CNSC-54. CENTRAL AND BOUNDARY-DRIVEN GROWTH PATTERNS DOMINATE RESPECTIVELY IDH WILD-TYPE AND MUTANT GLIOMAS
Kyriakidou M, Urbaniak K, Mbegbu M, Rockne R, Wesseling P, Eijgelaar R, Anderson K, Verhaak R, de Witt-Hamer P, Verburg N, Branciamore S, Barthel F. CNSC-54. CENTRAL AND BOUNDARY-DRIVEN GROWTH PATTERNS DOMINATE RESPECTIVELY IDH WILD-TYPE AND MUTANT GLIOMAS. Neuro-Oncology 2024, 26: viii53-viii53. PMCID: PMC11553254, DOI: 10.1093/neuonc/noae165.0210.Peer-Reviewed Original ResearchConsistent with neutral evolutionDiffuse gliomasLocal treatmentEvolutionary processWhole-genome sequencingSpread to distant sitesIDH wild-typePrimary malignant brain tumorImage-guided samplingPhylogeographic relationshipsDN/dS ratiosMalignant brain tumorsNeutral evolutionSomatic variantsGenetic heterogeneityIDHmut tumorsTumor centerMRI abnormalitiesStochastic mutationsTumor diffusionAdult patientsPoor prognosisTumor cellsIDH mutantTumor development