2023
Brain Networks and Adolescent Alcohol Use
Yip S, Lichenstein S, Liang Q, Chaarani B, Dager A, Pearlson G, Banaschewski T, Bokde A, Desrivières S, Flor H, Grigis A, Gowland P, Heinz A, Brühl R, Martinot J, Martinot M, Artiges E, Nees F, Orfanos D, Paus T, Poustka L, Hohmann S, Millenet S, Fröhner J, Smolka M, Vaidya N, Walter H, Whelan R, Schumann G, Garavan H. Brain Networks and Adolescent Alcohol Use. JAMA Psychiatry 2023, 80: 1131-1141. PMID: 37647053, PMCID: PMC10469292, DOI: 10.1001/jamapsychiatry.2023.2949.Peer-Reviewed Original ResearchConceptsAlcohol Use Disorders Identification TestAlcohol use riskAlcohol misuseUse riskAlcohol use disorderMale adolescentsDisorders Identification TestSingle-site studyIntervention effortsWhole-brain patternsMean ageAlcohol use dataLeading causeMagnetic resonance imaging dataMAIN OUTCOMEReward-related processesHigh riskSeparate cohortUse disordersAlcohol consumptionCurrent severityAdolescent neurodevelopmentAlcohol use behaviorsAlcohol useAUDIT scores
2018
Relationship between fMRI response during a nonverbal memory task and marijuana use in college students
Dager AD, Tice MR, Book GA, Tennen H, Raskin SA, Austad CS, Wood RM, Fallahi CR, Hawkins KA, Pearlson GD. Relationship between fMRI response during a nonverbal memory task and marijuana use in college students. Drug And Alcohol Dependence 2018, 188: 71-78. PMID: 29754029, PMCID: PMC6756147, DOI: 10.1016/j.drugalcdep.2018.03.025.Peer-Reviewed Original ResearchConceptsInferior frontal gyrusMJ usersFMRI responsesCollege studentsMemory taskMJ useFunctional magnetic resonance imaging (fMRI) responsesNonverbal memory tasksLower fMRI responseRecognition memoryNeural correlatesMagnetic resonance imaging responseFrontal gyrusVisual encodingRecognition taskOccupational functioningAge 18Memory dysfunctionMarijuana useAcademic performanceLeft hippocampusHippocampal dysfunctionGroup differencesRight hippocampusTaskLongitudinal Effects of Alcohol Consumption on the Hippocampus and Parahippocampus in College Students
Meda SA, Hawkins KA, Dager AD, Tennen H, Khadka S, Austad CS, Wood RM, Raskin S, Fallahi CR, Pearlson GD. Longitudinal Effects of Alcohol Consumption on the Hippocampus and Parahippocampus in College Students. Biological Psychiatry Cognitive Neuroscience And Neuroimaging 2018, 3: 610-617. PMID: 29680476, PMCID: PMC6062479, DOI: 10.1016/j.bpsc.2018.02.006.Peer-Reviewed Original ResearchConceptsAlcohol consumptionAlcohol use indicesHippocampal volume declineBrain magnetic resonanceLongitudinal effectsMemory scoresCalifornia Verbal Learning Test-IIAlcohol-induced memory blackoutsPara-hippocampusHippocampal volumeMemory blackoutsLongitudinal brainVolume declineDrinking indicesLongitudinal pipelinePoorer memory performancePoorer memory scoresHippocampusTest IICross-sectional literatureDrinking-related measuresBrainAlcohol researchMagnetic resonanceScores
2017
The effect of high-dose atorvastatin on neural activity and cognitive function
Taylor BA, Dager AD, Panza GA, Zaleski AL, Meda S, Book G, Stevens MC, Tartar S, White CM, Polk DM, Pearlson GD, Thompson PD. The effect of high-dose atorvastatin on neural activity and cognitive function. American Heart Journal 2017, 197: 166-174. PMID: 29447778, PMCID: PMC6083849, DOI: 10.1016/j.ahj.2017.10.027.Peer-Reviewed Original ResearchConceptsFunctional magnetic resonance imagingGreater activationStroop color-word scoresHopkins Verbal Learning Test-RevisedFigural memory tasksStandard neuropsychological assessmentColor-Word scoreStandard neuropsychological testsBrain activation patternsNeuropsychological test scoresSternberg taskBrain neural activationMemory taskFMRI taskTask versionsNeuropsychological testsNeural activationNeuropsychological assessmentCognitive testingEffect of statinsCognitive functionSignificant group-time interactionNeural activityBilateral precuneusClock TestLongitudinal influence of alcohol and marijuana use on academic performance in college students
Meda SA, Gueorguieva RV, Pittman B, Rosen RR, Aslanzadeh F, Tennen H, Leen S, Hawkins K, Raskin S, Wood RM, Austad CS, Dager A, Fallahi C, Pearlson GD. Longitudinal influence of alcohol and marijuana use on academic performance in college students. PLOS ONE 2017, 12: e0172213. PMID: 28273162, PMCID: PMC5342177, DOI: 10.1371/journal.pone.0172213.Peer-Reviewed Original ResearchEffects of Drinking Patterns on Prospective Memory Performance in College Students
Zamroziewicz M, Raskin SA, Tennen H, Austad CS, Wood RM, Fallahi CR, Dager AD, Sawyer B, Leen S, Pearlson GD. Effects of Drinking Patterns on Prospective Memory Performance in College Students. Neuropsychology 2017, 31: 191-199. PMID: 27841457, PMCID: PMC5280574, DOI: 10.1037/neu0000313.Peer-Reviewed Original ResearchConceptsAlcohol Effects QuestionnaireProspective memoryAlcohol-induced amnesiaPM taskRetrospective memoryTimeline Follow-BackCollege studentsMemory testingEvent-based PM taskTime-based PM taskMeasures of PMTime-based prospective memoryAlcohol useFourth-year college studentsYear college studentsPM itemsRM taskHeavy drinkersConsequences ScaleEffects of alcoholParticipants' abilityMental Disorders-Fourth EditionRM performanceHeavy alcohol useTraditional college students
2016
Neurobiological signatures associated with alcohol and drug use in the human adolescent brain
Silveri MM, Dager AD, Cohen-Gilbert JE, Sneider JT. Neurobiological signatures associated with alcohol and drug use in the human adolescent brain. Neuroscience & Biobehavioral Reviews 2016, 70: 244-259. PMID: 27377691, PMCID: PMC5494836, DOI: 10.1016/j.neubiorev.2016.06.042.Peer-Reviewed Original ResearchConceptsAdolescent brain developmentBrain developmentNeurobiological signatureHuman adolescent brainSubstance useInitiation of alcoholInitiation of useQuantity of useAdolescent brainAdolescent alcoholProspective InvestigationDrug usersFrontal lobeDrug useCommon alterationsMR studiesBody of workBrainSecond decadeAlterationsImportant directionMR modalitiesInitiation
2015
A Preliminary Prospective Study of an Escalation in ‘Maximum Daily Drinks’, Fronto-Parietal Circuitry and Impulsivity-Related Domains in Young Adult Drinkers
Worhunsky PD, Dager AD, Meda SA, Khadka S, Stevens MC, Austad CS, Raskin SA, Tennen H, Wood RM, Fallahi CR, Potenza MN, Pearlson GD. A Preliminary Prospective Study of an Escalation in ‘Maximum Daily Drinks’, Fronto-Parietal Circuitry and Impulsivity-Related Domains in Young Adult Drinkers. Neuropsychopharmacology 2015, 41: 1637-1647. PMID: 26514582, PMCID: PMC4832027, DOI: 10.1038/npp.2015.332.Peer-Reviewed Original ResearchConceptsAlcohol useYoung adult drinkersYoung adultsPreliminary prospective studyAdult drinkersExcessive alcohol useAlcohol use disorderFunctional network activityProspective studyUse disordersFunctional brain networksGo/No-Go taskNeurobiological alterationsDomain scoresGreater riskDaily drinksAddictive disordersDrinkersDrinking occasionsLongitudinal studyFronto-parietal circuitryBrain networks
2014
Shared Genetic Factors Influence Amygdala Volumes and Risk for Alcoholism
Dager AD, McKay DR, Kent JW, Curran JE, Knowles E, Sprooten E, Göring H, Dyer TD, Pearlson GD, Olvera RL, Fox PT, Lovallo WR, Duggirala R, Almasy L, Blangero J, Glahn DC. Shared Genetic Factors Influence Amygdala Volumes and Risk for Alcoholism. Neuropsychopharmacology 2014, 40: 412-420. PMID: 25079289, PMCID: PMC4443955, DOI: 10.1038/npp.2014.187.Peer-Reviewed Original ResearchConceptsAmygdala volumeSubcortical volumesFamily historyLifetime AUDAlcohol-related damageGenetic factorsSmaller amygdala volumesPre-existing deficitsAUD riskSuch family historyStructural brain imagesBrain shrinkageDorsal striatumAlcohol abuseNeurotoxic damageVentral striatumSubcortical structuresCommon genetic factorsShared genetic factorsCommon genetic featuresUnrelated controlsMexican-American individualsGenetic featuresStriatumRiskFunctional magnetic resonance imaging (fMRI) response to alcohol pictures predicts subsequent transition to heavy drinking in college students
Dager AD, Anderson BM, Rosen R, Khadka S, Sawyer B, Jiantonio‐Kelly R, Austad CS, Raskin SA, Tennen H, Wood RM, Fallahi CR, Pearlson GD. Functional magnetic resonance imaging (fMRI) response to alcohol pictures predicts subsequent transition to heavy drinking in college students. Addiction 2014, 109: 585-595. PMID: 24304235, PMCID: PMC3951577, DOI: 10.1111/add.12437.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAlcohol DrinkingAlcohol-Related DisordersAlcoholic BeveragesAlcoholismBinge DrinkingBrainBrain MappingCaudate NucleusCerebral CortexCuesFactor Analysis, StatisticalFemaleFunctional NeuroimagingGyrus CinguliHumansLongitudinal StudiesMagnetic Resonance ImagingMalePhotic StimulationPrefrontal CortexRisk FactorsStudentsUniversitiesYoung AdultConceptsHeavy drinkersAlcohol-related problemsBOLD responseFunctional magnetic resonance imaging (fMRI) blood oxygen level dependent (BOLD) responseBlood oxygen level-dependent (BOLD) responseLevel-dependent responsesSingle brain networkSubsequent heavy drinkingPictures of alcoholBaseline factorsRisk factorsModerate drinkersBilateral caudateAnterior cingulateGreater riskOrbitofrontal cortexHeavy drinkingYoung adultsDrinkersDrinking amountGroup differencesBaselineAlcohol cuesLongitudinal studyNeural responses
2013
fMRI response during figural memory task performance in college drinkers
Dager AD, Jamadar S, Stevens MC, Rosen R, Jiantonio-Kelly RE, Sisante JF, Raskin SA, Tennen H, Austad CS, Wood RM, Fallahi CR, Pearlson GD. fMRI response during figural memory task performance in college drinkers. Psychopharmacology 2013, 231: 167-179. PMID: 23949205, PMCID: PMC3877735, DOI: 10.1007/s00213-013-3219-1.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAlcohol DrinkingAlcoholismBrain MappingData Interpretation, StatisticalFemaleFrontal LobeHippocampusHumansImage Processing, Computer-AssistedMagnetic Resonance ImagingMaleMemoryOxygenParietal LobePsychomotor PerformanceReaction TimeRecognition, PsychologyVisual PerceptionYoung AdultConceptsFunctional magnetic resonance imagingAlcohol use disorderBOLD responseBilateral posterior parietal cortexMemory task performanceHeavy-drinking college studentsInferior frontal activationRight dorsolateral prefrontalCorrect encodingWorse memory performanceDefault mode regionsIncorrect encodingAlcohol-related impairmentMemory-related areasHeavy drinkersGreater BOLD responseLight drinkersPosterior parietal cortexBlood oxygen level-dependent functional magnetic resonance imagingQuantity/frequencyLevel-dependent functional magnetic resonance imagingInsula responseNeural correlatesFigural memoryFrontal activationInfluence of Alcohol Use on Neural Response to Go/No-Go Task in College Drinkers
Ahmadi A, Pearlson GD, Meda SA, Dager A, Potenza MN, Rosen R, Austad CS, Raskin SA, Fallahi CR, Tennen H, Wood RM, Stevens MC. Influence of Alcohol Use on Neural Response to Go/No-Go Task in College Drinkers. Neuropsychopharmacology 2013, 38: 2197-2208. PMID: 23670589, PMCID: PMC3773670, DOI: 10.1038/npp.2013.119.Peer-Reviewed Original ResearchConceptsSupplementary motor areaHeavy drinkersLight drinkersCollege-age drinkersAlcohol useResponse inhibitionBlood oxygen level-dependent (BOLD) responseHeavy alcohol drinkersImportant risk factorBilateral middle frontal gyrusAlcohol use disorderBrain activityAnterior cingulate cortexGreater BOLD responseLevel-dependent responsesMiddle frontal gyrusSuperior temporal gyrusImpaired response inhibitionAlcohol drinkersRisk factorsResponse inhibition taskRight hippocampusMotor areaWarrants additional investigationBilateral parietal lobules
2012
Influence of Alcohol Use and Family History of Alcoholism on Neural Response to Alcohol Cues in College Drinkers
Dager AD, Anderson BM, Stevens MC, Pulido C, Rosen R, Jiantonio‐Kelly R, Sisante J, Raskin SA, Tennen H, Austad CS, Wood RM, Fallahi CR, Pearlson GD. Influence of Alcohol Use and Family History of Alcoholism on Neural Response to Alcohol Cues in College Drinkers. Alcohol Clinical And Experimental Research 2012, 37: e161-e171. PMID: 23078363, PMCID: PMC3548054, DOI: 10.1111/j.1530-0277.2012.01879.x.Peer-Reviewed Original ResearchConceptsAlcohol cue reactivityFamily historyHeavy drinkersCue reactivityLight drinkersHeavy drinkingMagnetic resonance imaging responseBOLD responseBlood oxygen level-dependent (BOLD) contrastAlcohol cuesVisual association regionsAlcohol use disorderAlcohol imagesFunctional magnetic resonance imaging (fMRI) responsesMedial frontal cortexGreater BOLD responseLevel-dependent contrastTemporo-parietal regionsRisk factorsFrontal cortexDorsal striatumUse disordersAnterior cingulateBeverage imagesImaging response