2021
Video quality using outpatient smartphone videos in epilepsy: Results from the OSmartViE study
Tatum WO, Hirsch LJ, Gelfand MA, Acton EK, LaFrance WC, Duckrow RB, Chen D, Blum AS, Hixson J, Drazkowski J, Benbadis S, Cascino GD, Collaborators T. Video quality using outpatient smartphone videos in epilepsy: Results from the OSmartViE study. European Journal Of Neurology 2021, 28: 1453-1462. PMID: 33465822, DOI: 10.1111/ene.14744.Peer-Reviewed Original ResearchMeSH KeywordsAdultCohort StudiesElectroencephalographyEpilepsyFemaleHumansMiddle AgedOutpatientsProspective StudiesSmartphoneConceptsPsychogenic nonepileptic attacksNeurologic eventsEpileptic seizuresInpatient video-electroencephalography (EEG) monitoringPhysiologic nonepileptic eventsMulticenter cohort studyMajority of patientsVideo-electroencephalography monitoringVideo-EEG monitoringSimilar diagnostic accuracyHome video recordingEpilepsy outpatientsNeurological disease statesCohort studyNeurological eventsNonepileptic eventsNonepileptic attacksUnknown diagnosisAdequate durationClinical informationPatientsSenior neurology residentsAccurate diagnosisDiagnostic accuracyNeurology residents
2017
Brain‐responsive neurostimulation in patients with medically intractable mesial temporal lobe epilepsy
Geller EB, Skarpaas TL, Gross RE, Goodman RR, Barkley GL, Bazil CW, Berg MJ, Bergey GK, Cash SS, Cole AJ, Duckrow RB, Edwards JC, Eisenschenk S, Fessler J, Fountain NB, Goldman AM, Gwinn RP, Heck C, Herekar A, Hirsch LJ, Jobst BC, King‐Stephens D, Labar DR, Leiphart JW, Marsh WR, Meador KJ, Mizrahi EM, Murro AM, Nair DR, Noe KH, Park YD, Rutecki PA, Salanova V, Sheth RD, Shields DC, Skidmore C, Smith MC, Spencer DC, Srinivasan S, Tatum W, Van Ness PC, Vossler DG, Wharen RE, Worrell GA, Yoshor D, Zimmerman RS, Cicora K, Sun FT, Morrell MJ. Brain‐responsive neurostimulation in patients with medically intractable mesial temporal lobe epilepsy. Epilepsia 2017, 58: 994-1004. PMID: 28398014, DOI: 10.1111/epi.13740.Peer-Reviewed Original ResearchConceptsMesial temporal lobe epilepsyMesial temporal sclerosisSeizure-free periodTemporal lobe epilepsySeizure reductionAdverse eventsLobe epilepsyIntractable mesial temporal lobe epilepsySerious device-related adverse eventsIntractable partial-onset seizuresMedian percent seizure reductionMesial temporal lobe originBilateral mesial temporal lobe epilepsyDevice-related adverse eventsBrain-responsive neurostimulationImplant site infectionPercent seizure reductionPartial-onset seizuresProspective clinical trialsTemporal lobe originVagus nerve stimulationEffective treatment optionPercent of subjectsPreimplantation baselineTemporal sclerosisBrain‐responsive neurostimulation in patients with medically intractable seizures arising from eloquent and other neocortical areas
Jobst BC, Kapur R, Barkley GL, Bazil CW, Berg MJ, Bergey GK, Boggs JG, Cash SS, Cole AJ, Duchowny MS, Duckrow RB, Edwards JC, Eisenschenk S, Fessler AJ, Fountain NB, Geller EB, Goldman AM, Goodman RR, Gross RE, Gwinn RP, Heck C, Herekar AA, Hirsch LJ, King‐Stephens D, Labar DR, Marsh WR, Meador KJ, Miller I, Mizrahi EM, Murro AM, Nair DR, Noe KH, Olejniczak PW, Park YD, Rutecki P, Salanova V, Sheth RD, Skidmore C, Smith MC, Spencer DC, Srinivasan S, Tatum W, Van Ness P, Vossler DG, Wharen RE, Worrell GA, Yoshor D, Zimmerman RS, Skarpaas TL, Morrell MJ. Brain‐responsive neurostimulation in patients with medically intractable seizures arising from eloquent and other neocortical areas. Epilepsia 2017, 58: 1005-1014. PMID: 28387951, DOI: 10.1111/epi.13739.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultBrain MappingCerebral CortexDeep Brain StimulationDrug Resistant EpilepsyElectric Stimulation TherapyElectrodes, ImplantedElectroencephalographyEpilepsies, PartialEpilepsy, Complex PartialEpilepsy, Partial, MotorEpilepsy, Tonic-ClonicFeasibility StudiesFemaleFollow-Up StudiesHumansMaleMiddle AgedNeocortexYoung AdultConceptsSeizure-free periodSeizure reductionNeocortical onsetSeizure onsetNeocortical originIntractable partial-onset seizuresMedian percent seizure reductionBrain-responsive neurostimulationChronic neurologic deficitsPercent seizure reductionPrior epilepsy surgeryPartial-onset seizuresPercent of patientsProspective clinical trialsNormal MRI findingsVagus nerve stimulationEffective treatment optionEloquent cortical areasRate of infectionMagnetic resonance imagingPreimplantation baselineMRI lesionsAdverse eventsNeurologic deficitsPerioperative hemorrhage
2016
Regional and network relationship in the intracranial EEG second spectrum
Joshi RB, Gaspard N, Goncharova II, Duckrow RB, Duncan D, Gerrard JL, Spencer DD, Hirsch LJ, Zaveri HP. Regional and network relationship in the intracranial EEG second spectrum. Clinical Neurophysiology 2016, 127: 3485-3491. PMID: 27692590, DOI: 10.1016/j.clinph.2016.09.003.Peer-Reviewed Original ResearchElevated basal glutamate and unchanged glutamine and GABA in refractory epilepsy: Microdialysis study of 79 patients at the yale epilepsy surgery program
Çavuş I, Romanyshyn JC, Kennard JT, Farooque P, Williamson A, Eid T, Spencer SS, Duckrow R, Dziura J, Spencer DD. Elevated basal glutamate and unchanged glutamine and GABA in refractory epilepsy: Microdialysis study of 79 patients at the yale epilepsy surgery program. Annals Of Neurology 2016, 80: 35-45. PMID: 27129611, DOI: 10.1002/ana.24673.Peer-Reviewed Original ResearchConceptsGABA levelsEpilepsy patientsΓ-aminobutyric acid (GABA) neurotransmissionGlutamine levelsGABAergic antiepileptic drugsEpilepsy surgery programRefractory epilepsy patientsCommon pathological featureAberrant glutamateAnn NeurolNonepileptogenic cortexSeizure-onset sitesRefractory epilepsyBasal glutamateAntiepileptic drugsCortical lesionsMicrodialysis studyPatient groupInterictal levelsPathological featuresDifferent etiologiesNeocortical epilepsyGlutamate levelsSeizure generationElectroencephalogram evaluationThe relationship between seizures, interictal spikes and antiepileptic drugs
Goncharova II, Alkawadri R, Gaspard N, Duckrow RB, Spencer DD, Hirsch LJ, Spencer SS, Zaveri HP. The relationship between seizures, interictal spikes and antiepileptic drugs. Clinical Neurophysiology 2016, 127: 3180-3186. PMID: 27292227, DOI: 10.1016/j.clinph.2016.05.014.Peer-Reviewed Original ResearchConceptsFirst seizureSeizure occurrenceAED taperSpike rateEEG monitoringMarker of inhibitionIntracranial EEG monitoringOccurrence of seizuresScalp EEG monitoringConsecutive patientsAntiepileptic drugsDrug taperHigh spike ratesInterictal spikesSeizuresDay 4Intracranial electrodesPatientsAEDsSignificant relationshipProgressive change in sleep over multiple nights of intracranial EEG monitoring
Joshi RB, Gaspard N, Goncharova II, Pavlova M, Duckrow RB, Gerrard JL, Spencer DD, Hirsch LJ, Zaveri HP. Progressive change in sleep over multiple nights of intracranial EEG monitoring. Clinical Neurophysiology 2016, 127: 2302-2307. PMID: 27072103, DOI: 10.1016/j.clinph.2016.02.018.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultBrainBrain MappingElectroencephalographyEpilepsyFemaleHumansMaleMiddle AgedSleepYoung Adult50 Hz hippocampal stimulation in refractory epilepsy: Higher level of basal glutamate predicts greater release of glutamate
Cavus I, Widi GA, Duckrow RB, Zaveri H, Kennard JT, Krystal J, Spencer DD. 50 Hz hippocampal stimulation in refractory epilepsy: Higher level of basal glutamate predicts greater release of glutamate. Epilepsia 2016, 57: 288-297. PMID: 26749134, DOI: 10.1111/epi.13269.Peer-Reviewed Original ResearchConceptsBasal glutamate levelsRefractory epilepsyGlutamate effluxBasal glutamateGlutamate levelsElectrical stimulationEpileptic hippocampusGlutamate releaseSeizure groupHz stimulationBrain glutamate releaseHippocampus of patientsStimulation-induced increaseEpilepsy monitoring unitStimulation-induced changesEpileptogenic hippocampusInduced seizuresSeizure inductionSpontaneous seizuresInterictal levelsGlutamate increaseAtrophic hippocampusElectroencephalography evaluationHippocampal stimulationHippocampal electrodes
2014
The spatial and signal characteristics of physiologic high frequency oscillations
Alkawadri R, Gaspard N, Goncharova II, Spencer DD, Gerrard JL, Zaveri H, Duckrow RB, Blumenfeld H, Hirsch LJ. The spatial and signal characteristics of physiologic high frequency oscillations. Epilepsia 2014, 55: 1986-1995. PMID: 25470216, PMCID: PMC5123742, DOI: 10.1111/epi.12851.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultBiological ClocksBrainBrain MappingBrain WavesChildElectroencephalographyEpilepsyFemaleHumansMaleROC CurveYoung AdultConceptsPhysiologic high-frequency oscillationsSeizure onsetEpileptic networkNon-rapid eye movement sleepComprehensive Epilepsy CenterMesial temporal structuresEye movement sleepHighest HFO ratesHigh-frequency oscillationsFirst seizureInvasive evaluationEpilepsy centersIntracranial evaluationMovement sleepPerirolandic regionEpileptiform dischargesParietooccipital regionOccipital lobeEpileptic sitesPatientsNonepileptic regionsPhysiologic eventsFast ripplesHFO ratesLonger durationSubclinical seizures during intracranial EEG recording: Are they clinically significant?
Farooque P, Duckrow R. Subclinical seizures during intracranial EEG recording: Are they clinically significant? Epilepsy Research 2014, 108: 1790-1796. PMID: 25306063, DOI: 10.1016/j.eplepsyres.2014.09.020.Peer-Reviewed Original ResearchConceptsPoor surgical outcomesGood surgical outcomeSubclinical seizuresSurgical outcomesClinical seizuresIntracranial EEG recordingsGroup 2Group 1Extra-temporal lobe epilepsySeizure onset regionEEG recordingsExtra-temporal originResection correlatesSurgical resectionLobe epilepsyPoor outcomePrognostic valueClinical significanceBetter outcomesPatientsSeizuresEpileptic networkOnset zoneDifferent anatomical regionsEpilepsy database
2013
Reply to about the electrophysiological basis of resting state networks
Duncan D, Duckrow RB, Pincus SM, Goncharova I, Hirsch LJ, Spencer DD, Coifman RR, Zaveri HP. Reply to about the electrophysiological basis of resting state networks. Clinical Neurophysiology 2013, 125: 1713-1714. PMID: 24440225, DOI: 10.1016/j.clinph.2013.12.098.Commentaries, Editorials and Letters7T MR spectroscopic imaging in the localization of surgical epilepsy
Pan JW, Duckrow RB, Gerrard J, Ong C, Hirsch LJ, Resor SR, Zhang Y, Petroff O, Spencer S, Hetherington HP, Spencer DD. 7T MR spectroscopic imaging in the localization of surgical epilepsy. Epilepsia 2013, 54: 1668-1678. PMID: 23895497, PMCID: PMC3938332, DOI: 10.1111/epi.12322.Peer-Reviewed Original ResearchConceptsSevere metabolic abnormalitiesLocalization-related epilepsyMR spectroscopic imagingN-acetyl aspartateComplete resectionMetabolic abnormalitiesBetter outcomesMedial temporal lobe epilepsyResection regionTemporal lobe epilepsyNAA/CrSeizure onset zoneSurgical resectionLobe epilepsySurgical approachSeizure localizationMetabolic dysfunctionInternational LeagueSurgical epilepsyGray matterEpilepsyResectionAbnormalitiesMRSI abnormalitiesOutcome predictionIntracranially recorded interictal spikes: Relation to seizure onset area and effect of medication and time of day
Goncharova II, Spencer SS, Duckrow RB, Hirsch LJ, Spencer DD, Zaveri HP. Intracranially recorded interictal spikes: Relation to seizure onset area and effect of medication and time of day. Clinical Neurophysiology 2013, 124: 2119-2128. PMID: 23856192, DOI: 10.1016/j.clinph.2013.05.027.Peer-Reviewed Original ResearchIntracranial EEG evaluation of relationship within a resting state network
Duncan D, Duckrow RB, Pincus SM, Goncharova I, Hirsch LJ, Spencer DD, Coifman RR, Zaveri HP. Intracranial EEG evaluation of relationship within a resting state network. Clinical Neurophysiology 2013, 124: 1943-1951. PMID: 23790525, DOI: 10.1016/j.clinph.2013.03.028.Peer-Reviewed Original ResearchConceptsDefault mode networkIntracranial EEG evaluationMode networkLocalization-related epilepsyCross-approximate entropyNeuronal involvementHemodynamic measurementsIntracranial EEG recordingsEEG evaluationBackground activityGamma powerFMRI studyIntracranial EEGBrain activityPatientsEEG recordingsLow levelsT2EpilepsyMagnitude squared coherenceT1
2012
Metabolic networks in epilepsy by MR spectroscopic imaging
Pan JW, Spencer DD, Kuzniecky R, Duckrow RB, Hetherington H, Spencer SS. Metabolic networks in epilepsy by MR spectroscopic imaging. Acta Neurologica Scandinavica 2012, 126: 411-420. PMID: 22574807, PMCID: PMC3600585, DOI: 10.1111/j.1600-0404.2012.01665.x.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultBrainElectroencephalographyEpilepsy, Temporal LobeFemaleHumansMagnetic Resonance SpectroscopyMaleMetabolic Networks and PathwaysYoung AdultConceptsMTLE patientsBasal gangliaEpileptic networkMesial temporal lobe epilepsy patientsTemporal lobe epilepsy patientsLimbic seizure propagationBilateral basal gangliaNAA/CrMR spectroscopicIpsilateral insulaSeizure propagationBilateral hippocampusEpilepsy patientsHuman studiesIndependent factorsPatientsNeuronal functionThalamusGangliaEpilepsyInsulaFactor analysisFactorsHippocampusInjury
2011
Proceedings of the Second International Workshop on Advances in Electrocorticography
Ritaccio A, Boatman-Reich D, Brunner P, Cervenka MC, Cole AJ, Crone N, Duckrow R, Korzeniewska A, Litt B, Miller KJ, Moran DW, Parvizi J, Viventi J, Williams J, Schalk G. Proceedings of the Second International Workshop on Advances in Electrocorticography. Epilepsy & Behavior 2011, 22: 641-650. PMID: 22036287, PMCID: PMC3847909, DOI: 10.1016/j.yebeh.2011.09.028.Chapters
2010
A prospective study of loss of consciousness in epilepsy using virtual reality driving simulation and other video games
Yang L, Morland TB, Schmits K, Rawson E, Narasimhan P, Motelow JE, Purcaro MJ, Peng K, Raouf S, DeSalvo MN, Oh T, Wilkerson J, Bod J, Srinivasan A, Kurashvili P, Anaya J, Manza P, Danielson N, Ransom CB, Huh L, Elrich S, Padin-Rosado J, Naidu Y, Detyniecki K, Hamid H, Farooque P, Astur R, Xiao B, Duckrow RB, Blumenfeld H. A prospective study of loss of consciousness in epilepsy using virtual reality driving simulation and other video games. Epilepsy & Behavior 2010, 18: 238-246. PMID: 20537593, PMCID: PMC2914099, DOI: 10.1016/j.yebeh.2010.04.011.Peer-Reviewed Original ResearchConceptsVideo gamesVirtual realityComputer-based tasksDaily lifePerformance dataProspective studyEssential partGameContinuous video/EEG monitoringVideo/EEG monitoringTraffic accidentsSimulatorNetworkTaskNormal daily lifeSeizure typesDrivingEEG monitoringSeizuresDriving impairmentPatientsImpair consciousnessSpecific typesAnatomical networksRealityBackground intracranial EEG spectral changes with anti-epileptic drug taper
Zaveri HP, Pincus SM, Goncharova II, Novotny EJ, Duckrow RB, Spencer DD, Blumenfeld H, Spencer SS. Background intracranial EEG spectral changes with anti-epileptic drug taper. Clinical Neurophysiology 2010, 121: 311-317. PMID: 20075002, DOI: 10.1016/j.clinph.2009.11.081.Peer-Reviewed Original Research
2009
Concerning the observation of an electrical potential at a distance from an intracranial electrode contact
Zaveri HP, Duckrow RB, Spencer SS. Concerning the observation of an electrical potential at a distance from an intracranial electrode contact. Clinical Neurophysiology 2009, 120: 1873-1875. PMID: 19748311, DOI: 10.1016/j.clinph.2009.08.001.Commentaries, Editorials and LettersSpatial distribution of intracranially recorded spikes in medial and lateral temporal epilepsies
Goncharova II, Zaveri HP, Duckrow RB, Novotny EJ, Spencer SS. Spatial distribution of intracranially recorded spikes in medial and lateral temporal epilepsies. Epilepsia 2009, 50: 2575-2585. PMID: 19674048, DOI: 10.1111/j.1528-1167.2009.02258.x.Peer-Reviewed Original ResearchConceptsMedial temporal structuresInterictal spikesLT patientsCortical areasNeocortical seizure onsetsSleep-related increaseSpike rateLateral temporal epilepsyExtratemporal areasTemporal epilepsySeizure onsetIntracranial monitoringLT groupMT groupPatientsFrontal spikesSeizuresGreater numberSleepGroupTemporal structureEpilepsySpikes