2024
Temporal complexity of the BOLD-signal in preterm versus term infants
Mella A, Vanderwal T, Miller S, Weber A. Temporal complexity of the BOLD-signal in preterm versus term infants. Cerebral Cortex 2024, 34: bhae426. PMID: 39582376, PMCID: PMC11586500, DOI: 10.1093/cercor/bhae426.Peer-Reviewed Original ResearchConceptsBirth ageWeeks gestational agePreterm brainGestational ageTerm infantsPreterm birthPretermCerebral developmentTerm equivalentNeonatesBOLD signalBirthScan ageInfantsAgeMixed effects modelsLinear mixed effects modelsEstimation of myelinResting state networksBrainHuman Connectome ProjectEffects modelDiffusion weighted imaging data
2022
Type 2 immune polarization is associated with cardiopulmonary disease in preterm infants
Lao J, Bui C, Pang M, Cho S, Rudloff I, Elgass K, Schröder J, Maksimenko A, Mangan N, Starkey M, Skuza E, Sun Y, Beker F, Collins C, Kamlin O, König K, Malhotra A, Tan K, Theda C, Young M, McLean C, Wilson N, Sehgal A, Hansbro P, Pearson J, Polo J, Veldman A, Berger P, Nold-Petry C, Nold M. Type 2 immune polarization is associated with cardiopulmonary disease in preterm infants. Science Translational Medicine 2022, 14: eaaz8454. PMID: 35385341, DOI: 10.1126/scitranslmed.aaz8454.Peer-Reviewed Original ResearchConceptsPreterm infantsBronchopulmonary dysplasiaIL-13CD3<sup>+</sup>CD4<sup>+</sup> T cellsInterleukin-4BPD-associated pulmonary hypertensionMaternal magnesium sulfate therapyCD4<sup>+</sup> T cellsCardiopulmonary diseaseMagnesium sulfate therapyType 2 mediatorsHealthy term infantsType 2 polarizationType 2 cytokinesHepatitis B vaccineMultiple therapeutic approachesTerm infantsPulmonary hypertensionDisease in vivoT cellsLung inflammationYounger patientsIL-5B vaccineHigh treatment costs
2021
Birth Hospital Length of Stay and Rehospitalization During COVID-19
Handley SC, Gallagher K, Breden A, Lindgren E, Lo JY, Son M, Murosko D, Dysart K, Lorch SA, Greenspan J, Culhane JF, Burris HH. Birth Hospital Length of Stay and Rehospitalization During COVID-19. 2021, 149: e2021053498. PMID: 34889449, PMCID: PMC9645693, DOI: 10.1542/peds.2021-053498.Peer-Reviewed Original ResearchConceptsInfant rehospitalizationAdjusted odds ratioTerm infantsBirth hospitalization dischargeBirth hospitalization lengthHealthy term infantsRetrospective cohort studyCoronavirus disease 2019 eraDay of birthCOVID-19Hospitalization dischargePrepandemic eraHospital lengthMultivariable adjustmentCohort studyHospitalization lengthShorter LOSAdjusted analysisOdds ratioRehospitalizationInfantsHealth systemAdditional outcomesCOVID-19 eraMixed effects modelsMicroRNA 219-5p inhibits alveolarization by reducing platelet derived growth factor receptor-alpha
Freeman A, Qiao L, Olave N, Rezonzew G, Gentle S, Halloran B, Pryhuber G, Gaggar A, Tipple T, Ambalavanan N, Lal C. MicroRNA 219-5p inhibits alveolarization by reducing platelet derived growth factor receptor-alpha. Respiratory Research 2021, 22: 57. PMID: 33596914, PMCID: PMC7891005, DOI: 10.1186/s12931-021-01654-7.Peer-Reviewed Original ResearchConceptsPlatelet-derived growth factor receptor alphaGrowth factor receptor alphaBronchopulmonary dysplasiaPDGFR-AReceptor alphaDevelopment of bronchopulmonary dysplasiaPathogenesis of bronchopulmonary dysplasiaModel of bronchopulmonary dysplasiaExtremely preterm neonatesInhibited alveolar developmentMiR-219Lungs of infantsPulmonary epithelial cellsProspective cohort studyBPD mouse modelGenome-wide analysis studiesHuman infant lungsExposure to hyperoxiaRegulation of alveolarizationIn situ hybridizationPreterm infantsPreterm neonatesTerm infantsNormoxia controlLevel of miR-219
2020
Micronutrient Supplementation During Pregnancy, Birth Weight and Neonatal Mortality in Uganda: A Causal Mediation Analysis
Ssentongo P, Ba D, Fronterre C, Ericson J, Gernand A, Wang M, Du P, Liao D, Chinchilli V, Schiff S. Micronutrient Supplementation During Pregnancy, Birth Weight and Neonatal Mortality in Uganda: A Causal Mediation Analysis. Current Developments In Nutrition 2020, 4: nzaa053_117. PMCID: PMC7257698, DOI: 10.1093/cdn/nzaa053_117.Peer-Reviewed Original ResearchLow birth weightIFA supplementationNeonatal mortalityBirth weightCausal mediation analysisIron/folic acid supplementsRisk of LBWPrevalence of LBWMaternal iron deficiency anemiaAntenatal IFA supplementationFolic acid supplementsSignificant risk factorsIron deficiency anemiaRetrospective birth cohortLinear dose-response relationshipDays of lifeRisk of VLBWDose-response relationshipIFA supplementsTerm infantsNeonatal deathMicronutrient supplementationRisk factorsHealth SurveyNeonatal survival
2019
External validation of postnatal gestational age estimation using newborn metabolic profiles in Matlab, Bangladesh
Murphy MS, Hawken S, Cheng W, Wilson LA, Lamoureux M, Henderson M, Pervin J, Chowdhury A, Gravett C, Lackritz E, Potter BK, Walker M, Little J, Rahman A, Chakraborty P, Wilson K. External validation of postnatal gestational age estimation using newborn metabolic profiles in Matlab, Bangladesh. ELife 2019, 8: e42627. PMID: 30887951, PMCID: PMC6424558, DOI: 10.7554/elife.42627.Peer-Reviewed Original ResearchConceptsGestational ageGestational age estimationCord bloodNewborn metabolic profilesHeel prick samplesLow-resource settingsTerm infantsPreterm birthHeel prickPopulation-level estimatesPostnatal gestational age estimationBlood spotsMetabolic profileExternal validationInfantsScreening facilityAgeBloodFeasible optionMajority of samplesNewbornsPrickCordWeeks
2018
Correlations between near-infrared spectroscopy, perfusion index, and cardiac outputs in extremely preterm infants in the first 72 h of life
Janaillac M, Beausoleil TP, Barrington KJ, Raboisson MJ, Karam O, Dehaes M, Lapointe A. Correlations between near-infrared spectroscopy, perfusion index, and cardiac outputs in extremely preterm infants in the first 72 h of life. European Journal Of Pediatrics 2018, 177: 541-550. PMID: 29374830, DOI: 10.1007/s00431-018-3096-z.Peer-Reviewed Original ResearchConceptsCerebral regional tissue oxygen saturationRight ventricular outputRegional tissue oxygen saturationTissue oxygen saturationLow cardiac output stateExtremely preterm infantsCardiac output statePreterm infantsCardiac outputPerfusion indexOxygen saturationVentricular outputSuperior vena cava flowLow SVC flowLeft ventricular outputMedian gestational ageWeeks of gestationVena cava flowNon-invasive toolHaemodynamic assessmentSVC flowTerm infantsBlood pressureCerebral oxygenationGestational age
2017
Hypoglycemic relapse in term infants treated with glucose infusion
Sternberg J, Pfister R, Karam O. Hypoglycemic relapse in term infants treated with glucose infusion. Journal Of Clinical Neonatology 2017, 6: 163-167. DOI: 10.4103/jcn.jcn_10_17.Peer-Reviewed Original ResearchLow birth weightGlucose infusionBirth weightSingle-center retrospective studyProportion of infantsMain risk factorsTerm infantsConsecutive patientsNeonatal hypoglycemiaTerm newbornsGestational ageRetrospective studyRisk infantsRisk factorsMild severityRelapseInfusionProgressive weaningInfantsHypoglycemiaNewbornsSmall proportionLittle evidenceLevel 3Patients
2016
Optimal echo time for functional MRI of the infant brain identified in response to noxious stimulation
Goksan S, Hartley C, Hurley S, Winkler A, Duff E, Jenkinson M, Rogers R, Clare S, Slater R. Optimal echo time for functional MRI of the infant brain identified in response to noxious stimulation. Magnetic Resonance In Medicine 2016, 78: 625-631. PMID: 27654315, PMCID: PMC5516146, DOI: 10.1002/mrm.26455.Peer-Reviewed Original ResearchImpact of the Baby‐friendly Hospital Initiative on breastfeeding and child health outcomes: a systematic review
Pérez-Escamilla R, Martinez JL, Segura-Pérez S. Impact of the Baby‐friendly Hospital Initiative on breastfeeding and child health outcomes: a systematic review. Maternal And Child Nutrition 2016, 12: 402-417. PMID: 26924775, PMCID: PMC6860129, DOI: 10.1111/mcn.12294.Peer-Reviewed Original ResearchMeSH KeywordsAfrica South of the SaharaAsiaBreast FeedingChild HealthEuropeFemaleHealth EducationHealth Knowledge, Attitudes, PracticeHealth PromotionHospitalsHumansInfantObservational Studies as TopicProgram EvaluationRandomized Controlled Trials as TopicSocial SupportTreatment OutcomeUnited NationsUnited StatesWorld Health OrganizationConceptsBaby-Friendly Hospital InitiativeChild health outcomesHealth outcomesSystematic reviewBreastfeeding outcomesHospital InitiativeLong-term breastfeeding outcomesBFHI's Ten StepsInfant health outcomesYoung child feedingDose-response relationshipNarrative systematic reviewBF outcomesBFHI implementationBFHI stepsSteps womenTerm infantsObservational studyChild feedingTen StepsOutcomesBreastfeedingInfantsPrimary aimQuasi-experimental design
2015
Regulation of alveolar septation by microRNA-489
Olave N, Lal CV, Halloran B, Pandit K, Cuna AC, Faye-Petersen OM, Kelly DR, Nicola T, Benos PV, Kaminski N, Ambalavanan N. Regulation of alveolar septation by microRNA-489. American Journal Of Physiology - Lung Cellular And Molecular Physiology 2015, 310: l476-l487. PMID: 26719145, PMCID: PMC4773841, DOI: 10.1152/ajplung.00145.2015.Peer-Reviewed Original ResearchConceptsBronchopulmonary dysplasiaMiR-489Alveolar septationLung developmentInsulin-like growth factor-1Abnormal lung developmentGrowth factor-1MiR-489 overexpressionNormal pretermTerm infantsC57BL/6 miceMouse lung developmentTherapeutic strategiesMiRNA-489HyperoxiaEpithelial originFurther inhibitionIGF1Factor 1MiRNA antagonistsNormoxiaTenascin CMiRNA profilesCytomegalovirus promoterInfants
2014
New Generation Neonatal High Frequency Ventilators: Effect of Oscillatory Frequency and Working Principles on Performance
Grazioli S, Karam O, Rimensberger PC. New Generation Neonatal High Frequency Ventilators: Effect of Oscillatory Frequency and Working Principles on Performance. Respiratory Care 2014, 60: 363-370. PMID: 25406342, DOI: 10.4187/respcare.03048.Peer-Reviewed Original ResearchConceptsVolume-targeted modesInfant's conditionNeonatal ventilatorsPre-term infantsRespiratory system conditionsHigh-frequency ventilationExpiratory tidal volumeLung mechanical propertiesTerm infantsPreclinical dataVentilator settingsFrequency ventilationClinical conditionsLung characteristicsTidal volumeClinical relevanceInfant settingsVentilatorFurther studies
2012
Blood Pressure Changes during Pregnancy: Impact of Race, Body Mass Index, and Weight Gain
Boynton U, Kershaw T, Duffany K, Rising S, Ickovics J, Magriples U. Blood Pressure Changes during Pregnancy: Impact of Race, Body Mass Index, and Weight Gain. American Journal Of Perinatology 2012, 30: 415-424. PMID: 23059493, PMCID: PMC3938313, DOI: 10.1055/s-0032-1326987.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultBlack or African AmericanBlood PressureBody Mass IndexFemaleHispanic or LatinoHumansHypertensionHypertension, Pregnancy-InducedLongitudinal StudiesObesityOverweightPostpartum PeriodPregnancyPregnancy ComplicationsProspective StudiesRacial GroupsWeight GainWhite PeopleYoung AdultConceptsBody mass indexBlood pressure trajectoriesWeight gainBlood pressureMass indexHigher blood pressure readingsNormal body mass indexHigh pregnancy weight gainPostpartum weight reductionSingleton term infantsPregnancy weight gainDiastolic blood pressureBlood pressure changesBlood pressure readingsPressure trajectoriesAfrican American womenLongitudinal multivariate analysisCardiovascular riskOverweight womenTerm infantsPregnant womenPrenatal careWeeks postpartumPublic clinicsPregnancyA TIR domain receptor–associated protein (TIRAP) variant SNP (rs8177374) confers protection against premature birth
Karody V, Le M, Nelson S, Meskin K, Klemm S, Simpson P, Hines R, Sampath V. A TIR domain receptor–associated protein (TIRAP) variant SNP (rs8177374) confers protection against premature birth. Journal Of Perinatology 2012, 33: 341-346. PMID: 23047423, DOI: 10.1038/jp.2012.120.Peer-Reviewed Original ResearchConceptsToll-like receptorsPreterm infantsTerm infantsSingle nucleotide polymorphismsExact testProspective case-control studyTLR single nucleotide polymorphismsPregnancy-induced hypertensionRisk of PTBNuclear factor kappa B1Case-control studyFischer's exact testChi-square testIRAK1 variantsMultiplexed single-base extension assayPlacental abruptionPremature birthNeonatal bloodVariant single nucleotide polymorphismsInfantsCaucasian infantsWeeksModulate susceptibilityAfrican AmericansBirthRelationship between birth weight and exposure to airborne fine particulate potassium and titanium during gestation
Bell ML, Belanger K, Ebisu K, Gent JF, Leaderer BP. Relationship between birth weight and exposure to airborne fine particulate potassium and titanium during gestation. Environmental Research 2012, 117: 83-89. PMID: 22705336, PMCID: PMC3418490, DOI: 10.1016/j.envres.2012.05.004.Peer-Reviewed Original ResearchConceptsLow birth weightBirth weightAdverse pregnancy outcomesPregnancy outcomesTerm infantsAirborne fine particulate matterStudy populationIQR increaseMothers' exposureAfrican American mothersFirst birthInfantsEffect estimatesConfidence intervalsWhite mothersPregnancyHealth impactsRiskExposureFine particulate matterMothersMost studiesGestationWeight
2010
Respiratory Morbidity in Late Preterm Births
Hibbard J, Wilkins I, Sun L, Gregory K, Haberman S, Hoffman M, Kominiarek M, Reddy U, Bailit J, Branch D, Burkman R, Gonzalez Quintero V, Hatjis C, Landy H, Ramirez M, VanVeldhuisen P, Troendle J, Zhang J. Respiratory Morbidity in Late Preterm Births. JAMA 2010, 304: 419-425. PMID: 20664042, PMCID: PMC4146396, DOI: 10.1001/jama.2010.1015.Peer-Reviewed Original ResearchConceptsLate preterm birthNeonatal intensive care unitRespiratory distress syndromePreterm birthDistress syndromeRespiratory morbidityRespiratory failureTransient tachypneaVentilator supportRespiratory compromiseTerm birthsContemporary cohortMultivariate logistic regression analysisShort-term morbidityNeonatal hospital stayIntensive care unitWeeks of gestationLogistic regression analysisHospital stayRespiratory outcomesRespiratory supportTerm infantsRespiratory diagnosesWeeks' gestationTerm delivery
2008
Changing Patterns in Neonatal Escherichia coli Sepsis and Ampicillin Resistance in the Era of Intrapartum Antibiotic Prophylaxis
Bizzarro MJ, Dembry LM, Baltimore RS, Gallagher PG. Changing Patterns in Neonatal Escherichia coli Sepsis and Ampicillin Resistance in the Era of Intrapartum Antibiotic Prophylaxis. 2008, 121: 689-696. PMID: 18381532, DOI: 10.1542/peds.2007-2171.Peer-Reviewed Original ResearchMeSH KeywordsAmpicillinAmpicillin ResistanceAntibiotic ProphylaxisBacteremiaEscherichia coliEscherichia coli InfectionsFemaleFollow-Up StudiesHumansIncidenceInfant, NewbornInfectious Disease Transmission, VerticalMaleMultivariate AnalysisOdds RatioPregnancyPregnancy Complications, InfectiousPrenatal CareProbabilityRetrospective StudiesRisk AssessmentSeverity of Illness IndexStatistics, NonparametricSurvival RateConceptsE. coli early-onset sepsisEarly-onset sepsisLate-onset sepsisYale-New Haven HospitalIntrapartum antibiotic prophylaxisAntibiotic prophylaxisColi sepsisLow birth weight infantsAmpicillin resistanceAntibiotic prophylaxis practiceIntrapartum antibiotic exposureBirth weight infantsE. coli sepsisIndependent risk factorEscherichia coli sepsisAmpicillin exposureAmpicillin-resistant E. coliProphylaxis practicesSepsis rateWeight infantsNeonatal sepsisPreterm infantsTerm infantsRetrospective reviewRisk factors
2003
Regional Brain Volumes and Their Later Neurodevelopmental Correlates in Term and Preterm Infants
Peterson BS, Anderson AW, Ehrenkranz R, Staib LH, Tageldin M, Colson E, Gore JC, Duncan CC, Makuch R, Ment LR. Regional Brain Volumes and Their Later Neurodevelopmental Correlates in Term and Preterm Infants. 2003, 111: 939-948. PMID: 12728069, DOI: 10.1542/peds.111.5.939.Peer-Reviewed Original ResearchConceptsRegional brain volumesPreterm infantsCortical gray matterWhite matter volumeBrain volumeParieto-occipital regionsGray matterMatter volumeNeurodevelopmental outcomesWhite matterParieto-occipital gray matterRegional volumesHigh-resolution magnetic resonance imaging (MRI) scansMagnetic resonance imaging (MRI) scansCognitive outcomesLong-term outcomesRight-sided structuresResonance imaging scansCross-sectional studyNeonatal brain volumesGray matter volumeSubcortical gray matterInferior occipital cortexMidtemporal regionTerm infants
2001
Cardiorespiratory Events Recorded on Home Monitors: Comparison of Healthy Infants With Those at Increased Risk for SIDS
Ramanathan R, Corwin M, Hunt C, Lister G, Tinsley L, Baird T, Silvestri J, Crowell D, Hufford D, Martin R, Neuman M, Weese-Mayer D, Cupples L, Peucker M, Willinger M, Keens T, Group F. Cardiorespiratory Events Recorded on Home Monitors: Comparison of Healthy Infants With Those at Increased Risk for SIDS. JAMA 2001, 285: 2199-2207. PMID: 11325321, DOI: 10.1001/jama.285.17.2199.Peer-Reviewed Original ResearchConceptsSudden infant death syndromeHealthy term infantsCardiorespiratory eventsTerm infantsPreterm infantsPostconceptional ageHome monitorApparent life-threatening eventHome cardiorespiratory monitorsSiblings of infantsWeeks postconceptional ageLongitudinal cohort studyInfant death syndromeLife-threatening eventsRespiratory inductance plethysmographyMetropolitan medical centerCohort studyHealthy infantsIncreased riskCardiorespiratory monitorsMedical CenterDeath syndromeInductance plethysmographyInfantsStudy participants
2000
Not yet ‘Back to Sleep’: sleep position for infants in two inner‐city clinics
Colson E, Stille C, Payton J, Bernstein B, Dworkin P. Not yet ‘Back to Sleep’: sleep position for infants in two inner‐city clinics. Child Care Health And Development 2000, 6: 269-275. DOI: 10.1046/j.1467-0658.2000.00096.x.Peer-Reviewed Original ResearchSudden infant death syndromeHealth care providersInner-city clinicCare providersProne positionSleep positionHealth care provider practiceSleep position practicesHealth supervision visitsInfant death syndromeGroups of infantsPercent of parentsCONCLUSIONS/IMPLICATIONSSocio-demographic dataProne sleepingTerm infantsProne sleepResults ThirtySupervision visitsSupine positionProvider practicesDeath syndromeInfant sleepInfantsChildren's sleep
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