Paricalcitol (19-nor-1,25-dihydroxyvitamin D2) and calcitriol (1,25-dihydroxyvitamin D3) exert potent immunomodulatory effects on dendritic cells and inhibit induction of antigen-specific T cells
Sochorová K, Budinský V, Rožková D, Tobiasová Z, Dusilová-Sulková S, Špíšek R, Bartůňková J. Paricalcitol (19-nor-1,25-dihydroxyvitamin D2) and calcitriol (1,25-dihydroxyvitamin D3) exert potent immunomodulatory effects on dendritic cells and inhibit induction of antigen-specific T cells. Clinical Immunology 2009, 133: 69-77. PMID: 19660988, DOI: 10.1016/j.clim.2009.06.011.Peer-Reviewed Original ResearchConceptsAntigen-specific T cellsDendritic cellsT cellsVDR agonistsImmunomodulatory effectsChronic immune-mediated inflammatory diseaseEnd-stage renal disease patientsImmune-mediated inflammatory diseasesImmunomodulatory activityVitamin D receptor activatorsRenal disease patientsImmature dendritic cellsRisk of atherosclerosisPathogenesis of atherosclerosisPotent immunomodulatory effectsToll-like receptorsBioactive IL-12Functional TregsIL-12DC differentiationCalcium resorptionDisease patientsHypercalcemic effectInflammatory diseasesImmunomodulatory potency