2025
Method for generating right ventricular pressure–volume loops in routine practice
Kremer N, Glocker F, Schaefer S, Janetzko P, Yogeswaran A, Rako Z, Thal B, Hopf H, Seeger W, Ghofrani H, Heerdt P, Tello K. Method for generating right ventricular pressure–volume loops in routine practice. The Journal Of Heart And Lung Transplantation 2025 PMID: 40947078, DOI: 10.1016/j.healun.2025.09.002.Peer-Reviewed Original ResearchRoutine right heart catheterizationEnd-diastolic volumeConductance catheterizationEjection fractionFeasibility cohortStroke workRight ventricular pressure-volume loopsRight ventricular (RV) functionClinical cohortStroke volumeRight heart catheterizationBland-Altman analysisPreclinical cohortPV loopsEnd-systolic elastanceRV volumesHeart catheterizationPulmonary hypertensionVentricular pressure-volume loopsPressure-volume loopsRoutine clinical workflowCatheterizationGold standardClinical implementationArterial elastanceScreening for pulmonary hypertension in preterm infants with bronchopulmonary dysplasia: when, how often and does it matter?
Gentle S, Carlo W, Ambalavanan N. Screening for pulmonary hypertension in preterm infants with bronchopulmonary dysplasia: when, how often and does it matter? Archives Of Disease In Childhood Fetal & Neonatal 2025, fetalneonatal-2024-328405. PMID: 40912904, DOI: 10.1136/archdischild-2024-328405.Peer-Reviewed Original ResearchNegative predictive valueBPD-PHBronchopulmonary dysplasiaPostmenstrual ageEchocardiographic screeningAt-risk infantsDiagnostic accuracyPulmonary hypertensionScreening strategiesWeeks postmenstrual ageOptimal screening strategyEstimates of diagnostic accuracyDiagnostic echocardiogramPreterm infantsEchocardiogramCohort studyLate screeningInfantsPredictive valueEarly screeningInsufficient evidenceDysplasiaTrue negativesHypertensionWeeksRevisiting inhaled nitric oxide utilization in congenital diaphragmatic hernia: A national cohort study of major children’s hospitals in the United States
Sescleifer A, Chidiac C, Hellmann Z, McDermott K, Garcia A, Rhee D, Slidell M, Solomon D, Kunisaki S. Revisiting inhaled nitric oxide utilization in congenital diaphragmatic hernia: A national cohort study of major children’s hospitals in the United States. Journal Of Pediatric Surgery 2025, 60: 162423. PMID: 40562092, DOI: 10.1016/j.jpedsurg.2025.162423.Peer-Reviewed Original ResearchCongenital diaphragmatic herniaExtracorporeal membrane oxygenationCongenital diaphragmatic hernia neonatesMechanical ventilation durationLength of stayINO useVentilation durationEfficacy of inhaled nitric oxideCDH outcomesCongenital diaphragmatic hernia infantsPediatric Health Information System databaseEfficacy of iNOChildren's HospitalHealth Information System databaseHospital chargesHospital length of stayIn-Hospital MortalityIncreased hospital chargesLonger length of stayEvidence-based guidelinesNational cohort studyPulmonary hypertensionCannulation rateProspective trialsDiaphragmatic herniaA series of hydroxychloroquine-associated cardiotoxicity presenting with heart failure
Nazarenko N, Maliha M, Parker M, Borkowski P, Csecs I, Tauras J, Shin J, Pullman J, Sims D, Rochlani Y. A series of hydroxychloroquine-associated cardiotoxicity presenting with heart failure. Annals Of Medicine And Surgery 2025, 87: 1334-1340. PMID: 40213182, PMCID: PMC11981468, DOI: 10.1097/ms9.0000000000002997.Peer-Reviewed Original ResearchSystemic lupus erythematosusHCQ useHeart failureCardiac abnormalitiesCardiac magnetic resonance imagingDose-dependent complicationsRheumatoid arthritisCases of SLE patientsDiscontinuation of hydroxychloroquineResolution of symptomsLong-term therapyEarly detectionShortness of breathA-V blockHCQ therapyMagnetic resonance imagingPrompt discontinuationEndomyocardial biopsyPulmonary hypertensionEjection fractionHF therapyCardiac symptomsImprove patient outcomesSLE patientsSjogren's syndromeThe role of right ventricular systolic pressure and ARISCAT score in perioperative pulmonary risk assessment
Tatsuoka Y, He Z, Lin H, Notarianni A, Carr Z. The role of right ventricular systolic pressure and ARISCAT score in perioperative pulmonary risk assessment. Brazilian Journal Of Anesthesiology 2025, 75: 844597. PMID: 39971234, PMCID: PMC11914786, DOI: 10.1016/j.bjane.2025.844597.Peer-Reviewed Original ResearchConceptsRight ventricular systolic pressurePostoperative pulmonary complicationsArea under the curveARISCAT scoreVentricular systolic pressureReceiver operating characteristic curvePulmonary hypertensionRespiratory failureHigh-risk populationPrimary endpointRisk stratificationSurgical proceduresSystolic pressurePostoperative pulmonary complications incidenceSource of increased morbidityAssess Respiratory RiskDiagnosis of PHPreoperative risk assessmentAdjusted multivariable logistic regression modelsMultivariate logistic regression modelComposite of pneumoniaPulmonary complicationsPreoperative investigationsSecondary endpointsPulmonary aspirationDetection of pulmonary hypertension in preterm infants with bronchopulmonary dysplasia using oxygen saturation data
Ramanand P, Indic P, Gentle S, Ambalavanan N. Detection of pulmonary hypertension in preterm infants with bronchopulmonary dysplasia using oxygen saturation data. Pediatric Research 2025, 98: 144-151. PMID: 39915610, DOI: 10.1038/s41390-025-03891-8.Peer-Reviewed Original ResearchDetection of pulmonary hypertensionBronchopulmonary dysplasiaPreterm infantsPulmonary hypertensionClinical risk factorsOxygen saturation dataBedside markersPresence of patent ductus arteriosusRisk factorsSignificant clinical risk factorsPatent ductus arteriosusIncreased risk of mortalityMultivariate logistic regression modelIdentification of PHPresence of PHRisk of mortalityOxygen saturation variabilityDuctus arteriosusClinical courseBackgroundPulmonary hypertensionClinical featuresPretermLogistic regression modelsAssociated PHIncreased risk636 Is permissive hypercapnia associated with the development of bronchopulmonary dysplasia-associated pulmonary hypertension in preterm infants?
Bhatia K, Nayak A, Jeffcoat S, Carlo W, Ambalavanan N, Gentle S. 636 Is permissive hypercapnia associated with the development of bronchopulmonary dysplasia-associated pulmonary hypertension in preterm infants? The American Journal Of The Medical Sciences 2025, 369: s421-s422. DOI: 10.1016/s0002-9629(25)00642-1.Peer-Reviewed Original ResearchExercise Pulmonary Hypertension and Beyond: Insights in Exercise Pathophysiology in Pulmonary Arterial Hypertension (PAH) from Invasive Cardiopulmonary Exercise Testing
Tarras E, Singh I, Kreiger J, Joseph P. Exercise Pulmonary Hypertension and Beyond: Insights in Exercise Pathophysiology in Pulmonary Arterial Hypertension (PAH) from Invasive Cardiopulmonary Exercise Testing. Journal Of Clinical Medicine 2025, 14: 804. PMID: 39941482, PMCID: PMC11818252, DOI: 10.3390/jcm14030804.Peer-Reviewed Original ResearchInvasive cardiopulmonary exercise testingPulmonary arterial hypertensionCardiopulmonary exercise testingArterial hypertensionAssociated with pulmonary vascular remodelingExercise testRight heart failureExercise pulmonary hypertensionPulmonary vascular remodelingPulmonary hypertensionProgressive diseasePulmonary vasculatureTherapeutic optionsExercise pathophysiologyHigh morbidityHeart failureEarly diagnosisVascular remodelingTherapeutic approachesPersonalized treatmentHypertensionDisease subtypesDiagnosisSkeletal muscleDisease
2024
Home is where the right ventricle lives: bronchopulmonary dysplasia-associated pulmonary hypertension and home ventilation
Gentle S, Ambalavanan N. Home is where the right ventricle lives: bronchopulmonary dysplasia-associated pulmonary hypertension and home ventilation. Pediatric Research 2024, 97: 31-32. PMID: 39266628, PMCID: PMC11798836, DOI: 10.1038/s41390-024-03550-4.Peer-Reviewed Original ResearchBronchopulmonary dysplasia-associated pulmonary hypertensionPulmonary hypertensionHome ventilationHypertensionAchieved oxygen saturations and risk for bronchopulmonary dysplasia with pulmonary hypertension in preterm infants
Gentle S, Singh A, Travers C, Nakhmani A, Carlo W, Ambalavanan N. Achieved oxygen saturations and risk for bronchopulmonary dysplasia with pulmonary hypertension in preterm infants. Archives Of Disease In Childhood 2024, 109: 941-947. PMID: 38937062, PMCID: PMC11503043, DOI: 10.1136/archdischild-2024-327014.Peer-Reviewed Original ResearchConceptsBronchopulmonary dysplasia-associated pulmonary hypertensionOxygen saturation indexSurvival statusPreterm infantsPulmonary hypertensionHigher FiOLt;29 weeks' gestationFraction of inspired oxygenWeeks postmenstrual ageSingle-centre studyNon-invasive predictorCase-control studyPostmenstrual ageWeeks gestationBronchopulmonary dysplasiaRespiratory supportNon-survivorsInfantsOxygen saturationPatient outcomesPretermSurvivalHypertensionWeeksPredictorsTumoral Pulmonary Hypertension in a Patient With Metastatic Breast Cancer: Diagnostic Opportunity of the Right Heart Catheterization
Tarras E, Sen S, Wang H, Singh I. Tumoral Pulmonary Hypertension in a Patient With Metastatic Breast Cancer: Diagnostic Opportunity of the Right Heart Catheterization. 2024, a2208-a2208. DOI: 10.1164/ajrccm-conference.2024.209.1_meetingabstracts.a2208.Peer-Reviewed Original ResearchRecurrence of Pulmonary Arteriovenous Malformation after Embolization in Patients with Pulmonary Hypertension
Fish A, Wang D, Knight E, Pollak J, Schlachter T. Recurrence of Pulmonary Arteriovenous Malformation after Embolization in Patients with Pulmonary Hypertension. Journal Of Vascular And Interventional Radiology 2024, 35: 1148-1153. PMID: 38692392, DOI: 10.1016/j.jvir.2024.04.017.Peer-Reviewed Original ResearchPulmonary arteriovenous malformationsPulmonary hypertensionArteriovenous malformationsRecurrence of pulmonary arteriovenous malformationsFollow-upChest CT follow-upPresence of pulmonary hypertensionCT follow-upShorter surveillance intervalsPulmonary artery pressureHistory of smokingPresence of PHCuracao criteriaSurveillance intervalsSmoking historyArterial pressureMultivariate analysisRecurrenceGenetic testingOdds ratioHypertensionPatientsStratified analysisGeneral demographicsStudy periodEndothelial HIFα-PDGF-B to smooth muscle Beclin1 signaling sustains pathological muscularization in pulmonary hypertension
Saddouk F, Kuzemczak A, Saito J, Greif D. Endothelial HIFα-PDGF-B to smooth muscle Beclin1 signaling sustains pathological muscularization in pulmonary hypertension. JCI Insight 2024, 9: e162449. PMID: 38652543, PMCID: PMC11141934, DOI: 10.1172/jci.insight.162449.Peer-Reviewed Original ResearchSmooth muscle cellsArteriole smooth muscle cellsPulmonary hypertensionPlatelet-derived growth factor-BDistal muscularizationSugen 5416Endothelial cellsHuman idiopathic pulmonary arterial hypertensionHypoxia-induced pulmonary vascular remodelingPulmonary artery smooth muscle cellsIdiopathic pulmonary arterial hypertensionHypoxia-inducible factor (HIF)-1aArtery smooth muscle cellsDistal pulmonary arteriolesPulmonary arterial hypertensionPulmonary vascular remodelingDeletion of Hif1aLung endothelial cellsGrowth factor BEC-specific deletionPulmonary arteriolesArterial hypertensionLung lysatesMuscle cellsVascular remodelingPulmonary Hypertension and the Risk of 30-Day Postoperative Pulmonary Complications after Gastrointestinal Surgical or Endoscopic Procedures: A Retrospective Propensity Score-Weighted Cohort Analysis
Tatsuoka Y, Carr Z, Jayakumar S, Lin H, He Z, Farroukh A, Heerdt P. Pulmonary Hypertension and the Risk of 30-Day Postoperative Pulmonary Complications after Gastrointestinal Surgical or Endoscopic Procedures: A Retrospective Propensity Score-Weighted Cohort Analysis. Journal Of Clinical Medicine 2024, 13: 1996. PMID: 38610760, PMCID: PMC11012853, DOI: 10.3390/jcm13071996.Peer-Reviewed Original ResearchPostoperative pulmonary complicationsLength of stayPulmonary hypertensionPulmonary complicationsPulmonary embolismRespiratory failureEndoscopic proceduresRisk of postoperative complicationsPulmonary artery pressurePreoperative risk assessmentProlonged length of stayRetrospective cohort studySub-cohort analysisIncreased LOSPropensity score overlap weightingOverlap weightingAssociation of PHPH cohortPH patientsPostoperative complicationsAbdominal surgeryRate of RFCohort studyControl cohortArterial pressureMineralocorticoid Receptors in Vascular Smooth Muscle: Blood Pressure and Beyond
Camarda N, Ibarrola J, Biwer L, Jaffe I. Mineralocorticoid Receptors in Vascular Smooth Muscle: Blood Pressure and Beyond. Hypertension 2024, 81: 1008-1020. PMID: 38426347, PMCID: PMC11023801, DOI: 10.1161/hypertensionaha.123.21358.Peer-Reviewed Original ResearchSmooth muscle cellsSMC-MRMineralocorticoid receptorBlood pressurePulmonary hypertensionHeart failureVascular calcificationAngiotensin II type 1 receptorRegulation of vasomotor functionVascular smooth muscleMR knockout miceType 1 receptorAortic valve diseaseSystemic blood pressureSMC proliferationConnective tissue growth factorMatrix metallopeptidase-2Heart valve dysfunctionDiverse cardiovascular disordersResponse to hypertensionTissue growth factorIn vitro studiesIn vivo findingsMyogenic toneValve dysfunctionMitral Transcatheter Edge-to-Edge Repair Advancing Treatment Options for Degenerative Mitral Regurgitation
Zahid S, Anjali Garg J, Altibi A, Golwala H. Mitral Transcatheter Edge-to-Edge Repair Advancing Treatment Options for Degenerative Mitral Regurgitation. Interventional Cardiology Clinics 2024, 13: 155-165. PMID: 38432759, DOI: 10.1016/j.iccl.2024.01.001.Peer-Reviewed Original ResearchConceptsDegenerative mitral regurgitationMitral regurgitationMitral transcatheter edge-to-edge repairTranscatheter edge-to-edge repairEdge-to-edge repairEdge-to-edge repair devicesSevere MR patientsTranscatheter edge-to-edge repair deviceLeft ventricular dysfunctionHeart failure syndromeStandard of careAdverse heart remodelingPulmonary hypertensionVentricular dysfunctionTranscatheter therapyFailure syndromeMR patientsSurgical riskTreatment optionsSurgical patientsHeart remodelingClinical needRegurgitationPatientsRepair devices737 Echocardiographic screening for bronchopulmonary dysplasia associated pulmonary hypertension: when, how often, and does it impact outcomes?
Gentle S, Carlo W, Ambalavanan N. 737 Echocardiographic screening for bronchopulmonary dysplasia associated pulmonary hypertension: when, how often, and does it impact outcomes? The American Journal Of The Medical Sciences 2024, 367: s461-s462. DOI: 10.1016/s0002-9629(24)00787-0.Peer-Reviewed Original Research
2023
Minimum Supervision Levels Required for Pediatric Cardiology Fellowship Graduation by Pediatric Cardiology Fellowship Program Directors
Karnik R, Robinson B, Glickstein J, Schwartz A, Mink R, Neal A, Frank L, McMahon C, Kim M, Turner D, Srivastava S. Minimum Supervision Levels Required for Pediatric Cardiology Fellowship Graduation by Pediatric Cardiology Fellowship Program Directors. Pediatric Cardiology 2023, 46: 181-188. PMID: 38117291, DOI: 10.1007/s00246-023-03371-y.Peer-Reviewed Original ResearchPediatric cardiologistsCardiac problemsPatient careMinimum LOSCardiac intensive careEntrustable professional activitiesSafe patient careEffective patient carePulmonary hypertensionSurvey response rateIntensive careArrhythmia managementFellowship program directorsResponse rateInterventional cardiologyFellowship graduationDelphi processSafe practiceInvestigator networksLOSCareCardiologistsEntrustment levelsFellowship programsUnsupervised practicePerceived Gaps in Knowledge for the Advanced Heart Failure and Transplant Cardiology Fellow: the Results of a National Needs-Assessment Survey
Nabi W, Windish D, Beasley M. Perceived Gaps in Knowledge for the Advanced Heart Failure and Transplant Cardiology Fellow: the Results of a National Needs-Assessment Survey. Journal Of Cardiac Failure 2023, 30: 516-519. PMID: 38000732, DOI: 10.1016/j.cardfail.2023.11.015.Peer-Reviewed Original ResearchAdvanced heart failureHeart failureMechanical circulatory supportMedical knowledge competencyNational needs assessment surveyHeart transplantationPulmonary hypertensionCirculatory supportProgram directorsNeeds assessment surveyCardiology fellowsFellowship trainingCardiologyFellowship programsAdditional trainingAssessment surveyFailureMedical competenciesCurrent adequacyHypertensionPatientsTransplantationFellowsFuture fellowsInterdependence in the Cardiorespiratory Network of Preterm Infants with Pulmonary Hypertension Using Mutual Information Analysis
Ramanand P, Indic P, Gentle S, Ambalavanan N. Interdependence in the Cardiorespiratory Network of Preterm Infants with Pulmonary Hypertension Using Mutual Information Analysis. 2016 Computing In Cardiology Conference (CinC) 2023, 50: 1-4. DOI: 10.22489/cinc.2023.354.Peer-Reviewed Original ResearchBronchopulmonary dysplasiaPreterm infantsPulmonary hypertensionCardiorespiratory networkComplications of PHHeart ratePH groupMechanisms of disease progressionRespiratory rateDisease progressionPretermInfantsOxygen saturationCardiorespiratory morbidityHypertensionGroupMean delayDysplasiaComplicationsMorbidity
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