2025
Transcriptional signatures of endothelial cells shape immune responses in cardiopulmonary health and disease
Fließer E, Jandl K, Chen S, Wang M, Schupp J, Kuebler W, Baker A, Kwapiszewska G. Transcriptional signatures of endothelial cells shape immune responses in cardiopulmonary health and disease. JCI Insight 2025, 10: e191059. PMID: 40401523, PMCID: PMC12128986, DOI: 10.1172/jci.insight.191059.Peer-Reviewed Original ResearchConceptsEndothelial cellsCardiopulmonary vasculatureImmune responseImmune cell recruitmentRegulation of immune responsesFunction of endothelial cellsImmunoregulatory roleAntigen presentationCytokine secretionCell recruitmentCardiopulmonary healthDelivery of oxygenSingle-cell RNA sequencingImmunomodulatory propertiesCardiopulmonary diseaseClearance functionDisease pathogenesisTherapy targetTranscriptional signatureEC subpopulationsImmunomodulatory activityDiseaseLungVasculatureHeart
2023
ACR Appropriateness Criteria® Routine Chest Imaging
Imaging P, Bang T, Chung J, Walker C, Brixey A, Christensen J, Faiz S, Hanak M, Hobbs S, Kandathil A, Little B, Madan R, Moore W, Richman I, Setters B, Todd M, Yang S, Donnelly E. ACR Appropriateness Criteria® Routine Chest Imaging. Journal Of The American College Of Radiology 2023, 20: s224-s233. PMID: 37236745, DOI: 10.1016/j.jacr.2023.02.006.Peer-Reviewed Original ResearchConceptsRoutine chest imagingChest imagingInitial imagingRoutine chestAppropriateness CriteriaClinical scenariosAppropriateness of imagingACR Appropriateness CriteriaChronic cardiopulmonary diseaseMultidisciplinary expert panelRadiology Appropriateness CriteriaEvidence-based guidelinesAbsence of symptomsSpecific clinical conditionsSpecific clinical scenariosDifferent clinical scenariosRecommendations AssessmentHospital admissionNoncardiothoracic surgeryCardiopulmonary diseaseClinical conditionsAmerican CollegeGuideline developmentMedical literatureExpert panel
2022
Safety and feasibility of single use cholecystoscopy for guiding laser or mechanical cholelithotripsy, and mechanical cholelithotomy
Nezami N, Division of Interventional Radiology and Image-Guided Medicine D, Latich I, Chockalingam A, Arici M, Lee J, Lozada J, Schlachter T, Division of Vascular and Interventional Radiology D, Department of Surgery B, Department of Radiology M. Safety and feasibility of single use cholecystoscopy for guiding laser or mechanical cholelithotripsy, and mechanical cholelithotomy. Diagnostic And Interventional Radiology 2022, 28: 352-358. PMID: 35950279, PMCID: PMC9634924, DOI: 10.5152/dir.2022.20810.Peer-Reviewed Original ResearchConceptsAcute calculus cholecystitisCalculus cholecystitisCatheter placementClinical successSingle-institute retrospective analysisCommon bile duct stonesMinor procedure-related complicationsEarly clinical outcomesProcedure-related complicationsBile duct stonesMedian time intervalMean interval timeNumber of interventionsGallstone extractionCholecystostomy tubeEnd of lifeMorbid obesitySurgical contraindicationsSymptomatic cholelithiasisClinical outcomesDuct stonesCardiopulmonary diseaseDrainage catheterPurpose PatientsRetrospective analysisType 2 immune polarization is associated with cardiopulmonary disease in preterm infants
Lao J, Bui C, Pang M, Cho S, Rudloff I, Elgass K, Schröder J, Maksimenko A, Mangan N, Starkey M, Skuza E, Sun Y, Beker F, Collins C, Kamlin O, König K, Malhotra A, Tan K, Theda C, Young M, McLean C, Wilson N, Sehgal A, Hansbro P, Pearson J, Polo J, Veldman A, Berger P, Nold-Petry C, Nold M. Type 2 immune polarization is associated with cardiopulmonary disease in preterm infants. Science Translational Medicine 2022, 14: eaaz8454. PMID: 35385341, DOI: 10.1126/scitranslmed.aaz8454.Peer-Reviewed Original ResearchConceptsPreterm infantsBronchopulmonary dysplasiaIL-13CD3<sup>+</sup>CD4<sup>+</sup> T cellsInterleukin-4BPD-associated pulmonary hypertensionMaternal magnesium sulfate therapyCD4<sup>+</sup> T cellsCardiopulmonary diseaseMagnesium sulfate therapyType 2 mediatorsHealthy term infantsType 2 polarizationType 2 cytokinesHepatitis B vaccineMultiple therapeutic approachesTerm infantsPulmonary hypertensionDisease in vivoT cellsLung inflammationYounger patientsIL-5B vaccineHigh treatment costs
2021
Persistent Exertional Intolerance After COVID-19 Insights From Invasive Cardiopulmonary Exercise Testing
Singh I, Joseph P, Heerdt PM, Cullinan M, Lutchmansingh DD, Gulati M, Possick JD, Systrom DM, Waxman AB. Persistent Exertional Intolerance After COVID-19 Insights From Invasive Cardiopulmonary Exercise Testing. CHEST Journal 2021, 161: 54-63. PMID: 34389297, PMCID: PMC8354807, DOI: 10.1016/j.chest.2021.08.010.Peer-Reviewed Original ResearchConceptsInvasive cardiopulmonary exercise testingCardiopulmonary exercise testingCardiopulmonary diseaseExercise testingControl participantsPeak VOExertional limitationCOVID-19Greater ventilatory inefficiencyPeak cardiac indexSex-matched control participantsCohort of patientsSystemic oxygen extractionDead space ventilationOnly mild symptomsExertional intoleranceCardiac indexPulmonary hemodynamicsAcute infectionVentilatory inefficiencyExercise intolerancePathophysiologic mechanismsMild symptomsHyperventilatory responseOxygen extraction
2020
Systemic vascular distensibility relates to exercise capacity in connective tissue disease
Singh I, Oliveira RKF, Naeije R, Oldham WM, Faria-Urbina M, Waxman AB, Systrom DM. Systemic vascular distensibility relates to exercise capacity in connective tissue disease. Rheumatology 2020, 60: 1429-1434. PMID: 33001175, DOI: 10.1093/rheumatology/keaa510.Peer-Reviewed Original ResearchConceptsCTD patientsSystemic oxygen extractionExercise capacityVascular distensibilityCardiopulmonary diseaseOxygen extractionDecreased exercise capacityStroke volume augmentationReduced exercise capacityCommon clinical manifestationsRadial arterial catheterConnective tissue diseaseAerobic exercise capacityPulmonary vascular distensibilityCardio-pulmonary diseasePressure-flow plotsPulmonary hypertensionCardiopulmonary exerciseHeart failureArterial catheterExercise intoleranceTissue diseaseClinical manifestationsNormal controlsPatients
2013
Impact of congenital heart disease on outcomes of pediatric heart‐lung transplantation
Keeshan BC, Goldfarb SB, Lin KY, Kreindler JL, Kaufman BD, Gaynor JW, Shaddy RE, Rossano JW. Impact of congenital heart disease on outcomes of pediatric heart‐lung transplantation. Pediatric Transplantation 2013, 18: 204-210. PMID: 24373099, DOI: 10.1111/petr.12208.Peer-Reviewed Original ResearchConceptsPediatric heart-lung transplantationPretransplant mechanical ventilationWorse graft survivalHeart-lung transplantationComplex patient populationCongenital heart diseaseDiagnosis of CHDPretransplant PRATransplant eraGraft survivalPreoperative factorsUNOS databaseGraft failureMechanical ventilationMultivariable analysisWorse prognosisPatient survivalPoor outcomeCardiopulmonary diseasePatient populationAlternative therapiesHeart diseaseRetrospective analysisYounger ageCHDStandard Nonspecific Therapies in the Management of Pulmonary Arterial Hypertension
Sauler M, Fares WH, Trow TK. Standard Nonspecific Therapies in the Management of Pulmonary Arterial Hypertension. Clinics In Chest Medicine 2013, 34: 799-810. PMID: 24267305, DOI: 10.1016/j.ccm.2013.08.013.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsHigh-dose calcium channel blockersCommon cardiopulmonary diseasesPAH-specific therapyPulmonary arterial hypertensionTreatment of patientsCalcium channel blockersPAH therapyArterial hypertensionAdjunct therapyOxygen therapyMedical therapyNonspecific therapyCardiopulmonary diseasePathologic understandingChannel blockersSmall studyTherapyHypertension researchExpert opinionAnticoagulationHypertensionDiureticsPatientsBlockersDigoxin
2009
Chapter 42 Neonatal and Pediatric Transfusion Medicine
Hendrickson J, Josephson C. Chapter 42 Neonatal and Pediatric Transfusion Medicine. 2009, 235-239. DOI: 10.1016/b978-0-12-374432-6.00042-7.Peer-Reviewed Original ResearchCardiopulmonary diseaseSevere cardiopulmonary diseaseSmall-volume transfusionsFebrile transfusion reactionsPediatric transfusion medicineHLA alloimmunizationSymptomatic anemiaMajor surgeryPediatric patientsPremature infantsCMV transmissionTransfusion therapyNeonatal patientsPhysiologic changesTransfusion reactionsImmune systemNeonatesFetal periodAnticoagulant-preservative solutionInfantsTransfusionRBC productsTransfusion medicineDlPatients
1996
Alterations of Cardiovascular Performance During Laparoscopic Colectomy: A Combined Hemodynamic and Echocardiographic Analysis
Harris S, Ballantyne G, Luther M, Perrino A. Alterations of Cardiovascular Performance During Laparoscopic Colectomy: A Combined Hemodynamic and Echocardiographic Analysis. Anesthesia & Analgesia 1996, 83: 482. DOI: 10.1213/00000539-199609000-00007.Peer-Reviewed Original ResearchConceptsSystemic vascular resistanceEjection fraction areaCardiac indexLaparoscopic colectomyCardiovascular performanceCardiopulmonary diseasePulmonary capillary wedge pressureCapillary wedge pressurePulmonary artery catheterEnd-diastolic areaSignificant increaseHyperdynamic stateVascular resistanceWedge pressureArtery catheterPeritoneal insufflationVentricular preloadTrendelenburg positioningGeneral anesthesiaTransesophageal echocardiographyEchocardiographic analysisEchocardiographic dataIntraoperative maneuversHemodynamic responseHeart rateAlterations of Cardiovascular Performance During Laparoscopic Colectomy
Harris S, Ballantyne G, Luther M, Perrino A. Alterations of Cardiovascular Performance During Laparoscopic Colectomy. Anesthesia & Analgesia 1996, 83: 482-487.. PMID: 8780267, DOI: 10.1097/00000539-199609000-00007.Peer-Reviewed Original ResearchConceptsEjection fraction areaSystemic vascular resistanceCoexisting cardiopulmonary diseaseCardiac indexLaparoscopic colectomyCardiovascular performancePulmonary capillary wedge pressureCardiopulmonary diseaseEnd-diastolic areaCapillary wedge pressurePulmonary artery catheterTransesophageal echocardiographyIntraoperative maneuversWedge pressurePeritoneal insufflationEchocardiographic dataVentricular preloadHyperdynamic stateArtery catheterVascular resistanceHemodynamic monitoringGeneral anesthesiaColectomyInsufflationTrendelenburg
1995
Diagnostic utility of contrast echocardiography and lung perfusion scan in patients with hepatopulmonary syndrome
Abrams G, Jaffe C, Hoffer P, Binder H, Fallon M. Diagnostic utility of contrast echocardiography and lung perfusion scan in patients with hepatopulmonary syndrome. Gastroenterology 1995, 109: 1283-1288. PMID: 7557096, DOI: 10.1016/0016-5085(95)90589-8.Peer-Reviewed Original ResearchConceptsLung perfusion scanHepatopulmonary syndromeIntrapulmonary vascular dilatationEchocardiogram resultsPerfusion scanContrast echocardiographyVascular dilatationDiagnosis of HPSBiopsy-proven cirrhosisConcurrent cardiopulmonary diseaseIntrinsic lung diseaseLung scan resultsPositive contrast echocardiogramChest radiograph abnormalitiesArterial blood gasesGas exchange abnormalitiesScan resultsUseful screening testIntrapulmonary vasodilatationPositive echocardiogramRadiograph abnormalitiesConsecutive outpatientsCardiopulmonary diseaseLung diseasePositive lung
1990
Heart-lung transplantation: initial experience in New England.
Letsou G, Franco K, Kopf G, Dewar M, Elefteriades J, Hammond G, Baldwin J. Heart-lung transplantation: initial experience in New England. Connecticut Medicine 1990, 54: 419-24. PMID: 2225808.Peer-Reviewed Original ResearchConceptsPulmonary hypertensionEnd-stage cardiopulmonary diseaseAssociated pulmonary hypertensionNormal cardiopulmonary functionHeart-lung transplantationHeart-lung transplantsPrimary pulmonary hypertensionDoxorubicin-Induced CardiomyopathyPulse steroidsRejection episodesDonor surgeryFluid overloadCardiopulmonary bypassCardiopulmonary functionCardiopulmonary diseaseEffective therapyPrimary disorderFunctional capacityPatientsCystic fibrosisInitial experienceGraftAge 33HypertensionAge 16
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