Jean-Leon Thomas, PhD

Overview

Projet 1: Hox paralog group 2 genes in oligodendrocyte development and myelin repair

(funded by ARSEP, 2010)

Projet 2: Neurogenesis through VEGF-C/VEGFR-3 signaling

(funded by ANR 2010)

Medical Research Interests

Cell Differentiation; Cell Proliferation; Neurogenesis; Stem Cells

Public Health Interests

Perinatal/Prenatal Health; Behavioral Health

ORCID
0000-0003-3397-0292

Research at a Glance

Yale Co-Authors

Frequent collaborators of Jean-Leon Thomas's published research.

Publications

2024

Monoclonal antibodies that block Roundabout 1 and 2 signaling target pathological ocular neovascularization through myeloid cells
Geraldo L, Xu Y, Mouthon G, Furtado J, Leser F, Blazer L, Adams J, Zhang S, Zheng L, Song E, Robinson M, Thomas J, Sidhu S, Eichmann A. Monoclonal antibodies that block Roundabout 1 and 2 signaling target pathological ocular neovascularization through myeloid cells. Science Translational Medicine 2024, 16: eadn8388. PMID: 39565875, DOI: 10.1126/scitranslmed.adn8388.
Peer-Reviewed Original Research
MeSH Keywords and Concepts
The glymphatic system as a nexus between obesity and neurological diseases
Chen B, Lenck S, Thomas J, Schneeberger M. The glymphatic system as a nexus between obesity and neurological diseases. Nature Reviews Endocrinology 2024, 1-2. PMID: 39304738, DOI: 10.1038/s41574-024-01042-3.
Peer-Reviewed Original Research
Concepts
Incidence de la circulation lymphatique méningée sur la réponse à un accident vasculaire cérébral
Thomas J, Boisserand L, Kamouh M. Incidence de la circulation lymphatique méningée sur la réponse à un accident vasculaire cérébral. Médecine/sciences 2024, 40: 604-608. PMID: 39303108, DOI: 10.1051/medsci/2024086.
Peer-Reviewed Original Research
MeSH Keywords
Meningeal lymphatic function promotes oligodendrocyte survival and brain myelination
das Neves S, Delivanoglou N, Ren Y, Cucuzza C, Makuch M, Almeida F, Sanchez G, Barber M, Rego S, Schrader R, Faroqi A, Thomas J, McLean P, Oliveira T, Irani S, Piehl F, Da Mesquita S. Meningeal lymphatic function promotes oligodendrocyte survival and brain myelination. Immunity 2024, 57: 2328-2343.e8. PMID: 39217987, PMCID: PMC11464205, DOI: 10.1016/j.immuni.2024.08.004.
Peer-Reviewed Original Research
Concepts
Meningeal lymphatic vessel dysfunction driven by CGRP signaling causes migraine-like pain in mice
Thomas J, Schindler E, Gottschalk C. Meningeal lymphatic vessel dysfunction driven by CGRP signaling causes migraine-like pain in mice. Journal Of Clinical Investigation 2024, 134: e182556. PMID: 39087472, PMCID: PMC11290958, DOI: 10.1172/jci182556.
Peer-Reviewed Original Research
MeSH Keywords and Concepts
Elucidating a new path of CSF transport in the CNS
Benveniste H, Thomas J. Elucidating a new path of CSF transport in the CNS. The Lancet Neurology 2024, 23: 553-554. PMID: 38760087, DOI: 10.1016/s1474-4422(24)00164-9.
Peer-Reviewed Original Research
MeSH Keywords
VEGF-C prophylaxis favors lymphatic drainage and modulates neuroinflammation in a stroke model
Boisserand L, Geraldo L, Bouchart J, Kamouh M, Lee S, Sanganahalli B, Spajer M, Zhang S, Lee S, Parent M, Xue Y, Skarica M, Yin X, Guegan J, Boyé K, Leser F, Jacob L, Poulet M, Li M, Liu X, Velazquez S, Singhabahu R, Robinson M, Askenase M, Osherov A, Sestan N, Zhou J, Alitalo K, Song E, Eichmann A, Sansing L, Benveniste H, Hyder F, Thomas J. VEGF-C prophylaxis favors lymphatic drainage and modulates neuroinflammation in a stroke model. Journal Of Experimental Medicine 2024, 221: e20221983. PMID: 38442272, PMCID: PMC10913814, DOI: 10.1084/jem.20221983.
Peer-Reviewed Original Research
MeSH Keywords and Concepts
Complementary and Inducible creERT2 Mouse Models for Functional Evaluation of Endothelial Cell Subtypes in the Bone Marrow
Poulos M, Ramalingam P, Winiarski A, Gutkin M, Katsnelson L, Carter C, Pibouin-Fragner L, Eichmann A, Thomas J, Miquerol L, Butler J. Complementary and Inducible creERT2 Mouse Models for Functional Evaluation of Endothelial Cell Subtypes in the Bone Marrow. Stem Cell Reviews And Reports 2024, 20: 1135-1149. PMID: 38438768, PMCID: PMC11087254, DOI: 10.1007/s12015-024-10703-9.
Peer-Reviewed Original Research
Concepts
Compartmentalized ocular lymphatic system mediates eye–brain immunity
Yin X, Zhang S, Lee J, Dong H, Mourgkos G, Terwilliger G, Kraus A, Geraldo L, Poulet M, Fischer S, Zhou T, Mohammed F, Zhou J, Wang Y, Malloy S, Rohner N, Sharma L, Salinas I, Eichmann A, Thomas J, Saltzman W, Huttner A, Zeiss C, Ring A, Iwasaki A, Song E. Compartmentalized ocular lymphatic system mediates eye–brain immunity. Nature 2024, 628: 204-211. PMID: 38418880, PMCID: PMC10990932, DOI: 10.1038/s41586-024-07130-8.
Peer-Reviewed Original Research
Concepts

2023

Editorial Expression of Concern: The netrin receptor UNC5B mediates guidance events controlling morphogenesis of the vascular system
Lu X, le Noble F, Yuan L, Jiang Q, de Lafarge B, Sugiyama D, Bréant C, Claes F, De Smet F, Thomas J, Autiero M, Carmeliet P, Tessier-Lavigne M, Eichmann A. Editorial Expression of Concern: The netrin receptor UNC5B mediates guidance events controlling morphogenesis of the vascular system. Nature 2023, 625: e12-e12. PMID: 38110575, DOI: 10.1038/s41586-023-06944-2.
Peer-Reviewed Original Research

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Appointments

Contact Info

Titles

Biography

Appointments

Neurology

Other Departments & Organizations

Education & Training

Overview

Medical Research Interests

Public Health Interests

ORCID

Research at a Glance

Yale Co-Authors

Anne Eichmann, PhD

Akiko Iwasaki, PhD

Anita Huttner, MD

Emma Ristori, PhD

Huiping Dong

Kaya Bilguvar, MD, PhD

Publications

2024

2023

Media

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News

Recap & Reflections: Vascular Biology & Therapeutics Program & Cardiovascular Research Center 2023 Retreat

The Brain’s Drainage System in 3 Dimensions

Yale Scientists Breach Brain Barriers to Attack Tumors

Research in the news: Yale team identifies key process in brain development

Contacts