2025
Long-Term Engraftment of Cryopreserved Human Neurons for In Vivo Disease Modeling in Neurodegenerative Disease
Marmion D, Deng P, Hiller B, Lewis R, Harms L, Cameron D, Nolta J, Kordower J, Fink K, Wakeman D. Long-Term Engraftment of Cryopreserved Human Neurons for In Vivo Disease Modeling in Neurodegenerative Disease. Biology 2025, 14: 217. PMID: 40001985, PMCID: PMC11852092, DOI: 10.3390/biology14020217.Peer-Reviewed Original ResearchCentral nervous systemStriatum of Sprague-Dawley ratsForebrain GABAergic neuronsLong-term engraftmentHuman induced pluripotent stem cellsHuman neuronsSprague-Dawley ratsWild-type controlsPluripotent stem cellsPrefrontal cortexMature neuronal phenotypeRNU ratsHost striatumDisease in vivoGABAergic neuronsPost-transplantationImmunodeficient ratsIn vivo disease modelsIGABAHuntington's diseaseCynomolgus monkeysNeuronal phenotypeHD miceCNS environmentNeuronal survival
2024
Antioxidant Efficacy of Hwangryunhaedok-tang through Nrf2 and AMPK Signaling Pathway against Neurological Disorders In Vivo and In Vitro
Bae S, Lee W, Bak S, Lee S, Hwang S, Kim G, Koo B, Park S, Yoo H, Kim C, Kang H, Oh T, Kim Y. Antioxidant Efficacy of Hwangryunhaedok-tang through Nrf2 and AMPK Signaling Pathway against Neurological Disorders In Vivo and In Vitro. International Journal Of Molecular Sciences 2024, 25: 2313. PMID: 38396988, PMCID: PMC10889506, DOI: 10.3390/ijms25042313.Peer-Reviewed Original ResearchConceptsFormation of neurofibrillary tanglesNeurofibrillary tanglesAlzheimer's diseaseImpaired clearance of amyloid betaSignaling pathwayClearance of amyloid betaAMPK Signaling PathwayActivate signaling pathwaysAlzheimer's disease in vivoInhibition of cell apoptosisCause of dementiaAmyloid-betaHT-22 cellsNeuritic plaquesIn vitroMitochondrial dysfunctionOxidative stressCell apoptosisDisease in vivoROS generationHT-22Prevent ADAMPKDisorders in vivoProtein levels
2022
Type 2 immune polarization is associated with cardiopulmonary disease in preterm infants
Lao J, Bui C, Pang M, Cho S, Rudloff I, Elgass K, Schröder J, Maksimenko A, Mangan N, Starkey M, Skuza E, Sun Y, Beker F, Collins C, Kamlin O, König K, Malhotra A, Tan K, Theda C, Young M, McLean C, Wilson N, Sehgal A, Hansbro P, Pearson J, Polo J, Veldman A, Berger P, Nold-Petry C, Nold M. Type 2 immune polarization is associated with cardiopulmonary disease in preterm infants. Science Translational Medicine 2022, 14: eaaz8454. PMID: 35385341, DOI: 10.1126/scitranslmed.aaz8454.Peer-Reviewed Original ResearchConceptsPreterm infantsBronchopulmonary dysplasiaIL-13CD3<sup>+</sup>CD4<sup>+</sup> T cellsInterleukin-4BPD-associated pulmonary hypertensionMaternal magnesium sulfate therapyCD4<sup>+</sup> T cellsCardiopulmonary diseaseMagnesium sulfate therapyType 2 mediatorsHealthy term infantsType 2 polarizationType 2 cytokinesHepatitis B vaccineMultiple therapeutic approachesTerm infantsPulmonary hypertensionDisease in vivoT cellsLung inflammationYounger patientsIL-5B vaccineHigh treatment costs
2016
Implications of Cellular Senescence on Aging and Disease in the Brain
Crowe E, Tuzer S, Cohen J, Yetkin E, D’Agostino L, Sell C, Torres C. Implications of Cellular Senescence on Aging and Disease in the Brain. Healthy Ageing And Longevity 2016, 263-286. DOI: 10.1007/978-3-319-26239-0_14.Peer-Reviewed Original ResearchSenescence in vitroDisease in vivoAccumulation of senescent astrocytesHIV-associated dementiaIrreversible mitotic arrestSignificant neuronal lossResistance to apoptosisLow regenerative capacityPro-inflammatory signalingCNS cell typesResponse to insultsSenescence-like phenotypeProgenitor cellsAging BrainStress in vitroLoss of astrocyte functionMouse modelNeuroinflammatory functionsSynaptic plasticityInflammatory stressNeural stemNeurodegenerative diseasesGrowth factorRegenerative capacityReactive astrogliosis
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