2024
Prophylactic Transfusion Strategies in Children Supported by Extracorporeal Membrane Oxygenation: The Pediatric Extracorporeal Membrane Oxygenation Anticoagulation CollaborativE Consensus Conference
Nellis M, Moynihan K, Sloan S, Delaney M, Kneyber M, DiGeronimo R, Alexander P, Muszynski J, Gehred A, Lyman E, Karam O, in collaboration with the Pediatric Critical Care Blood Research Network A. Prophylactic Transfusion Strategies in Children Supported by Extracorporeal Membrane Oxygenation: The Pediatric Extracorporeal Membrane Oxygenation Anticoagulation CollaborativE Consensus Conference. Pediatric Critical Care Medicine 2024, 25: e25-e34. PMID: 38959357, PMCID: PMC11216389, DOI: 10.1097/pcc.0000000000003493.Peer-Reviewed Original ResearchMeSH KeywordsBlood TransfusionChildChild, PreschoolConsensusDelphi TechniqueExtracorporeal Membrane OxygenationHumansInfantInfant, NewbornConceptsExtracorporeal membrane oxygenationProphylactic transfusion strategyTransfusion strategyMembrane oxygenationProphylactic blood product transfusionsPediatric extracorporeal membrane oxygenationConsensus statementPediatric ECMO patientsBlood product transfusionExpert consensus statementPractice statementsStandardized data extraction formProphylactic transfusionECMO patientsProduct transfusionModified Delphi consensusWeak recommendationConsensus conferenceRecommendations AssessmentData extraction formDelphi processStudy assessed useModified Delphi processLiterature searchDelphi consensus
2022
Transfusion Strategies in the 21st Century A Case-Based Narrative Report
Shenker J, Abuelhija H, Karam O, Nellis M. Transfusion Strategies in the 21st Century A Case-Based Narrative Report. Critical Care Clinics 2022, 39: 287-298. PMID: 36898774, DOI: 10.1016/j.ccc.2022.09.005.Peer-Reviewed Original Research
2021
Transfusion practices for pediatric oncology and hematopoietic stem cell transplantation patients: Data from the National Heart Lung and Blood Institute Recipient Epidemiology and Donor Evaluation Study‐III (REDS‐III)
Goel R, Nellis ME, Karam O, Hanson SJ, Tormey CA, Patel RM, Birch R, Sachais BS, Sola‐Visner M, Hauser RG, Luban NLC, Gottschall J, Josephson CD, Hendrickson JE, Karafin MS, Study‐IV‐Pediatric F. Transfusion practices for pediatric oncology and hematopoietic stem cell transplantation patients: Data from the National Heart Lung and Blood Institute Recipient Epidemiology and Donor Evaluation Study‐III (REDS‐III). Transfusion 2021, 61: 2589-2600. PMID: 34455598, DOI: 10.1111/trf.16626.Peer-Reviewed Original ResearchConceptsInternational normalized ratioBlood Institute Recipient EpidemiologyDonor Evaluation Study-IIINational Heart LungTransfusion practicePediatric oncologyRecipient EpidemiologyHSCT patientsPlasma transfusionRed blood cellsPlatelet countHeart LungHematopoietic stem cell transplantation patientsHematopoietic stem cell transplant patientsMedian international normalized ratioStem cell transplant patientsStem cell transplantation patientsLower INR valuesPre-transfusion HbMedian platelet countMulticenter retrospective studyCell transplant patientsCell transplantation patientsStudy IIIAcute myeloid leukemiaTransfusion Practices in Pediatric Cardiac Surgery Requiring Cardiopulmonary Bypass: A Secondary Analysis of a Clinical Database
Hanson SJ, Karam O, Birch R, Goel R, Patel RM, Sola-Visner M, Sachais BS, Hauser RG, Luban NLC, Gottschall J, Josephson CD, Hendrickson JE, Karafin MS, Nellis ME, Lung A. Transfusion Practices in Pediatric Cardiac Surgery Requiring Cardiopulmonary Bypass: A Secondary Analysis of a Clinical Database. Pediatric Critical Care Medicine 2021, 22: 978-987. PMID: 34261944, PMCID: PMC8570986, DOI: 10.1097/pcc.0000000000002805.Peer-Reviewed Original ResearchConceptsCongenital heart diseaseBiventricular surgeryCardiopulmonary bypass surgeryHeart diseaseMedian internationalBypass surgeryMembrane oxygenationPlatelet countBlood componentsVentricular surgeryHemoglobin valuesBlood Institute Recipient EpidemiologyDonor Evaluation Study-IIIHigher median platelet countNormal international normalized ratioIntraoperative platelet transfusionLimited physiologic reserveMultiple blood productsPretransfusion platelet countU.S. hospitalsMedian platelet countBlood component transfusionBlood component usageExtracorporeal membrane oxygenationInternational normalized ratioTransfusion practices in a large cohort of hospitalized children
Nellis ME, Goel R, Hendrickson JE, Birch R, Patel RM, Karafin MS, Hanson SJ, Sachais BS, Hauser RG, Luban NLC, Gottschall J, Sola‐Visner M, Josephson CD, Karam O, Study‐IV‐Pediatric F. Transfusion practices in a large cohort of hospitalized children. Transfusion 2021, 61: 2042-2053. PMID: 33973660, DOI: 10.1111/trf.16443.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentBlood Component TransfusionBlood TransfusionChildChild, PreschoolDatasets as TopicDiagnosis-Related GroupsFemaleHospital MortalityHospitals, CommunityHospitals, TeachingHumansInfantInfant, NewbornInpatientsMaleProcedures and Techniques UtilizationRetrospective StudiesUnited StatesConceptsRBC transfusionCardiopulmonary bypassTransfusion practiceHospitalized childrenInpatient encountersBlood componentsLarge cohortHospital settingBlood Institute Recipient EpidemiologyDonor Evaluation Study-IIIPatient blood management initiativesDiagnostic categoriesFrequency of transfusionInstitutional transfusion guidelinesCohort of patientsInternational normalized ratioPercent of encountersNational Heart LungPediatric hospital settingYears of ageSubset of childrenRecipient EpidemiologyTransfusion guidelinesRed blood cellsEntire cohortVariation in Neonatal Transfusion Practice
Patel RM, Hendrickson JE, Nellis ME, Birch R, Goel R, Karam O, Karafin MS, Hanson SJ, Sachais BS, Hauser RG, Luban NLC, Gottschall J, Josephson CD, Sola-Visner M, National Heart L, Mast A, Hod E, Custer B, Vichinsky E, Spencer B, Mathew S, Harris D, Busch M, Norris P, Ness P, Kleinman S, Tamburro R, Glynn S, Malkin K. Variation in Neonatal Transfusion Practice. The Journal Of Pediatrics 2021, 235: 92-99.e4. PMID: 33836184, PMCID: PMC8316298, DOI: 10.1016/j.jpeds.2021.04.002.Peer-Reviewed Original ResearchConceptsWeeks of gestationEntire cohortPretransfusion hemoglobinPlatelet countNeonatal transfusionBlood Institute Recipient EpidemiologyDonor Evaluation Study-IIIInternational normalized ratio (INR) valuesHematologic valuesNeonatal transfusion practicesPretransfusion platelet countRetrospective cohort studyBlood product transfusionGestational age groupsPatient blood managementNational Heart LungRecipient EpidemiologyInitial hospitalizationProduct transfusionCohort studyRed blood cellsGestational ageTransfusion practiceHeart LungBlood managementTransfusion management for children supported by extracorporeal membrane oxygenation
Karam O, Nellis ME. Transfusion management for children supported by extracorporeal membrane oxygenation. Transfusion 2021, 61: 660-664. PMID: 33491189, DOI: 10.1111/trf.16272.Peer-Reviewed Original Research
2020
Designing Appropriate and Individualized Transfusion Strategies: Finding the Sweet Spot.
Demaret P, Karam O. Designing Appropriate and Individualized Transfusion Strategies: Finding the Sweet Spot. Pediatric Critical Care Medicine 2020, 21: 770-772. PMID: 32769943, DOI: 10.1097/pcc.0000000000002369.Commentaries, Editorials and LettersPreoperative erythropoietin within a patient blood management program decreases both blood transfusion and postoperative anemia: a prospective observational study
Biboulet P, Motais C, Pencole M, Karam O, Dangelser G, Smilevitch P, Maissiat G, Capdevila X, Bringuier S. Preoperative erythropoietin within a patient blood management program decreases both blood transfusion and postoperative anemia: a prospective observational study. Transfusion 2020, 60: 1732-1740. PMID: 32681743, DOI: 10.1111/trf.15900.Peer-Reviewed Original ResearchConceptsPatient blood management programBlood management programBlood transfusionPostoperative anemiaPreoperative erythropoietinObservational studyElective primary hipProspective observational studyMajor thromboembolicPreoperative hemoglobinCardiovascular eventsPreoperative treatmentTransfusion rateHospital dischargePostoperative infusionPostoperative periodIntraoperative administrationMajor complicationsTranexamic acidPrimary hipKnee arthroplastySingle hospitalTransfusionPatientsSpecific efficacyPediatric Plasma and Platelet Transfusions on Extracorporeal Membrane Oxygenation: A Subgroup Analysis of Two Large International Point-Prevalence Studies and the Role of Local Guidelines.
Nellis ME, Saini A, Spinella PC, Davis PJ, Steiner ME, Tucci M, Cushing M, Demaret P, Stanworth SJ, Leteurtre S, Karam O. Pediatric Plasma and Platelet Transfusions on Extracorporeal Membrane Oxygenation: A Subgroup Analysis of Two Large International Point-Prevalence Studies and the Role of Local Guidelines. Pediatric Critical Care Medicine 2020, 21: 267-275. PMID: 31644453, PMCID: PMC7060816, DOI: 10.1097/pcc.0000000000002160.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentBlood TransfusionChildChild, PreschoolExtracorporeal Membrane OxygenationFemaleHemorrhageHumansInfantInfant, NewbornIntensive Care Units, PediatricInternational Normalized RatioMalePlasmaPlatelet CountPlatelet TransfusionPractice Guidelines as TopicProspective StudiesSurveys and QuestionnairesConceptsExtracorporeal membrane oxygenationMembrane oxygenationPlatelet transfusionsTotal platelet countPlasma transfusionPlatelet countSubgroup analysisInstitutional protocolMedian increaseInternational point prevalence studyPediatric extracorporeal membrane oxygenationTotal median doseInternational normalized ratioML/Point prevalence studyPlatelet count valuesScreening weekMedian doseMild coagulopathyNormalized ratioInterventional studyLocal guidelinesObservational studyMedian reductionTransfusion
2019
Quantifiable Bleeding in Children Supported by Extracorporeal Membrane Oxygenation and Outcome.
Nellis ME, Dalton H, Karam O. Quantifiable Bleeding in Children Supported by Extracorporeal Membrane Oxygenation and Outcome. Critical Care Medicine 2019, 47: e886-e892. PMID: 31449061, PMCID: PMC8608374, DOI: 10.1097/ccm.0000000000003968.Peer-Reviewed Original ResearchConceptsChest tube bleedingExtracorporeal membrane oxygenationCollaborative Pediatric Critical Care Research NetworkMembrane oxygenationChest tubeClinical outcomesPlatelet countML/Large observational cohort studyEunice Kennedy Shriver National InstituteCritical Care Research NetworkPICU-free daysPercent of patientsObservational cohort studyWorse clinical outcomesHuman Development Collaborative Pediatric Critical Care Research NetworkMembrane oxygenation specialistsHospital mortalityTransfusion volumeCohort studyHeparin doseConsecutive patientsThrombotic eventsPediatric institutionHemostatic testsTransfusion Management in Pediatric Oncology Patients
Nellis ME, Goel R, Karam O. Transfusion Management in Pediatric Oncology Patients. Hematology/Oncology Clinics Of North America 2019, 33: 903-913. PMID: 31466612, DOI: 10.1016/j.hoc.2019.05.011.Peer-Reviewed Original ResearchMeSH KeywordsBlood TransfusionChildErythrocyte TransfusionHematologic DiseasesHumansLeukocyte TransfusionMedical OncologyNeoplasmsPlatelet TransfusionConceptsPediatric oncology patientsOncology patientsBlood productsStrong evidence-based guidelinesRestrictive transfusion strategyEvidence-based guidelinesNumerous transfusionsPlasma transfusionRed blood cellsTransfusion strategyTransfusion managementPatient populationBlood cellsTransfusionPatientsMorbidity
2018
Assessing our current practice: point prevalence studies in transfusion medicine
Nellis ME, Karam O. Assessing our current practice: point prevalence studies in transfusion medicine. Transfusion 2018, 58: 843-845. PMID: 29380394, DOI: 10.1111/trf.14492.Peer-Reviewed Original Research
2016
Massive Transfusion in Children
Karam O, Tucci M. Massive Transfusion in Children. Transfusion Medicine Reviews 2016, 30: 213-216. PMID: 27287298, DOI: 10.1016/j.tmrv.2016.05.010.Peer-Reviewed Original ResearchConceptsMassive transfusionTransfusion protocolTransfusion strategyPacked red blood cellsPediatric trauma patientsGoal-directed therapyWhole bloodMassive transfusion protocolHigh-quality evidenceCritical illnessRed blood cellsTransfusion supportAdjunctive treatmentTrauma patientsQuality evidenceClinical indicatorsTransfusionLaboratory testsBlood componentsBlood cellsFurther studiesAdditional investigationChildrenAdverse consequencesBlood
2013
Plasma transfusion strategies for critically ill patients
Karam O, Tucci M, Combescure C, Lacroix J, Rimensberger PC. Plasma transfusion strategies for critically ill patients. Cochrane Database Of Systematic Reviews 2013, cd010654. PMID: 24374651, DOI: 10.1002/14651858.cd010654.pub2.Peer-Reviewed Original ResearchConceptsIll patientsPlasma transfusionTransfusion strategyCoagulation testsCochrane Injuries Group's Specialised RegisterInjuries Group Specialised RegisterGroup Specialised RegisterMild coagulation abnormalitiesAbnormal coagulation testsCochrane Central RegisterRisk of bleedingWorse clinical outcomesNon-Indexed CitationsSpecialised RegisterLack of evidenceTransfusion thresholdTrial qualityCentral RegisterCoagulation abnormalitiesCochrane HandbookControlled TrialsReview authorsTrials RegistryClinical effectsClinical outcomes