2023
Functional networks in the infant brain during sleep and wake states
Yates T, Ellis C, Turk-Browne N. Functional networks in the infant brain during sleep and wake states. Cerebral Cortex 2023, 33: 10820-10835. PMID: 37718160, DOI: 10.1093/cercor/bhad327.Peer-Reviewed Original ResearchConceptsFunctional connectivityMagnetic resonance imaging (MRI) scansFunctional magnetic resonance imaging (fMRI) scansWhole-brain functional connectivityResonance imaging scansInfant stateFunctional networksImaging scansAdult stateNatural sleepFunctional brain networksInfantsAwake restAwake fMRIInfant brainSleepBrain networksAdultsFrontoparietal control networkWake statesState of consciousnessDevelopmental changesBrainAnalysis of brain edema in RHAPSODY
Schleicher R, Vorasayan P, McCabe M, Bevers M, Davis T, Griffin J, Hinduja A, Jadhav A, Lee J, Sawyer R, Zlokovic B, Sheth K, Fedler J, Lyden P, Kimberly W, Investigators O. Analysis of brain edema in RHAPSODY. International Journal Of Stroke 2023, 19: 68-75. PMID: 37382409, PMCID: PMC10789908, DOI: 10.1177/17474930231187268.Peer-Reviewed Original ResearchConceptsNet water uptakeMidline shiftCerebral edemaMarkers of edemaImaging markerClinical outcomesBrain magnetic resonance imaging (MRI) scansMass effectMagnetic resonance imaging (MRI) scansSupratentorial ischemic lesionsAcute ischemic strokeBaseline stroke volumeProtein C treatmentResonance imaging scansCerebrospinal fluid volumeTime courseIschemic strokeBaseline visitIschemic lesionsTrial cohortBrain edemaTreatment armsSecondary complicationsFuture trialsImaging scansExamining the Schenck KD I Classification in Patients With Documented Tibiofemoral Knee Dislocations: A Multicenter Retrospective Case Series
Green J, Yalcin S, Moran J, Vasavada K, Kahan J, Li Z, Alaia M, Medvecky M. Examining the Schenck KD I Classification in Patients With Documented Tibiofemoral Knee Dislocations: A Multicenter Retrospective Case Series. Orthopaedic Journal Of Sports Medicine 2023, 11: 23259671231168892. PMID: 37378278, PMCID: PMC10291419, DOI: 10.1177/23259671231168892.Peer-Reviewed Original ResearchMultiligament knee injuriesTibiofemoral knee dislocationTibiofemoral dislocationKnee dislocationCase seriesSports medicine fellowship-trained surgeonsMulticenter retrospective case seriesMagnetic resonance imaging (MRI) scansRetrospective case seriesRetrospective chart reviewResonance imaging scansFellowship-trained surgeonsFuture outcome studiesLevel of evidenceBicruciate injuriesChart reviewI injuryRadiological evidenceSurgical managementKnee injuriesExtensor mechanismCruciate ligamentImaging scansKnee radiographsCollateral injuryOvernight Abstinence, Ventrostriatal-Insular Connectivity, and Tridimensional Personality Traits in Cigarette Smokers
Chen Y, Li C. Overnight Abstinence, Ventrostriatal-Insular Connectivity, and Tridimensional Personality Traits in Cigarette Smokers. Journal Of Integrative Neuroscience 2023, 22: 66. PMID: 37258442, DOI: 10.31083/j.jin2203066.Peer-Reviewed Original ResearchConceptsPersonality traitsOvernight abstinenceTridimensional Personality QuestionnaireState functional magnetic resonance imaging scansFunctional magnetic resonance imaging (fMRI) scansPersonality risk factorsIndividual personality traitsMagnetic resonance imaging (MRI) scansState functional connectivityShort-term abstinenceResonance imaging scansRisk of smokingInter-regional connectivityNicotine deprivationHarm avoidanceConnectivity correlatesNeural markersCigarette smokingFunctional connectivityCigarette smokersPersonality QuestionnaireImaging scansRisk factorsDorsal striatumNicotine dependence
2022
Dorsal bed nucleus of stria terminalis in depressed and nondepressed temporal lobe epilepsy patients
Dhaher R, Bronen RA, Spencer L, Colic L, Brown F, Mian A, Sandhu M, Pittman B, Spencer D, Blumberg HP, Altalib H. Dorsal bed nucleus of stria terminalis in depressed and nondepressed temporal lobe epilepsy patients. Epilepsia 2022, 63: 2561-2570. PMID: 35883245, DOI: 10.1111/epi.17377.Peer-Reviewed Original ResearchConceptsTemporal lobe epilepsyDorsal bed nucleusTLE patientsEpilepsy patientsBed nucleusHC subjectsStria terminalisTemporal lobe epilepsy patientsMini International Neuropsychiatric InterviewMagnetic resonance imaging (MRI) scansTreatment-resistant depressionComprehensive Epilepsy CenterHealthy control subjectsStructural magnetic resonance imaging (MRI) scansResonance imaging scansNumber of patientsCase-control studyInternational Neuropsychiatric InterviewMajor depressive disorderCommon comorbid disordersHuman clinical studiesEpilepsy centersLobe epilepsyComorbid depressionControl subjectsRegional Brain Volume Abnormalities and Long-term Cognitive Outcome in Preterm Infants
Peterson B, Vohr B, Staib L, Cannistraci C, Dolberg A, Schneider K, Katz K, Westerveld M, Sparrow S, Anderson A, Duncan C, Makuch R, Gore J, Ment L. Regional Brain Volume Abnormalities and Long-term Cognitive Outcome in Preterm Infants. 2022, 215-223. DOI: 10.4324/9780203822937-21.Peer-Reviewed Original ResearchRegional brain volumesLong-term cognitive outcomesBrain volumePreterm infantsRegional brain volume abnormalitiesMagnetic resonance imaging (MRI) scansCognitive outcomesTerm control childrenPerinatal risk factorsResonance imaging scansBrain volume abnormalitiesPreterm cohortRisk factorsImaging scansPreterm childrenHigh prevalenceVolume abnormalitiesBehavioral disturbancesControl childrenTerm controlsAbnormalitiesInfantsChildrenOutcomesCognitive measures
2021
Injury to the Meniscofemoral Portion of the Deep MCL Is Associated with Medial Femoral Condyle Bone Marrow Edema in ACL Ruptures
Moran J, Katz LD, Schneble CA, Li D, Kahan JB, Wang A, Porrino J, Jokl P, Hewett TE, Medvecky MJ. Injury to the Meniscofemoral Portion of the Deep MCL Is Associated with Medial Femoral Condyle Bone Marrow Edema in ACL Ruptures. JBJS Open Access 2021, 6: e21.00069. PMID: 34841192, PMCID: PMC8613370, DOI: 10.2106/jbjs.oa.21.00069.Peer-Reviewed Original ResearchMedial meniscal tearsBone marrow edemaDeep medial collateral ligamentMedial collateral ligamentAcute anterior cruciate ligamentACL ruptureMarrow edemaMCL injuryPosterior hornMedial meniscusPreoperative magnetic resonance imaging (MRI) scansBoard-certified musculoskeletal radiologistsMagnetic resonance imaging (MRI) scansSuperficial medial collateral ligamentSuspicion of injuryACL graft failureACL reconstruction surgeryAnterior cruciate ligamentResonance imaging scansPotential risk factorsChi-square testingMeniscofemoral portionGraft failureInsertion sitePhysical examinationRisk Factors and Time to Clinical Symptoms of Multiple Sclerosis Among Patients With Radiologically Isolated Syndrome
Lebrun-Frénay C, Rollot F, Mondot L, Zephir H, Louapre C, Le Page E, Durand-Dubief F, Labauge P, Bensa C, Thouvenot E, Laplaud D, de Seze J, Ciron J, Bourre B, Cabre P, Casez O, Ruet A, Mathey G, Berger E, Moreau T, Al Khedr A, Derache N, Clavelou P, Guennoc AM, Créange A, Neau JP, Tourbah A, Camdessanché JP, Maarouf A, Callier C, Vermersch P, Kantarci O, Siva A, Azevedo C, Makhani N, Cohen M, Pelletier D, Okuda D, Vukusic S, Kantarci O, Siva A, Pelletier D, Okuda D, Azevedo C, Makhani N, Radji F, Morel N, Grosset-Jeannin D, Ungureanu A, Boyer L, Suchet L, Elias Z, Lebrun-Frénay C, Cohen M, Mondot L, Thouvenot E, Ciron J, Durand-Dubief F, Brochet B, Ruet A, Ouallet J, Defer G, Branger P, Derache N, Clavelou P, Taithe F, Alkhedr A, Fromont A, Moreau T, Tourbah A, Casez O, Berger E, Zephir H, Outteryck O, Vermersch P, Hautecoeur P, Androdias G, Ionescu I, Pelletier J, Audoin B, Maarouf A, Ayrignac X, Carra-Dalliere C, Labauge P, Debouverie M, Mathey G, Cabre P, Laplaud D, Wiertlevski S, Bresch S, Castelnovo G, Papeix C, Louapre C, Maillart E, Lubetzki C, Stankoff B, Fontaine B, Giannesini C, Heinzleff O, Créange A, Bourre B, Gout O, Guegen A, Bensa C, Le Page E, Michel L, Magy L, De Seze J, Collongues N, Leray E, Guennoc A, Biotti D, Camdessanché J, De Broucker T, Sehaki S, Devys-Meyer N, Bereau M, Cappe C, Kounkou K, Dumont E, Lescieux E, Protin A, Kane M, Boucher J, Petit J, Tabellah Kasonde I, De Vilmarrest A, Nicol M, Malbezin M, Olaiz J, Rigaud-Bully C, Casey R, Rollot F, Vukusic I, Debard N, Cotton F, Abdelalli A, Di Lelio B, Pinna F, Guillemin F, Ziegler A, Callier C, Zehrouni K, Hodel J, Wahab A, Zedet M, Fagniez O, Laage C, Pottier C, Slesari I, Sampaio M, Neau J, Rabois E, Castex C, Hebant B, Guillaume M, Vimont C, Muraz R, Le Port D, Henry C, Berthe C, Freitas N, Visneux V, Forestier M, Beltran S, Meunier G, Servan J, Pico F, Chatagner V. Risk Factors and Time to Clinical Symptoms of Multiple Sclerosis Among Patients With Radiologically Isolated Syndrome. JAMA Network Open 2021, 4: e2128271. PMID: 34633424, PMCID: PMC8506228, DOI: 10.1001/jamanetworkopen.2021.28271.Peer-Reviewed Original ResearchConceptsGadolinium-enhancing lesionsSpinal cord lesionsClinical eventsMultiple sclerosisRisk of conversionCord lesionsRisk factorsMRI scansPhase III clinical trialsMagnetic resonance imaging (MRI) scansEarly clinical diseaseFirst clinical eventDisease-modifying therapiesEarly clinical eventsSpinal cord involvementAge 37 yearsResonance imaging scansPotential treatment effectsMS careCohort studyCord involvementStudy entryTertiary centerClinical symptomsOligoclonal bandsRelationship Between Patellar Morphology and Known Anatomic Risk Factors for Patellofemoral Instability
Jimenez AE, Levy BJ, Grimm NL, Andelman SM, Cheng C, Hedgecock JP, Cohen A, Pace JL. Relationship Between Patellar Morphology and Known Anatomic Risk Factors for Patellofemoral Instability. Orthopaedic Journal Of Sports Medicine 2021, 9: 2325967120988690. PMID: 33748306, PMCID: PMC7940750, DOI: 10.1177/2325967120988690.Peer-Reviewed Original ResearchPatellar instabilityPatellar morphologyAnterior cruciate ligament tearsMagnetic resonance imaging (MRI) scansAnatomic risk factorsCruciate ligament tearsYoung adult patientsResonance imaging scansCross-sectional studyLevel of evidenceRegression analysisAxial MRI scansStudy patientsAdult patientsControl patientsLigament tearsRisk factorsImaging scansTrochlear dysplasiaRadiologic measurementsMRI scansPatellofemoral instabilityControl groupPatientsSignificant association
2020
Low-motion fMRI data can be obtained in pediatric participants undergoing a 60-minute scan protocol
Horien C, Fontenelle S, Joseph K, Powell N, Nutor C, Fortes D, Butler M, Powell K, Macris D, Lee K, Greene AS, McPartland JC, Volkmar FR, Scheinost D, Chawarska K, Constable RT. Low-motion fMRI data can be obtained in pediatric participants undergoing a 60-minute scan protocol. Scientific Reports 2020, 10: 21855. PMID: 33318557, PMCID: PMC7736342, DOI: 10.1038/s41598-020-78885-z.Peer-Reviewed Original ResearchConceptsPediatric participantsMRI protocolMagnetic resonance imaging (MRI) scansFunctional magnetic resonance imaging (fMRI) scansShorter MRI protocolsScan protocolResonance imaging scansImaging scansMRI sessionsFMRI connectivity analysisFMRI dataFMRI findingsSignificant confoundScansReplication groupConnectivity analysisAutism spectrum disorderMock scanSpectrum disorderParticipantsHead motionProtocolBone Scans Have Little Utility in the Evaluation of Well-Differentiated Cartilaginous Lesions of the Humerus.
Samuel AM, Munger AM, Lee FY, Friedlaender GE, Ibe IK, Lindskog DM. Bone Scans Have Little Utility in the Evaluation of Well-Differentiated Cartilaginous Lesions of the Humerus. Orthopedics 2020, 43: e498-e502. PMID: 32882054, DOI: 10.3928/01477447-20200827-05.Peer-Reviewed Original ResearchConceptsRadionuclide bone scanBone scanMRI scansPositive findingsNegative findingsMagnetic resonance imaging (MRI) scansBone scan findingsProgression of lesionsResonance imaging scansDiagnosis of enchondromaAcademic medical centerBivariate logistic regressionAssociation of boneScan findingsAggressive featuresRadiographic findingsEndosteal scallopingBenign enchondromaImaging scansMedical recordsMedical CenterMalignant lesionsCartilaginous lesionsEnchondromaPatientsSpontaneous Resolution of Primary Hypercortisolism of Cushing Disease After Pituitary Hemorrhage
Siwakoti K, Omay SB, Inzucchi SE. Spontaneous Resolution of Primary Hypercortisolism of Cushing Disease After Pituitary Hemorrhage. AACE Clinical Case Reports 2020, 6: e23-e29. PMID: 32984518, PMCID: PMC7279773, DOI: 10.4158/accr-2019-0292.Peer-Reviewed Original ResearchPituitary apoplexySpontaneous resolutionBiochemical remissionPrimary hypercortisolismSellar massLow-dose dexamethasone suppression testDose dexamethasone suppression testMagnetic resonance imaging (MRI) scansUrine free cortisolSymptoms of hypercortisolismDexamethasone suppression testResonance imaging scansSymptomatic hemorrhageSurgical resectionCushing's diseaseInitial presentationPituitary hemorrhageFree cortisolFunctional adenomasImaging scansElevated plasmaSerum cortisolSuppression testClinical signsPathologic information
2019
Introduction to the Charcot Foot: Limb Salvage Pathway and Algorithm
Petrova N, Sumpio B, Tang W, Edmonds M. Introduction to the Charcot Foot: Limb Salvage Pathway and Algorithm. 2019, 135-138. DOI: 10.1007/978-3-319-17918-6_10.Peer-Reviewed Original ResearchCharcot footMagnetic resonance imaging (MRI) scansResonance imaging scansTomography bone scansSingle photon emissionActive CharcotBone scanDiagnostic abnormalitiesTomography/Imaging scansEarly diagnosisPhoton emissionDeformityFootExternal reconstructionModern managementScansSalvage pathwayAbnormalitiesSex modulates the ApoE ε4 effect on brain tau deposition measured by 18F-AV-1451 PET in individuals with mild cognitive impairment
Liu M, Paranjpe MD, Zhou X, Duy PQ, Goyal MS, Benzinger TLS, Lu J, Wang R, Zhou Y. Sex modulates the ApoE ε4 effect on brain tau deposition measured by 18F-AV-1451 PET in individuals with mild cognitive impairment. Theranostics 2019, 9: 4959-4970. PMID: 31410194, PMCID: PMC6691387, DOI: 10.7150/thno.35366.Peer-Reviewed Original ResearchConceptsBrain tau depositionMild cognitive impairmentAPOE ε4 carrier statusΕ4 carrier statusAPOE ε4Tau depositionCSF tauF-AVP-tauT-tauCognitive impairmentAlzheimer's diseaseSex interaction effectsApolipoprotein E type 4 alleleCerebrospinal fluid (CSF) total tauStrongest genetic risk factorMagnetic resonance imaging (MRI) scansCarrier statusPET spatial normalizationStandardized uptake value ratio (SUVR) imagesCSF p-tauCSF t-tauStructural magnetic resonance imaging (MRI) scansResonance imaging scansType 4 alleleIncreased ventromedial prefrontal cortex activity and connectivity predict poor sertraline treatment outcome in late‐life depression
Emam H, Steffens DC, Pearlson G, Wang L. Increased ventromedial prefrontal cortex activity and connectivity predict poor sertraline treatment outcome in late‐life depression. International Journal Of Geriatric Psychiatry 2019, 34: 730-737. PMID: 30761621, PMCID: PMC6480406, DOI: 10.1002/gps.5079.Peer-Reviewed Original ResearchConceptsLate-life depressionSelective serotonin reuptake inhibitorsNonresponder groupFunctional connectivitySSRI responseMADRS scoresResting-state functional magnetic resonance imaging (fMRI) scansMontgomery-Åsberg Depression Rating ScaleMajor depressive disorder patientsPrefrontal cortexMagnetic resonance imaging (MRI) scansFunctional magnetic resonance imaging (fMRI) scansSubgenual cingulate areaSerotonin reuptake inhibitorsDepressive disorder patientsAcute treatment responseResonance imaging scansDepression Rating ScaleLower functional connectivityHigher functional connectivityFalse discovery rate correctionResting-state activityDefault mode networkROI connectivityAntidepressant treatment
2018
S22. A TRANSDIAGNOSTIC NEUROANATOMICAL SIGNATURE OF PSYCHIATRIC ILLNESS
Qiyong G, Scarpazza C, Dai J, He M, Xu X, Shi Y, Zhou B, Vreira S, McCrory E, Yang C, Zang F, Lui S, Mechelli A. S22. A TRANSDIAGNOSTIC NEUROANATOMICAL SIGNATURE OF PSYCHIATRIC ILLNESS. Schizophrenia Bulletin 2018, 44: s331-s331. PMCID: PMC5888883, DOI: 10.1093/schbul/sby018.809.Peer-Reviewed Original ResearchGray matter volumeHealthy controlsPsychiatric illnessMatter volumeMagnetic resonance imaging (MRI) scansHigher gray matter volumeFamilial vulnerabilityStructural magnetic resonance imaging (MRI) scansResonance imaging scansUnaffected first-degree relativesFirst-degree relativesSeverity of symptomsGreater gray matter volumePost-traumatic stress disorderDifferent diagnostic categoriesPutamen enlargementObsessive-compulsive disorderImaging scansBilateral putamenPsychiatric diagnosisPutamen volumeTrans-diagnostic approachPsychiatric groupsGeneral psychopathologyNeuroanatomical signature
2015
Langerhans Cell Histiocytosis of the Temporal Bone with Otic Capsule Involvement
Blumberg JM, Malhotra A, Wu X, Virk RK, Kveton JF, Michaelides EM. Langerhans Cell Histiocytosis of the Temporal Bone with Otic Capsule Involvement. Clinical Neuroradiology 2015, 27: 163-168. PMID: 26341354, DOI: 10.1007/s00062-015-0461-4.Peer-Reviewed Original ResearchConceptsOtic capsule involvementLangerhans cell histiocytosisCases of LCHCapsule involvementTemporal boneCell histiocytosisMagnetic resonance imaging (MRI) scansMethodsWith institutional review board approvalOtic capsuleInstitutional review board approvalRetrospective case reviewTreatment of patientsResonance imaging scansReview board approvalComplete restorationPosttreatment imagingAudiologic findingsPosttreatment followDestructive lesionsInstitutional databaseHistologic diagnosisImaging scansCommon siteAppropriate treatmentAdequate treatmentAnterior Cortical Development During Adolescence in Bipolar Disorder
Najt P, Wang F, Spencer L, Johnston JA, Lippard E, Pittman BP, Lacadie C, Staib LH, Papademetris X, Blumberg HP. Anterior Cortical Development During Adolescence in Bipolar Disorder. Biological Psychiatry 2015, 79: 303-310. PMID: 26033826, PMCID: PMC4595154, DOI: 10.1016/j.biopsych.2015.03.026.Peer-Reviewed Original ResearchConceptsWhite matter expansionBipolar disorderWhite matterAnterior cortexHealthy adolescentsHigh-resolution magnetic resonance imaging (MRI) scansMagnetic resonance imaging (MRI) scansWhite matter increasesResonance imaging scansGray matter decreasesDorsolateral prefrontal cortexMatter expansionHealthy groupImaging scansCortical volumeFrontal cortexNeurodevelopmental abnormalitiesCortical developmentAnterior paralimbicNeurodevelopmental modelLongitudinal neuroimagingPrefrontal cortexCortexLongitudinal studyAdolescents
2014
GABA, Resting-State Connectivity and the Developing Brain
Kwon SH, Scheinost D, Lacadie C, Benjamin J, Myers EH, Qiu M, Schneider KC, Rothman DL, Constable RT, Ment LR. GABA, Resting-State Connectivity and the Developing Brain. Neonatology 2014, 106: 149-155. PMID: 24970028, PMCID: PMC4134402, DOI: 10.1159/000362433.Peer-Reviewed Original ResearchConceptsGamma-aminobutyric acidTerm-equivalent agePreterm infantsGABA concentrationTerm controlsFunctional connectivityMagnetic resonance imaging (MRI) scansFunctional magnetic resonance imaging (fMRI) scansResting-state functional connectivityRegional GABA concentrationTerm control groupResonance imaging scansResting-state connectivityRight frontal lobeConcentration of GABANAA/cholineMagnetic resonance spectroscopyPreclinical dataImaging scansFrontal lobeControl groupInfantsBrainMRI dataAge
2012
Safety and biomarker effects of solanezumab in patients with Alzheimer's disease
Farlow M, Arnold SE, van Dyck C, Aisen PS, Snider BJ, Porsteinsson AP, Friedrich S, Dean RA, Gonzales C, Sethuraman G, DeMattos RB, Mohs R, Paul SM, Siemers ER. Safety and biomarker effects of solanezumab in patients with Alzheimer's disease. Alzheimer's & Dementia 2012, 8: 261-271. PMID: 22672770, DOI: 10.1016/j.jalz.2011.09.224.Peer-Reviewed Original ResearchMeSH KeywordsAgedAged, 80 and overAlzheimer DiseaseAmyloid beta-PeptidesAntibodies, Monoclonal, HumanizedCognition DisordersDose-Response Relationship, DrugDouble-Blind MethodElectroencephalographyEnzyme-Linked Immunosorbent AssayFemaleFollow-Up StudiesHumansMaleMiddle AgedNeuropsychological TestsPeptide FragmentsPsychiatric Status Rating ScalesPyridinesTomography, Emission-Computed, Single-PhotonTreatment OutcomeConceptsAlzheimer's Disease Assessment Scale-cognitive portionAntibody administrationDose-dependent mannerAlzheimer's diseaseAntibody treatmentAnti-β-amyloid antibodiesPlacebo-controlled clinical trialMagnetic resonance imaging (MRI) scansCerebrospinal fluid examinationClinical laboratory valuesActive treatment periodCSF cell countResonance imaging scansModerate Alzheimer's diseaseDose-dependent increaseMagnetic resonance imagingWeekly infusionsAdverse eventsFluid examinationImaging scansClinical trialsLaboratory valuesTreatment periodAmyloid plaquesCell count
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