2022
Cellular recovery after prolonged warm ischaemia of the whole body
Andrijevic D, Vrselja Z, Lysyy T, Zhang S, Skarica M, Spajic A, Dellal D, Thorn SL, Duckrow RB, Ma S, Duy PQ, Isiktas AU, Liang D, Li M, Kim SK, Daniele SG, Banu K, Perincheri S, Menon MC, Huttner A, Sheth KN, Gobeske KT, Tietjen GT, Zaveri HP, Latham SR, Sinusas AJ, Sestan N. Cellular recovery after prolonged warm ischaemia of the whole body. Nature 2022, 608: 405-412. PMID: 35922506, PMCID: PMC9518831, DOI: 10.1038/s41586-022-05016-1.Peer-Reviewed Original ResearchConceptsSingle-nucleus transcriptomic analysesSpecific gene expression patternsCellular recoveryGene expression patternsCellular processesMammalian cellsTranscriptomic analysisLarge mammalsExpression patternsCellular repair processesCell deathComprehensive resourceUnderappreciated potentialPhysiological challengesTissue integrityRepair processSpecific changesPorcine brainMammalsOrgansMultiple organs
1995
Decreased cerebral blood flow during acute hyperglycemia
Duckrow R. Decreased cerebral blood flow during acute hyperglycemia. Brain Research 1995, 703: 145-150. PMID: 8719626, DOI: 10.1016/0006-8993(95)01077-7.Peer-Reviewed Original ResearchConceptsAcute hyperglycemiaCerebral blood flow decreasesPlasma osmolalityBlood flow decreasePentobarbital-anesthetized ratsCerebral blood flowLaser Doppler flowmetryAcute elevationMannitol injectionCBF increaseIntraperitoneal injectionTransient depressionBlood flowBaseline levelsHyperglycemiaElectroencephalographic activityTransient increaseFlow decreasesCBFOsmolalityBrief transient increaseInjectionContinuous measureFlowmetryRats
1994
Localization of muscarinic receptor subtypes in brain stem areas regulating sleep
Baghdoyan H, Mallios V, Duckrow R, Mash D. Localization of muscarinic receptor subtypes in brain stem areas regulating sleep. Neuroreport 1994, 5: 1631-1634. PMID: 7819535, DOI: 10.1097/00001756-199408150-00022.Peer-Reviewed Original ResearchConceptsREM sleep generationBrain stem areasSleep generationMAChR subtypesBrain stemRapid eye movement (REM) sleepMuscarinic cholinergic receptorsMuscarinic receptor subtypesEye movement sleepPontine brain stemDorsal rapheCholinergic receptorsMovement sleepLocus coeruleusReceptor subtypesReticular formationRadioligand bindingSubtypesAutoradiographic techniquesVivo studiesSleepStem areasGreater levelsCoeruleusRaphe
1993
A brief hypoperfusion precedes spreading depression if nitric oxide synthesis is inhibited
Duckrow R. A brief hypoperfusion precedes spreading depression if nitric oxide synthesis is inhibited. Brain Research 1993, 618: 190-195. PMID: 8374751, DOI: 10.1016/0006-8993(93)91265-t.Peer-Reviewed Original Research
1992
Hyperglycemia and Blood-Brain Barrier Glucose Transport
Pelligrino DA, LaManna JC, Duckrow RB, Bryan RM, Harik SI. Hyperglycemia and Blood-Brain Barrier Glucose Transport. Cerebrovascular And Brain Metabolism Reviews 1992, 12: 887-899. PMID: 1400643, DOI: 10.1038/jcbfm.1992.126.Peer-Reviewed Original ResearchCortical hypoperfusion following spreading depression is not altered by tirilazad mesylate (U-74006F) in awake rats
Duckrow R, Beard D. Cortical hypoperfusion following spreading depression is not altered by tirilazad mesylate (U-74006F) in awake rats. Brain Research 1992, 572: 296-299. PMID: 1611527, DOI: 10.1016/0006-8993(92)90488-u.Peer-Reviewed Original Research
1991
Regional Cerebral Blood Flow during Spreading Cortical Depression in Conscious Rats
Duckrow R. Regional Cerebral Blood Flow during Spreading Cortical Depression in Conscious Rats. Cerebrovascular And Brain Metabolism Reviews 1991, 11: 150-154. PMID: 1983999, DOI: 10.1038/jcbfm.1991.18.Peer-Reviewed Original ResearchConceptsConscious ratsCortical depressionCBF changesRegional CBFRegional cerebral blood flowCerebral cortex contralateralConscious restrained ratsCerebral blood flowEarly transient increaseDirect current stimulationLateral frontal cortexRelative hyperperfusionCortex contralateralVascular responsesFrontal cortexRestrained ratsBlood flowCerebral hemispheresRatsCurrent stimulationTransient increaseBrain dissectionEEG activityCBFHyperperfusion
1990
Effect of hemodilution on regional cerebral blood flow during chronic hyperglycemia in rats.
Duckrow RB. Effect of hemodilution on regional cerebral blood flow during chronic hyperglycemia in rats. Stroke 1990, 21: 1072-1076. PMID: 2368109, DOI: 10.1161/01.str.21.7.1072.Peer-Reviewed Original ResearchConceptsRegional cerebral blood flowCerebral blood flowReduced regional cerebral blood flowAverage cerebral blood flowChronic hyperglycemiaBlood flowElevated hematocritBrain regionsCerebral blood flow decreasesRegional cerebral blood flow decreasesBlood flow decreaseEffect of hemodilutionIsovolemic hemodilutionRestrained ratsHyperglycemiaHemodilutionHematocritRatsFlow decreasesStreptozotocinDissection
1988
Regional cerebral blood flow and glucose utilization during hyperinsulinemia
Duckrow R. Regional cerebral blood flow and glucose utilization during hyperinsulinemia. Brain Research 1988, 462: 363-366. PMID: 3191397, DOI: 10.1016/0006-8993(88)90566-5.Peer-Reviewed Original ResearchGlucose transfer into rat brain during acute and chronic hyperglycemia
Duckrow R. Glucose transfer into rat brain during acute and chronic hyperglycemia. Metabolic Brain Disease 1988, 3: 201-209. PMID: 3221811, DOI: 10.1007/bf00999236.Peer-Reviewed Original ResearchConceptsPermeability-surface area productChronic hyperglycemiaBrain capillary permeability-surface area productBlood-brain barrierBrain glucose contentAcute hyperglycemiaGlucose transportIntraperitoneal injectionHyperglycemic ratsRestrained ratsRat brainHyperglycemiaCapillary permeability-surface area productGlucose transferRatsFacilitated glucose transportArea productBrain
1987
Regional Cerebral Glucose Utilization During Hyperglycemia
Duckrow R, Bryan R. Regional Cerebral Glucose Utilization During Hyperglycemia. Journal Of Neurochemistry 1987, 48: 989-993. PMID: 2949062, DOI: 10.1111/j.1471-4159.1987.tb05614.x.Peer-Reviewed Original ResearchConceptsRegional cerebral blood flowRegional cerebral glucose utilizationCerebral glucose utilizationChronic hyperglycemiaAcute hyperglycemiaGlucose utilizationCerebral blood flowCerebral metabolic rateMetabolic rateIntraperitoneal injectionRestrained ratsRCMRglBlood flowHyperglycemiaKetone bodiesOxidative metabolismBrainPrevious dataStreptozotocinDecreaseRatsWeeksRegional cerebral blood flow decreases during chronic and acute hyperglycemia.
Duckrow RB, Beard DC, Brennan RW. Regional cerebral blood flow decreases during chronic and acute hyperglycemia. Stroke 1987, 18: 52-58. PMID: 2949400, DOI: 10.1161/01.str.18.1.52.Peer-Reviewed Original ResearchConceptsRegional cerebral blood flowChronic hyperglycemiaAcute hyperglycemiaPlasma glucoseAcute elevationCerebral blood flow decreasesRegional cerebral blood flow decreasesIschemic cell damageBlood flow decreasePresence of hyperglycemiaCerebral blood flowMicrons/Blood flow changesAwake restrained ratsFlow reductionBrain ischemiaNeuronal damageStroke patientsCardiac arrestBlood glucosePeritoneal spaceRestrained ratsBlood flowForebrain regionsHyperglycemia
1985
Regional cerebral blood flow decreases during hyperglycemia
Duckrow R, Beard D, Brennan R. Regional cerebral blood flow decreases during hyperglycemia. Annals Of Neurology 1985, 17: 267-272. PMID: 3922283, DOI: 10.1002/ana.410170308.Peer-Reviewed Original ResearchConceptsRegional cerebral blood flowBrain ischemiaCerebral blood flow decreasesRegional cerebral blood flow decreasesStroke-related morbidityBlood flow decreasePlasma osmolalityPresence of hyperglycemiaCerebral blood flowEffects of hyperglycemiaAcute hyperglycemiaPlasma glucoseIntraperitoneal injectionNormal salineAwake ratsRestrained ratsBlood flowQuantitative autoradiographyHyperglycemiaExperimental animalsFlow limitationIschemiaRatsOsmolalityGlucose
1984
A simplified method for computerized densitometry of complex shapes in 2-deoxyglucose autoradiographs
Kauer J, Reddy D, Duckrow R, Shepherd G. A simplified method for computerized densitometry of complex shapes in 2-deoxyglucose autoradiographs. Journal Of Neuroscience Methods 1984, 11: 143-158. PMID: 6492858, DOI: 10.1016/0165-0270(84)90032-3.Peer-Reviewed Original Research
1982
Sensitive and inexpensive dual-wavelength reflection spectrophotometry using interference filters
Duckrow RB, LaManna JC, Rosenthal M. Sensitive and inexpensive dual-wavelength reflection spectrophotometry using interference filters. Analytical Biochemistry 1982, 125: 13-23. PMID: 6293337, DOI: 10.1016/0003-2697(82)90377-3.Peer-Reviewed Original Research
1981
Disparate recovery of resting and stimulated oxidative metabolism following transient ischemia.
Duckrow RB, LaManna JS, Rosenthal M. Disparate recovery of resting and stimulated oxidative metabolism following transient ischemia. Stroke 1981, 12: 677-686. PMID: 6272454, DOI: 10.1161/01.str.12.5.677.Peer-Reviewed Original ResearchConceptsMinutes of reperfusionTransient ischemiaMetabolic dysfunctionElectrocortical activityHours of reperfusionTransient cerebral ischemiaCarotid artery ligationOxidative responseLocal blood volumeOxidative metabolic functionCerebral ischemiaIschemic intervalArtery ligationRat brainBlood volumeElectrical stimulationCerebral surfaceReperfusionIschemiaOxidative metabolismMitochondrial redox stateDysfunctionEventual recoveryMetabolic functionsDisparate recoveryCerebral compensation for chronic noradrenergic denervation induced by locus ceruleus lesion: recovery of receptor binding, isoproterenol- induced adenylate cyclase activity, and oxidative metabolism
Harik SI, Duckrow RB, LaManna JC, Rosenthal M, Sharma VK, Banerjee SP. Cerebral compensation for chronic noradrenergic denervation induced by locus ceruleus lesion: recovery of receptor binding, isoproterenol- induced adenylate cyclase activity, and oxidative metabolism. Journal Of Neuroscience 1981, 1: 641-649. PMID: 7346572, PMCID: PMC6564177, DOI: 10.1523/jneurosci.01-06-00641.1981.Peer-Reviewed Original ResearchConceptsLocus ceruleus lesionNoradrenergic denervationCerebral cortexReceptor bindingNoradrenergic receptor bindingOxidative metabolismRat cerebral cortexDirect cortical stimulationVivo oxidative metabolismBlood volume shiftsCyclic AMP generationAdenylate cyclase activityCerebral compensationNoradrenaline depletionLocus ceruleusUnilateral injectionCortical stimulationCerebral noradrenalineLong-term effectsAMP generationMonophosphate generationLesionsDenervationCyclase activityWeeksOxidative metabolic activity of cerebral cortex after fluid-percussion head injury in the cat.
Duckrow R, LaManna J, Rosenthal M, Levasseur J, Patterson J. Oxidative metabolic activity of cerebral cortex after fluid-percussion head injury in the cat. Journal Of Neurosurgery 1981, 54: 607-14. PMID: 7229699, DOI: 10.3171/jns.1981.54.5.0607.Peer-Reviewed Original ResearchConceptsPosttraumatic periodCerebral cortexBlood volumeFluid percussion head injuryCortical blood volumeImmediate posttraumatic periodLocal blood volumeOxidative metabolic activityTransient hypertensionRelationship of metabolismVascular effectsCerebral circulationHead traumaVascular toneCranial windowHead injuryTrauma altersInjuryCortical surfaceCortexCatsMetabolic activityHypertensionReflection spectrophotometryPeriod
1977
The effect of diphenylhydantoin on self-mutilation in rats produced by unilateral multiple dorsal rhizotomy
Duckrow RB, Taub A. The effect of diphenylhydantoin on self-mutilation in rats produced by unilateral multiple dorsal rhizotomy. Experimental Neurology 1977, 54: 33-41. PMID: 556697, DOI: 10.1016/0014-4886(77)90232-1.Peer-Reviewed Original ResearchConceptsDorsal rhizotomyCentral dysfunctionMultiple dorsal rhizotomiesPossible etiologic roleEffect of diphenylhydantoinSpinal cord histologyFemale albino ratsSpinal pathwaysAfferent pathwaysEtiologic roleCord histologyAlbino ratsRhizotomyDiphenylhydantoinRatsSelf-MutilationDysfunctionDrug vehicleAnimalsDaysVideotape techniqueAnesthesiaHistologyIncidencePathway
1973
Form and Role of Deformation in Excitation of an Insect Mechanoreceptor
CHAPMAN KM, DUCKROW RB, MORAN DT. Form and Role of Deformation in Excitation of an Insect Mechanoreceptor. Nature 1973, 244: 453-454. PMID: 4582504, DOI: 10.1038/244453a0.Peer-Reviewed Original Research