2025
Differences in pain episodes among children with complex chronic conditions at end of life
Bogetz J, Phan M, Ayala E, Alayli Y, Johnston E, Ananth P, McGalliard J, Strub B, Bradford M, Rosenberg A. Differences in pain episodes among children with complex chronic conditions at end of life. Journal Of Pain And Symptom Management 2025 PMID: 40998221, DOI: 10.1016/j.jpainsymman.2025.09.015.Peer-Reviewed Original ResearchComplex chronic conditionsEnd-of-lifePain episodesChronic conditionsIntensive care unitYoung adults aged 0End of lifeElectronic health recordsDays of lifeHighest proportion of childrenAdults aged 0Proportion of childrenPearson chi-square testHealth disparitiesRetrospective studyHealth recordsChi-square testHighest proportionRetrospective study of childrenDescriptive statisticsStudy of childrenSevere pain episodesAged 0Demographic factorsU.S. academic institutionsAgreement Between Self-Reported and Proxy-Reported Pain in Veterans With Advanced Heart Failure.
Akgün K, Han L, Zhan Y, Abel E, Feder S. Agreement Between Self-Reported and Proxy-Reported Pain in Veterans With Advanced Heart Failure. American Journal Of Hospice And Palliative Medicine® 2025, 10499091251364232. PMID: 40741915, DOI: 10.1177/10499091251364232.Peer-Reviewed Original ResearchVeterans Affairs Medical CenterNumerical rating scaleProxy-reported painEnd of lifePatient pain assessmentAdvanced heart failureRetrospective cohort studySelf-ReportPatient self-reportPatient-reported painAffairs Medical CenterPatient-reported Numeric Rating ScaleEOL careHeart failurePain assessmentPain outcomesPain categoriesPain reportsAdvanced heart failure patientsMedical CenterDays of lifeNo painModerate agreementVeteransFamily Survey589. Late Onset Invasive Group B Streptococcal Disease Outbreak in a Neonatal Intensive Care Unit Identified Through Whole Genome Sequencing — Connecticut, 2020–2024
Lambert M, Jones S, Mueller K, Maloney M, Perera N, Incekara K, Petit S, Ramachandran V, Grossman M, Valderrama A, Chochua S, McGee L, Metcalf B, Schrag S, Sosa L. 589. Late Onset Invasive Group B Streptococcal Disease Outbreak in a Neonatal Intensive Care Unit Identified Through Whole Genome Sequencing — Connecticut, 2020–2024. Open Forum Infectious Diseases 2025, 12: ofae631.184. PMCID: PMC11778314, DOI: 10.1093/ofid/ofae631.184.Peer-Reviewed Original ResearchNeonatal intensive care unitGroup B streptococciGroup B Streptococcus isolatesWhole-genome sequencingIntensive care unitLate-onset diseaseOutbreak-related casesSingle nucleotide polymorphismsColonized infantsCare unitColon screeningGroup B streptococcus colonizationActive Bacterial Core surveillance programIntegration of whole genome sequencingDepartment of Public HealthAssessment of infection preventionDays of lifeIPC gapsLOD casesNeonatal sepsisB streptococciReview of dataConnecticut Department of Public HealthOutbreak-relatedIllness onset
2024
Clinical and environmental considerations for neonatal, office-based circumcisions compared with operative circumcisions
Press B, Jalfon M, Solomon D, Hittelman A. Clinical and environmental considerations for neonatal, office-based circumcisions compared with operative circumcisions. Frontiers In Urology 2024, 4: 1380154. PMID: 40777091, PMCID: PMC12327250, DOI: 10.3389/fruro.2024.1380154.Peer-Reviewed Original ResearchAmerican College of Obstetricians and GynecologistsNeonatal circumcisionDays of lifeAmerican Academy of PediatricsGeneral anesthesiaNeonatal circumcision ratesObstetricians and GynecologistsNeonatal male circumcisionMonths of lifeChanging insurance coverageAcademy of PediatricsAnd GynecologistsCircumcision ratesAmerican CollegeMale circumcisionMedical indicationsClinical providersUnited StatesOutpatient settingOperating roomCircumcisionNeurotoxic effectsAmerican AcademyHealthcare systemMinimal risk
2023
A comparison of end‐of‐life care quality for Veterans receiving hospice in VA nursing homes and community nursing homes
Wachterman M, Smith D, Carpenter J, Griffin H, Thorpe J, Feder S, Hoelter J, Ersek M, Shreve S, Kutney‐Lee A. A comparison of end‐of‐life care quality for Veterans receiving hospice in VA nursing homes and community nursing homes. Journal Of The American Geriatrics Society 2023, 72: 59-68. PMID: 37947240, PMCID: PMC10842969, DOI: 10.1111/jgs.18606.Peer-Reviewed Original ResearchCommunity nursing homesVeterans Health AdministrationBereaved Family SurveyElectronic medical recordsVA CLCsNursing homesEOL careAdjusted proportionVA electronic medical recordsVA nursing homesLife care qualityDays of lifeQuality of endNumber of veteransBFS itemsSecondary outcomesPrimary outcomeSymptom managementOverall careMedical recordsRetrospective analysisHospice careLife careHealth AdministrationVA Community1632-P: Effects of MTOR Signaling in Muscle-Specific Irs1/2 Knockout Mice
STOEHR O, COPPS K, TAO R, WHITE M. 1632-P: Effects of MTOR Signaling in Muscle-Specific Irs1/2 Knockout Mice. Diabetes 2023, 72 DOI: 10.2337/db23-1632-p.Peer-Reviewed Original ResearchMTKO miceGlucose uptakeMTOR pathwayMdKO miceReduced ejection fractionCardiac fatty acid uptakeHigh-fat dietInsulin-resistant heartMuscle glucose uptakeDays of lifeWhite adipose tissueCardiac glucose uptakeFatty acid uptakeEffects of mTORInsulin-stimulated conditionsEjection fractionFat dietFat massMuscle atrophyIRS2 expressionCardiac hypertrophyEarly deathCardiac energyKnockout miceAdipose tissueNeurosteroid pathway derangement in asphyctic infants treated with hypothermia: an untargeted metabolomic approach
Valerio E, Stocchero M, Pirillo P, D’Errico I, Bonadies L, Galderisi A, Giordano G, Baraldi E. Neurosteroid pathway derangement in asphyctic infants treated with hypothermia: an untargeted metabolomic approach. EBioMedicine 2023, 92: 104636. PMID: 37257315, PMCID: PMC10244906, DOI: 10.1016/j.ebiom.2023.104636.Peer-Reviewed Original ResearchConceptsAsphyctic infantsHypoxic-ischemic encephalopathyHealthy newbornsPerinatal asphyxiaMetabolic effectsSingle-center longitudinal studyDays of lifeTherapeutic hypothermiaUrinary metabolomePathobiological mechanismsSteroid levelsInfantsHypothermiaSteroidogenesis pathwayUntargeted metabolomics approachNewbornsSteroid contentTranslational researchLongitudinal studyPotential roleAsphyxiaEncephalopathyMetabolomics approachPathway analysisUntargeted metabolomicsAssociations of Early Completion of Advance Directives With Key End-of-Life Quality Measures: Analysis of an ASCO Quality Oncology Practice Initiative Patient Cohort
Power S, Bickel K, Chen R, Chiang A, Garrett-Mayer L, Makhoul I, Mougalian S, Shapiro C, Siegel R, Smith C, Rocque G, Kozlik M, Crist S, Kamal A. Associations of Early Completion of Advance Directives With Key End-of-Life Quality Measures: Analysis of an ASCO Quality Oncology Practice Initiative Patient Cohort. JCO Oncology Practice 2023, 19: e520-e526. PMID: 36669136, DOI: 10.1200/op.22.00464.Peer-Reviewed Original ResearchConceptsDays of lifeEmergency room visitsAD completionChemotherapy receiptRoom visitsAdvance directivesIntensive care unit admissionLife quality measuresCare unit admissionEOL quality measuresOutcomes of patientsIntensive care unitPatient-level dataChi-square testHigh rateUnit admissionHospice enrollmentCare unitOncology visitsPatient cohortPatient enrollmentPatientsCancer diagnosisVisitsQuality measures
2022
End-of-Life Care for Patients With Metastatic Renal Cell Carcinoma in the Era of Oral Anticancer Therapy
Dzimitrowicz H, Wilson L, Jackson B, Spees L, Baggett C, Greiner M, Kaye D, Zhang T, George D, Scales C, Pritchard J, Leapman M, Gross C, Dinan M, Wheeler S. End-of-Life Care for Patients With Metastatic Renal Cell Carcinoma in the Era of Oral Anticancer Therapy. JCO Oncology Practice 2022, 19: e213-e227. PMID: 36413741, PMCID: PMC9970274, DOI: 10.1200/op.22.00401.Peer-Reviewed Original ResearchConceptsMetastatic renal cell carcinomaOral anticancer agentsDays of lifeRenal cell carcinomaEOL careSystemic therapySEER-MedicareHospital deathCell carcinomaLife careIntensive care unit admissionCancer informationAggressive EOL careHigh-quality EOLOral anticancer therapySystemic therapy useCare unit admissionMultivariable logistic regressionQuality of endUnit admissionED visitsOlder patientsYounger patientsHospital admissionTherapy useEnd‐of‐life care quality for children with cancer who receive palliative care
Ananth P, Lindsay M, Nye R, Mun S, Feudtner C, Wolfe J. End‐of‐life care quality for children with cancer who receive palliative care. Pediatric Blood & Cancer 2022, 69: e29841. PMID: 35686746, PMCID: PMC10498672, DOI: 10.1002/pbc.29841.Peer-Reviewed Original ResearchConceptsIntensive care unit admissionCare unit admissionLife care qualityDistressing symptomsCancer decedentsEnd of lifeUnit admissionMechanical ventilationCare qualityPalliative Care DatabaseDays of lifeLower household incomeAnnual household incomeHospice enrollmentHospital admissionMultivariable analysisPatient factorsUnivariable analysisPalliative careCare databaseHospice servicesLower oddsResearch DatabaseCancer typesHospital servicesImpact of prelacteal feeds and neonatal introduction of breast milk substitutes on breastfeeding outcomes: A systematic review and meta‐analysis
Pérez‐Escamilla R, Hromi‐Fiedler A, Rhodes EC, Neves PAR, Vaz J, Vilar‐Compte M, Segura‐Pérez S, Nyhan K. Impact of prelacteal feeds and neonatal introduction of breast milk substitutes on breastfeeding outcomes: A systematic review and meta‐analysis. Maternal And Child Nutrition 2022, 18: e13368. PMID: 35489107, PMCID: PMC9113480, DOI: 10.1111/mcn.13368.Peer-Reviewed Original ResearchConceptsBF outcomesBreast milkNeonatal periodSystematic reviewProspective studyRisk factorsSuboptimal breastfeeding outcomesLate neonatal periodOnly prospective studiesSignificant risk factorsEarly introductionDays of lifeWeb of SciencePrelacteal feedsBF durationBreastfeeding outcomesWeeks postpartumInclusion criteriaPrelactealsStudy designEffective interventionsObserved associationsOutcomesFeeding studyCessationEarly-life factors associated with neurobehavioral outcomes in preterm infants during NICU hospitalization
Zhao T, Griffith T, Zhang Y, Li H, Hussain N, Lester B, Cong X. Early-life factors associated with neurobehavioral outcomes in preterm infants during NICU hospitalization. Pediatric Research 2022, 92: 1695-1704. PMID: 35338349, PMCID: PMC9509490, DOI: 10.1038/s41390-022-02021-y.Peer-Reviewed Original ResearchConceptsNeonatal Infant Stressor ScalePreterm infantsNeurobehavioral outcomesBreastmilk intakeGestational ageNICU hospitalizationMaternal breastmilkAssociated with increasing GADay of NICU hospitalizationWeeks post-menstrual ageNICU Network Neurobehavioral ScalePoorer quality of movementOlder gestational agePost-menstrual ageMethodsA prospective cohort studyNISS scoresInfant neurobehavioral outcomesProspective cohort studyDays of lifeConclusionsPreterm infantsGA infantsYounger GAPain/stressNeurobehavioral ScalePretermFactors associated with the quality of end-of-life care for patients with metastatic renal cell carcinoma.
Dzimitrowicz H, Wilson L, Jackson B, Spees L, Baggett C, Greiner M, Kaye D, Zhang T, George D, Scales C, Pritchard J, Leapman M, Gross C, Dinan M, Wheeler S. Factors associated with the quality of end-of-life care for patients with metastatic renal cell carcinoma. Journal Of Clinical Oncology 2022, 40: 300-300. DOI: 10.1200/jco.2022.40.6_suppl.300.Peer-Reviewed Original ResearchMetastatic renal cell carcinomaOral anti-cancer agentsRenal cell carcinomaSEER-MedicareDays of lifeSystemic therapyICU admissionCell carcinomaOdds ratioLife careSEER-Medicare cohortSystemic therapy useMultivariable logistic regressionUse of hospiceQuality of endHigh-quality endMRCC diagnosisAnti-cancer agentsMost patientsOlder patientsHospital admissionMedian ageTherapy useImmunotherapy treatmentRetrospective study
2021
Fluid Intake in the First Week of Life and the Duration of Hemodynamically Significant Patent Ductus Arteriosus in Extremely Preterm Infants
Mirza H, Garcia J, Bell C, Jones K, Flynn V, Pepe J, Oh W. Fluid Intake in the First Week of Life and the Duration of Hemodynamically Significant Patent Ductus Arteriosus in Extremely Preterm Infants. American Journal Of Perinatology 2021, 40: 1345-1350. PMID: 34384119, DOI: 10.1055/a-1585-6093.Peer-Reviewed Original ResearchConceptsHemodynamically significant patent ductus arteriosusDaily fluid intakeSignificant patent ductus arteriosusAssociated with prolonged durationDays of lifeExtremely preterm infantsPreterm infantsPatent ductus arteriosusHigh fluid intakeFluid intakeWeeks of lifeDuctus arteriosusDiagnosis of hemodynamically significant patent ductus arteriosusMultivariate analysisNeonatal intensive care unitScoring systemTotal fluid intakeRetrospective cohort studyIntensive care unitActual fluid intakeProlonged ventilationTrophic feedingBirth weightFluid administrationCohort studyPerceptions of Hospice and Transfusion Access Among Patients with Advanced Blood Cancers: Results from a Best-Worst Scaling Survey
Odejide O, Huntington S, Shi E, Johnson K, Tulsky J, Abel G. Perceptions of Hospice and Transfusion Access Among Patients with Advanced Blood Cancers: Results from a Best-Worst Scaling Survey. Blood 2021, 138: 3020. DOI: 10.1182/blood-2021-153304.Peer-Reviewed Original ResearchBlood cancersCancer CenterHematologic malignanciesHospice servicesUtility scoresLarge cancer centerConfidence intervalsPerceptions of patientsBlood cancer patientsPerspectives of patientsDays of lifeYears of ageQuality of lifeCaregiver focus groupsEligible patientsHematologic oncologistsBlood transfusionMedian ageCommon diagnosisOutpatient visitsCancer patientsHospice useStudy inclusionAcute leukemiaPatients' perceptionsTrends in end-of- life (EOL) systemic oncologic treatment in contemporary clinical practice: Insights from real-world data.
Canavan M, Wang X, Ascha M, Miksad R, Showalter T, Calip G, Gross C, Adelson K. Trends in end-of- life (EOL) systemic oncologic treatment in contemporary clinical practice: Insights from real-world data. Journal Of Clinical Oncology 2021, 39: 253-253. DOI: 10.1200/jco.2020.39.28_suppl.253.Peer-Reviewed Original ResearchDay of deathReal-world practiceTraditional chemotherapyCancer treatmentStudy periodPractice-level factorsOverall healthcare utilizationSystemic cancer treatmentRates of chemotherapyDays of lifeDe-identified databaseContemporary clinical practiceLogistic regression modelsElectronic health recordsCancer care organizationsSystemic therapySystemic treatmentOncologic treatmentHealthcare utilizationImmune therapyTargeted therapyStratified analysisHigher total costsLife careOncolytic therapyFluid Intake in the First Week of Life and the Duration of Hemodynamically Significant Patent Ductus Arteriosus in Extremely Preterm Infants
Mirza H, Garcia J, Bell C, Jones K, Flynn V, Pepe J, Oh W. Fluid Intake in the First Week of Life and the Duration of Hemodynamically Significant Patent Ductus Arteriosus in Extremely Preterm Infants. American Journal Of Perinatology 2021 DOI: 10.1055/s-0041-1735623.Peer-Reviewed Original ResearchHemodynamically significant patent ductus arteriosusDaily fluid intakeSignificant patent ductus arteriosusDays of lifeExtremely preterm infantsPatent ductus arteriosusHigh fluid intakePreterm infantsFluid intakeWeeks of lifeDuctus arteriosusDiagnosis of hemodynamically significant patent ductus arteriosusMultivariate analysisNeonatal intensive care unitAssociated with prolonged durationTotal fluid intakeRetrospective cohort studyIntensive care unitActual fluid intakeProlonged ventilationTrophic feedingBirth weightFluid administrationGroup BCohort studyExamining the Association of Billed Advance Care Planning With End-of-Life Hospital Admissions Among Advanced Cancer Patients in Hospice
Prater LC, O’Rourke B, Schnell P, Xu W, Li Y, Gustin J, Lockwood B, Lustberg M, White S, Happ MB, Retchin SM, Wickizer TM, Bose-Brill S. Examining the Association of Billed Advance Care Planning With End-of-Life Hospital Admissions Among Advanced Cancer Patients in Hospice. American Journal Of Hospice And Palliative Medicine® 2021, 39: 504-510. PMID: 34427154, DOI: 10.1177/10499091211039449.Peer-Reviewed Original ResearchConceptsAdvance care planningDays of lifeHospital admissionAdvanced cancerCare planningACP servicesCross-sectional retrospective cohort studySystematic advance care planningLife hospital admissionsMedical claims analysisRetrospective cohort studyAdvanced cancer patientsInpatient hospital admissionsPopulation of patientsAdvanced cancer diagnosisQuality of careHospice referralCohort studyIBM MarketScanEOL outcomesInpatient admissionsStudy criteriaCancer patientsHospice careCare preferencesSociodemographic and hospital‐based predictors of intense end‐of‐life care among children, adolescents, and young adults with hematologic malignancies
Mun S, Wang R, Ma X, Ananth P. Sociodemographic and hospital‐based predictors of intense end‐of‐life care among children, adolescents, and young adults with hematologic malignancies. Cancer 2021, 127: 3817-3824. PMID: 34185881, PMCID: PMC8478813, DOI: 10.1002/cncr.33764.Peer-Reviewed Original ResearchConceptsHematologic malignanciesYoung adultsLife careMultivariable logistic regression modelCancer-directed treatmentPremier Healthcare DatabaseRetrospective cohort studyEmergency department visitsIntensive care unitHigh-intensity endDays of lifeMajority of childrenLogistic regression modelsIntravenous chemotherapyTracheostomy placementCohort studyDepartment visitsCare unitMechanical ventilationHospital characteristicsMultivariable modelCardiopulmonary resuscitationType of insuranceHealthcare databasesMalignancyAssociations Between Health Literacy and End-of-Life Care Intensity Among Medicare Beneficiaries
Luo Q, Shi K, Hung P, Wang SY. Associations Between Health Literacy and End-of-Life Care Intensity Among Medicare Beneficiaries. American Journal Of Hospice And Palliative Medicine® 2021, 38: 626-633. PMID: 33472379, DOI: 10.1177/1049909120988506.Peer-Reviewed Original ResearchConceptsAggressive EOL careLow health literacyEOL careHealth literacyMedicare beneficiariesHospital deathCare intensityHigher oddsEOL care intensityLife care intensityPatient-provider communicationProportion of decedentsMonths of lifeDays of lifeHospice enrollmentHL scoreMultivariable analysisHospice useCare measuresRetrospective analysisLife careMedicare feeService decedentsDecedentsCare
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