2025
Predicting cognitive functioning in early psychosis: factors supporting and limiting generalizability of connectome-based models
O’Neill A, Pax M, Parent J, Sepulcre J, Camprodon J, Noble S, Roffman J, Eryilmaz H. Predicting cognitive functioning in early psychosis: factors supporting and limiting generalizability of connectome-based models. NPP—Digital Psychiatry And Neuroscience 2025, 3: 11. PMID: 40475845, PMCID: PMC12133584, DOI: 10.1038/s44277-025-00032-1.Peer-Reviewed Original ResearchConnectome-based predictive modelingEarly psychosisCognitive functionGoal of precision psychiatryPredictors of cognitive functionPrediction of cognitive functionPredicting cognitive performancePredicting cognitive functionModels of cognitionConnectome-based modelsPersonalized treatment developmentBrain connectivity patternsImpact functional outcomesHuman Connectome ProjectFluid cognitionPsychotic disordersSomatomotor networkCognitive abilitiesCognitive performancePrecision psychiatryVirtual lesion analysisTreatment developmentPsychosisCognitive outcomesCognitive impairmentElevated serum leucine levels are associated with cognitive impairment and reduced gray matter and cerebral volume across the Alzheimer’s disease continuum
Nasiri H, Azargoonjahromi A, Nouri Z, Azimi S, Zand H, Shourideh A, Heydari S, Mahmoudvand B, Barabadi S, Samadpour N, Mohamadhosseini A, Khodadadi A, Shakeri S, Mayeli M, Initiative F. Elevated serum leucine levels are associated with cognitive impairment and reduced gray matter and cerebral volume across the Alzheimer’s disease continuum. Neuroscience 2025, 577: 47-53. PMID: 40348165, DOI: 10.1016/j.neuroscience.2025.05.013.Peer-Reviewed Original ResearchConceptsCognitive performanceBrain volumeMediation analysisAlzheimer's Disease Assessment Scale-cognitive subscaleReduced gray matterGray matter volumeStructural brain volumesAssociated with cognitive impairmentAlzheimer's diseaseGray matterMagnetic resonance imagingPoor cognitive outcomesAlzheimer's disease continuumMatter volumeT1-weighted magnetic resonance imagingBrain structuresCognitive outcomesCerebral volumeCognitive impairmentCognitive declineBrain atrophyAD continuumBrainSerum leucine levelsAD pathologyWhole-brain white matter variation across childhood environments
Carozza S, Kletenik I, Astle D, Schwamm L, Dhand A. Whole-brain white matter variation across childhood environments. Proceedings Of The National Academy Of Sciences Of The United States Of America 2025, 122: e2409985122. PMID: 40193606, PMCID: PMC12012481, DOI: 10.1073/pnas.2409985122.Peer-Reviewed Original ResearchConceptsAdolescent Brain Cognitive DevelopmentAssociated with later difficultiesFractional anisotropyWhite matter fractional anisotropyWhite matter FAGray matter maturationWhite matter differencesEffects of adversityLower white matter fractional anisotropyLowest values of FACourse of childhoodExperience-dependent mannerInterpersonal adversityGray matter regionsReceptive languageCognitive effectsDevelopmental theoryEarly environmentCognitive outcomesCognitive developmentNeighborhood adversityChildhood environmentCross-sectional associationsMatter regionsAdversityIndividualized Net Benefit of Intensive Blood Pressure Lowering Among Community‐Dwelling Older Adults in SPRINT
Jamshidian M, Scherzer R, Estrella M, Kravitz R, Boxer R, Tancredi D, Berry J, de Lemos J, Ginsberg C, Ix J, Shlipak M, Ascher S. Individualized Net Benefit of Intensive Blood Pressure Lowering Among Community‐Dwelling Older Adults in SPRINT. Journal Of The American Geriatrics Society 2025, 73: 1441-1453. PMID: 39967308, PMCID: PMC12100678, DOI: 10.1111/jgs.19395.Peer-Reviewed Original ResearchSystolic Blood Pressure Intervention TrialCommunity-dwelling older adultsIntensive blood pressureSystolic BP targetOlder adultsBlood pressureIndividual net benefitsIntensive BPBP targetsAdvanced ageSystolic Blood Pressure Intervention Trial participantsBenefits of BPOptimal blood pressureTreatment-related harmsCategories of ageAdverse eventsPositive net benefitsFrailty statusCardiovascular outcomesCognitive outcomesIntervention trialsCox modelRisk differenceSystolicPolypharmacyAge‐associated differences in FIRES: Characterizing prodromal presentation and long‐term outcomes via the web‐based NORSE/FIRES Family Registry
Kazazian K, Gaspard N, Hirsch L, Kellogg M, Hocker S, Wong N, Farias‐Moeller R, Eschbach K, Gofton T. Age‐associated differences in FIRES: Characterizing prodromal presentation and long‐term outcomes via the web‐based NORSE/FIRES Family Registry. Epilepsia 2025, 66: e35-e40. PMID: 39804054, PMCID: PMC11908657, DOI: 10.1111/epi.18260.Peer-Reviewed Original ResearchConceptsFamily RegistryFebrile infection-related epilepsy syndromeAnti-seizure medicationsSelf-reported qualityQuality of lifePediatric patientsLong-term outcomesWeb-based registryProdromal symptomsAnxiety outcomesPoor cognitionAnti-seizure medication useClinical presentationSeizure burdenAdult survivorsProdromal presentationInternational web-based registryBad moodRegistryAge groupsRefractory status epilepticusAdultsCognitive outcomesOutcomesAge-associated differencesExposure to School Racial Segregation and Late-Life Cognitive Outcomes
Lin Z, Wang Y, Gill T, Chen X. Exposure to School Racial Segregation and Late-Life Cognitive Outcomes. JAMA Network Open 2025, 8: e2452713. PMID: 39752159, PMCID: PMC11699536, DOI: 10.1001/jamanetworkopen.2024.52713.Peer-Reviewed Original ResearchConceptsCross-sectional studyCognitive scoresOlder adultsTelephone Interview for Cognitive StatusBlack participantsLate-life cognitive outcomesWhite participantsSchool racial segregationCognitive impairmentHealth and Retirement StudyNon-Hispanic whitePrevalence of cognitive impairmentAssociated with late-life cognitionEducational attainmentUS older adultsLikelihood of cognitive impairmentNon-Hispanic blacksLate-life cognitionCognitive outcomesNationally Representative SampleLater-life cognitionMultilevel regression analysisStudy of BlackDementia occurrenceHealth inequalities
2024
Neural hyperscanning in caregiver-child dyads: A paradigm for studying the long-term effects of facilitated vs. disrupted attention on working memory and executive functioning in young children
Rosen M, Li A, Mikkelsen C, Aslin R. Neural hyperscanning in caregiver-child dyads: A paradigm for studying the long-term effects of facilitated vs. disrupted attention on working memory and executive functioning in young children. Developmental Review 2024, 75: 101170. PMID: 39802123, PMCID: PMC11720965, DOI: 10.1016/j.dr.2024.101170.Peer-Reviewed Original ResearchDevelopment of working memoryExecutive functionParent-child interactionsChildren's attentionMaturing executive functionsEye-tracking paradigmExecutive function abilitiesComplex cognitive functionsDevelopment of attentionParent-child dyadsYoung childrenChild cognitive outcomesPatterns of interactionCaregiver-child dyadsWorking memoryDisrupt attentionEngaging infantsNeural basisCognitive functionHyperscanning techniqueBrain synchronyChild behaviorCognitive outcomesNaturalistic experimentTracking paradigmPolygenic hazard score predicts synaptic and axonal degeneration and cognitive decline in Alzheimer's disease continuum
Farhadieh M, Mozafar M, Sanaaee S, Sodeifi P, Kousha K, Zare Y, Zare S, Rad N, Jamshidi-Goharrizi F, Allahverdloo M, Rahimi A, Sadeghi M, Shafie M, Mayeli M, Initiative F. Polygenic hazard score predicts synaptic and axonal degeneration and cognitive decline in Alzheimer's disease continuum. Archives Of Gerontology And Geriatrics 2024, 127: 105576. PMID: 39096557, DOI: 10.1016/j.archger.2024.105576.Peer-Reviewed Original ResearchConceptsPolygenic hazard scoreMild cognitive impairmentCognitive declineCognitive impairmentLevel of cognitive impairmentFollow-up cognitive assessmentHazard scoreMCI patientsFollow-up cognitive testingCognitive measuresAssociated with cognitive declineFollow-up pointsAlzheimer's diseaseAlzheimer's disease continuumCognitive AssessmentAssociated with specific biomarkersCognitively normal controlsCognitive testsCompared to low-risk patientsLongitudinal analysisHigh riskLow riskLow-risk patientsDisease continuumCognitive outcomesLong-term outcomes after treatment of delirium during critical illness with antipsychotics (MIND-USA): a randomised, placebo-controlled, phase 3 trial
Mart M, Boehm L, Kiehl A, Gong M, Malhotra A, Owens R, Khan B, Pisani M, Schmidt G, Hite R, Exline M, Carson S, Hough C, Rock P, Douglas I, Feinstein D, Hyzy R, Schweickert W, Bowton D, Masica A, Orun O, Raman R, Pun B, Strength C, Rolfsen M, Pandharipande P, Brummel N, Hughes C, Patel M, Stollings J, Ely E, Jackson J, Girard T. Long-term outcomes after treatment of delirium during critical illness with antipsychotics (MIND-USA): a randomised, placebo-controlled, phase 3 trial. The Lancet Respiratory Medicine 2024, 12: 599-607. PMID: 38701817, PMCID: PMC11296889, DOI: 10.1016/s2213-2600(24)00077-8.Peer-Reviewed Original ResearchEffects of antipsychotic treatmentCognitive impairmentAssociated with long-term cognitive impairmentTreat deliriumLong-term cognitive impairmentLong-term outcomesTreatment of deliriumCritically ill patientsAntipsychotic treatmentZiprasidone groupHaloperidol groupFollow-upQuality-of-life outcomesAssessed survivorsZiprasidoneHaloperidolAntipsychoticsCognitive outcomesTreatment group assignmentDepartment of Veterans AffairsQuality-of-lifeIll patientsPlacebo-ControlledCritical illnessLong-term follow-upExamining amyloid reduction as a surrogate endpoint through latent class analysis using clinical trial data for dominantly inherited Alzheimer's disease
Wang G, Li Y, Xiong C, Benzinger T, Gordon B, Hassenstab J, Aschenbrenner A, McDade E, Clifford D, Libre‐Guerra J, Shi X, Mummery C, van Dyck C, Lah J, Honig L, Day G, Ringman J, Brooks W, Fox N, Suzuki K, Levin J, Jucker M, Delmar P, Bittner T, Bateman R, Team F. Examining amyloid reduction as a surrogate endpoint through latent class analysis using clinical trial data for dominantly inherited Alzheimer's disease. Alzheimer's & Dementia 2024 PMID: 38400532, DOI: 10.1002/alz.13735.Peer-Reviewed Original ResearchLatent classesPositron emission tomographyAmyloid reductionCognitive efficacyLatent class analysisAmyloid positron emission tomographyCognitive outcomesCognitive declineDominantly Inherited Alzheimer's Network Trials UnitSurrogate biomarkerBaseline characteristicsInherited Alzheimer's diseaseMultiple measuresClass analysisEmission tomographyTrials UnitAlzheimer's diseaseClinical trialsSurrogate endpointsTreatment effectsGuidelines for Seizure Prophylaxis in Adults Hospitalized with Moderate–Severe Traumatic Brain Injury: A Clinical Practice Guideline for Health Care Professionals from the Neurocritical Care Society
Frontera J, Gilmore E, Johnson E, Olson D, Rayi A, Tesoro E, Ullman J, Yuan Y, Zafar S, Rowe S. Guidelines for Seizure Prophylaxis in Adults Hospitalized with Moderate–Severe Traumatic Brain Injury: A Clinical Practice Guideline for Health Care Professionals from the Neurocritical Care Society. Neurocritical Care 2024, 40: 819-844. PMID: 38316735, DOI: 10.1007/s12028-023-01907-x.Peer-Reviewed Original ResearchModerate-severe TBITraumatic brain injuryGrading of recommendations assessmentAntiseizure medicationsResultsThe initial literature searchAdverse eventsHealth care professionalsBrain injuryClinical practice guidelinesMeta-analysis of articlesEffects of antiseizure medicationsEarly seizuresLate seizuresCare professionalsCognitive outcomesRecommendations AssessmentDuration of prophylaxisPractice guidelinesSystematic reviewProphylactic antiseizure medicationPICO 1Meta-analysisLiterature searchFunctional outcomesGrading criteriaImpact of Sleep Disorders and Disturbed Sleep on Brain Health: A Scientific Statement From the American Heart Association
Gottesman R, Lutsey P, Benveniste H, Brown D, Full K, Lee J, Osorio R, Pase M, Redeker N, Redline S, Spira A, Hypertension O. Impact of Sleep Disorders and Disturbed Sleep on Brain Health: A Scientific Statement From the American Heart Association. Stroke 2024, 55: e61-e76. PMID: 38235581, DOI: 10.1161/str.0000000000000453.Peer-Reviewed Original ResearchConceptsBrain healthSleep disordersDisturbed sleepDevelopment of sleep disordersCognitive outcomesImpact of sleep disordersDevelopment of Alzheimer's diseaseSleep disturbanceBiological basisDisordersBrainSleepAlzheimer's disease-related dementiasAlzheimer's diseaseBenefits of treatmentEarly treatmentScientific statementAmerican Heart AssociationSleep-disordered breathingDementiaAlzheimer
2023
Scalable Multi‐Sensor At Home Assessment of Sleep and Activity in Adults At High Risk for Dementia
Lim A, Centen A, Montazeri N, Gibson E, Dang‐Vu T, Carrier J, Chan S, Belleville S, Nygaard H, Montero‐Odasso M, Feldman H, Chertkow H, Group C. Scalable Multi‐Sensor At Home Assessment of Sleep and Activity in Adults At High Risk for Dementia. Alzheimer's & Dementia 2023, 19 DOI: 10.1002/alz.076469.Peer-Reviewed Original ResearchLifestyle interventionHigh riskSleep featuresOlder adultsSleep electroencephalographyRisk factor interventionHealth support programAccelerometry data collectionNights of recordingFactor interventionSleep disruptionDays of wearWrist accelerometrySleep assessmentHome assessmentDementiaWrist accelerometerCognitive outcomesStudy centersInterventionAdultsEEG recordingsElectroencephalographySleepRiskEARLY-LIFE CIRCUMSTANCES AND RACIAL DISPARITIES IN COGNITION AMONG US OLDER ADULTS
Lin Z, Ye J, Allore H, Gill T, Chen X. EARLY-LIFE CIRCUMSTANCES AND RACIAL DISPARITIES IN COGNITION AMONG US OLDER ADULTS. Innovation In Aging 2023, 7: 304-304. PMCID: PMC10735771, DOI: 10.1093/geroni/igad104.1011.Peer-Reviewed Original Research6 Graph Analysis of Resting State Functional Brain Networks and Associations with Cognitive Outcomes in Survivors on Pediatric Brain Tumor
Semmel E, Calhoun V, Hillary F, Morris R, King T. 6 Graph Analysis of Resting State Functional Brain Networks and Associations with Cognitive Outcomes in Survivors on Pediatric Brain Tumor. Journal Of The International Neuropsychological Society 2023, 29: 316-317. DOI: 10.1017/s135561772300437x.Peer-Reviewed Original ResearchSurvivors of pediatric brain tumorsFunctional brain networksWorking memoryBrain networksCognitive outcomesProcessing speedLong-term neuropsychological deficitsResting state functional magnetic resonance imagingFunctional magnetic resonance imagingMeasures of attentionCore cognitive skillsLong-term cognitive outcomesStructural brain changesSmall-moderate effect sizeFunctional network propertiesSurvivors of brain tumorsBrain tumor survivorsGraph metricsResting state dataGlobal efficiencyNeuropsychological deficitsNeuropsychological testsBrain changesGroup differencesIndependence in adulthoodBeneficial Effect of Societal Factors on APOE-ε2 and ε4 Carriers’ Brain Health: A Systematic Review
Aravena J, Lee J, Schwartz A, Nyhan K, Wang S, Levy B. Beneficial Effect of Societal Factors on APOE-ε2 and ε4 Carriers’ Brain Health: A Systematic Review. The Journals Of Gerontology Series A 2023, 79: glad237. PMID: 37792627, PMCID: PMC10803122, DOI: 10.1093/gerona/glad237.Peer-Reviewed Original ResearchBrain healthSocietal factorsAPOE ε4Cognitive outcomesApolipoprotein E ε4APOE ε4 carriersAPOE ε2Beneficial effectsΕ4 carriersSystematic reviewAPOE ε4 allele carriersHigh schoolAPOE ε2 carriersDetrimental effectsBasic needsHealthy People 2030Beneficial impactExternal stimuliHarmful impactSDH categoriesInclusion criteriaAllele carriersAlzheimer's diseaseCommunity-level policySocial determinantsP13-029-23 Cross-Sectional Associations of Serum Fatty Acids and Self-Reported Cognitive Outcomes in Women With Breast Cancer Undergoing Chemotherapy
Melink Z, Schnell P, Ormiston K, Weinhold K, Kopec R, Lustberg M, Orchard T. P13-029-23 Cross-Sectional Associations of Serum Fatty Acids and Self-Reported Cognitive Outcomes in Women With Breast Cancer Undergoing Chemotherapy. Current Developments In Nutrition 2023, 7: 100485. DOI: 10.1016/j.cdnut.2023.100485.Peer-Reviewed Original ResearchGraph analysis of resting state functional brain networks and associations with cognitive outcomes in survivors of pediatric brain tumor
Semmel E, Calhoun V, Hillary F, Morris R, King T. Graph analysis of resting state functional brain networks and associations with cognitive outcomes in survivors of pediatric brain tumor. Neuroimage Reports 2023, 3: 100178. PMID: 40568453, PMCID: PMC12172936, DOI: 10.1016/j.ynirp.2023.100178.Peer-Reviewed Original ResearchSurvivors of pediatric brain tumorsFunctional brain networksWorking memoryBrain networksFunctional magnetic resonance imagingLong-term cognitive difficultiesCognitive outcomes in adulthoodCore cognitive skillsFunctional network propertiesOutcomes in adulthoodBrain tumor survivorsGraph metricsNeuroimaging researchNeuropsychological testsBrain changesCognitive difficultiesProcessing speedCognitive outcomesHub regionsSmall-worldCognitive skillsPost Hoc AnalysisTumor survivorsPediatric brain tumor patientsSmall-world propertiesAssociation of Delirium With Functional and Cognitive Outcomes Among Older Survivors of a COVID-19 Hospitalization
Kaushik R, McAvay G, Murphy T, Cohen A, Hajduk A, Ferrante L. Association of Delirium With Functional and Cognitive Outcomes Among Older Survivors of a COVID-19 Hospitalization. 2023, a2754-a2754. DOI: 10.1164/ajrccm-conference.2023.207.1_meetingabstracts.a2754.Peer-Reviewed Original ResearchCognitive outcomesOlder survivorsIdentifying significant correlates of purpose in life in older US military veterans: results from the national health and resilience in veterans study
Fischer I, Feldman D, Tsai J, Harpaz-Rotem I, Lucas K, Schulenberg S, Pietrzak R. Identifying significant correlates of purpose in life in older US military veterans: results from the national health and resilience in veterans study. International Psychogeriatrics 2023, 35: 560-565. PMID: 36715004, DOI: 10.1017/s1041610222001223.Peer-Reviewed Original ResearchConceptsUS military veteransNational HealthMilitary veteransSignificant correlatesOlder US veteransAdverse health outcomesModifiable psychosocial factorsAdverse outcomesElastic net analysisUS veteransDepressive symptomsPsychosocial factorsHealth outcomesVeterans StudyPsychosocial variablesTreatment effortsCognitive outcomesCross-sectional dataVeteransOutcomesSocial supportCommunity integrationImportant correlatesHealthCorrelates
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