2025
Risk factors for perioperative nerve injury associated with total knee arthroplasty: Analysis of a national administrative database
Jayaram R, Kim L, Day W, Doshi R, Rubin L, Grauer J. Risk factors for perioperative nerve injury associated with total knee arthroplasty: Analysis of a national administrative database. PLOS ONE 2025, 20: e0324527. PMID: 40455711, PMCID: PMC12129142, DOI: 10.1371/journal.pone.0324527.Peer-Reviewed Original ResearchConceptsBody mass indexIndependent risk factorNerve injuryElixhauser Comorbidity IndexRisk factorsMultivariate analysisAssociated with nerve injuryInvestigate independent risk factorsOdds ratioRevision surgeryIncidence of nerve injuryRisk of nerve injuryPostoperative nerve injuryUnderweight body mass indexType of surgeryDay of surgeryAdministrative databasesNational administrative databaseTKA proceduresPatient ageRisk stratificationMass indexAdverse outcomesDecreased riskFemale sexAssociation of lifestyle factors and pathological characteristics in patients with early breast cancer and overweight/obesity: Results from the Breast Cancer Weight Loss (BWEL) trial.
Sposetti C, Ballman K, McCall L, Goodwin P, Weiss A, Thomson C, Hahn O, Hershman D, Paskett E, Minasian L, Nebeling L, Mayer E, Hopkins J, Bernstein V, Stearns V, White J, Winer E, Partridge A, Carey L, Ligibel J. Association of lifestyle factors and pathological characteristics in patients with early breast cancer and overweight/obesity: Results from the Breast Cancer Weight Loss (BWEL) trial. Journal Of Clinical Oncology 2025, 43: 561-561. DOI: 10.1200/jco.2025.43.16_suppl.561.Peer-Reviewed Original ResearchHEI scoresModerate/vigorous PAPhysical activityLifestyle factorsMenopausal statusDiet qualityAssociation of lifestyle factorsBreast cancerAssociated with breast cancerAssessment of PAHealthy Eating IndexProgesterone receptorHigher diet qualityWeight loss interventionBody mass indexEating IndexEstrogen receptorHealthier dietsLinear regression modelsDiagnosis to enrollmentOlder womenMass indexPhase III trialsEarly breast cancerMin/wk0740 Loop Gain Predicts Residual Sleep Apnea Events Among People Using Positive Airway Pressure
Eschbach E, Kushida C, Peker Y, Xu Z, Deng A, Azarbarzin A, Wellman A, Yaggi H, Sands S, Zinchuk A. 0740 Loop Gain Predicts Residual Sleep Apnea Events Among People Using Positive Airway Pressure. Sleep 2025, 48: a321-a321. DOI: 10.1093/sleep/zsaf090.0740.Peer-Reviewed Original ResearchPositive airway pressureObstructive sleep apneaPositive airway pressure therapyBody mass indexSleep apneaBaseline AHIPAP therapyAirway pressurePharyngeal collapseIncreased riskOdds ratioPositive airway pressure devicesAssociated with increased riskCoronary artery diseaseSleep apnea eventsEpisodic airway obstructionBaseline polysomnogramRandomized Controlled TrialsBaseline polysomnographyHigh LGAdjunctive therapyAirway obstructionUpper airwayMass indexApnea0728 Predicting Sleep State from Continuous Positive Airway Pressure Flow in Patients with Obstructive Sleep Apnea
Ahsan M, Yaggi H, Anwar A, Chen H, Chen C, Zinchuk A, Wu H. 0728 Predicting Sleep State from Continuous Positive Airway Pressure Flow in Patients with Obstructive Sleep Apnea. Sleep 2025, 48: a316-a317. DOI: 10.1093/sleep/zsaf090.0728.Peer-Reviewed Original ResearchObstructive sleep apneaApnea-hypopnea indexBody mass indexNegative predictive valuePositive predictive valueResidual apnea-hypopnea indexSleep apneaObstructive sleep apnea patientsPredictive valuePositive airway pressureSleep stateFirst-line treatmentFlow signalsCPAP effectsCPAP titrationCPAP adherenceCPAP devicesCPAP levelAirway pressureSleep centerCPAPPolysomnography recordingsMass indexInclusion criteriaRespiratory rate variabilityBody mass index and benign prostatic hyperplasia correlate with urinary microbiome diversity and lower urinary tract symptoms in men
Bowie K, Garzotto M, Orwoll E, Karstens L. Body mass index and benign prostatic hyperplasia correlate with urinary microbiome diversity and lower urinary tract symptoms in men. Communications Medicine 2025, 5: 159. PMID: 40328908, PMCID: PMC12056106, DOI: 10.1038/s43856-025-00866-y.Peer-Reviewed Original ResearchLower urinary tract symptomsBenign prostatic hyperplasiaUrinary tract symptomsBody mass indexUrinary microbiomeProstatic hyperplasiaMass indexAssociated with lower urinary tract symptomsLower urinary tractAbsence of infectionCohort of menOsteoporotic fracturesUrinary tractClinical characteristicsSignificant associationBackgroundSeveral studiesUrine samplesHyperplasiaSymptomsStudy designIllumina MiSeqRRNA geneAlpha diversityMenMicrobiome diversityInfluence of Body Mass Index on Hypoglossal Nerve Stimulation Efficacy Depends on the Site of Pharyngeal Collapse in Obstructive Sleep Apnea
Vena D, Kezirian E, Wellman A, Kent D, D'Agostino M, Monteiro J, Azarbarzin A, Sands S, Huyett P. Influence of Body Mass Index on Hypoglossal Nerve Stimulation Efficacy Depends on the Site of Pharyngeal Collapse in Obstructive Sleep Apnea. American Journal Of Respiratory And Critical Care Medicine 2025, 211: a6928-a6928. DOI: 10.1164/ajrccm.2025.211.abstracts.a6928.Peer-Reviewed Original ResearchSex differences in cerebrospinal fluid proteomics of patients with restless legs syndrome
Mogavero M, Peng G, Marchese G, Lanza G, Ferini-Strambi L, Ferri R, Koo B. Sex differences in cerebrospinal fluid proteomics of patients with restless legs syndrome. Sleep 2025, zsaf112. PMID: 40289925, DOI: 10.1093/sleep/zsaf112.Peer-Reviewed Original ResearchRestless legs syndromeProteomic signatureCerebrospinal fluid proteomeUntreated RLS patientsObservational cross-sectional studyBody mass indexProteome of patientsCerebrospinal fluid samplesSex-specific mechanismsCross-sectional studyRLS patientsSex-specific analysesMass indexSex differencesTherapeutic strategiesImmune responseInflammatory pathwaysEffective treatmentCerebrospinal fluid proteome of patientsDisease pathophysiologyPatientsSyndromeProtein levelsFluid samplesProteomic alterationsAssociation of food environment with diet quality and Body Mass Index (BMI) of school-going adolescents in Nepal
Sharma P, Limaye N, Sah R, Shrestha A. Association of food environment with diet quality and Body Mass Index (BMI) of school-going adolescents in Nepal. PLOS ONE 2025, 20: e0321524. PMID: 40258020, PMCID: PMC12011221, DOI: 10.1371/journal.pone.0321524.Peer-Reviewed Original ResearchConceptsGlobal dietary recommendationsBody mass indexSchool-going adolescentsHome food environmentNon-communicable diseasesDiet qualityFood environmentAvailability of healthy foodsCalculate body mass indexHealthy food environmentsMass indexFood environmental factorsBody mass index scoresAssess diet qualityDiet quality questionnaireAdolescent diet qualityCross-sectional analytical studyWeight of participantsUnhealthy itemsHealth outcomesHealthy dietWalking timeHealthy foodStata 14Dietary recommendationsEditorial Commentary: Older Age, Higher Body Mass Index, and Female Sex May Be Associated with Inferior Long-Term Outcomes in Patients Undergoing Primary Hip Arthroscopy for Femoroacetabular Impingement, but with Modification of Risk Factors, Positive Results Can Still Be Achieved
Moran J, Salandra J, Jimenez A. Editorial Commentary: Older Age, Higher Body Mass Index, and Female Sex May Be Associated with Inferior Long-Term Outcomes in Patients Undergoing Primary Hip Arthroscopy for Femoroacetabular Impingement, but with Modification of Risk Factors, Positive Results Can Still Be Achieved. Arthroscopy The Journal Of Arthroscopic And Related Surgery 2025 PMID: 40262710, DOI: 10.1016/j.arthro.2025.04.019.Peer-Reviewed Original ResearchHigher Body Mass IndexBody mass indexPrimary hip arthroscopyHip arthroscopy surgeryModifiable risk factorsFemoroacetabular impingement syndromeHip arthroscopyRisk factorsMass indexFemale sexTime of primary surgeryLong-term clinical outcomesOptimization of modifiable risk factorsImpingement syndromeArthroscopy surgeryAssociated with postoperative outcomesRisk of reoperationMinority of patientsPresence of degenerative changesRevision hip arthroscopyModification of risk factorsPrimary surgeryPostoperative outcomesFemale patientsPreoperative counselingFish consumption and gastric cancer within the Stomach cancer Pooling (StoP) Project
Franchi C, Ardoino I, Mandelli S, Patel L, Pelucchi C, Bonzi R, Camargo M, Rabkin C, Liao L, Sinha R, Johnson K, Hu J, Zhang Z, Palli D, Ferraroni M, Negri E, Turati F, Yu G, Lunet N, Morais S, López-Carrillo L, Tsugane S, Hidaka A, Malekzadeh R, Zaridze D, Maximovitch D, Vioque J, Gonzalez-Palacios S, Ward M, Aragonés N, Castaño-Vinyals G, Curado M, Dias-Neto E, Hamada G, Hernández-Ramirez R, Pakseresht M, Pourfarzi F, Mu L, Lagiou A, Lagiou P, López-Cervantes M, Dolci A, Boccia S, Pastorino R, Boffetta P, D’Avanzo B, La Vecchia C. Fish consumption and gastric cancer within the Stomach cancer Pooling (StoP) Project. Scientific Reports 2025, 15: 13099. PMID: 40240417, PMCID: PMC12003686, DOI: 10.1038/s41598-025-96658-4.Peer-Reviewed Original ResearchConceptsRisk of gastric cancerCancer riskAssociated with gastric cancer riskFamily history of gastric cancerStomach cancer PoolingStomach cancer riskHistory of gastric cancerGastric cancer riskIncreased intake of fishBody mass indexCase-control studyIntake of fishGeographical differencesFish consumptionGastric cancerPooling ProjectFamily historyMass indexCancer deathCanned fish consumptionFish intakeEnergy intakeMeta-analysisIncreased intakeHelicobacter pylori infectionCryolipolysis and associated health outcomes, adverse events, and satisfaction: A systematic review and meta‐analysis
Ravindran R, Pizzol D, Rahmati M, Caminada S, Yon D, Shin J, Veronese N, Soysal P, Fond G, Boyer L, López‐Gil J, Kostev K, Gawronska J, Smith L. Cryolipolysis and associated health outcomes, adverse events, and satisfaction: A systematic review and meta‐analysis. Obesity Reviews 2025, 26: e13925. PMID: 40211915, PMCID: PMC12246886, DOI: 10.1111/obr.13925.Peer-Reviewed Original ResearchConceptsAssociated health outcomesHealth outcomesMeta-analysisAdverse eventsPatient satisfactionSystematic reviewWaist-to-hip ratioConfidence intervalsReduced body mass indexWaist-to-hipSystematic review protocolPooled effect sizeBody mass indexRandom-effects modelReview protocolMinor adverse eventsMonths follow-upAdiposity parametersMass indexMeta-analysesEffect sizeSatisfaction rateAbdominal circumferenceFollow-upSatisfactionModifiable risk factors for stroke, dementia and late-life depression: a systematic review and DALY-weighted risk factors for a composite outcome
Senff J, Tack R, Mallick A, Gutierrez-Martinez L, Duskin J, Kimball T, Tan B, Chemali Z, Newhouse A, Kourkoulis C, Rivier C, Falcone G, Sheth K, Lazar R, Ibrahim S, Pikula A, Tanzi R, Fricchione G, Brouwers H, Rinkel G, Yechoor N, Rosand J, Anderson C, Singh S. Modifiable risk factors for stroke, dementia and late-life depression: a systematic review and DALY-weighted risk factors for a composite outcome. Journal Of Neurology Neurosurgery & Psychiatry 2025, 96: 515-527. PMID: 40180437, DOI: 10.1136/jnnp-2024-334925.Peer-Reviewed Original ResearchConceptsModifiable risk factorsLate-life depressionDisability-adjusted life yearsMeta-analysesRisk factorsComposite outcomeRelevant meta-analysesBody mass indexPhysical activityIdentified risk factorsComposite outcome of strokeHearing lossIncidence of strokeDepressive symptomsPrevention strategiesLife yearsOutcome of strokeSystematic reviewInclusion criteriaMass indexDementiaFasting Plasma GlucoseEffect sizeSystematic literature reviewSocial engagementThe Association between All-Cause Mortality and Obstructive Sleep Apnea in Adults: A U-Shaped Curve.
Azarian M, Ramezani A, Sharafkhaneh A, Maghsoudi A, Kryger M, Thomas R, Westover M, Razjouyan J. The Association between All-Cause Mortality and Obstructive Sleep Apnea in Adults: A U-Shaped Curve. Annals Of The American Thoracic Society 2025, 22: 581-590. PMID: 39746198, PMCID: PMC12005042, DOI: 10.1513/annalsats.202407-755oc.Peer-Reviewed Original ResearchApnea-hypopnea indexAll-Cause MortalitySleep apneaBody mass indexAssociated with apnea-hypopnea indexApnea hypopnea index categoriesInterpretation of sleep studiesOdds ratioOdds of all-cause mortalityObstructive sleep apneaSeverity of SAAll-cause mortality ratesElixhauser Comorbidity IndexSleep studiesPropensity-matchedMass indexSevere SAComorbidity indexAll-CauseMortality rateMortalityEffects of ageApneaLogistic regressionAge groupsAlcohol use disorder and body mass index show genetic pleiotropy and shared neural associations
Malone S, Davis C, Piserchia Z, Setzer M, Toikumo S, Zhou H, Winterlind E, Gelernter J, Justice A, Leggio L, Rentsch C, Kranzler H, Gray J. Alcohol use disorder and body mass index show genetic pleiotropy and shared neural associations. Nature Human Behaviour 2025, 9: 1056-1066. PMID: 40164914, DOI: 10.1038/s41562-025-02148-y.Peer-Reviewed Original ResearchConceptsAlcohol use disorderUse disorderBrain regionsGenotype-Tissue ExpressionSingle-nucleotide polymorphismsPolygenic overlapAssociated with alcohol use disorderCaudate nucleus volumeBody mass indexMultiple brain regionsConjunctional false discovery rateNeurobiological overlapExecutive functionNeurobiological mechanismsNeural associationsBrain phenotypesNucleus volumeFalse discovery rate methodFalse discovery rateGenetic architectureVariant effectsMass indexGenetic pleiotropyDiscovery rateTissue enrichmentEffects of Tirzepatide in Type 2 Diabetes Individual Variation and Relationship to Cardiometabolic Outcomes
Aminorroaya A, Oikonomou E, Biswas D, Jastreboff A, Khera R. Effects of Tirzepatide in Type 2 Diabetes Individual Variation and Relationship to Cardiometabolic Outcomes. Journal Of The American College Of Cardiology 2025, 85: 1858-1872. PMID: 40368575, PMCID: PMC12186526, DOI: 10.1016/j.jacc.2025.03.516.Peer-Reviewed Original ResearchConceptsElevated body mass indexCardiometabolic abnormalitiesBody mass indexOdds of elevated body mass indexType 2 diabetesIndividual Participant Data Meta-AnalysisMass indexParticipant data meta-analysisOdds of MetSCardiometabolic risk factorsComponents of metabolic syndromeData Meta-AnalysisHigh-density lipoprotein cholesterolCardiometabolic healthStudy design differencesMixed-effects modelsBaseline usePhase 3 randomized clinical trialSodium-glucose cotransporter 2 inhibitorsOddsStudy outcomesEffects of tirzepatideMeta-analysisRisk factorsClinical subpopulationsEvaluation of the relationship between brainstem lesions and apnea hypopnea index in patients with multiple sclerosis
Levit E, Cohen I, Mahajan A, Ulano A, Longbrake E, Solomon A. Evaluation of the relationship between brainstem lesions and apnea hypopnea index in patients with multiple sclerosis. Multiple Sclerosis Journal 2025, 31: 802-812. PMID: 40156308, DOI: 10.1177/13524585251327875.Peer-Reviewed Original ResearchConceptsElevated apnea-hypopnea indexApnea-hypopnea indexObstructive sleep apneaDemyelinating brainstem lesionsClinically isolated syndromeBrainstem lesionsBody mass indexMagnetic resonance imagingMultiple sclerosisSleep study typeYears of polysomnographyAssociated with higher oddsHypopnea indexSleep apneaDemyelinating lesionsMass indexPolysomnographyLesionsResonance imagingBrainstemHigher oddsApneaStudy centersPatientsStudy typeSex differences in proteomics of cardiovascular disease – Results from the Yale-CMD registry
Liu Y, Wang Z, Collins S, Testani J, Safdar B. Sex differences in proteomics of cardiovascular disease – Results from the Yale-CMD registry. IJC Heart & Vasculature 2025, 58: 101667. PMID: 40224648, PMCID: PMC11987697, DOI: 10.1016/j.ijcha.2025.101667.Peer-Reviewed Original ResearchCMD patientsUpregulation of immune pathwaysCardiovascular diseaseProximity extension assayBody mass indexRegulation of blood flowSex differencesProteomic profilingIschemic symptomsCAD patientsMass indexIncreased angiogenesisGlucose metabolic pathwaysDifferential protein expressionPatientsSex-specific pathwaysProtein expressionImmune pathwaysBlood flowBlood samplesPrecision medicineINSL3Metabolic pathwaysPathway analysisExtension assayRisk factors for underlying bilateral vestibular weakness in cochlear implant candidates
Reeder A, Canner J, Schwartz N. Risk factors for underlying bilateral vestibular weakness in cochlear implant candidates. Otology & Neurotology Open 2025, 5: e066-e066. PMID: 40161476, PMCID: PMC11949288, DOI: 10.1097/ono.0000000000000066.Peer-Reviewed Original ResearchBilateral vestibular weaknessVestibular weaknessBilateral weaknessQuality of lifeCochlear implantationAudiological dataVestibular dysfunctionWorse-hearing earCochlear implant candidatesHigher Body Mass IndexBody mass indexCI candidatesImplanted earHearing thresholdsImplant candidatesPrognostic indicatorVestibular evaluationRetrospective cohort studyVestibular testsCaloric testUnilateral weaknessVestibular functionCohort studyMass indexRisk factorsBenzene exposure and risk of colorectal cancer by anatomical subsite in the Norwegian offshore petroleum workers cohort
Babigumira R, Veierød M, Larsen I, Berge L, Shala N, Marjerrison N, Samuelsen S, Bråtveit M, Kirkeleit J, Nordby K, Hosgood H, Demers P, Vermeulen R, Kromhout H, Engel L, Nilsen T, Silverman D, Friesen M, Rothman N, Lan Q, Grimsrud T, Stenehjem J. Benzene exposure and risk of colorectal cancer by anatomical subsite in the Norwegian offshore petroleum workers cohort. Environmental Research 2025, 276: 121407. PMID: 40118315, DOI: 10.1016/j.envres.2025.121407.Peer-Reviewed Original ResearchRisk of colorectal cancerOffshore petroleum workersJob-exposure matrixHazard ratioColorectal cancerAnatomic subsiteColorectal cancer riskConfidence intervalsColorectal cancer casesEstimate hazard ratiosCase-cohort analysisPetroleum workersWork historyExposure-response associationsPositive exposure-response associationsBody mass indexRight-sided colon cancerPublic health implicationsPhysical activityBenzene exposureMeat intakeAlcohol intakeQuartile 4Mass indexCase cohortA Randomized Phase 3 Study Evaluating the Efficacy and Safety of Alogliptin in Pediatric Participants with Type 2 Diabetes Mellitus
Peng X, Klingensmith G, Hsia D, Xie Y, Czerniak R, Tamborlane W, Shah A. A Randomized Phase 3 Study Evaluating the Efficacy and Safety of Alogliptin in Pediatric Participants with Type 2 Diabetes Mellitus. Diabetes Therapy 2025, 16: 865-883. PMID: 40032809, PMCID: PMC12006607, DOI: 10.1007/s13300-025-01700-3.Peer-Reviewed Original ResearchType 2 diabetes mellitusAlogliptin treatmentEfficacy endpointPediatric patientsAntihyperglycemic therapyOral dipeptidyl peptidase-4 inhibitorHbA1c levelsRandomized phase 3 studyDipeptidyl peptidase-4 inhibitorsSafety of alogliptinPlacebo-controlled trialPhase 3 studyBaseline to weekPeptidase-4 inhibitorsBody mass indexImprove glycemic controlDouble-blindPlacebo groupSecondary endpointsBackground metforminSchedule APharmacological therapyMass indexGlycosylated hemoglobinInsulin therapy
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