Lais Osmani, MD, BA
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Biography
Lais grew up in Newton, MA. He graduated from Boston University in 2010. After college, he worked on the COMBREX (Computational Bridges to Experiments) project which sought to accelerate microbial genome annotation through collaboration between computational and experimental biologists. He then attended the University of Illinois College of Medicine and graduated in 2015. He completed a Pathology residency at Johns Hopkins Hospital, during which time he was involved in identifying the antigen specificity of the monoclonal immunoglobulin in patients with Schnitzler syndrome. He most recently completed a second residency in Internal Medicine at Dartmouth-Hitchcock Medical Center. During this time, he investigated the role of neutrophils in lupus nephritis. He is interested in leveraging omics data to study the pathogenesis and heterogeneity of autoimmune diseases and to identify potential therapeutic targets.
Appointments
Rheumatology
InstructorPrimary
Other Departments & Organizations
- Internal Medicine
- Rheumatology
- Rheumatology, Allergy, & Immunology
- Yale Medicine
Education & Training
- Fellowship
- Yale University (2024)
- Resident
- Dartmouth-Hitchcock Medical Center (2021)
- Residency
- Johns Hopkins Hospital (2018)
- MD
- University of Illinois College of Medicine (2015)
Research
Research at a Glance
Yale Co-Authors
Publications Timeline
Adam Mecca, MD, PhD
Christopher van Dyck, MD
Heather Allore, PhD
Hong-Jai Park
Insoo Kang, MD
Juan Young, MD, MHS
Publications
2023
Aging gene signature of memory CD8+ T cells is associated with neurocognitive functioning in Alzheimer’s disease
Young J, Park H, Kim M, Par-Young J, Bartlett H, Kim H, Unlu S, Osmani L, Shin M, Bucala R, van Dyck C, Allore H, Mecca A, You S, Kang I. Aging gene signature of memory CD8+ T cells is associated with neurocognitive functioning in Alzheimer’s disease. Immunity & Ageing 2023, 20: 71. PMID: 38042785, PMCID: PMC10693128, DOI: 10.1186/s12979-023-00396-y.Peer-Reviewed Original ResearchCitationsAltmetricConceptsPeripheral bloodT cellsAlzheimer's diseaseEM CD8Memory CD8Gene signatureAge-related immune changesIL-7 receptor alphaEffector memory CD8Strong risk factorT cell expansionAD genesAge-associated expansionImmune changesRisk factorsCD8Dementia patientsIL-7RNeuropsychological testingReceptor alphaNeurocognitive functionRT-qPCR resultsDisease severityPatientsNormal personsInvestigating the functional heterogeneity of Monocytes and Macrophages in Systemic Lupus Erythematosus
Osmani L, Shin MS, Cai H, Lee SJ, Kim H, Yoo J, You S, Li C, Dong MX, Gomez-Villalobos J, Bucala R, Kang I. Investigating the functional heterogeneity of Monocytes and Macrophages in Systemic Lupus Erythematosus. Single Cell Analyses conference at Cold Spring Harbor Laboratory. Nov 2023. Cold Spring Harbor, NY.Peer-Reviewed Original Research
2021
204 The role of neutrophils in the clinical severity of lupus nephritis patients with concurrent skin disease
Osmani L, Pettus J, Roy A, Skopelja-Gardner S. 204 The role of neutrophils in the clinical severity of lupus nephritis patients with concurrent skin disease. Lupus Science & Medicine 2021, 8: a5-a5. DOI: 10.1136/lupus-2021-lupus21century.8.Peer-Reviewed Original ResearchConceptsConcurrent skin diseasesHigher neutrophil countLupus nephritisSkin rashLN flareSkin diseasesSkin inflammationHigh neutrophilLN patientsLupus patientsNeutrophil countLupus nephritis biopsiesNeutrophil-lymphocyte ratioWorse kidney functionOnly female patientsRole of neutrophilsAnti-dsDNA IgGActivation of neutrophilsT-testStudent's t-testRenal inflammatoryActive diseaseKidney injuryChart reviewIgA deposition
2019
Ultrasound-Guided Transthoracic Fine-Needle Aspiration: A Reliable Tool in Diagnosis and Molecular Profiling of Lung Masses
Rodriguez EF, Pastorello R, Osmani L, Hopkins M, Kryatova M, Kawamoto S, Maleki Z. Ultrasound-Guided Transthoracic Fine-Needle Aspiration: A Reliable Tool in Diagnosis and Molecular Profiling of Lung Masses. Acta Cytologica 2019, 64: 208-215. PMID: 31362293, DOI: 10.1159/000501421.Peer-Reviewed Original ResearchCitationsMeSH Keywords and ConceptsConceptsLung massPulmonary adenocarcinomaMedical recordsTransthoracic fine needle aspirationConcurrent core biopsyAdvanced stage diseaseInstitutional review board approvalMajority of patientsTransthoracic needle aspirationCarcinoma/adenocarcinomaPatients' medical recordsFine-needle aspirationReview board approvalStage diseaseCommon diagnosisMean agePulmonary lesionsCore biopsyMalignant diagnosisNeedle aspirationPrior historyCytologic diagnosisInvasive proceduresBoard approvalCytology specimens
2017
Current WHO guidelines and the critical role of immunohistochemical markers in the subclassification of non-small cell lung carcinoma (NSCLC): Moving from targeted therapy to immunotherapy
Osmani L, Askin F, Gabrielson E, Li QK. Current WHO guidelines and the critical role of immunohistochemical markers in the subclassification of non-small cell lung carcinoma (NSCLC): Moving from targeted therapy to immunotherapy. Seminars In Cancer Biology 2017, 52: 103-109. PMID: 29183778, PMCID: PMC5970946, DOI: 10.1016/j.semcancer.2017.11.019.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsNon-small cell lung carcinomaCell lung carcinomaLung cancerWorld Health OrganizationLung carcinomaSignificant prognostic impactLung cancer patientsRecent large-scale genomic studiesSmall biopsy specimensDriver gene mutationsPrognostic impactCancer patientsBiopsy specimensTargeted therapyOncologic practiceAccurate subclassificationIHC biomarkersImmunohistochemical markersPatient careAccurate diagnosisImmunotherapyTherapyCancerSubclassificationCritical roleCurrent insight in the localized insulin-derived amyloidosis (LIDA): clinico-pathological characteristics and differential diagnosis
Ansari AM, Osmani L, Matsangos AE, Li QK. Current insight in the localized insulin-derived amyloidosis (LIDA): clinico-pathological characteristics and differential diagnosis. Pathology - Research And Practice 2017, 213: 1237-1241. PMID: 28935176, DOI: 10.1016/j.prp.2017.08.013.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsInsulin-derived amyloidosisSystemic amyloidosisDiabetic patientsGlycemic controlDifferential diagnosisAccurate diagnosisAggressive systemic therapyBlood glycemic controlCommon side effectsCase series studyClinico-pathological characteristicsNon-surgical approachSubcutaneous insulin injectionsPrimary cutaneous amyloidosisAnti-insulin antibodiesAutonomic neuropathyInsulin requirementsClinical suspicionKey diagnostic featuresRare complicationSystemic therapySurgical excisionSurgical interventionCase reportInsulin injectionsBiomarkers in the accurate subclassification of non-small-cell lung carcinoma for targeted therapy: issues and prospects
Osmani L, Li QK. Biomarkers in the accurate subclassification of non-small-cell lung carcinoma for targeted therapy: issues and prospects. Biomarkers In Medicine 2017, 11: 405-407. PMID: 28621614, DOI: 10.2217/bmm-2017-0059.Peer-Reviewed Original ResearchCitationsAltmetric
2013
The COMBREX Project: Design, Methodology, and Initial Results
Anton BP, Chang YC, Brown P, Choi HP, Faller LL, Guleria J, Hu Z, Klitgord N, Levy-Moonshine A, Maksad A, Mazumdar V, McGettrick M, Osmani L, Pokrzywa R, Rachlin J, Swaminathan R, Allen B, Housman G, Monahan C, Rochussen K, Tao K, Bhagwat AS, Brenner SE, Columbus L, de Crécy-Lagard V, Ferguson D, Fomenkov A, Gadda G, Morgan RD, Osterman AL, Rodionov DA, Rodionova IA, Rudd KE, Söll D, Spain J, Xu SY, Bateman A, Blumenthal RM, Bollinger JM, Chang WS, Ferrer M, Friedberg I, Galperin MY, Gobeill J, Haft D, Hunt J, Karp P, Klimke W, Krebs C, Macelis D, Madupu R, Martin MJ, Miller JH, O'Donovan C, Palsson B, Ruch P, Setterdahl A, Sutton G, Tate J, Yakunin A, Tchigvintsev D, Plata G, Hu J, Greiner R, Horn D, Sjölander K, Salzberg SL, Vitkup D, Letovsky S, Segrè D, DeLisi C, Roberts RJ, Steffen M, Kasif S. The COMBREX Project: Design, Methodology, and Initial Results. PLOS Biology 2013, 11: e1001638. PMID: 24013487, PMCID: PMC3754883, DOI: 10.1371/journal.pbio.1001638.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords
2012
Thousands of missed genes found in bacterial genomes and their analysis with COMBREX
Wood DE, Lin H, Levy-Moonshine A, Swaminathan R, Chang YC, Anton BP, Osmani L, Steffen M, Kasif S, Salzberg SL. Thousands of missed genes found in bacterial genomes and their analysis with COMBREX. Biology Direct 2012, 7: 37. PMID: 23111013, PMCID: PMC3534567, DOI: 10.1186/1745-6150-7-37.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsProtein-coding genesProkaryotic genome annotationCost of sequencingGenome annotationHypothetical proteinsBacterial genomesProkaryotic genomesShort genesArcady MushegianLikely geneGenesPhenotype informationGenomeHomologPotential targetPathogenic organismsAnnotationSequencingProteinFunction databaseAnnotation methodDramatic reductionGenBankOrganismsPharmaceutical research
2010
COMBREX: a project to accelerate the functional annotation of prokaryotic genomes
Roberts RJ, Chang YC, Hu Z, Rachlin JN, Anton BP, Pokrzywa RM, Choi HP, Faller LL, Guleria J, Housman G, Klitgord N, Mazumdar V, McGettrick MG, Osmani L, Swaminathan R, Tao KR, Letovsky S, Vitkup D, Segrè D, Salzberg SL, Delisi C, Steffen M, Kasif S. COMBREX: a project to accelerate the functional annotation of prokaryotic genomes. Nucleic Acids Research 2010, 39: d11-d14. PMID: 21097892, PMCID: PMC3013729, DOI: 10.1093/nar/gkq1168.Peer-Reviewed Original ResearchCitationsAltmetric
Clinical Care
Overview
Clinical Specialties
Board Certifications
Internal Medicine
- Certification Organization
- AB of Internal Medicine
- Original Certification Date
- 2021
Are You a Patient?
View this doctor's clinical profile on the Yale Medicine website for information about the services we offer and making an appointment.
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News
- October 16, 2024
Welcome New Staff, Faculty, Postdocs & Postgrads (October 2024)
- September 16, 2024
Introducing the New Yale Rheumatology, Allergy and Immunology Faculty
- April 20, 2023
Fellow Focus in Four: Lais Osmani, MD, Rheumatology