2014
The VMAT-2 Inhibitor Tetrabenazine Affects Effort-Related Decision Making in a Progressive Ratio/Chow Feeding Choice Task: Reversal with Antidepressant Drugs
Randall P, Lee C, Nunes E, Yohn S, Nowak V, Khan B, Shah P, Pandit S, Vemuri V, Makriyannis A, Baqi Y, Müller C, Correa M, Salamone J. The VMAT-2 Inhibitor Tetrabenazine Affects Effort-Related Decision Making in a Progressive Ratio/Chow Feeding Choice Task: Reversal with Antidepressant Drugs. PLOS ONE 2014, 9: e99320. PMID: 24937131, PMCID: PMC4061002, DOI: 10.1371/journal.pone.0099320.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntidepressive AgentsBenzazepinesBenzophenonesBupropionCannabinoid Receptor AntagonistsChoice BehaviorDepressionDopamine AntagonistsDrug Evaluation, PreclinicalFeeding BehaviorMaleNitrophenolsPyrazolesRats, Sprague-DawleySalicylamidesSelegilineTetrabenazineTolcaponeVesicular Monoamine Transport ProteinsXanthinesConceptsChow intakeAdenosine A2A antagonist MSX-3Vesicular monoamine transport (VMAT-2) inhibitor tetrabenazineCB1 receptor neutral antagonistsMAO-B inhibitor deprenylEffort-related decisionAppetite suppressant drugsVMAT-2 inhibitor tetrabenazineProgressive ratioDA antagonist haloperidolInhibitor tetrabenazineEffort-related effectsMSX-3High-carbohydrate foodsAntagonist haloperidolDepressed patientsMajor depressionAntidepressant drugsLab chowRodent modelsDepressive symptomsMotivational symptomsAnimal modelsSelective dopaminePsychomotor retardation
2013
Effort-Related Motivational Effects of the VMAT-2 Inhibitor Tetrabenazine: Implications for Animal Models of the Motivational Symptoms of Depression
Nunes E, Randall P, Hart E, Freeland C, Yohn S, Baqi Y, Müller C, López-Cruz L, Correa M, Salamone J. Effort-Related Motivational Effects of the VMAT-2 Inhibitor Tetrabenazine: Implications for Animal Models of the Motivational Symptoms of Depression. Journal Of Neuroscience 2013, 33: 19120-19130. PMID: 24305809, PMCID: PMC3850037, DOI: 10.1523/jneurosci.2730-13.2013.Peer-Reviewed Original ResearchMeSH KeywordsAdenosine A2 Receptor AntagonistsAdrenergic Uptake InhibitorsAnimalsAntidepressive Agents, Second-GenerationBehavior, AnimalBupropionConditioning, OperantDepressionDisease Models, AnimalDopamineDopamine and cAMP-Regulated Phosphoprotein 32EnkephalinsFeeding BehaviorImmunohistochemistryMaleMicrodialysisMotivationNucleus AccumbensProto-Oncogene Proteins c-fosRatsRats, Sprague-DawleySubstance PTetrabenazineVesicular Monoamine Transport ProteinsXanthinesConceptsMotivational symptomsAnimal modelsEffort-related choice behaviorAdenosine A2A antagonist MSX-3Vesicular monoamine transport (VMAT-2) inhibitor tetrabenazineEffort-related motivational effectsEffort-related motivational symptomsAccumbens medium spiny neuronsVMAT-2 inhibitor tetrabenazineD2 DA receptorsDepression-like effectsDose-related decreaseMedium spiny neuronsEffects of tetrabenazineInhibitor tetrabenazineEffort-related choiceEffort-related effectsDA receptorsAntidepressant bupropionChow intakeMSX-3Spiny neuronsMajor depressionExtracellular dopamineFood intake