2025
Outcomes of Reduced Elective Nodal Radiation Dose and Volume for Laryngeal, Hypopharyngeal, and p16‐Negative Oropharyngeal Cancers
Zakeri K, Wren S, Shang T, Yu Y, Chen L, Shamseddine A, Safavi A, Kang J, Tsai C, Sherman E, Wong R, McBride S, Gelblum D, Riaz N, Lee N. Outcomes of Reduced Elective Nodal Radiation Dose and Volume for Laryngeal, Hypopharyngeal, and p16‐Negative Oropharyngeal Cancers. Head & Neck 2025 PMID: 40515499, DOI: 10.1002/hed.28217.Peer-Reviewed Original ResearchP16-negative oropharyngeal cancerNodal recurrenceLocoregional recurrenceP16-negativeDistant recurrenceOropharyngeal cancerHead and neck cancer patientsRadiation doseDecrease treatment toxicityNeck cancer patientsPrimary outcome measureConcurrent chemoradiationRadiotherapy doseMedian followConsecutive patientsTreatment toxicityImprove quality of lifeConsecutive cohortCancer patientsRecurrenceQuality of lifeHypopharyngealDosePatientsOutcome measuresNexfin versus conventional oscillometric cuff for blood pressure monitoring during neuro-endovascular procedures
Chen H, Njonkou-Tchoquessi R, Colasurdo M, Cobb C, Payabvash S, Malhotra A, Gandhi D. Nexfin versus conventional oscillometric cuff for blood pressure monitoring during neuro-endovascular procedures. Brain Circulation 2025 DOI: 10.4103/bc.bc_146_24.Peer-Reviewed Original ResearchNeuro-endovascular proceduresBlood pressureSystolic BPArterial lineNeurological injurySingle-center retrospective studyPredictive valueNegative predictive valuePositive predictive valueAcute neurological injuryBlood pressure monitoringArterial line measurementsConsecutive patientsRelative hypotensionRetrospective studyNeuro-endovascular treatmentNeuroendovascular interventionsNeuroendovascular proceduresSBP dropNexfinClinical scenariosNoninvasive blood pressureBP monitoringPatientsConventional cuffUnderstanding Surgical Management and Outcomes in Mitral Valve Endocarditis
Dzilic E, Niedermayer S, Burri M, Amabile A, Krane M, Vitanova K. Understanding Surgical Management and Outcomes in Mitral Valve Endocarditis. Journal Of Clinical Medicine 2025, 14: 2712. PMID: 40283542, PMCID: PMC12027858, DOI: 10.3390/jcm14082712.Peer-Reviewed Original ResearchMitral valve endocarditisMitral valve repairValve endocarditisValve repairPropensity score matchingValve replacementScore matchingNative mitral valve endocarditisMitral valve replacementRetrospective cohort studyLong-term survivalConsecutive patientsSurgical outcomesValve reconstructionAbscess formationSingle-centerSurgical managementEndocarditisSurgical patientsFollow-upCohort studyPatientsTreatment assignment biasMortality rateSurvivalClinical characteristics and outcomes of disseminated intravascular coagulation in patients with severe fever with thrombocytopenia syndrome
Zhang Z, Hu X, Du Q, Mo P, Chen X, Luo M, Jiang Q, Deng L, Xiong Y. Clinical characteristics and outcomes of disseminated intravascular coagulation in patients with severe fever with thrombocytopenia syndrome. BMC Infectious Diseases 2025, 25: 508. PMID: 40217170, PMCID: PMC11992865, DOI: 10.1186/s12879-025-10900-y.Peer-Reviewed Original ResearchConceptsDisseminated intravascular coagulationOutcomes of disseminated intravascular coagulationPresence of disseminated intravascular coagulationNon-DIC groupIndependent risk factorIntravascular coagulationClinical characteristicsRisk factorsDisseminated intravascular coagulation groupThrombocytopenia syndromeMultivariate logistic regression analysisAssociated with high mortalityIn-hospital mortality of patientsCumulative survival rateZhongnan Hospital of Wuhan UniversityMortality of patientsIn-Hospital MortalitySevere feverLogistic regression analysisConsecutive patientsFerritin levelsD-dimerViral loadClinical dataCystatin CMorphometric analysis of the inferior petrosal sinus and cerebellopontine angle cistern to assess feasibility of endovascular shunting in pediatric patients
Colasurdo M, Chen K, Chen H, McIntyre M, Matouk C, Selim M, Whitehead W, Heilman C, Malek A, Kan P. Morphometric analysis of the inferior petrosal sinus and cerebellopontine angle cistern to assess feasibility of endovascular shunting in pediatric patients. Journal Of NeuroInterventional Surgery 2025, jnis-2025-023137. PMID: 40169197, DOI: 10.1136/jnis-2025-023137.Peer-Reviewed Original ResearchInferior petrosal sinusCerebellopontine angle cisternShunt placementPetrosal sinusAnatomical criteriaHigh-resolution brain MRISurgical shunt placementYears of ageConsecutive patientsPediatric patientsMultivariable adjustmentBrain MRIAdult criteriaPatientsPediatric hospitalEndovascular shuntYounger ageLeft sidePediatric applicationsLimited dataSinusAssociated with differencesRegression analysisAgeSchool ageReal-World Evidence of Administration of Biologic Agents in Patients with Severe Asthma: An Analysis of the Respiratory Department of University Hospital of Patras Asthma Registry
Papaioannou O, Christopoulos I, Tsiri P, Sampsonas F, Karkoulias K, Lykouras D, Sotiropoulou V, Theohari E, Papalexatos D, Komninos D, Christopoulos A, Tzouvelekis A. Real-World Evidence of Administration of Biologic Agents in Patients with Severe Asthma: An Analysis of the Respiratory Department of University Hospital of Patras Asthma Registry. Journal Of Clinical Medicine 2025, 14: 2174. PMID: 40217624, PMCID: PMC11989620, DOI: 10.3390/jcm14072174.Peer-Reviewed Original ResearchTime of diagnosisOral corticosteroidsSevere asthmaFollow-upBiological agentsBlood eosinophilsAdministration of biological agentsInitiation of biologic treatmentMedian valueTreated with biologic agentsTreated with omalizumabUncontrolled severe asthmaUse of corticosteroidsSevere asthma exacerbationsAsthma outpatient clinicLongitudinal useConsecutive patientsMedian ageDisease phenotypic characteristicsRetrospective studyNever smokersCorticosteroidsAsthma exacerbationsAsthma flaresLung functionThe Use of Intravascular Ultrasound During Deep Venous Interventions in a Tertiary Care Center
Ali S, Rodriguez P, Abualanain E, Li Y, Khalil M, Aboloyoun H, Lozada J, Aboian E, Attaran R, Chaar C. The Use of Intravascular Ultrasound During Deep Venous Interventions in a Tertiary Care Center. Vascular And Endovascular Surgery 2025, 59: 505-512. PMID: 40096827, DOI: 10.1177/15385744251326989.Peer-Reviewed Original ResearchConceptsDeep venous interventionsPrimary patency rateVenous interventionsLoss of patencyPatency ratesAssociated with loss of patencyAssociated with fewer complicationsIVUS useMethodsThis retrospective studyTertiary care centerLower extremity interventionsChronic kidney diseaseMultiplanar venographyAssociated with lossConsecutive patientsRates of COPDPrimary patencyVenous stentingTechnical successFewer complicationsSymptomatic improvementVenous stenosisAnticoagulant useRetrospective studyHypercoagulable stateHigh Risk of Persistence and Risk of Dysplasia After Diagnosis of Ultrashort Barrett's Esophagus.
Skef W, Haydel J, Rao A, Allencherril R, George R, Ketwaroo G, Thrift A, El-Serag H, Wenker T. High Risk of Persistence and Risk of Dysplasia After Diagnosis of Ultrashort Barrett's Esophagus. The American Journal Of Gastroenterology 2025 PMID: 40052679, DOI: 10.14309/ajg.0000000000003383.Peer-Reviewed Original ResearchFollow-up EGDRisk of dysplasiaBody mass indexBarrett's esophagusPersistent BEFollow-upCohort of United States veteransWhite raceLong segment BEUnited States veteransHispanic ethnicityPredictor of dysplasiaFollow-up endoscopyClinical risk factorsRetrospective cohort studyNon-Hispanic black patientsNon-HispanicRisk of persistenceProportion of non-HispanicChi-square testConsecutive patientsStates veteransPathology databaseHighest risk of persistenceBE diagnosisVoxel-Wise Map of Intracerebral Hemorrhage Locations Associated With Worse Outcomes
Karam G, Chen M, Zeevi D, Harms B, Berson E, Torres-Lopez V, Rivier C, Malhotra A, Qureshi A, Falcone G, Sheth K, Payabvash S. Voxel-Wise Map of Intracerebral Hemorrhage Locations Associated With Worse Outcomes. Stroke 2025, 56: 868-877. PMID: 40052269, PMCID: PMC11932768, DOI: 10.1161/strokeaha.124.048453.Peer-Reviewed Original ResearchConceptsImpact of intracerebral hemorrhageAssociated with worse outcomesClinical risk factorsVoxel-wise mapsMapping of brain regionsBaseline hematomaVoxel-wise analysisHematoma volumeICH locationBrain regionsValidation cohortWorse outcomesPresence of intraventricular hemorrhageRisk factorsBaseline hematoma volumeModified Rankin Scale scorePoor scan qualityMulticenter clinical trialRankin Scale scoreDeep white matterLow-risk categoryComprehensive stroke centerIntraventricular hemorrhageConsecutive patientsPatient ageComparison of prognostic accuracy of HCC staging systems in patients undergoing TACE
Kasolowsky V, Gross M, Madoff D, Duncan J, Taddei T, Strazzabosco M, Jaffe A, Chapiro J. Comparison of prognostic accuracy of HCC staging systems in patients undergoing TACE. Clinical Imaging 2025, 120: 110438. PMID: 40049074, PMCID: PMC11967406, DOI: 10.1016/j.clinimag.2025.110438.Peer-Reviewed Original ResearchConceptsOverall survival of patientsBCLC staging systemTransarterial chemoembolizationOverall survivalStaging systemHepatocellular carcinomaStaging systems of hepatocellular carcinomaHepatocellular carcinoma staging systemsRetrospective single center studyKaplan Meier survival analysisInternational Staging SystemSingle center studyLog-rank testTertiary care centerPredicting Overall SurvivalMeier survival analysisConsecutive patientsPrognostic stratificationStudy endpointPrognostic accuracyCenter studyPrognostic powerStratify outcomesMultivariate analysisPatientsAtrial Functional Tricuspid Regurgitation Contemporary Characteristics, Outcomes, and Novel Risk Score
Fava A, Nakhla M, Hajj Ali A, Akintoye E, Akyuz K, Arockiam A, Haroun E, El Dahdah J, Liao Y, Popovic Z, Gillinov M, Pettersson G, Griffin B, Desai M, Wang T. Atrial Functional Tricuspid Regurgitation Contemporary Characteristics, Outcomes, and Novel Risk Score. JACC Advances 2025, 4: 101623. PMID: 40009906, PMCID: PMC11908566, DOI: 10.1016/j.jacadv.2025.101623.Peer-Reviewed Original ResearchRegurgitant orifice areaRight atrial volumeAF-TRTricuspid regurgitationAtrial volumeOrifice areaAtrial functional tricuspid regurgitationAssociated with 1-year mortalityEffective regurgitant orifice areaRisk scoreFunctional tricuspid regurgitationSevere tricuspid regurgitationEffective regurgitant orificeRight heart failureCohort of patientsSystolic pressure ratioIncreasing clinical recognitionMultivariate logistic regressionMedian survivalAdverse prognosticatorEchocardiographic characteristicsConsecutive patientsValve lesionsPoor prognosisRisk stratificationPrognosis of p16 and Human Papillomavirus Discordant Oropharyngeal Cancers and the Exploration of Using Natural Language Processing to Analyze Free-Text Pathology Reports
Shin E, Choi J, Hung T, Poon C, Riaz N, Yu Y, Kang J. Prognosis of p16 and Human Papillomavirus Discordant Oropharyngeal Cancers and the Exploration of Using Natural Language Processing to Analyze Free-Text Pathology Reports. JCO Clinical Cancer Informatics 2025, 9: e2400177. PMID: 39965177, DOI: 10.1200/cci-24-00177.Peer-Reviewed Original ResearchConceptsProgression-free survivalCancer-specific survivalOropharyngeal cancerHPV testingPathology reportsTreatment de-escalationCurative radiation therapyHPV+ oropharyngeal cancerPrimary end pointMinority of patientsPositive predictive valueStandard-of-careCancer-related deathsIn situ hybridizationStatistically significant differenceP16 statusP16-negativeHPV statusRadiation therapyInferior prognosisOverall survivalConsecutive patientsAcademic cancer centerDiscordant tumorsTreatment deintensification
2024
Evaluating fatigue and excessive daytime sleepiness: a comparative analysis of prevalence and correlating factors in interstitial lung disease patients and healthy controls
Ouyang X, Shen Q, Zhou S, Zhou P, Song M, Guo T, Guo W, Zhang Y, Peng H. Evaluating fatigue and excessive daytime sleepiness: a comparative analysis of prevalence and correlating factors in interstitial lung disease patients and healthy controls. Annals Of Medicine 2024, 56: 2398729. PMID: 39624966, PMCID: PMC11616753, DOI: 10.1080/07853890.2024.2398729.Peer-Reviewed Original ResearchInterstitial lung disease patientsInterstitial lung diseaseDiminished exercise capacityExcessive daytime sleepinessHealthy volunteersExercise capacityDaytime sleepinessEpworth Sleepiness Scale scoreQuality of lifePulmonary diffusion functionSleepiness Scale scoreFactors associated with excessive daytime sleepinessSecond Xiangya HospitalLogistic regressionLung disease patientsMultivariate logistic regressionDecreased quality of lifeCentral South UniversityCross-sectional studyPrevalence of fatigueChest painConsecutive patientsClinical characteristicsNon-ED patientsLung diseaseRhabdomyolysis in Severe Fever With Thrombocytopenia Syndrome: Associations With Acute Kidney Injury and Mortality
Zhang Z, Hu X, Du Q, Liu J, Chen X, Mo P, Luo M, Jiang Q, Deng L, Xiong Y. Rhabdomyolysis in Severe Fever With Thrombocytopenia Syndrome: Associations With Acute Kidney Injury and Mortality. Journal Of Medical Virology 2024, 96: e70095. PMID: 39624019, DOI: 10.1002/jmv.70095.Peer-Reviewed Original ResearchConceptsAcute kidney injuryKidney injuryRhabdomyolysis groupLaboratory parametersClinical characteristicsLevels of laboratory parametersThrombocytopenia syndromeMultivariate binary logistic regression analysisCumulative survival rateHigh viral loadMortality of patientsSevere feverBinary logistic regression analysisLogistic regression analysisAbdominal painConsecutive patientsSFTS patientsSerum levelsViral loadChest distressAdverse outcomesRhabdomyolysisSurvival ratePatientsSystem injuryArtificial Intelligence–Driven Patient Selection for Preoperative Portal Vein Embolization for Patients with Colorectal Cancer Liver Metastases
Kuhn T, Engelhardt W, Kahl V, Alkukhun A, Gross M, Iseke S, Onofrey J, Covey A, Camacho J, Kawaguchi Y, Hasegawa K, Odisio B, Vauthey J, Antoch G, Chapiro J, Madoff D. Artificial Intelligence–Driven Patient Selection for Preoperative Portal Vein Embolization for Patients with Colorectal Cancer Liver Metastases. Journal Of Vascular And Interventional Radiology 2024, 36: 477-488. PMID: 39638087, DOI: 10.1016/j.jvir.2024.11.025.Peer-Reviewed Original ResearchTotal liver volumeMetastatic colorectal cancer patientsPreoperative portal vein embolizationColorectal cancer liver metastasesPortal vein embolizationCancer liver metastasesMulticenter retrospective studyColorectal cancer patientsStudent's t-testBoard-certified radiologistsVein embolizationConsecutive patientsLiver metastasesLiver volumePatient selectionRetrospective studyCancer patientsRadiomic featuresInclusion criteriaPatientsSemi-automatic segmentationLab valuesT-testSDAUCOutcomes and Recurrence Rates Among Patients With Provoked and Cryptogenic Cerebral Venous Thrombosis
Al Kasab S, Almallouhi E, Shu L, Kicielinski K, Salehi Omran S, Liebeskind D, Zubair A, Vedovati M, Paciaroni M, Antonenko K, Heldner M, de Havenon A, Henninger N, Yaghi S. Outcomes and Recurrence Rates Among Patients With Provoked and Cryptogenic Cerebral Venous Thrombosis. Neurology Clinical Practice 2024, 15: e200381. PMID: 39399562, PMCID: PMC11464219, DOI: 10.1212/cpj.0000000000200381.Peer-Reviewed Original ResearchRisk of recurrent venous thromboembolismRecurrent venous thromboembolismCerebral venous thrombosisVenous thromboembolismFemale patientsVenous thrombosisBaseline characteristicsOutcome of cerebral venous thrombosisRate of recurrent venous thromboembolismProvoking factorsRare cause of strokeTransient provoking factorsKaplan-Meier survival analysisDuration of anticoagulationOutcomes of patientsMann-Whitney <i>Cause of strokeConsecutive patientsRare causeRecurrence rateMale patientsMulticenter studyRetrospective databaseStandard treatmentCox regression6620 Serum Steroid Profiling For The Diagnosis Of Adrenocortical Carcinoma: A Prospective Cross-Sectional Study From A Tertiary Center
Yu K, Athimulam S, Saini J, Kaur R, Singh R, Grebe S, Xue Q, Bancos I. 6620 Serum Steroid Profiling For The Diagnosis Of Adrenocortical Carcinoma: A Prospective Cross-Sectional Study From A Tertiary Center. Journal Of The Endocrine Society 2024, 8: bvae163.290. PMCID: PMC11454475, DOI: 10.1210/jendso/bvae163.290.Peer-Reviewed Original ResearchDiagnosing ACCDiagnosis of adrenocortical carcinomaArea under receiver operating curveAdrenocortical carcinomaUrine steroid profileAdrenocortical adenomaHounsfield unit measurementsSteroid profileAdrenal malignancyAdrenal massProspective cross-sectional studyExogenous glucocorticoid useCongenital adrenal hyperplasiaMeasurement of 11-deoxycortisolFasting serum samplesSerum steroid profilesNon-ACC groupsReceiver operating curveCross-sectional studyAdrenal tumorsAdrenal hyperplasiaConsecutive patientsGlucocorticoid useTertiary centerSerum steroidsDocetaxel Versus Androgen-Receptor Signaling Inhibitors (ARSI) as Second-Line Therapy After Failure of First-Line Alternative ARSI for the Elderly ≥ 75 Years Old With Metastatic Castration-Resistant Prostate Cancer (mCRPC): A SPARTACUSS—Meet-URO 26 Real-World Study
Patrikidou A, Saieva C, Lee-Ying R, Nuzzo P, Zarif T, McClure H, Davidsohn M, Eid M, Spinelli G, Catalano F, Cremante M, Fotia G, Rossetti S, Valenca L, Vauchier C, Ottanelli C, Andrade L, Gennusa V, Mestre R, Fornarini G, Pignata S, Procopio G, Santini D, Ravi P, Sweeney C, Heng D, De Giorgi U, Fizazi K, Russo A, Francini E, Group S. Docetaxel Versus Androgen-Receptor Signaling Inhibitors (ARSI) as Second-Line Therapy After Failure of First-Line Alternative ARSI for the Elderly ≥ 75 Years Old With Metastatic Castration-Resistant Prostate Cancer (mCRPC): A SPARTACUSS—Meet-URO 26 Real-World Study. Clinical Genitourinary Cancer 2024, 22: 102230. PMID: 39461026, DOI: 10.1016/j.clgc.2024.102230.Peer-Reviewed Original ResearchConceptsMetastatic castration-resistant prostate cancerAndrogen receptor signaling inhibitorsCastration-resistant prostate cancerAbiraterone acetateOverall survivalProstate cancerElderly patientsSignaling InhibitorsCohort of consecutive patientsSecond-line therapyStandard first-lineReal-world studySecond-lineConsecutive patientsTreatment toxicityFirst-lineD. CONCLUSIONSPatient comorbiditiesIdentified patientsRetrospective designToxicity outcomesD groupInternational cohortPatientsNo differenceRelative Cerebral Blood Flow as an Indirect Imaging Surrogate in Patients With Anterior Circulation Large Vessel Occlusion and Association of Baseline Characteristics With Poor Collateral Status
Salim H, Hamam O, Parilday G, Moustafa R, Ghandour S, Rutgers M, Sharara M, Cho A, Mazumdar I, Radmard M, Shin C, Montes D, Malhotra A, Romero J, Yedavalli V. Relative Cerebral Blood Flow as an Indirect Imaging Surrogate in Patients With Anterior Circulation Large Vessel Occlusion and Association of Baseline Characteristics With Poor Collateral Status. Journal Of The American Heart Association 2024, 13: e034581. PMID: 39158542, PMCID: PMC11963935, DOI: 10.1161/jaha.124.034581.Peer-Reviewed Original ResearchConceptsAnterior circulation large vessel occlusionAcute ischemic strokeLarge vessel occlusionCollateral statusAdmission laboratory valuesChronic kidney diseaseBaseline characteristicsCerebral blood flowVessel occlusionPoor CSConsecutive patientsMale sexLaboratory valuesComputed tomography perfusion dataPretreatment computed tomography perfusionKidney diseasePredictors of favorable outcomeAssociation of baseline characteristicsRetrospective multicenter studyBlood flowPoor collateral statusIndications of CSCerebral perfusion parametersPatient baseline characteristicsRelative cerebral blood flowHypoperfusion Intensity Ratio as an Indirect Imaging Surrogate in Patients With Anterior Circulation Large‐Vessel Occlusion and Association of Baseline Characteristics With Poor Collateral Status
Hamam O, Gudenkauf J, Moustafa R, Cho A, Montes D, Sharara M, Moustafa A, Radmard M, Nabi M, Chen K, Sepehri S, Shin C, Mazumdar I, Kim M, Mohseni A, Malhotra A, Romero J, Yedavalli V. Hypoperfusion Intensity Ratio as an Indirect Imaging Surrogate in Patients With Anterior Circulation Large‐Vessel Occlusion and Association of Baseline Characteristics With Poor Collateral Status. Journal Of The American Heart Association 2024, 13: e030897. PMID: 39158547, PMCID: PMC11963918, DOI: 10.1161/jaha.123.030897.Peer-Reviewed Original ResearchConceptsAnterior circulation large-vessel occlusionHypoperfusion intensity ratioLarge-vessel occlusionAcute ischemic strokeAdmission laboratory findingsCollateral statusAIS-LVOAdmission National InstitutesBaseline characteristicsLaboratory findingsConsecutive patientsPoor CSCryptogenic causeComputed tomography perfusion dataPretreatment computed tomography perfusionAssociation of baseline characteristicsPoor collateral statusPatient baseline characteristicsComputed tomography perfusionMultivariate logistic regressionInfarct growth rateMale patientsRetrospective studyClinical outcomesLogistic regression models
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