2014
The VMAT-2 Inhibitor Tetrabenazine Affects Effort-Related Decision Making in a Progressive Ratio/Chow Feeding Choice Task: Reversal with Antidepressant Drugs
Randall P, Lee C, Nunes E, Yohn S, Nowak V, Khan B, Shah P, Pandit S, Vemuri V, Makriyannis A, Baqi Y, Müller C, Correa M, Salamone J. The VMAT-2 Inhibitor Tetrabenazine Affects Effort-Related Decision Making in a Progressive Ratio/Chow Feeding Choice Task: Reversal with Antidepressant Drugs. PLOS ONE 2014, 9: e99320. PMID: 24937131, PMCID: PMC4061002, DOI: 10.1371/journal.pone.0099320.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntidepressive AgentsBenzazepinesBenzophenonesBupropionCannabinoid Receptor AntagonistsChoice BehaviorDepressionDopamine AntagonistsDrug Evaluation, PreclinicalFeeding BehaviorMaleNitrophenolsPyrazolesRats, Sprague-DawleySalicylamidesSelegilineTetrabenazineTolcaponeVesicular Monoamine Transport ProteinsXanthinesConceptsChow intakeAdenosine A2A antagonist MSX-3Vesicular monoamine transport (VMAT-2) inhibitor tetrabenazineCB1 receptor neutral antagonistsMAO-B inhibitor deprenylEffort-related decisionAppetite suppressant drugsVMAT-2 inhibitor tetrabenazineProgressive ratioDA antagonist haloperidolInhibitor tetrabenazineEffort-related effectsMSX-3High-carbohydrate foodsAntagonist haloperidolDepressed patientsMajor depressionAntidepressant drugsLab chowRodent modelsDepressive symptomsMotivational symptomsAnimal modelsSelective dopaminePsychomotor retardation
2012
Dopaminergic Modulation of Effort-Related Choice Behavior as Assessed by a Progressive Ratio Chow Feeding Choice Task: Pharmacological Studies and the Role of Individual Differences
Randall P, Pardo M, Nunes E, Cruz L, Vemuri V, Makriyannis A, Baqi Y, Müller C, Correa M, Salamone J. Dopaminergic Modulation of Effort-Related Choice Behavior as Assessed by a Progressive Ratio Chow Feeding Choice Task: Pharmacological Studies and the Role of Individual Differences. PLOS ONE 2012, 7: e47934. PMID: 23110135, PMCID: PMC3478264, DOI: 10.1371/journal.pone.0047934.Peer-Reviewed Original ResearchMeSH Keywords3,3'-DiaminobenzidineAdenosine A2 Receptor AntagonistsAnalysis of VarianceAnimal FeedAnimal Nutritional Physiological PhenomenaAnimalsChoice BehaviorDopamineDopamine and cAMP-Regulated Phosphoprotein 32Dopamine AntagonistsFeeding BehaviorHaloperidolImmunohistochemistryIndividualityMalePiperidinesPyrazolesRatsRats, Sprague-DawleyXanthinesConceptsProgressive ratioLever pressesPrimary food motivationNucleus accumbens coreCB1 inverse agonistsFood-seeking behaviorChow intakeMSX-3DA transmissionDA antagonismDopaminergic modulationDrug treatmentHigh respondersLaboratory chowLow respondersChow consumptionEffort-related processesSignal transduction activityAccumbens coreMesolimbic dopaminePharmacological studiesFood-reinforced tasksInverse agonistBehavioral activationFood motivation
2010
The novel cannabinoid CB1 antagonist AM6545 suppresses food intake and food-reinforced behavior
Randall P, Vemuri V, Segovia K, Torres E, Hosmer S, Nunes E, Santerre J, Makriyannis A, Salamone J. The novel cannabinoid CB1 antagonist AM6545 suppresses food intake and food-reinforced behavior. Pharmacology Biochemistry And Behavior 2010, 97: 179-184. PMID: 20713079, PMCID: PMC3522179, DOI: 10.1016/j.pbb.2010.07.021.Peer-Reviewed Original ResearchConceptsAppetite suppressant drugsFood-motivated behaviorHigh-fat dietCentral nervous systemFood-reinforced behaviorSame dose rangeCB1 inverse agonistsUndesirable side effectsChow intakeIntraperitoneal administrationAM6545CB1 receptorsAppetite suppressantsCannabinoid antagonistFood intakeHigh doseSide effectsNervous systemPoor penetrabilityInverse agonistNeutral antagonistsDose rangeMild suppressionIntakeAntagonist
2009
Intracerebroventricular administration of cannabinoid CB1 receptor antagonists AM251 and AM4113 fails to alter food-reinforced behavior in rats
Sink K, Segovia K, Nunes E, Collins L, Vemuri V, Thakur G, Makriyannis A, Salamone J. Intracerebroventricular administration of cannabinoid CB1 receptor antagonists AM251 and AM4113 fails to alter food-reinforced behavior in rats. Psychopharmacology 2009, 206: 223-232. PMID: 19588124, PMCID: PMC4425366, DOI: 10.1007/s00213-009-1602-8.Peer-Reviewed Original ResearchMeSH KeywordsAnalysis of VarianceAnimalsBehavior, AnimalConditioning, OperantDose-Response Relationship, DrugDrug Administration RoutesDrug InteractionsEatingFood DeprivationInjections, IntraventricularMaleMotor ActivityPiperidinesPyrazolesRatsRats, Sprague-DawleyReceptor, Cannabinoid, CB1Reinforcement ScheduleReinforcement, PsychologyConceptsFood-reinforced behaviorCB1 receptorsLocomotor suppressionFood-motivated behaviorCannabinoid CB1 receptorsCB1 neutral antagonistsSame dose rangeModulation of locomotionIntracerebroventricular administrationICV administrationLocus of actionLower brainstemReceptor transmissionPeripheral receptorsSystemic administrationLateral ventricleAppetite suppressantsNucleus accumbensAM251AM4113Inverse agonistNeutral antagonistsDose rangeAdministrationReceptors