2024
Stiffening of the human proximal pulmonary artery with increasing age
Manning E, Mishall P, Ramachandra A, Hassab A, Lamy J, Peters D, Murphy T, Heerdt P, Singh I, Downie S, Choudhary G, Tellides G, Humphrey J. Stiffening of the human proximal pulmonary artery with increasing age. Physiological Reports 2024, 12: e16090. PMID: 38884325, PMCID: PMC11181131, DOI: 10.14814/phy2.16090.Peer-Reviewed Original ResearchConceptsProximal pulmonary arteriesPulmonary arteryAge-related stiffeningRight ventricular ejection fractionVentricular ejection fractionMean wall thicknessEjection fractionNo significant differenceSystemic circulationLuminal caliberDiffusing capacityArterial stiffeningIncreasing ageSignificant differenceDistensionArteryWall thicknessAdverse effectsWall strainVessel diameterCyclic biaxial strainOrgan donorsAgeMicrostructural remodeling
2022
GERONTOLOGIC BIOSTATISTICS: MERGING WITH DATA SCIENCE AND TOWARD PERSONALIZED MEDICINE
Shardell M, Murphy T, Allore H. GERONTOLOGIC BIOSTATISTICS: MERGING WITH DATA SCIENCE AND TOWARD PERSONALIZED MEDICINE. Innovation In Aging 2022, 6: 177-177. PMCID: PMC9770254, DOI: 10.1093/geroni/igac059.708.Peer-Reviewed Original ResearchStudy of older personsEpidemiology of agingHealth-related interventionsAssessment of healthHeterogeneity of treatment effectsOlder personsOlder adultsIndividual sessionsTreatment effectsOlder patientsMultifactorial naturePublished studiesData scienceSessionsMultiple streams of dataStreams of dataMultimodal approachPersonalized medicineProgressive deteriorationIntegration of data scienceBehavioral phenotypesPatientsAgeInteractive visualizationPractice