Mohammad Abdullah Zafar, MBBS
Associate Research ScientistCards
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Associate Research Scientist
Biography
Dr. Mohammad Abdullah Zafar is an Associate Research Scientist, the Research Director, and Yale-Masone Aortic Research Fellow at the Aortic Institute at Yale-New Haven Hospital, Section of Cardiac Surgery, Department of Surgery. The Aortic Institute at Yale-New Haven Hospital is one of the world's largest multidisciplinary clinical and research centers dedicated to the care of patients with thoracic aortic disease. It includes experts in cardiothoracic surgery, cardiology, vascular surgery, vascular radiology, interventional radiology, cardiovascular anesthesiology, bioengineering, epidemiology, molecular genetics, and basic science research in vascular medicine. It is among the first such formally designated centers.
After completing his medical degree with honors and an internship in thoracic surgery in Pakistan, Dr. Zafar joined the Aortic Institute in 2015. Over the past nine years, his research has been focused on advancing the fundamental biomedical understanding of thoracic aortic disease via scientific studies targeted at fostering a better understanding of the natural history and risk prediction, early detection and diagnosis, molecular genetics, and optimal therapies of thoracic aortic disease. Dr. Zafar's work has directly informed the latest U.S. and European Aortic Disease Clinical Practice Guidelines.
As the Aortic Research Fellow and Research Director, Dr. Zafar's role is to bridge the academic, clinical, and research arms of the Aortic Institute to continue to ensure the delivery of state-of-the-art expert and personalized care to aneurysm patients at Yale. Dr. Zafar supervises all investigations at the Institute and leads, mentors, and aids the recruitment of diverse members of the research team that includes high school students, undergraduate students, Yale and visiting medical students, residents, physician associates, postdoctoral fellows, physicians, and surgeons from across the United States and the world. Dr. Zafar has helped establish the Aortic Institute clinical database, tissue bank, and advanced thoracic aortic aneurysm and dissection genetic testing program and database, some of the largest repositories of their kind in the world.
Dr. Zafar has published over one hundred twenty peer-reviewed scientific articles, book chapters, editorials, and commentaries on thoracic aortic disease. He has presented his research work at leading national and international conferences, delivered lectures and Grand Rounds at the Yale School of Medicine, Yale-New Haven Hospital, and other institutions, serves as a peer-reviewer for journals, and serves as an editor for the journal AORTA. Dr. Zafar is completing a Master of Health Science (Clinical Investigation Track) degree from the Yale School of Medicine.
An avid Manchester United fan, Dr. Zafar enjoys playing and watching soccer, strength training, British crime and sci-fi shows, mindful productivity, brunch, and spending time with friends and family.
Appointments
Cardiac Surgery
Associate Research ScientistPrimary
Other Departments & Organizations
Education & Training
- MBBS
- University of Health Sciences (2013)
Research
Overview
Medical Research Interests
ORCID
0000-0003-1666-199X
Research at a Glance
Yale Co-Authors
Publications Timeline
Research Interests
John Elefteriades, MD
Sandip Mukherjee, MD, FACC
Bulat A. Ziganshin, MD, PhD
Syed Usman Bin Mahmood, MBBS
Hamid Mojibian, MD
Gabe Weininger
Aorta
Cardiac Surgical Procedures
Dissection, Thoracic Aorta
Publications
2024
Efficacy of beta blockers in patients with thoracic aortic aneurysm: meta-analysis of randomized controlled trials
Tanriverdi L, Barrett A, Kalyanasundaram A, Zafar M, Ziganshin B, Elefteriades J. Efficacy of beta blockers in patients with thoracic aortic aneurysm: meta-analysis of randomized controlled trials. European Heart Journal 2024, 45: ehae666.2256. DOI: 10.1093/eurheartj/ehae666.2256.Peer-Reviewed Original ResearchConceptsThoracic aortic aneurysmRandomized controlled trialsPooled risk ratioB-blockersAortic aneurysmAortic dissectionControlled trialsAortic eventsRisk ratioPrimary outcomePooled risk estimatesRisk of aortic dissectionRisk of bias assessmentNo treatmentMeta-analysis of randomized controlled trialsInverse variance-weighted random-effects modelMeta-analysisLiterature searchB-blocker treatmentSystematic review protocolInternational Prospective RegisterCochrane Central Register of Controlled TrialsEfficacy of beta blockersCentral Register of Controlled TrialsSummary effect measuresGenetics of aortic aneurysm disease: 10 key points for the practitioner
Elefteriades J, Zafar M, Ziganshin B. Genetics of aortic aneurysm disease: 10 key points for the practitioner. JTCVS Open 2024, 21: 58-63. PMID: 39534337, PMCID: PMC11551243, DOI: 10.1016/j.xjon.2024.07.014.Peer-Reviewed Original ResearchSomatic Variants Acquired Later in Life Associated with Thoracic Aortic Aneurysms: JAK2 V617F
Waldron C, Zafar M, Ma D, Zhang H, Dykas D, Ziganshin B, Popa A, Jha A, Kwan J, Elefteriades J. Somatic Variants Acquired Later in Life Associated with Thoracic Aortic Aneurysms: JAK2 V617F. Genes 2024, 15: 883. PMID: 39062663, PMCID: PMC11276600, DOI: 10.3390/genes15070883.Peer-Reviewed Original ResearchConceptsThoracic aortic aneurysmDevelopment of thoracic aortic aneurysmAortic aneurysmJAK2 V617FMyeloproliferative neoplasmsSomatic variantsPrevalence of thoracic aortic aneurysmsDescending thoracic aortic aneurysmJAK2 V617F burdenAortic valve diseaseTarget of therapyDriver of myeloproliferative neoplasmsSurgical aortic replacementVariant allele fractionAscending thoracic aortic aneurysmAortic replacementAneurysm sizeAneurysm patientsValve diseaseVariant carriersIncreased riskJAK2 geneExome sequencing databaseAllele fractionAneurysmPatient-specific ascending aortic intervention criteria
Kalogerakos P, Zafar M, Li Y, Ellauzi H, Mukherjee S, Ziganshin B, Rizzo J, Elefteriades J. Patient-specific ascending aortic intervention criteria. European Journal Of Cardio-Thoracic Surgery 2024, 65: ezae162. PMID: 38632077, DOI: 10.1093/ejcts/ezae162.Peer-Reviewed Original ResearchCitationsConceptsAdverse aortic eventsRisk of adverse eventsAortic eventsAortic rootAneurysm patientsAscending aortaAdverse eventsIncreased risk of adverse eventsThoracic aortic aneurysm patientsAscending aortic aneurysmHigher risk of adverse eventsAortic aneurysm patientsAscending thoracic aortic aneurysm patientsBody surface areaGeneral populationPersonalized risk stratificationAortic diameterAneurysm locationRisk stratificationAortic aneurysmIncreased riskAscending diameterPatientsHigh riskZ-scoreGene Commonality in Arterial Circuits Throughout the Body
Harling L, Zafar M, Ziganshin B, Elefteriades J. Gene Commonality in Arterial Circuits Throughout the Body. Aorta 2024, 12: 008-012. PMID: 39532283, PMCID: PMC11606663, DOI: 10.1055/s-0044-1791667.Peer-Reviewed Original Research
2023
Intricacies of aortic risk assessment studies: not a simple matter
Zafar M, Wu J, Elefteriades J. Intricacies of aortic risk assessment studies: not a simple matter. European Heart Journal 2023, 45: 735-736. PMID: 38087929, DOI: 10.1093/eurheartj/ehad795.Peer-Reviewed Original ResearchCitationsAltmetricMidterm follow-up of composite graft replacement of the aortic root (30-year experience)—remarkably safe, effective, and durable
Jeoffrey S, Zafar M, Velasco J, Khattak A, Ellauzi H, Nasir A, Kalyanasundaram A, Ziganshin B, Elefteriades J. Midterm follow-up of composite graft replacement of the aortic root (30-year experience)—remarkably safe, effective, and durable. JTCVS Open 2023, 17: 1-13. PMID: 38420531, PMCID: PMC10897671, DOI: 10.1016/j.xjon.2023.11.007.Peer-Reviewed Original ResearchAltmetricConceptsAortic root replacementOperative mortalityTerm outcomesDistal aortic segmentsLong-term bleedingAortic root diseaseComposite graft replacementType A DissectionFirst-time operationsAge/genderARR patientsConcomitant CABGLate reoperationAcute typeRoot replacementAdverse eventsGraft failureGraft replacementRedo proceduresCabrol procedureUrgent operationAortic rootAortic segmentsPatientsOperative choiceDecision-making in aortic disease
Wu J, Zafar M, Elefteriades J. Decision-making in aortic disease. European Heart Journal 2023, 45: 633-634. PMID: 37936301, DOI: 10.1093/eurheartj/ehad699.Peer-Reviewed Original ResearchCitationsEvidence Accumulates: Patients with Ascending Aneurysms Are Strongly Protected from Atherosclerotic Disease
Waldron C, Zafar M, Ziganshin B, Weininger G, Grewal N, Elefteriades J. Evidence Accumulates: Patients with Ascending Aneurysms Are Strongly Protected from Atherosclerotic Disease. International Journal Of Molecular Sciences 2023, 24: 15640. PMID: 37958625, PMCID: PMC10650782, DOI: 10.3390/ijms242115640.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsThoracic aortic aneurysmAortic aneurysmCarotid intima-media thicknessLow-density lipoprotein levelsIntima-media thicknessDevelopment of atherosclerosisMatrix metalloproteinase proteinsAscending aneurysmAortic calcificationAtherosclerotic diseaseLipoprotein levelsMyocardial infarctionLeading causeAneurysmsMetalloproteinase proteinsGrowth factorProtective relationshipDiseasePossible mechanismCurrent understandingMorbidityInfarctionAtherosclerosisPatientsPathophysiologyBicuspid Aortopathy is NOT More Virulent: Data from the Yale Aortic Institute
Zafar M, Ziganshin B, Elefteriades J. Bicuspid Aortopathy is NOT More Virulent: Data from the Yale Aortic Institute. Aorta 2023, 11: 1-18. DOI: 10.1055/s-0044-1787955.Peer-Reviewed Original Research
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