2022
Type 2 immune polarization is associated with cardiopulmonary disease in preterm infants
Lao J, Bui C, Pang M, Cho S, Rudloff I, Elgass K, Schröder J, Maksimenko A, Mangan N, Starkey M, Skuza E, Sun Y, Beker F, Collins C, Kamlin O, König K, Malhotra A, Tan K, Theda C, Young M, McLean C, Wilson N, Sehgal A, Hansbro P, Pearson J, Polo J, Veldman A, Berger P, Nold-Petry C, Nold M. Type 2 immune polarization is associated with cardiopulmonary disease in preterm infants. Science Translational Medicine 2022, 14: eaaz8454. PMID: 35385341, DOI: 10.1126/scitranslmed.aaz8454.Peer-Reviewed Original ResearchConceptsPreterm infantsBronchopulmonary dysplasiaIL-13CD3<sup>+</sup>CD4<sup>+</sup> T cellsInterleukin-4BPD-associated pulmonary hypertensionMaternal magnesium sulfate therapyCD4<sup>+</sup> T cellsCardiopulmonary diseaseMagnesium sulfate therapyType 2 mediatorsHealthy term infantsType 2 polarizationType 2 cytokinesHepatitis B vaccineMultiple therapeutic approachesTerm infantsPulmonary hypertensionDisease in vivoT cellsLung inflammationYounger patientsIL-5B vaccineHigh treatment costs
2020
Association of Antenatal Corticosteroids and Magnesium Sulfate Therapy With Neurodevelopmental Outcome in Extremely Preterm Children.
Gentle S, Carlo W, Tan S, Gargano M, Ambalavanan N, Chawla S, Bell E, Bann C, Hintz S, Heyne R, Tita A, Higgins R. Association of Antenatal Corticosteroids and Magnesium Sulfate Therapy With Neurodevelopmental Outcome in Extremely Preterm Children. Obstetrics And Gynecology 2020, 135: 1377-1386. PMID: 32459430, PMCID: PMC7278037, DOI: 10.1097/aog.0000000000003882.Peer-Reviewed Original ResearchMeSH KeywordsAdrenal Cortex HormonesChild, PreschoolDatabases, FactualFemaleGestational AgeHumansInfantInfant MortalityInfant, Extremely PrematureInfant, NewbornLogistic ModelsMagnesium SulfateMaleNeurodevelopmental DisordersPregnancyPregnancy OutcomePrenatal CarePrenatal Exposure Delayed EffectsProspective StudiesUnited StatesConceptsSevere neurodevelopmental impairmentExposed to antenatal corticosteroidsExposure to antenatal corticosteroidsAntenatal corticosteroidsWeeks of gestationNeurodevelopmental impairmentMagnesium sulfateAssociation of antenatal corticosteroidsEunice Kennedy Shriver National Institute of Child HealthMagnesium sulfate therapyNational Institute of Child HealthInstitute of Child HealthAssociated with lower ratesExposure groupRate of deathPreterm childrenNeurodevelopmental outcomesLogistic regression modelsCorticosteroidsFollow-upPrimary outcomeSecondary outcomesTherapyGestationNetwork hospitals
2012
Preeclampsia in Low and Middle Income Countries—Health Services Lessons Learned From the PRE-EMPT (PRE-Eclampsia–Eclampsia Monitoring, Prevention & Treatment) Project
von Dadelszen P, Firoz T, Donnay F, Gordon R, Hofmeyr G, Lalani S, Payne BA, Roberts JM, Teela KC, Vidler M, Sawchuck D, Magee LA. Preeclampsia in Low and Middle Income Countries—Health Services Lessons Learned From the PRE-EMPT (PRE-Eclampsia–Eclampsia Monitoring, Prevention & Treatment) Project. Journal Of Obstetrics And Gynaecology Canada 2012, 34: 917-926. PMID: 23067947, DOI: 10.1016/s1701-2163(16)35405-6.Peer-Reviewed Original ResearchConceptsHypertensive disordersAdverse eventsMiddle-income countriesMillennium Development Goal 5Impact of preeclampsiaMagnesium sulfate therapyIncome countriesParticular preeclampsiaPreeclampsia preventionSulfate therapyRisk stratificationHealth burdenPreeclampsiaHealth servicesMobile healthGoal 5WomenDisordersPriority focusLesser extentComplicationsPregnancyTherapyPrevention
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