Association Between Antibiotic Redosing Before Incision and Risk of Incisional Site Infection in Children With Appendicitis
Cramm S, Chandler N, Graham D, Kunisaki S, Russell R, Blakely M, Lipskar A, Allukian M, Aronowitz D, Campbell B, Collins D, Commander S, Cowles R, DeFazio J, Esparaz J, Feng C, Griggs C, Guyer R, Hanna D, Kahan A, Keane O, Lamoshi A, Lopez C, Pace E, Regan M, Santore M, Scholz S, Tracy E, Williams S, Zhang L, Rangel S. Association Between Antibiotic Redosing Before Incision and Risk of Incisional Site Infection in Children With Appendicitis. Annals Of Surgery 2022, 278: e863-e869. PMID: 36317528, DOI: 10.1097/sla.0000000000005747.Peer-Reviewed Original ResearchConceptsIncisional surgical site infectionHour of incisionPediatric National Surgical Quality Improvement ProgramNational Surgical Quality Improvement ProgramSurgical Quality Improvement ProgramSite infectionQuality Improvement ProgramAntibiotic redosingIncisional surgical site infection rateMulticenter retrospective cohort studyDisease severityDiagnosis of appendicitisSurgical site infectionRetrospective cohort studyRedosing of antibioticsOperative report dataMultivariate logistic regressionHospital-level clusteringIncreased disease severityAntibiotic regimensInitial doseAntibiotic administrationPatient demographicsAntibiotic utilizationChart review