2018
Use of Renin Angiotensin System Blockers After Acute Kidney Injury: Balancing Tradeoffs.
Alpern RJ, Peixoto AJ. Use of Renin Angiotensin System Blockers After Acute Kidney Injury: Balancing Tradeoffs. JAMA Internal Medicine 2018, 178: 1690-1692. PMID: 30422208, DOI: 10.1001/jamainternmed.2018.4757.Peer-Reviewed Original Research
2017
Randomized, Controlled Trial of TRC101 to Increase Serum Bicarbonate in Patients with CKD
Bushinsky DA, Hostetter T, Klaerner G, Stasiv Y, Lockey C, McNulty S, Lee A, Parsell D, Mathur V, Li E, Buysse J, Alpern R. Randomized, Controlled Trial of TRC101 to Increase Serum Bicarbonate in Patients with CKD. Clinical Journal Of The American Society Of Nephrology 2017, 13: 26-35. PMID: 29102959, PMCID: PMC5753317, DOI: 10.2215/cjn.07300717.Peer-Reviewed Original ResearchConceptsSerum bicarbonateEnd of treatmentMetabolic acidosisTreatment groupsBaseline serum bicarbonateMean baseline eGFRMEq/LSignificant adverse effectsBaseline eGFRGastrointestinal eventsAdverse eventsFirst doseControlled TrialsHeart failurePatientsCKDBaseline levelsMean increaseAbstractTextUnit studiesAcidosisAdverse effectsPlaceboTreatmentDays
2015
Research in academic medical centers: Two threats to sustainable support
Levine AS, Alpern RJ, Andrews NC, Antman K, Balser JR, Berg JM, Davis PB, Fitz JG, Golden RN, Goldman L, Jameson JL, Lee VS, Polonsky KS, Rappley MD, Reece EA, Rothman PB, Schwinn DA, Shapiro LJ, Spiegel AM. Research in academic medical centers: Two threats to sustainable support. Science Translational Medicine 2015, 7: 289fs22-289fs22. PMID: 26019216, DOI: 10.1126/scitranslmed.aac5200.Peer-Reviewed Original Research
2013
Treatment of Severe Metabolic Alkalosis in a Patient With Congestive Heart Failure
Peixoto AJ, Alpern RJ. Treatment of Severe Metabolic Alkalosis in a Patient With Congestive Heart Failure. American Journal Of Kidney Diseases 2013, 61: 822-827. PMID: 23481366, DOI: 10.1053/j.ajkd.2012.10.028.Peer-Reviewed Original ResearchConceptsCongestive heart failureHeart failureMetabolic alkalosisLow bicarbonate dialysisRenal bicarbonate excretionRenin-angiotensin systemSevere metabolic alkalosisDistal sodium deliveryCommon acid-base disorderAcid-base disordersDiuretic regimenDiuretic therapyAldosterone antagonistsNeurohormonal activationCirculatory failureBicarbonate excretionKidney failurePotassium repletionSodium deliveryBase excessUrine acidificationAppropriate managementAlkalosisDisease statesBicarbonate retention
2011
Competencies in Premedical and Medical Education: The AAMC–HHMI Report
Alpern RJ, Belitsky R, Long S. Competencies in Premedical and Medical Education: The AAMC–HHMI Report. Perspectives In Biology And Medicine 2011, 54: 30-35. PMID: 21399381, DOI: 10.1353/pbm.2011.0001.Peer-Reviewed Original ResearchConceptsScience educationPremedical curriculumMedical educationSchool science curriculumAmerican Medical CollegesMedical school admissionsHoward Hughes Medical InstituteImportance of scienceScience curriculumMedical curriculumCourse requirementsMedical studentsSchool admissionsCurriculumNumber of recommendationsEducationBiological sciencesScientific knowledge basePhysical sciencesPractice of medicineStudentsCompetenciesMedical CollegeScienceKnowledge baseDefining hypercalciuria in nephrolithiasis
Pak CY, Sakhaee K, Moe OW, Poindexter J, Adams-Huet B, Pearle MS, Zerwekh JE, Preminger GM, Wills MR, Breslau NA, Bartter FC, Brater DC, Heller HJ, Odvina CV, Wabner CL, Fordtran JS, Oh M, Garg A, Harvey JA, Alpern RJ, Snyder WH, Peters PC. Defining hypercalciuria in nephrolithiasis. Kidney International 2011, 80: 777-782. PMID: 21775970, PMCID: PMC4354881, DOI: 10.1038/ki.2011.227.Peer-Reviewed Original ResearchConceptsAbsorptive hypercalciuria type IUrinary calcium excretionMean urinary calciumCalcium excretionUrinary calciumStone formersUpper normal limitKidney stone formersType IOptimal cutoff pointNon-stone formersCharacteristic curve analysisAbsorptive hypercalciuriaRetrospective studyNormal limitsDietary variablesHypercalciuriaCutoff pointDietary influencesNormal individualsPatientsCurve analysisExcretionConstant dietDiet
2010
Pre-medical education for future physicians: evolution at Yale and beyond.
Segraves W, Alpern R, Salovey P. Pre-medical education for future physicians: evolution at Yale and beyond. Connecticut Medicine 2010, 74: 529-32. PMID: 21073011.Peer-Reviewed Original Research
2009
Science for Future Physicians
Long S, Alpern R. Science for Future Physicians. Science 2009, 324: 1241-1241. PMID: 19498132, DOI: 10.1126/science.1176994.Peer-Reviewed Original Research
2004
A consensus sequence in the endothelin-B receptor second intracellular loop is required for NHE3 activation by endothelin-1
Laghmani K, Sakamoto A, Yanagisawa M, Preisig PA, Alpern RJ. A consensus sequence in the endothelin-B receptor second intracellular loop is required for NHE3 activation by endothelin-1. American Journal Of Physiology. Renal Physiology 2004, 288: f732-f739. PMID: 15598844, DOI: 10.1152/ajprenal.00300.2004.Peer-Reviewed Original ResearchConceptsEndothelin-1Second intracellular loopET-1 stimulationNHE3 activityIntracellular loopEndothelin-A receptorAdenylyl cyclase inhibitionET-1 regulationProximal tubule apical membraneET receptorsCyclase inhibitionOKP cellsNHE3 activationOpossum kidneyExchanger 3ReceptorsStimulationProtein tyrosine phosphorylationReceptor chimerasPresent studyCellsAdditional mechanismTyrosine phosphorylationApical membraneSimilar pattern
2003
Treating dyslipidemia to slow the progression of chronic renal failure
Palmer BF, Alpern RJ. Treating dyslipidemia to slow the progression of chronic renal failure. The American Journal Of Medicine 2003, 114: 411-412. PMID: 12714133, DOI: 10.1016/s0002-9343(03)00070-6.Peer-Reviewed Original Research
2002
Reversible acute renal failure and nephrotic syndrome in a Type 1 diabetic patient
Avilés-Santa L, Alpern R, Raskin P. Reversible acute renal failure and nephrotic syndrome in a Type 1 diabetic patient. Journal Of Diabetes And Its Complications 2002, 16: 249-254. PMID: 12015196, DOI: 10.1016/s1056-8727(01)00221-5.Peer-Reviewed Original ResearchConceptsReversible acute renal failureAcute renal failureBlood urea nitrogenNephrotic syndromeRenal failureDiabetic nephropathyDiabetic patientsRenal parametersRenal conditionsAcute oliguric renal failureEnd-stage renal diseaseType 1 diabetic patientsDiscontinuation of dialysisOliguric renal failureEarly diabetic nephropathyUrinary protein excretionMinimal change diseasePatient's renal conditionDiuretic therapyOvert proteinuriaRenal insufficiencyRenal functionSerum creatinineRenal biopsyRenal disease2001 presidential address.
Alpern RJ. 2001 presidential address. Journal Of The American Society Of Nephrology 2002, 13: 1119-1123. PMID: 11912274, DOI: 10.1681/asn.v1341119.Peer-Reviewed Original Research
1999
Role of glucocorticoids in acidosis
Hamm L, Ambühl P, Alpern R. Role of glucocorticoids in acidosis. American Journal Of Kidney Diseases 1999, 34: 960-965. PMID: 10561158, DOI: 10.1016/s0272-6386(99)70059-4.Peer-Reviewed Original Research
1998
Converting enzyme inhibition causes hypocitraturia independent of acidosis or hypokalemia
Melnick J, Preisig P, Haynes S, Pak C, Sakhaee K, Alpern R. Converting enzyme inhibition causes hypocitraturia independent of acidosis or hypokalemia. Kidney International 1998, 54: 1670-1674. PMID: 9844143, DOI: 10.1046/j.1523-1755.1998.00150.x.Peer-Reviewed Original ResearchConceptsUrinary citrate excretionCitrate excretionUrinary citrateMetabolic acidosisATP-citrate lyaseEffects of enalaprilRenal citrate metabolismUrine citrate concentrationRenal cortical tissueChronic metabolic acidosisProximal tubular cellsPlasma pHNa/H antiporterAngiotensin IIIntracellular acidosisEnalaprilTubular cellsCitrate lyaseHypokalemiaEnzyme inhibitorsATP citrate lyase activityAcidosisCortical tissueRatsCitrate metabolismLiddle’s Syndrome
Palmer B, Alpern R, In collaboration with The American Physiological Society T. Liddle’s Syndrome. The American Journal Of Medicine 1998, 104: 301-309. PMID: 9552093, DOI: 10.1016/s0002-9343(98)00018-7.Peer-Reviewed Original Research
1997
Metabolic alkalosis.
Palmer BF, Alpern RJ. Metabolic alkalosis. Journal Of The American Society Of Nephrology 1997, 8: 1462-9. PMID: 9294840, DOI: 10.1681/asn.v891462.Peer-Reviewed Original ResearchPathogenesis of edema formation in the nephrotic syndrome.
Palmer BF, Alpern RJ. Pathogenesis of edema formation in the nephrotic syndrome. Kidney International Supplement 1997, 59: s21-7. PMID: 9185099.Peer-Reviewed Original ResearchConceptsPlasma oncotic pressureEdema formationNephrotic syndromeOncotic pressurePlasma volumeEffective circulatory volumeMost nephrotic patientsPrimary salt retentionPrimary sodium retentionMinority of patientsCapillary fluid filtrationAtrial natriuretic peptideDevelopment of edemaNeurohumoral markersIntrarenal mechanismsNatriuretic effectNephrotic patientsSodium retentionCirculatory volumeIntravascular volumeNatriuretic peptideEffector mechanismsUrinary lossTubular resistanceIntravascular spaceDoes hyperphosphaturla underlle hypercalciuria?
Alpern R, Sakhaee K. Does hyperphosphaturla underlle hypercalciuria? The Lancet 1997, 349: 518-519. PMID: 9048785, DOI: 10.1016/s0140-6736(97)80080-3.Peer-Reviewed Original ResearchThe clinical spectrum of chronic metabolic acidosis: Homeostatic mechanisms produce significant morbidity
Alpern R, Sakhaee K. The clinical spectrum of chronic metabolic acidosis: Homeostatic mechanisms produce significant morbidity. American Journal Of Kidney Diseases 1997, 29: 291-302. PMID: 9016905, DOI: 10.1016/s0272-6386(97)90045-7.Peer-Reviewed Original ResearchConceptsChronic metabolic acidosisMetabolic acidosisHomeostatic responseSerum HCO3Acid loadBody's homeostatic responseHomeostatic mechanismsMuscle protein breakdownNormal homeostatic mechanismsSignificant morbidityClinical spectrumMeat ingestionBone demineralizationRenal growthClinical conditionsPathologic processesPathologic consequencesAcidosisProtein breakdownBloodResponseMorbidityPatientsNephrolithiasisIngestion
1995
Chronic regulation of the proximal tubular Na/H antiporter: From HCO3 to SRC
Alpern R, Moe O, Preisig P. Chronic regulation of the proximal tubular Na/H antiporter: From HCO3 to SRC. Kidney International 1995, 48: 1386-1396. PMID: 8544394, DOI: 10.1038/ki.1995.427.Peer-Reviewed Original ResearchConceptsNa/H antiporterChronic regulationH secretionProximal tubulesH antiporterNaCl absorptionProximal tubular acidificationMajor siteNa/K pumpCitrate reabsorptionBasolateral membraneTubular acidificationAcute regulationLuminal membraneK pumpExcretionReabsorptionSecretionPivotal roleVacuolar H-ATPaseH-ATPaseTubules