2024
APOE đ4ârelated bloodâbrain barrier breakdown is associated with microstructural abnormalities
Reas E, Solders S, Tsiknia A, Triebswetter C, Shen Q, Rivera C, Andrews M, AldersonâMyers A, Brewer J. APOE đ4ârelated bloodâbrain barrier breakdown is associated with microstructural abnormalities. Alzheimer's & Dementia 2024, 20: 8615-8624. PMID: 39411970, PMCID: PMC11667544, DOI: 10.1002/alz.14302.Peer-Reviewed Original ResearchAPOE4 carriersAlzheimer's diseaseAmyloid-negative individualsAmyloid-betaAmyloid-positive individualsApoE4AD cascadeAmyloidBlood-brain barrierAPOE 4Magnetic resonance imagingBrain microstructureAbsence of cognitive declinePreclinical ADLinear regression assessed associationsAmyloid positivityNeurodegenerative changesCortical gray matterCognitive declineMicrostructural abnormalitiesAssociated with microstructural abnormalitiesCognitive statusApoNeurodegenerationOlder adultsCOCAINE SELF-ADMINISTRATION BEHAVIOR IS ASSOCIATED WITH SUBCORTICAL AND CORTICAL GRAY MATTER IN INDIVIDUALS WITH COCAINE USE DISORDER
Kohler R, Zhornitsky S, Potenza M, Yip S, Worhunsky P, Angarita G. COCAINE SELF-ADMINISTRATION BEHAVIOR IS ASSOCIATED WITH SUBCORTICAL AND CORTICAL GRAY MATTER IN INDIVIDUALS WITH COCAINE USE DISORDER. Drug And Alcohol Dependence 2024, 260: 110081. DOI: 10.1016/j.drugalcdep.2023.110081.Peer-Reviewed Original ResearchSex-driven variability in TSPO-expressing microglia in MS patients and healthy individuals
Laaksonen S, Saraste M, Nylund M, Hinz R, Snellman A, Rinne J, Matilainen M, Airas L. Sex-driven variability in TSPO-expressing microglia in MS patients and healthy individuals. Frontiers In Neurology 2024, 15: 1352116. PMID: 38445263, PMCID: PMC10913932, DOI: 10.3389/fneur.2024.1352116.Peer-Reviewed Original ResearchDistribution volume ratioNormal-appearing white matterMale MS patientsCortical gray matterMS patientsPositron emission tomographyTSPO bindingMultiple sclerosisDisease progressionHealthy individualsClinical disease progressionWhole-brainBrain positron emission tomographySex differencesMales compared to femalesFemale patientsHealthy womenDisability progressionGreater likelihoodGray matterHealthy controlsStudy cohortFemale controlsEmission tomographyBrain
2020
Non-congenital viral infections of the central nervous system: from the immunocompetent to the immunocompromised child
Moltoni G, DâArco F, Pasquini L, Carducci C, Bhatia A, Longo D, Kaliakatsos M, Lancella L, Romano A, Di Napoli A, Bozzao A, Rossi-Espagnet M. Non-congenital viral infections of the central nervous system: from the immunocompetent to the immunocompromised child. Pediatric Radiology 2020, 50: 1757-1767. PMID: 32651625, DOI: 10.1007/s00247-020-04746-6.Peer-Reviewed Original ResearchConceptsCentral nervous systemRadiological patternsViral infectionNervous systemGray matterCerebrospinal fluid analysisSevere clinical conditionDeep gray matterCortical gray matterViral tropismViral encephalomyelitisAetiological diagnosisClinical conditionsFluid analysisWhite matterPictorial essayDiagnosisInfectionBrainstemEncephalomyelitisTropismSpineCerebellumSymptoms
2018
Changes in Cerebral Cortical Thickness Related to Weight Loss Following Bariatric Surgery
Bohon C, Garcia LC, Morton JM. Changes in Cerebral Cortical Thickness Related to Weight Loss Following Bariatric Surgery. Obesity Surgery 2018, 28: 2578-2582. PMID: 29876838, PMCID: PMC6400222, DOI: 10.1007/s11695-018-3317-6.Peer-Reviewed Original ResearchConceptsCerebral cortical thicknessCortical thicknessBariatric surgeryWeight Loss Following Bariatric SurgeryGreater excess weight lossExcess weight lossCortical gray matterMagnetic resonance imaging dataBrain changesPatientsGray matterSurgeryWeight lossPreliminary evidenceNeurocognitive measuresFurther investigationMemory recallImaging dataPrevious studiesObesityGlobal measuresLarge sampleMonthsLongitudinal Trajectories of Brain Volume and Cortical Thickness in Treated and Untreated Primary Human Immunodeficiency Virus Infection
Sanford R, Ances BM, Meyerhoff DJ, Price RW, Fuchs D, Zetterberg H, Spudich S, Collins DL. Longitudinal Trajectories of Brain Volume and Cortical Thickness in Treated and Untreated Primary Human Immunodeficiency Virus Infection. Clinical Infectious Diseases 2018, 67: 1697-1704. PMID: 29697762, PMCID: PMC6233681, DOI: 10.1093/cid/ciy362.Peer-Reviewed Original ResearchConceptsCombination antiretroviral therapyHuman immunodeficiency virusPrimary HIV infectionChronic HIV infectionCortical thicknessHIV infectionCortical thinningUntreated infectionTemporal lobeBrain volumeImpact of HIVPrimary human immunodeficiency virus (HIV) infectionEarly combination antiretroviral therapyUntreated human immunodeficiency virusHuman immunodeficiency virus (HIV) infectionLongitudinal magnetic resonance imagingImmunodeficiency virus infectionCerebrospinal fluid biomarkersStructural brain changesCortical gray matterMagnetic resonance imagingBrain morphometric measuresCART durationAntiretroviral therapySubcortical atrophy
2017
In utero exposure to maternal smoking is associated with DNA methylation alterations and reduced neuronal content in the developing fetal brain
Chatterton Z, Hartley B, Seok M, Mendelev N, Chen S, Milekic M, Rosoklija G, Stankov A, Trencevsja-Ivanovska I, Brennand K, Ge Y, Dwork A, Haghighi F. In utero exposure to maternal smoking is associated with DNA methylation alterations and reduced neuronal content in the developing fetal brain. Epigenetics & Chromatin 2017, 10: 4. PMID: 28149327, PMCID: PMC5270321, DOI: 10.1186/s13072-017-0111-y.Peer-Reviewed Original ResearchMeSH KeywordsBrainDNA MethylationFemaleFetal DevelopmentFetusGestational AgeGTP-Binding Protein alpha Subunits, Gq-G11HumansImmunohistochemistryInduced Pluripotent Stem CellsMaleMaternal ExposureNeural Stem CellsNeuronsPregnancyPregnancy Trimester, SecondPromoter Regions, GeneticSmokingSuccinate DehydrogenaseTubulinConceptsMaternal smokingDorsolateral prefrontal cortexNeuronal contentCortical gray matterFetal brain growthDifferentiation of neuronsBehavioral problemsFalse discovery correctionSignificant DMRsSmoking exposureGestational ageSecond trimesterUtero exposurePrenatal exposureCortical developmentFetal brainExposure altersSmokingBrain growthGray matterCell proportionFetusesPrefrontal cortexDNA methylationMethylation profiles
2015
Brain region and activity-dependent properties of M for calibrated fMRI
Shu CY, Herman P, Coman D, Sanganahalli BG, Wang H, Juchem C, Rothman DL, de Graaf RA, Hyder F. Brain region and activity-dependent properties of M for calibrated fMRI. NeuroImage 2015, 125: 848-856. PMID: 26529646, PMCID: PMC4691415, DOI: 10.1016/j.neuroimage.2015.10.083.Peer-Reviewed Original Research
2012
Detecting cortical lesions in multiple sclerosis at 7 T using white matter signal attenuation
Bluestein KT, Pitt D, Sammet S, Zachariah CR, Nagaraj U, Knopp MV, Schmalbrock P. Detecting cortical lesions in multiple sclerosis at 7 T using white matter signal attenuation. Magnetic Resonance Imaging 2012, 30: 907-915. PMID: 22578928, PMCID: PMC3402634, DOI: 10.1016/j.mri.2012.03.006.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAged, 80 and overAlgorithmsCerebral CortexFemaleHumansImage EnhancementImage Interpretation, Computer-AssistedMagnetic Resonance ImagingMaleMiddle AgedMultiple SclerosisNerve Fibers, MyelinatedReproducibility of ResultsSensitivity and SpecificitySubtraction TechniqueYoung Adult
2010
Genetic Associations of Brain Structural Networks in Schizophrenia: A Preliminary Study
Jagannathan K, Calhoun VD, Gelernter J, Stevens MC, Liu J, Bolognani F, Windemuth A, RuaĂąo G, Assaf M, Pearlson GD. Genetic Associations of Brain Structural Networks in Schizophrenia: A Preliminary Study. Biological Psychiatry 2010, 68: 657-666. PMID: 20691427, PMCID: PMC2990476, DOI: 10.1016/j.biopsych.2010.06.002.Peer-Reviewed Original ResearchConceptsSpecific structural brain abnormalitiesMagnetic resonance imaging (MRI) scansSmall sample sizeHealthy control subjectsStructural brain abnormalitiesStructural magnetic resonance imaging (MRI) scansGray matter deficitsResonance imaging scansCortical gray matterNormal central nervous system developmentRisk genesCentral nervous system developmentBrain structural networksControl subjectsImaging scansBrain abnormalitiesNervous system developmentIllness markersSchizophrenia pathophysiologySchizophrenia risk genesGenetic componentTemporal lobeBrain areasEuropean-American subjectsSchizophrenia patients
2003
Regional Brain Volumes and Their Later Neurodevelopmental Correlates in Term and Preterm Infants
Peterson BS, Anderson AW, Ehrenkranz R, Staib LH, Tageldin M, Colson E, Gore JC, Duncan CC, Makuch R, Ment LR. Regional Brain Volumes and Their Later Neurodevelopmental Correlates in Term and Preterm Infants. 2003, 111: 939-948. PMID: 12728069, DOI: 10.1542/peds.111.5.939.Peer-Reviewed Original ResearchConceptsRegional brain volumesPreterm infantsCortical gray matterWhite matter volumeBrain volumeParieto-occipital regionsGray matterMatter volumeNeurodevelopmental outcomesWhite matterParieto-occipital gray matterRegional volumesHigh-resolution magnetic resonance imaging (MRI) scansMagnetic resonance imaging (MRI) scansCognitive outcomesLong-term outcomesRight-sided structuresResonance imaging scansCross-sectional studyNeonatal brain volumesGray matter volumeSubcortical gray matterInferior occipital cortexMidtemporal regionTerm infants
2001
Calpain proteolysis of ÎąII-spectrin in the normal adult human brain
Huh G, Glantz S, Je S, Morrow J, Kim J. Calpain proteolysis of ÎąII-spectrin in the normal adult human brain. Neuroscience Letters 2001, 316: 41-44. PMID: 11720774, DOI: 10.1016/s0304-3940(01)02371-0.Peer-Reviewed Original ResearchConceptsAdult human brainCalpain activationEvident neurological diseaseHuman brainCortical gray matterLong-term potentiationNormal adult human brainDendrites of neuronsCerebellar Purkinje cellsCalpain processingReactive astrocytesCerebral cortexPyramidal neuronsSynaptic remodelingClinical conditionsNeuronal apoptosisAdult brainPositive cellsNeurological diseasesGray matterPurkinje cellsTopographic distributionAlphaII-spectrinBrainCalpain proteolysis
1991
MRI of the normal hippocampus
Bronen R, Cheung G. MRI of the normal hippocampus. Magnetic Resonance Imaging 1991, 9: 497-500. PMID: 1779720, DOI: 10.1016/0730-725x(91)90035-k.Peer-Reviewed Original ResearchConceptsHippocampal signal intensityCortical gray matterSpecific anatomic locationsNormal hippocampusHippocampal changesAnatomic locationDisease processNormal volunteersHippocampal sizeGray matterPathologic disordersMR studiesHippocampusMemory disordersNormal variationDisordersSignal intensityMild variationEpilepsy
1985
Primate frontal eye fields. II. Physiological and anatomical correlates of electrically evoked eye movements
Bruce C, Goldberg M, Bushnell M, Stanton G. Primate frontal eye fields. II. Physiological and anatomical correlates of electrically evoked eye movements. Journal Of Neurophysiology 1985, 54: 714-734. PMID: 4045546, DOI: 10.1152/jn.1985.54.3.714.Peer-Reviewed Original ResearchConceptsFrontal eye fieldEye fieldArcuate sulcusPresaccadic neuronsSaccade directionArea 8Frontal eye field neuronsEye movementsBrodmann area 8Cortical gray matterSaccadic eye movementsAwake macaque monkeysArea 8APresaccadic activityAnterior bankVentrolateral portionDorsomedial portionElicited saccadesElectrical stimulationLarge saccadesMacaque monkeysGray matterElectrode penetrationsAnatomical correlatesSmall saccades
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