa P. Effects of human plasma proteins on maturation of monocyte-derived dendritic cells. Immunol Lett 2005, 100: 113-9. PMID: 16154491, DOI: 10.1016/j.imlet.2005.03.009.Peer-Reviewed Original ResearchMethods of dendritic cell preparation for acute lymphoblastic leukemia immunotherapy in children
Pospíšilová D, Borovičková J, Rožková D, Stary J, Seifertová D, Tobiásová Z, Špišek R, Bartůnková J. Methods of dendritic cell preparation for acute lymphoblastic leukemia immunotherapy in children. Medical Oncology 2005, 22: 79-88. PMID: 15750200, DOI: 10.1385/mo:22:1:079.Peer-Reviewed Original ResearchCitationsMeSH Keywords and ConceptsConceptsDendritic cellsPeripheral mononuclear cellsAcute lymphoblastic leukemiaMononuclear cellsCostimulatory moleculesBone marrow leukemic blastsPreparation of DCsPeripheral blood mononuclear cellsDendritic cell preparationsSpecific cytotoxic lymphocytesTime of remissionTime of diagnosisMature dendritic cellsBlood mononuclear cellsEfficiency of immunotherapyAutologous lymphocyte proliferationHematopoietic malignant cellsEvidence of inductionInduction chemotherapyBM blastsPediatric patientsCell immunotherapyB-ALLLymphoblastic leukemiaLeukemic blasts
2004
Immunotherapy--perspectives in therapy of ovarian carcinomas.
Zapletalová K, Tobiasová Z, Spísek R, Rob L, Bartůnková J. Immunotherapy--perspectives in therapy of ovarian carcinomas. Česká Gynekologie 2004, 69: 372-5. PMID: 15587893.Peer-Reviewed Original ResearchMeSH Keywords and ConceptsConceptsUniversity Hospital MotolMonoclonal antibody therapyCytokine therapyAntibody therapyMalignant ovarian epithelial tumorsCombination of surgeryDepartment of GynecologyOvarian cancer patientsOvarian epithelial tumorsDendritic cellsVaccine therapyMedical FacultyCancer patientsIL-2Clinical studiesTherapeutic protocolsEpithelial tumorsTherapyGM-CSFImmunotherapyTumor cellsMotolChemotherapySurgeryUsual standard