2025
Marginalized Neighborhoods and Health Outcomes in Younger Myocardial Infarction Survivors
Akioyamen L, Sivaswamy A, Haldenby O, Abdel-Qadir H, Sud M, Alter D, Atzema C, Austin P, Jackevicius C, Kapral M, Krumholz H, Tu K, Wijeysundera H, Ko D. Marginalized Neighborhoods and Health Outcomes in Younger Myocardial Infarction Survivors. JAMA Network Open 2025, 8: e2518826. PMID: 40601315, PMCID: PMC12223890, DOI: 10.1001/jamanetworkopen.2025.18826.Peer-Reviewed Original ResearchConceptsAcute myocardial infarctionAMI survivorsUniversal health care systemCohort studyMarginalized neighborhoodsHealth service utilizationPopulation-based retrospective cohortPrimary care physiciansHealth care systemUniversal health careNeighbourhood marginalizationAdjusted hazard ratiosMyocardial infarction survivorsProportional hazards regression modelsAcute myocardial infarction patientsYears of follow-upNeighbourhood quintilesHazards regression modelsCare physiciansService utilizationHealth outcomesHealth careCare systemAdministrative databasesNeighborhood characteristicsCost Disparities with Age in the Treatment of Advanced Non-Small-Cell Lung Cancer (NSCLC) in Ontario, Canada
Wang Y, Pond G, Gafni A, Kong C, Ellis P. Cost Disparities with Age in the Treatment of Advanced Non-Small-Cell Lung Cancer (NSCLC) in Ontario, Canada. Current Oncology 2025, 32: 346. PMID: 40558289, PMCID: PMC12191781, DOI: 10.3390/curroncol32060346.Peer-Reviewed Original ResearchConceptsCancer-attributable costsPhase of careNon-small-cell lung cancerAdvanced non-small-cell lung cancerInstitute for Clinical Evaluative SciencesHealthcare costsEnd-of-lifePre-diagnosis costsCost disparityEnd-of-life phaseDiagnosis of advanced non-small-cell lung cancerStage IV non-small-cell lung cancerTreatment of advanced non-small-cell lung cancerIV non-small-cell lung cancerRetrospective cohort studyLung cancerEvaluative SciencesPre-DiagnosisCancer diagnosisCohort studyOlder patientsDeceased patientsCareReceiving chemotherapyMedian ageAt-home Breast Oncology care Delivered with EHealth solutions (ABODE) study protocol: a randomised controlled trial
Mac A, Kalia M, Reel E, Amir E, Isenberg A, Kim R, Kennedy E, Koch C, Li M, McCready D, Metcalfe K, Okrainec A, Papadakos J, Rotstein S, Rodin G, Xu W, Zhong T, Cleland J, Forbes R, Easson A, Escallon J, Haykal S, Jarvis S, Leong W, McCuaig J, Santa Mina D, Peck L, Reedijk M, Sarvanantham S, Schaffer D, Thain E, Walimohamed F, Cil T. At-home Breast Oncology care Delivered with EHealth solutions (ABODE) study protocol: a randomised controlled trial. BMJ Open 2025, 15: e091579. PMID: 40345693, PMCID: PMC12067776, DOI: 10.1136/bmjopen-2024-091579.Peer-Reviewed Original ResearchConceptsRandomised controlled trialsPatient activationStandard careEHealth solutionsCancer care continuumPatient-reported outcome measuresHealth service outcomesBreast cancerMeasuring patient activationControlled TrialsAmbulatory care servicesTertiary care cancer centreMonths post-diagnosisIn-person servicesPatient-reported outcomesMeasured waiting timePeer-reviewed journalsQuality of lifeCare continuumCare servicesIntervention groupHealthcare deliveryRemote carePatient programmeIndividualised support
2024
Biopsychosocial Associates of Psychological Distress and Post-Traumatic Growth among Canadian Cancer Patients during the COVID-19 Pandemic
Zhang K, Mukherjee S, Pond G, Roque M, Meyer R, Sussman J, Ellis P, Bryant-Lukosius D. Biopsychosocial Associates of Psychological Distress and Post-Traumatic Growth among Canadian Cancer Patients during the COVID-19 Pandemic. Current Oncology 2024, 31: 5354-5366. PMID: 39330023, PMCID: PMC11431811, DOI: 10.3390/curroncol31090395.Peer-Reviewed Original ResearchConceptsPost-traumatic growthCanadian cancer patientsPsychological distressAssociation of psychological distressAssociated with psychological distressLevels of psychological distressModerate to severe levelsPsychological patient outcomesFear of recurrenceAssociated with levels of distressCancer patientsSevere psychological distressCross-sectional surveyLevels of distressDisease-related informationRegional Cancer CentrePatient health recordsSelf-report questionnairesCOVID-19 pandemicSafety behaviorCancer careIllness perceptionsHealth recordsNegative psychological outcomesOngoing careBarriers and facilitators to improving the cascade of HIV care in Ontario: a mixed method study
Mbuagbaw L, Fernando S, Lee C, Owino M, Youssef C, Snow M. Barriers and facilitators to improving the cascade of HIV care in Ontario: a mixed method study. BMC Health Services Research 2024, 24: 48. PMID: 38200516, PMCID: PMC10782539, DOI: 10.1186/s12913-023-10481-z.Peer-Reviewed Original ResearchConceptsAdherence to antiretroviral therapyMobile health interventionsTheoretical Domains FrameworkHealth workersHealth interventionsVirtual careEffective interventionsCascade of HIV careAdherence to ARTSequential explanatory mixed methods studyInitiation of ARTExplanatory mixed methods studyHIV care cascadeMixed methods studyEvidence-based strategiesClient preparednessDomains FrameworkCare cascadeHIV careTailored careHealthcare deliveryElectronic interventionPeer supportHIV clinicInvestigate barriers
2023
Association of Neighborhood-Level Marginalization With Health Care Use and Clinical Outcomes Following Hospital Discharge in Patients Who Underwent Coronary Catheterization for Acute Myocardial Infarction in a Single-Payer Health Care System
Akioyamen L, Abdel-Qadir H, Han L, Sud M, Mistry N, Alter D, Atzema C, Austin P, Bhatia R, Booth G, Dhalla I, Ha A, Jackevicius C, Kapral M, Krumholz H, Lee D, McNaughton C, Roifman I, Schull M, Sivaswamy A, Tu K, Udell J, Wijeysundera H, Ko D. Association of Neighborhood-Level Marginalization With Health Care Use and Clinical Outcomes Following Hospital Discharge in Patients Who Underwent Coronary Catheterization for Acute Myocardial Infarction in a Single-Payer Health Care System. Circulation Cardiovascular Quality And Outcomes 2023, 16: e010063. PMID: 38050754, DOI: 10.1161/circoutcomes.123.010063.Peer-Reviewed Original ResearchConceptsAcute myocardial infarctionMyocardial infarctionHealth care systemHospital dischargeClinical outcomesSocioeconomic statusFirst acute myocardial infarctionProportional hazards regression modelsCare systemSecondary prevention medicationsWorse clinical outcomesHealth service usePopulation-based studyPrimary care physiciansHealth care useHazards regression modelsGreater long-term riskPrescription medication useSingle-payer health care systemUniversal health care systemLong-term riskLow socioeconomic statusCause mortalityDays postdischargePrevention medicationsAssociation of Beta-Blocker Therapy With Cardiovascular Outcomes in Patients With Stable Ischemic Heart Disease
Godoy L, Farkouh M, Austin P, Shah B, Qiu F, Jackevicius C, Wijeysundera H, Krumholz H, Ko D. Association of Beta-Blocker Therapy With Cardiovascular Outcomes in Patients With Stable Ischemic Heart Disease. Journal Of The American College Of Cardiology 2023, 81: 2299-2311. PMID: 37316110, DOI: 10.1016/j.jacc.2023.04.021.Peer-Reviewed Original ResearchConceptsStable coronary artery diseaseCoronary artery diseaseBeta-blocker groupRecent myocardial infarctionHeart failureMyocardial infarctionCardiovascular eventsCoronary angiographyPrescription claimsObstructive coronary artery diseaseIndex coronary angiographyBeta-blocker therapyBeta-blocker useHeart failure hospitalizationElective coronary angiographyNew-user designMyocardial infarction hospitalizationsCause deathCardiovascular outcomesCause mortalityFailure hospitalizationCardioprotective benefitsArtery diseasePrimary outcomeIschemic heartDevelopment and external validation of machine learning algorithms for postnatal gestational age estimation using clinical data and metabolomic markers
Hawken S, Ducharme R, Murphy M, Olibris B, Bota A, Wilson L, Cheng W, Little J, Potter B, Denize K, Lamoureux M, Henderson M, Rittenhouse K, Price J, Mwape H, Vwalika B, Musonda P, Pervin J, Chowdhury A, Rahman A, Chakraborty P, Stringer J, Wilson K. Development and external validation of machine learning algorithms for postnatal gestational age estimation using clinical data and metabolomic markers. PLOS ONE 2023, 18: e0281074. PMID: 36877673, PMCID: PMC9987787, DOI: 10.1371/journal.pone.0281074.Peer-Reviewed Original ResearchConceptsGestational ageCord blood dataClinical dataBlood dataMetabolomic markersEarly pregnancy ultrasoundHeel-prick blood sampleProspective birth cohortMultivariable linear regressionBlood sample dataExternal validationGestational age estimationRetrospective cohortPregnancy ultrasoundHeel prickExternal cohortIndependent cohortBlood samplesBirth cohortNewbornsPostnatal gestational age estimationCohortUltrasound estimatesInternal model validationLow-income countries
2022
Association of Neighborhood-Level Material Deprivation With Atrial Fibrillation Care in a Single-Payer Health Care System: A Population-Based Cohort Study
Abdel-Qadir H, Akioyamen LE, Fang J, Pang A, Ha ACT, Jackevicius CA, Alter DA, Austin PC, Atzema CL, Bhatia RS, Booth GL, Johnston S, Dhalla I, Kapral MK, Krumholz HM, McNaughton CD, Roifman I, Tu K, Udell JA, Wijeysundera HC, Ko DT, Schull MJ, Lee DS. Association of Neighborhood-Level Material Deprivation With Atrial Fibrillation Care in a Single-Payer Health Care System: A Population-Based Cohort Study. Circulation 2022, 146: 159-171. PMID: 35678171, PMCID: PMC9287095, DOI: 10.1161/circulationaha.122.058949.Peer-Reviewed Original ResearchConceptsYears of ageCohort studyUniversal health careAF-related adverse eventsNeighbourhood-level material deprivationPopulation-based cohort studyPrimary care physician visitsCause-specific hazards regressionRhythm control interventionsHigh cardiovascular disease burdenCardiovascular disease burdenHealth careAtrial fibrillation careNeighborhood material deprivationSingle-payer health care systemMaterial deprivation quintileAtrial fibrillation diagnosisHealth care systemNoncardiovascular comorbiditiesAdverse eventsHeart failurePhysician visitsHazards regressionAdverse outcomesDeprivation quintile
2021
Long-Term Kidney Outcomes Following Dialysis-Treated Childhood Acute Kidney Injury: A Population-Based Cohort Study
Robinson CH, Jeyakumar N, Luo B, Wald R, Garg AX, Nash DM, McArthur E, Greenberg J, Askenazi D, Mammen C, Thabane L, Goldstein S, Parekh RS, Zappitelli M, Chanchlani R. Long-Term Kidney Outcomes Following Dialysis-Treated Childhood Acute Kidney Injury: A Population-Based Cohort Study. Journal Of The American Society Of Nephrology 2021, 32: 2005-2019. PMID: 34039667, PMCID: PMC8455253, DOI: 10.1681/asn.2020111665.Peer-Reviewed Original ResearchMeSH KeywordsAcute Kidney InjuryAdolescentCase-Control StudiesChildChild, PreschoolFemaleFollow-Up StudiesHumansHypertensionIncidenceInfantInfant, NewbornKidney Failure, ChronicMaleMortalityOntarioProportional Hazards ModelsRenal DialysisRenal Insufficiency, ChronicRetrospective StudiesRisk FactorsSurvivorsTime FactorsConceptsAKI survivorsKidney failureLong-term riskCohort studyCox proportional hazards regression analysisAdverse short-term outcomesChildhood acute kidney injuryProportional hazards regression analysisHigher long-term riskAcute kidney injuryHealth administrative databasesRetrospective cohort studyHazards regression analysisShort-term outcomesLong-term outcomesBasis of ageAKI episodesPediatric AKISubsequent AKIKidney injuryComposite outcomeCardiac surgeryHospitalized cohortMechanical ventilationPediatric hospitalizationsRelative risks of COVID-19 fatality between the first and second waves of the pandemic in Ontario, Canada
Hsu SH, Chang SH, Gross C, Wang SY. Relative risks of COVID-19 fatality between the first and second waves of the pandemic in Ontario, Canada. International Journal Of Infectious Diseases 2021, 109: 189-191. PMID: 34216734, PMCID: PMC8245301, DOI: 10.1016/j.ijid.2021.06.059.Peer-Reviewed Original ResearchConceptsCase fatality rateRelative riskTesting ratesPooled RR estimateCOVID-19 case fatality ratePublic health unitsCOVID-19 case fatalityCOVID-19 testingCOVID-19 testing ratesHigher testing ratesCase fatalityCOVID-19 casesCOVID-19 fatalitiesHealth unitsFatality rateSecond waveRR estimatesFirst waveCOVID-19RiskFatalitiesOntarioThe impact of a universal human papilloma virus (HPV) vaccination program on lower genital tract dysplasia and genital warts
Clark M, Jembere N, Kupets R. The impact of a universal human papilloma virus (HPV) vaccination program on lower genital tract dysplasia and genital warts. Preventive Medicine 2021, 150: 106641. PMID: 34048822, DOI: 10.1016/j.ypmed.2021.106641.Peer-Reviewed Original ResearchConceptsSchool-based human papillomavirus (HPV) vaccination programLower genital tract dysplasiaPre-invasive diseaseTreatment of HPVVaccination programGenital wartsCervical dysplasiaCytologic abnormalitiesRelative riskHuman papilloma virus vaccination programmesLow-grade cytologic abnormalitiesHuman papillomavirus vaccination programmeLower genital tractHigh-grade abnormalitiesRelative risk ratiosCervical conizationUnvaccinated womenVaccinated womenHPV vaccineColposcopy servicesUnvaccinated groupVaccinated groupRisk ratioCytology resultsAdministrative databasesSurvival of Older Women With Cervical Cancer Based on Screening History.
Clark M, Jembere N, Wang L, Kupets R. Survival of Older Women With Cervical Cancer Based on Screening History. Journal Of Lower Genital Tract Disease 2021, 25: 9-14. PMID: 33347044, DOI: 10.1097/lgt.0000000000000582.Peer-Reviewed Original ResearchConceptsInvasive cervical cancerWomen 50 yearsPrimary care physiciansCervical cancerOverall survivalScreening historyCare physiciansPopulation-level retrospective cohort studyMultivariate analysisHealth care administrative databasesFour-year OSRetrospective cohort studyCervical screening historyUnscreened womenAdvanced diseaseCohort studyScreened groupSurvival benefitImproved survivalCervical screeningKaplan-MeierUnivariate analysisAdministrative databasesOlder womenAge groups
2020
Magnetic Resonance Imaging-Guided Transurethral Ultrasound Ablation of Localized Prostate Cancer: Preliminary Experience from a Single Center in a Prospective, Multi-Center, Single-Arm Clinical Trial
Sundaram KM, Staruch R, Burtnyk M, Lane JS, Penson DF, Arora SS. Magnetic Resonance Imaging-Guided Transurethral Ultrasound Ablation of Localized Prostate Cancer: Preliminary Experience from a Single Center in a Prospective, Multi-Center, Single-Arm Clinical Trial. Journal Of Vascular And Interventional Radiology 2020, 31: 740-746.e4. PMID: 32307311, DOI: 10.1016/j.jvir.2019.12.802.Peer-Reviewed Original ResearchMeSH KeywordsAblation TechniquesAgedAged, 80 and overHumansMagnetic Resonance Imaging, InterventionalMaleMiddle AgedNeoplasm GradingNeoplasm StagingOntarioPreliminary DataProspective StudiesProstatic NeoplasmsTime FactorsTransurethral Resection of ProstateTreatment OutcomeUltrasonic Surgical ProceduresConceptsTransurethral ultrasound ablationProstate cancerMagnetic resonance imaging-guided transurethral ultrasound ablationIntermediate-risk prostate cancerUltrasound ablationIntermediate-risk diseaseSingle-center experienceGastrointestinal side effectsLocalized prostate cancerArm clinical trialMagnetic resonance imagingHistologic benefitPostprocedural changesPrimary endpointSingle centerClinical trialsMulti-centerSide effectsPreliminary experienceResonance imagingPatientsProstate treatmentCancerAblationBiopsyReadmission and Mortality After Hospitalization for Myocardial Infarction and Heart Failure
Ko DT, Khera R, Lau G, Qiu F, Wang Y, Austin PC, Koh M, Lin Z, Lee DS, Wijeysundera HC, Krumholz HM. Readmission and Mortality After Hospitalization for Myocardial Infarction and Heart Failure. Journal Of The American College Of Cardiology 2020, 75: 736-746. PMID: 32081282, DOI: 10.1016/j.jacc.2019.12.026.Peer-Reviewed Original ResearchConceptsAcute myocardial infarctionPost-discharge mortalityHospital mortalityReadmission ratesHospitalization ratesMyocardial infarctionMortality rateRisk-adjusted mortality ratesHospital Readmissions Reduction ProgramHF hospitalization ratesHeart failure hospitalizationPatients 65 yearsReadmissions Reduction ProgramFailure hospitalizationHF patientsSecondary outcomesHospital readmissionPrimary outcomeReadmissionMortalityAMI hospitalization ratesStudy periodPattern of outcomesHospitalizationOutcomes
2019
Risk Factors for Upstaging, Recurrence, and Mortality in Clinical T1-2 Renal Cell Carcinoma Patients Upstaged to pT3a Disease: An International Analysis Utilizing the 8th Edition of the Tumor-Node-Metastasis Staging Criteria
Hamilton Z, Capitanio U, Pruthi D, Ghali F, Larcher A, Patel D, Eldefrawy A, Patel S, Cotta B, Bradshaw A, Meagher M, Miller N, Carenzi C, Wan F, Liss M, McGregor T, Montorsi F, Derweesh I. Risk Factors for Upstaging, Recurrence, and Mortality in Clinical T1-2 Renal Cell Carcinoma Patients Upstaged to pT3a Disease: An International Analysis Utilizing the 8th Edition of the Tumor-Node-Metastasis Staging Criteria. Urology 2019, 138: 60-68. PMID: 31836465, DOI: 10.1016/j.urology.2019.11.036.Peer-Reviewed Original ResearchConceptsRecurrence-free survivalRisk of recurrenceRenal cell carcinomaKaplan-Meier analysisHigher clinical stageClinical stageOverall survivalMultivariable analysisPT3a upstagingRisk factorsTumor-NodeT3a renal cell carcinomaRenal cell carcinoma patientsRisk of upstagingCell carcinoma patientsMulticenter retrospective analysisPerinephric fat invasionInitial clinical stageRenal vein invasionType of surgeryPT3a diseaseCarcinoma patientsPrimary outcomeFat invasionRenal veinPhase IIb, Randomized, Double-Blind Trial of GC4419 Versus Placebo to Reduce Severe Oral Mucositis Due to Concurrent Radiotherapy and Cisplatin For Head and Neck Cancer
Anderson C, Lee C, Saunders D, Curtis A, Dunlap N, Nangia C, Lee A, Gordon S, Kovoor P, Arevalo-Araujo R, Bar-Ad V, Peddada A, Colvett K, Miller D, Jain A, Wheeler J, Blakaj D, Bonomi M, Agarwala S, Garg M, Worden F, Holmlund J, Brill J, Downs M, Sonis S, Katz S, Buatti J. Phase IIb, Randomized, Double-Blind Trial of GC4419 Versus Placebo to Reduce Severe Oral Mucositis Due to Concurrent Radiotherapy and Cisplatin For Head and Neck Cancer. Journal Of Clinical Oncology 2019, 37: 3256-3265. PMID: 31618127, PMCID: PMC6881100, DOI: 10.1200/jco.19.01507.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAged, 80 and overAntineoplastic AgentsChemoradiotherapyChemoradiotherapy, AdjuvantCisplatinDouble-Blind MethodFemaleHumansIncidenceMaleMiddle AgedMouth NeoplasmsOntarioOrganometallic CompoundsOropharyngeal NeoplasmsRadiation InjuriesRadiation-Protective AgentsRadiotherapy, Intensity-ModulatedRisk FactorsSeverity of Illness IndexStomatitisTime FactorsTreatment OutcomeUnited StatesConceptsDouble-blind trialOral mucositisRadiation therapyCancer Institute Common Terminology Criteria for Adverse EventsNational Cancer Institute Common Terminology Criteria for Adverse EventsPhase IIbCommon Terminology Criteria for Adverse EventsLocally advanced oral cavityPostoperative intensity-modulated RTToxicity of radiation therapyHead and neck cancerGrades of OMIntensity-modulated RTSevere oral mucositisAdverse events gradePhase III trialsAdvanced oral cavityActive dose levelsClinically meaningful reductionsConcurrent radiotherapyIMRT fractionsSevere OMDebilitating toxicityOropharynx cancerTumor characteristicsMisinterpreted Myoepithelial Carcinoma of Salivary Gland
Xu B, Mneimneh W, Torrence D, Higgins K, Klimstra D, Ghossein R, Katabi N. Misinterpreted Myoepithelial Carcinoma of Salivary Gland. The American Journal Of Surgical Pathology 2019, 43: 601-609. PMID: 30789358, PMCID: PMC7480003, DOI: 10.1097/pas.0000000000001218.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAged, 80 and overBiomarkers, TumorBiopsyCarcinomaCase-Control StudiesCell ProliferationDiagnostic ErrorsDisease ProgressionFemaleHumansMaleMiddle AgedMyoepitheliomaNeoplasm InvasivenessNeoplasm Recurrence, LocalNew York CityOntarioPredictive Value of TestsSalivary Gland NeoplasmsTime FactorsTreatment OutcomeConceptsMyoepithelial carcinomaPleomorphic adenomaHistological featuresCase of myoepithelial carcinomaLobulated patternDiagnosis of PARisk of recurrenceDiagnostic histological featuresAtypical PALocal recurrenceDistant metastasisBenign mimicsMyoepithelial proliferationBenign diagnosisMalignant natureBenign neoplasmsMorphologic spectrumFollow-upPatientsControl groupCellular distributionRecurrenceDiagnosisCellular PACarcinomaExternal validation of postnatal gestational age estimation using newborn metabolic profiles in Matlab, Bangladesh
Murphy MS, Hawken S, Cheng W, Wilson LA, Lamoureux M, Henderson M, Pervin J, Chowdhury A, Gravett C, Lackritz E, Potter BK, Walker M, Little J, Rahman A, Chakraborty P, Wilson K. External validation of postnatal gestational age estimation using newborn metabolic profiles in Matlab, Bangladesh. ELife 2019, 8: e42627. PMID: 30887951, PMCID: PMC6424558, DOI: 10.7554/elife.42627.Peer-Reviewed Original ResearchConceptsGestational ageGestational age estimationCord bloodNewborn metabolic profilesHeel prick samplesLow-resource settingsTerm infantsPreterm birthHeel prickPopulation-level estimatesPostnatal gestational age estimationBlood spotsMetabolic profileExternal validationInfantsScreening facilityAgeBloodFeasible optionMajority of samplesNewbornsPrickCordWeeksLimitations in Correspondence Programs for Cervical Cancer Screening: Who Are the Women We Are Missing?
Clark M, Lee A, Kupets R. Limitations in Correspondence Programs for Cervical Cancer Screening: Who Are the Women We Are Missing? Journal Of Obstetrics And Gynaecology Canada 2019, 41: 1410-1415. PMID: 30803876, DOI: 10.1016/j.jogc.2018.11.034.Peer-Reviewed Original ResearchConceptsPrimary care physiciansCare physiciansHealth care encountersCervical cancerCare encountersMore health care encountersRetrospective observational studyCervical cancer screeningHealth care servicesBasis of ageEligible womenCancer screeningAdministrative databasesObservational studyScreening programCare servicesHealth servicesPhysiciansCorrespondence programWomenFurther riskOutreach methodsCancerMailingInfrequent users
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