Lorenzo Sewanan
Research
Publications
2024
Distinct mechanisms drive divergent phenotypes in hypertrophic and dilated cardiomyopathy associated TPM1 variants
Halder S, Rynkiewicz M, Kim L, Barry M, Zied A, Sewanan L, Kirk J, Moore J, Lehman W, Campbell S. Distinct mechanisms drive divergent phenotypes in hypertrophic and dilated cardiomyopathy associated TPM1 variants. Journal Of Clinical Investigation 2024 PMID: 39436707, DOI: 10.1172/jci179135.Peer-Reviewed Original ResearchTPM1 mutationActin thin filamentsDilated cardiomyopathyE54KPhenotypic diversityMyosin activityStem cell-derived cardiomyocytesGene expressionHuman engineered heart tissueIncreased calcium sensitivitySarcomeric proteinsCell-derived cardiomyocytesThin filamentsK mutationMolecular eventsTPM1MutationsClinical phenotypePhenotypeAllosteric interactionsGenesMuscle contractilityCalcium sensitivityInherited disorderAssociation rateAdded prognostic value of visually estimated coronary artery calcium among heart transplant recipients
Clerkin K, Sewanan L, Griffin J, DeFilippis E, Peng B, Chernovolenko M, Harris E, Prasad N, Colombo P, Yuzefpolskaya M, Fried J, Raikhelkar J, Topkara V, Castillo M, Lam E, Latif F, Takeda K, Uriel N, Sayer G, Einstein A. Added prognostic value of visually estimated coronary artery calcium among heart transplant recipients. The Journal Of Heart And Lung Transplantation 2024, 43: 1795-1805. PMID: 39122222, PMCID: PMC11532001, DOI: 10.1016/j.healun.2024.07.024.Peer-Reviewed Original ResearchCardiac allograft vasculopathyCoronary artery calciumHeart transplantationArtery calciumFollow-upHybrid positron emission tomography/computed tomographyPositron emission tomography/computed tomographyAssociated with adverse cardiovascular outcomesAdult HT patientsEmission tomography/computed tomographyMedian follow-upHeart transplant recipientsMultivariable proportional hazards regressionAdverse cardiovascular outcomesCoronary artery diseaseProportional hazards regressionSurveillance PET/CTAllograft vasculopathyTomography/computed tomographyCardiac PET/CTHT patientsMedian ageTransplant recipientsPrognostic valueDeath/retransplantationMechano-inhibition of endocytosis sensitizes cancer cells to Fas-induced Apoptosis
Kural M, Djakbarova U, Cakir B, Tanaka Y, Chan E, Arteaga Muniz V, Madraki Y, Qian H, Park J, Sewanan L, Park I, Niklason L, Kural C. Mechano-inhibition of endocytosis sensitizes cancer cells to Fas-induced Apoptosis. Cell Death & Disease 2024, 15: 440. PMID: 38909035, PMCID: PMC11193792, DOI: 10.1038/s41419-024-06822-3.Peer-Reviewed Original ResearchConceptsFas-induced apoptosisCell surface Fas expressionDeath receptor FasInhibition of endocytosisSurface Fas expressionPlasma membrane tensionCancer cell apoptosisEndocytosis dynamicsApoptotic signalingReceptor FasGlioblastoma cell growthFas expressionPlasma membraneCell growthEndocytosisXenograft mouse modelSoluble FasLCell apoptosisFasApoptosisRho-kinase inhibitorCancer cellsMembrane tensionNonmalignant cellsInduce tumor regressionEvolving Strategies for the Management of Obstructive Hypertrophic Cardiomyopathy
Liang L, Lumish H, Sewanan L, Shimada Y, Maurer M, Weiner S, Clerkin K. Evolving Strategies for the Management of Obstructive Hypertrophic Cardiomyopathy. Journal Of Cardiac Failure 2024, 30: 1136-1153. PMID: 38777216, PMCID: PMC11415289, DOI: 10.1016/j.cardfail.2024.04.024.Peer-Reviewed Original ResearchObstructive hypertrophic cardiomyopathyHypertrophic cardiomyopathyObstructive HCMLeft ventricular outflow tract obstructionVentricular outflow tract obstructionImproved cardiac energeticsSeptal reduction therapyOutflow tract obstructionTreatment of hypertrophic cardiomyopathyRandomized clinical trialsReal-world populationSpecific therapiesPatient selectionHeterogeneous diseaseReduction therapyClinical trialsCardiac energeticsMavacamtenExercise capacityActin-myosin interactionPatientsMyosin modulatorsCardiomyopathyLong-term dataTherapy
News
News
- July 27, 2022
Uncovering New Approaches to a Common Inherited Heart Disorder
- May 24, 2021
CONGRATULATIONS to the 2021 MD-PhD Program Graduates and Graduation Prize Recipients
- February 04, 2020
Yale researchers find that ubiquitous protein plays lead role in cell survival
- October 20, 2019
$2M Federal Funding for Stem Cell-Based Therapy