2025
Association between Hospital Safety-Net Status and Delivery of Rehabilitation to Older Adults with Acute Respiratory Failure
Jimenez J, Zhang L, Lin Z, Ferrante L, Falvey J, Walkey A, Krumholz H, Jain S. Association between Hospital Safety-Net Status and Delivery of Rehabilitation to Older Adults with Acute Respiratory Failure. CHEST Journal 2025 PMID: 40818773, DOI: 10.1016/j.chest.2025.07.4079.Peer-Reviewed Original ResearchSafety-net hospitalMedian odds ratioSafety-net hospital statusDelivery of rehabilitationOlder adultsRehabilitation deliveryNon-SNHsIntensive care unitSocioeconomic disadvantageRetrospective cohort studyCohort study of older adultsHospital safety-net statusDisproportionate share hospital indexRetrospective cohort study of older adultsHierarchical multivariable logistic regression modelsStudy of older adultsSafety-net statusMedicare Provider AnalysisMultivariate logistic regression modelCritical illnessLogistic regression modelsRehabilitation servicesSocioeconomic disparitiesHospital characteristicsUS hospitalsChanges in Cardiovascular Risk Factors and Health Care Expenditures Among Patients Prescribed Semaglutide
Lu Y, Liu Y, Totojani T, Kim C, Khera R, Xu H, Brush J, Krumholz H, Abaluck J. Changes in Cardiovascular Risk Factors and Health Care Expenditures Among Patients Prescribed Semaglutide. JAMA Network Open 2025, 8: e2526013. PMID: 40779264, PMCID: PMC12334959, DOI: 10.1001/jamanetworkopen.2025.26013.Peer-Reviewed Original ResearchConceptsHealth care expendituresCardiovascular risk factorsCare expendituresCohort studyRisk factorsYale New Haven Health SystemCohort study of adultsType 2 diabetes statusLong-term impactStudy of adultsHealth systemRetrospective cohort studyBlood pressureHemoglobin A1c reductionMain OutcomesTotal cholesterolSentara HealthcareInpatient staySecondary outcomesGlucagon-like peptide-1 receptor agonistsPrimary outcomeHealthPeptide-1 receptor agonistsAssociated with clinical outcomesAssociated with reductionsDischarge Disposition Following Acute Ischemic Stroke in the Veterans Health Administration: A Retrospective Cohort Study
Waddell K, Perkins A, Myers L, Daggy J, Ding Q, Sexson A, Taylor S, Sico J, Bravata D. Discharge Disposition Following Acute Ischemic Stroke in the Veterans Health Administration: A Retrospective Cohort Study. Journal Of Stroke And Cerebrovascular Diseases 2025, 108435. DOI: 10.1016/j.jstrokecerebrovasdis.2025.108435.Peer-Reviewed Original ResearchInpatient rehabilitation facilitySkilled nursing facilityVeterans Health AdministrationDischarge dispositionHealth AdministrationAssociated with higher oddsAssociated with discharge dispositionHome health servicesOdds of dischargeAcute ischemic strokeIschemic strokeProportion of dischargesCochrane-Armitage testAssociated with dischargeMultinomial logistic regressionAcute hospitalsOlder veteransNursing facilitiesFacility characteristicsHealth servicesRehabilitation facilityRetrospective cohort studyOlder adultsUnadjusted trendsHigher oddsTiming of repeat epinephrine to inform paediatric anaphylaxis observation periods: a retrospective cohort study
Dribin T, Sampson H, Zhang Y, Boyd S, Zhang N, Michelson K, Neuman M, Brousseau D, Mistry R, Freedman S, Aronson P, Bergmann K, Boswell B, Chinta S, Chua W, Cohen A, Cohen J, Daggett A, Davis J, Freeman J, Khanna K, Knoles C, Kwan K, Larsen C, Lee J, Lubell T, Metcalf A, Moake M, Nesiama J, Ngo T, Pulcini C, Russo C, Singh N, Srivastava G, Strutt J, Thapar V, Vander Wyst C, Walsh P, Wolnerman Y, Schnadower D, Academy of Pediatrics P, Kanngiesser A, McGarghan F, Dulchavsky A, Costalez J, DesPain A, Armanious M, Haghnazarian E, Brown-Whitehorn T, Weigert R, Dayan P, Meltzer J, Chowdhury N, Benedetti J, Sinziana C, Handorf A, Ruthford M, Devens M, Mecham C, Holland J, Casas T, Brown J, Panda P, Morrow A, Maready M, Nathani Y, Stevens M, Abraham G, Yen K, Cooper-Sood J, Woolf S. Timing of repeat epinephrine to inform paediatric anaphylaxis observation periods: a retrospective cohort study. The Lancet Child & Adolescent Health 2025, 9: 484-496. PMID: 40506197, DOI: 10.1016/s2352-4642(25)00139-7.Peer-Reviewed Original ResearchConceptsElectronic medical recordsEmergency departmentRetrospective cohort studyCohort studyMedical recordsDocumentation of symptomsCardiovascular involvementHealth-care facilitiesEpinephrine doseAcute allergic reactionsNational Institutes of HealthCumulative incidenceNational Center for Advancing Translational SciencesInstitutes of HealthChildren Aged 6 MonthsClinical ModificationHospital wardsIncidence rateICD-10Observation periodPrimary outcomeAllergic reactionsSecondary to medicationsInitiation to discontinuationKaplan-Meier analysisTiming of Disability Diagnosis and Accommodations During Medical School by First-Generation Status, Race, Ethnicity, and Gender.
Nguyen M, Green C, Mason H, Pereira-Lima K, Sheets Z, Schroth S, Smeltz L, Moreland C, Betchkal R, Growbowski C, Boatright D, Kim M, Meeks L. Timing of Disability Diagnosis and Accommodations During Medical School by First-Generation Status, Race, Ethnicity, and Gender. Academic Medicine 2025 PMID: 40550131, DOI: 10.1097/acm.0000000000006147.Peer-Reviewed Original ResearchMedical school matriculantsClinical accommodationsSchool matriculantsMedical studentsTime of diagnosisDisability diagnosisModified Poisson regressionAssociated with likelihoodPhases of medical trainingNo significant associationRetrospective cohort studyDiagnosis of disabilityPoisson regressionMedical trainingRelative riskDisability typeCohort studyRequesting accommodationsMedical schoolsSignificant associationGraduation statusAccommodation requestsDisabilityFirst-generation college graduatesTimely diagnosisPrevalence of Hypertension in the Late Postpartum Period by Hypertensive Status in Pregnancy
Sinnott C, Culhane J, Lundsberg L, Partridge C, Denoble A. Prevalence of Hypertension in the Late Postpartum Period by Hypertensive Status in Pregnancy. O&G Open 2025, 2: e093. DOI: 10.1097/og9.0000000000000093.Peer-Reviewed Original ResearchElevated blood pressureLate postpartum periodBlood pressurePostpartum periodAcademic health care systemHypertension statusDelivery hospitalization dischargeWeeks of gestationRetrospective cohort studyHealth care systemNormal blood pressureDiastolic blood pressureElectronic medical recordsPrevalence of hypertensionSystolic blood pressureRates of hypertensionPostpartum hypertensionMm HgCare systemCohort studyMonths postpartumPregnancyLate postpartumPatient attributesMedical recordsUnderstanding Racial and Ethnic Disparities in Myasthenia Gravis Outcomes
McLaren N, Roy B, Nowak R. Understanding Racial and Ethnic Disparities in Myasthenia Gravis Outcomes. Neurology Clinical Practice 2025, 15: e200503. PMID: 40584640, PMCID: PMC12204767, DOI: 10.1212/cpj.0000000000200503.Peer-Reviewed Original ResearchLong-term outcomes of patientsOutcomes of patientsLong-term outcomesAA patientsNon-Hispanic patientsMyasthenia gravisWhite patientsHistory of thymomaLong-term outcome analysisRetrospective cohort studyYears of follow-up dataDiagnosis of MGRepetitive nerve stimulationFollow-up dataSingle-fiber electromyographyMG crisisClinical featuresClinical profileLogistic regression modelsEthnic differencesAntibody seropositivityCohort studyNerve stimulationOutcome analysisPatientsCriminal Justice-Involved Veterans Not Engaged in Primary Care in the Veterans Health Administration.
Tsai J, Lampros A, Clark S, Dunn A, O'Toole T. Criminal Justice-Involved Veterans Not Engaged in Primary Care in the Veterans Health Administration. Journal Of Primary Care & Community Health 2025, 16: 21501319251348134. PMID: 40525421, PMCID: PMC12174793, DOI: 10.1177/21501319251348134.Peer-Reviewed Original ResearchConceptsVeterans Health AdministrationPrimary care visitsPrimary careJustice-involved veteransCare visitsHealth AdministrationVeterans Health Administration medical recordsMental health/substance use treatmentVeterans Health Administration facilitiesIntegrated care initiativesVA primary careOutpatient medical careMilitary sexual traumaCare initiativesService useAssociated with useCriminal justice systemHealthcare needsService utilizationNon-HispanicRetrospective cohort studySubstance use disordersBehavioral healthcareMental healthSociodemographic characteristicsCost Disparities with Age in the Treatment of Advanced Non-Small-Cell Lung Cancer (NSCLC) in Ontario, Canada
Wang Y, Pond G, Gafni A, Kong C, Ellis P. Cost Disparities with Age in the Treatment of Advanced Non-Small-Cell Lung Cancer (NSCLC) in Ontario, Canada. Current Oncology 2025, 32: 346. PMID: 40558289, PMCID: PMC12191781, DOI: 10.3390/curroncol32060346.Peer-Reviewed Original ResearchConceptsCancer-attributable costsPhase of careNon-small-cell lung cancerAdvanced non-small-cell lung cancerInstitute for Clinical Evaluative SciencesHealthcare costsEnd-of-lifePre-diagnosis costsCost disparityEnd-of-life phaseDiagnosis of advanced non-small-cell lung cancerStage IV non-small-cell lung cancerTreatment of advanced non-small-cell lung cancerIV non-small-cell lung cancerRetrospective cohort studyLung cancerEvaluative SciencesPre-DiagnosisCancer diagnosisCohort studyOlder patientsDeceased patientsCareReceiving chemotherapyMedian ageRisk of Thyroid Tumors With GLP-1 Receptor Agonists: A Retrospective Cohort Study.
Morales D, Bu F, Viernes B, DuVall S, Matheny M, Simon K, Falconer T, Richter L, Ostropolets A, Lau W, Man K, Chattopadhyay S, Mathioudakis N, Minty E, Nishimura A, Sun F, Yin C, Seager S, Chai Y, Zhou J, Lu Y, Reyes C, Pistillo A, Duarte-Salles T, Blacketer C, Schuemie M, Ryan P, Krumholz H, Hripcsak G, Khera R, Suchard M. Risk of Thyroid Tumors With GLP-1 Receptor Agonists: A Retrospective Cohort Study. Diabetes Care 2025 PMID: 40465422, DOI: 10.2337/dc25-0154.Peer-Reviewed Original ResearchRisk of thyroid tumorThyroid tumorsGLP-1RADPP-4isHazard ratioThyroid malignancyCohort studyIncreased riskSodium-glucose cotransporter 2 inhibitorsElectronic health record databaseGlucagon-like peptide 1 receptor agonistsEstimate hazard ratiosRandom-effects meta-analysisGLP-1 receptor agonistsPeptide 1 receptor agonistsDipeptidyl peptidase 4 inhibitorsThyroid tumor incidenceUsers of SGLT2isHealth record databaseSecond-line treatmentType 2 diabetes mellitusNew-user cohort studyRetrospective cohort studyUsers of sulfonylureasIntention-to-treatA Novel Electronic Health Record-Integrated Clinical Pathway for Nephrolithiasis: Development and Management Outcomes.
Lokeshwar S, Choksi A, Smani S, Heacock D, Kanaparthy N, Shaheen D, Dashevsky M, Martin T, Singh D, Motamedinia P, Sangal R. A Novel Electronic Health Record-Integrated Clinical Pathway for Nephrolithiasis: Development and Management Outcomes. Urology Practice 2025, 101097upj0000000000000847. PMID: 40459510, DOI: 10.1097/upj.0000000000000847.Peer-Reviewed Original ResearchEmergency departmentRenal colicClinical pathwayPain controlEvidence-based pain managementED patient careInadequate discharge planningAcute renal colicMedical expulsive therapyUrological follow-upMann-Whitney <i>Retrospective cohort studyEnhanced pain controlDischarge planningHealth systemDischarge practicesKetorolac doseOpioid alternativesPatient careExpulsive therapyLidocaine usePathway useOpioid useStandard carePain managementThe COVID-19 Pandemic and Goals-of-Care Conversations in Veterans Health Administration Clinics
Linsky A, Canter B, Glickman M, Qian S, Ryan S, Still M, Fried T, Wiener R. The COVID-19 Pandemic and Goals-of-Care Conversations in Veterans Health Administration Clinics. JAMA Network Open 2025, 8: e2515980. PMID: 40522660, PMCID: PMC12171934, DOI: 10.1001/jamanetworkopen.2025.15980.Peer-Reviewed Original ResearchConceptsAdvance care planningGoals-of-care conversationsHealth care deliveryCare planningCare deliveryRetrospective cohort studyUS Veterans Health Administration facilitiesImprove advance care planningVeterans Health Administration clinicsVeterans Health Administration facilitiesGoals-of-careFacility-level characteristicsCOVID-19 pandemicHealth care systemYear 3First-everCohort study of patientsRetrospective cohort study of patientsFacility levelStaffing shortagesCare systemOutpatient appointmentsMain OutcomesAdministration facilitiesSecondary analysisBiomarker-Specific Survival and Medication Cost for Patients With Non–Small Cell Lung Cancer
Tan J, Yang S, Dinan M, Chiang A, Gross C, Wang S. Biomarker-Specific Survival and Medication Cost for Patients With Non–Small Cell Lung Cancer. JAMA Network Open 2025, 8: e2514519. PMID: 40493365, PMCID: PMC12152704, DOI: 10.1001/jamanetworkopen.2025.14519.Peer-Reviewed Original ResearchConceptsAdvanced non-small cell lung cancerNon-small cell lung cancerEGFR variationPD-L1ALK rearrangementCell lung cancerDriver alterationsMedical costsLung cancerCohort studyProgrammed cell death 1 ligand 1Cell death 1 ligand 1Biomarker statusMedian overall survivalRetrospective cohort studyLower medical costsOverall survivalTargeted therapyNon-smallPatient cohortMonthly medical costsFollow-upStudy cohortBiomarker testingAssociated with higher costsP-450 Two for the Price of One: Twins and Multiple Births Following a Natural vs. Programmed Single Frozen Blastocyst Transfer Cycle
Meyers A, Mensah V, Morse B, Sakkas D, Vaughan D. P-450 Two for the Price of One: Twins and Multiple Births Following a Natural vs. Programmed Single Frozen Blastocyst Transfer Cycle. Human Reproduction 2025, 40: deaf097.756. DOI: 10.1093/humrep/deaf097.756.Peer-Reviewed Original ResearchFrozen embryo transferMultiple pregnanciesHigher-order multiplesEmbryo transferNatural frozen embryo transferRisk of monozygotic twinningRisk of multiple pregnancyNatural cycle groupPregnancy outcome dataRetrospective cohort studyElectronic medical record databaseNatural cyclesLikelihood of pregnancySingleton pregnanciesMedical record databaseTwin pregnanciesChi-square testFetal sacMethods PatientsOvulated oocytesUnassisted conceptionWider implicationsCohort studyPregnancyTheoretical riskEvaluating palliative care needs of early-phase clinical trial patients.
Crowley F, Zeng L, Hobensack M, Lehrman S, Afezolli D, Kelly L, Wey W, Chen J, Austin V, Easton E, Pagala A, Wu K, Lucas N, Wilk J, Marron T, Smith C, Gelfman L, Doroshow D. Evaluating palliative care needs of early-phase clinical trial patients. Journal Of Clinical Oncology 2025, 43: 12086-12086. DOI: 10.1200/jco.2025.43.16_suppl.12086.Peer-Reviewed Original ResearchPalliative careEnd-of-lifeEarly phase clinical trialsOutpatient PCReferral systemPalliative care needsSpecialty palliative careCancer type distributionPC servicesCare needsRetrospective cohort studyEvaluate demographic characteristicsPrevalent symptomsRate of constipationPC guidelinesPhysical discomfortCohort studyIncrease accessFisher's exact testPhase clinical trialsClinical trial patientsDemographic characteristicsMann-Whitney U testChi-squareCategorical variablesO-147 Biochemical or clinical pregnancy loss following the first embryo frozen transfer does not increase the risk of pregnancy loss in the subsequent embryo transfer
Barrett F, Kalafat E, Margolis C, Werner M, Ata B, Seli E. O-147 Biochemical or clinical pregnancy loss following the first embryo frozen transfer does not increase the risk of pregnancy loss in the subsequent embryo transfer. Human Reproduction 2025, 40: deaf097.147. DOI: 10.1093/humrep/deaf097.147.Peer-Reviewed Original ResearchRisk of pregnancy lossEuploid embryosImplant failurePregnancy lossEndometrial thicknessEmbryo transferUltrasound evidenceSerum beta-hCG levelsIncreased risk of pregnancy lossDay of blastulationMedian endometrial thicknessBeta-hCG levelsRisk of aneuploidyClinical pregnancy lossRisk of recurrenceRetrospective cohort studyEvidence of pregnancyPearson chi-square testRate of livebirthsEmbryo-fetalEuploid transfersGestational sacFET cyclesBeta-hCGChi-square testP-688 The validity of serum anti-Müllerian hormone (AMH) levels as predictors of ovarian response to stimulation decreases after 3 months
Reig A, Kalafat E, Ata B, Seli E. P-688 The validity of serum anti-Müllerian hormone (AMH) levels as predictors of ovarian response to stimulation decreases after 3 months. Human Reproduction 2025, 40: deaf097.994. DOI: 10.1093/humrep/deaf097.994.Peer-Reviewed Original ResearchOocyte yieldOvarian stimulationAMH measurementOvarian response to stimulationPredicting oocyte yieldPrivate fertility centerSerum AMH measurementLack of prospective validationAntral follicle countPredictive valueRetrospective cohort studyMonths prior to initiationEffects regression modelsFertility centerResponse to stimulationFollicle countEstradiol levelsOlder age groupsValidation setProspective validationRetrospective natureWider implicationsCohort studyAMHLinear mixed effects regression modelsP-332 Does endometrial thickness impact live birth rate following a frozen embryo transfer or is there a self-fulfilling prophecy: outcomes of 30,676 euploid single embryo transfers
Genovese H, Mayo C, Kalafat E, Ata B, Fatemi H, Garcia-Velasco J, Seli E. P-332 Does endometrial thickness impact live birth rate following a frozen embryo transfer or is there a self-fulfilling prophecy: outcomes of 30,676 euploid single embryo transfers. Human Reproduction 2025, 40: deaf097.640. DOI: 10.1093/humrep/deaf097.640.Peer-Reviewed Original ResearchLive birth rateModified natural cycleEndometrial thicknessReceiver operating characteristic curveBirth rateFET cyclesEmbryo transferInternational multicenter retrospective cohort studyOdds of live birth rateEuploid single embryo transfersPredictor of live birth rateMulticenter retrospective cohort studyEuploid FET cyclesEndometrial preparation protocolsIn vitro fertilization centerMultivariate logistic regression analysisSingle embryo transferFrozen embryo transferImpact of ETRetrospective cohort studyPredicting live birthLogistic regression analysisOperating characteristics curvePercentage of cyclesEuploid blastocystsFactors associated with decreased treatment intensity in patients with metastatic colon cancer: A real world analysis.
Forman R, Wang R, Yasin F, Kwaramba T, Lacy J, Ma X, Dinan M. Factors associated with decreased treatment intensity in patients with metastatic colon cancer: A real world analysis. Journal Of Clinical Oncology 2025, 43: 11168-11168. DOI: 10.1200/jco.2025.43.16_suppl.11168.Peer-Reviewed Original ResearchMetastatic colon cancerNon-intensive therapyNational Comprehensive Cancer NetworkPoor performance statusIntensive therapyFlatiron Health electronic health record-derived deidentified databaseColon cancerIntensive first-line therapyUndertreatment of older patientsNational Comprehensive Cancer Network guidelinesOdds ratioAssociated with treatment choiceFirst-line therapyAssociated with female sexComprehensive Cancer NetworkRetrospective cohort studyYear of diagnosisShorter overall survivalNon-frail patientsOlder ageNon-frailMultivariate logistic regressionEstimate odds ratiosAssociated with receiptTreatment intensityClostridium difficile Induced Coagulopathy: Implications for Microsurgery in the Setting of Limb Salvage
Rohrich R, Li K, Azimi R, Junn A, Ferdousian S, Lin R, Lee W, Currin M, Youn R, Attinger C, Akbari C, Evans K. Clostridium difficile Induced Coagulopathy: Implications for Microsurgery in the Setting of Limb Salvage. Journal Of Plastic Reconstructive & Aesthetic Surgery 2025 DOI: 10.1016/j.bjps.2025.06.010.Peer-Reviewed Original ResearchClostridium difficile infectionCDI groupFlap takebacksNon-CDI groupImpact of Clostridium difficile infectionPartial flap necrosisLower extremitiesRetrospective cohort studyC. diff infectionFlap complicationsMicrosurgical outcomesFlap necrosisThrombotic complicationsDifficile infectionPedicle thrombosisMicrovascular thrombosisFollow-upClinical managementMultivariate regression modelCohort studyIncreased riskC. difficilePlastic surgeonsPatientsLimb salvage
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