Multilayer network analysis reveals instability of brain dynamics in untreated first-episode schizophrenia
Gao Z, Xiao Y, Zhu F, Tao B, Zhao Q, Yu W, Sweeney J, Gong Q, Lui S. Multilayer network analysis reveals instability of brain dynamics in untreated first-episode schizophrenia. Cerebral Cortex 2024, 34: bhae402. PMID: 39375878, DOI: 10.1093/cercor/bhae402.Peer-Reviewed Original ResearchConceptsDorsal attention networkFirst-episode schizophreniaNetwork switching rateAntipsychotic treatmentSchizophrenia patientsReduction of negative symptomsResting-state functional magnetic resonance imaging dataUntreated first-episode schizophreniaDrug-naive schizophrenia patientsHealthy controlsFunctional magnetic resonance imaging dataEarly-stage schizophreniaFirst-episode drug-naive schizophrenia patientsInferior parietal lobuleFunctional network activityBrain network activityMagnetic resonance imaging dataNetwork activityAntipsychotic medicationNegative symptomsParietal lobuleAcute psychosisParietal regionsSchizophreniaMultilayer network analysisProgressive alterations of resting-state hypothalamic dysconnectivity in schizophrenia
Li X, Zeng J, Liu N, Yang C, Tao B, Sun H, Gong Q, Zhang W, Li C, Lui S. Progressive alterations of resting-state hypothalamic dysconnectivity in schizophrenia. Progress In Neuro-Psychopharmacology And Biological Psychiatry 2024, 135: 111127. PMID: 39181307, DOI: 10.1016/j.pnpbp.2024.111127.Peer-Reviewed Original ResearchHypothalamic functional connectivityBilateral anterior cingulate cortexAnterior cingulate cortexFunctional connectivityFES patientsCingulate cortexFC decreaseRight thalamusChronically treated schizophrenia patientsHealthy controlsSeed-based functional connectivityFirst-episode patientsPathogenesis of schizophreniaNature of schizophreniaAge-related declineAntipsychotic treatmentAntipsychotic medicationRight caudateLeft putamenIllness durationAnalysis of covarianceSchizophreniaDiagnostic groupsHC groupHypothalamus dysfunctionMultivariate associations between neuroanatomy and cognition in unmedicated and medicated individuals with schizophrenia
Zhao Q, Gao Z, Yu W, Xiao Y, Hu N, Wei X, Tao B, Zhu F, Li S, Lui S. Multivariate associations between neuroanatomy and cognition in unmedicated and medicated individuals with schizophrenia. Schizophrenia 2024, 10: 62. PMID: 39004627, PMCID: PMC11247086, DOI: 10.1038/s41537-024-00482-0.Peer-Reviewed Original ResearchFirst-episode schizophreniaCortical surface areaSubcortical volumesMedicated individualsFirst-episode schizophrenia sampleCortical thicknessBrain-behavior profilesAnterior cingulate cortexRight parahippocampal gyrusVerbal fluency testInferior parietal lobuleMultiple cognitive domainsVerbal memory performanceSample of individualsAntipsychotic doseAntipsychotic medicationPsychopathological symptomsCingulate cortexNeurobiological basisFluency testRight caudateMemory performanceParietal lobuleCognitive domainsIllness duration