2023
Pharmacologic and Genetic Downregulation of Proprotein Convertase Subtilisin/Kexin Type 9 and Survival From Sepsis
Lawler P, Manvelian G, Coppi A, Damask A, Cantor M, Ferreira M, Paulding C, Banerjee N, Li D, Jorgensen S, Attre R, Carey D, Krebs K, Milani L, Hveem K, Damås J, Solligård E, Stender S, Tybjærg-Hansen A, Nordestgaard B, Hernandez-Beeftink T, Rogne T, Flores C, Villar J, Walley K, Liu V, Fohner A, Lotta L, Kyratsous C, Sleeman M, Scemama M, DelGizzi R, Pordy R, Horowitz J, Baras A, Martin G, Steg P, Schwartz G, Szarek M, Goodman S. Pharmacologic and Genetic Downregulation of Proprotein Convertase Subtilisin/Kexin Type 9 and Survival From Sepsis. Critical Care Explorations 2023, 5: e0997. PMID: 37954898, PMCID: PMC10635596, DOI: 10.1097/cce.0000000000000997.Peer-Reviewed Original ResearchProprotein convertase subtilisin/kexin type 9Convertase subtilisin/kexin type 9Subtilisin/kexin type 9Human cohort studiesODYSSEY OUTCOMESCohort studyType 9Isotype-matched controlExperimental murine modelSepsis ratePCSK9 inhibitionPCSK9 inhibitorsSepsis complicationsSepsis mortalitySepsis outcomeImproved survivalBacterial sepsisClinical outcomesBloodstream clearanceSepsis modelClinical trialsOdds ratioCardiovascular diseasePretreatment settingSepsis diagnosis
2008
Changing Patterns in Neonatal Escherichia coli Sepsis and Ampicillin Resistance in the Era of Intrapartum Antibiotic Prophylaxis
Bizzarro MJ, Dembry LM, Baltimore RS, Gallagher PG. Changing Patterns in Neonatal Escherichia coli Sepsis and Ampicillin Resistance in the Era of Intrapartum Antibiotic Prophylaxis. 2008, 121: 689-696. PMID: 18381532, DOI: 10.1542/peds.2007-2171.Peer-Reviewed Original ResearchMeSH KeywordsAmpicillinAmpicillin ResistanceAntibiotic ProphylaxisBacteremiaEscherichia coliEscherichia coli InfectionsFemaleFollow-Up StudiesHumansIncidenceInfant, NewbornInfectious Disease Transmission, VerticalMaleMultivariate AnalysisOdds RatioPregnancyPregnancy Complications, InfectiousPrenatal CareProbabilityRetrospective StudiesRisk AssessmentSeverity of Illness IndexStatistics, NonparametricSurvival RateConceptsE. coli early-onset sepsisEarly-onset sepsisLate-onset sepsisYale-New Haven HospitalIntrapartum antibiotic prophylaxisAntibiotic prophylaxisColi sepsisLow birth weight infantsAmpicillin resistanceAntibiotic prophylaxis practiceIntrapartum antibiotic exposureBirth weight infantsE. coli sepsisIndependent risk factorEscherichia coli sepsisAmpicillin exposureAmpicillin-resistant E. coliProphylaxis practicesSepsis rateWeight infantsNeonatal sepsisPreterm infantsTerm infantsRetrospective reviewRisk factors
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